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Suresh Kumar V.,Sree Narayana Guru Institute of Science and Technology | Aramudhan,Perunthalaivar Kamarajar Engineering College
Journal of Theoretical and Applied Information Technology | Year: 2014

Cloud computing is computing service delivery over the Internet. Cloud services allow people and businesses to use software/hardware managed by third parties in remote locations. Cloud computing ensures access to information and computer resources from wherever a network connection is available. Task scheduling is fundamental to achieving cloud computing efficiency. But, it is a challenge to efficiently schedule algorithm design and implement it, as general scheduling is a NP-complete problem. Most taskscheduling cloud computing methods consider task resource requirements for CPU and memory, and not bandwidth requirements. This paper proposes to optimize scheduling using BAT-Gravitational hybrid algorithm with resources being chosen on trust. © 2005 - 2014 JATIT & LLS. All rights reserved. Source


Salil G.,Kerala University | Salil G.,Mar Baselios Dental College | Nevin K.G.,Kerala University | Nevin K.G.,Sree Narayana Guru Institute of Science and Technology | Rajamohan T.,Kerala University
Journal of the Science of Food and Agriculture | Year: 2012

Background: Coconut kernel protein (CKP) has been reported to contain significant amounts of L-arginine. Its potential effect on glucose homeostasis, possibly through the nitric oxide synthase (NO) pathway, was therefore investigated in alloxan-induced diabetic rats. Diabetes was induced by a single intraperitoneal dose of alloxan (150 mg kg -1 body weight). Experimental rats were grouped as follows: Group I, normal control; Group II, diabetic control; Group III, diabetic + CKP; Group IV, diabetic + L-arginine; Group V, diabetic + L-arginine + L-N G-Nitroarginine methyl ester (L-NAME). Purified CKP isolated from dried coconut kernel and L-arginine was administered to rats along with a semi-synthetic diet for 45 days. L-NAME (0.5 mg kg -1 body weight) was given to Group V animals. After the experimental period, serum glucose, insulin, activities of liver nitric oxide synthase and arginase, liver glycogen levels and histopathology of the pancreas were evaluated. Results: Serum glucose, insulin and antioxidant enzyme activities and liver glycogen levels were found to be restored to basal levels in CKP-fed rats. Decreased arginase and increased nitric oxide synthase (NOS) activities were found in CKP- and arginine-fed rats. L-NAME treatment showed a partial effect on these parameters. Histopathology revealed that CKP and L-arginine feeding reduced the diabetes-related pancreatic damage in treated rats compared to the diabetic control. Conclusion: The results observed in this study indicate that the potential antidiabetic activity of CKP may be through an arginine-NO pathway leading to pancreatic beta cell regeneration. © 2012 Society of Chemical Industry. Source


Salil G.,Kerala University | Salil G.,Mar Baselios Dental College | Nevin K.G.,Kerala University | Nevin K.G.,Sree Narayana Guru Institute of Science and Technology | Rajamohan T.,Kerala University
Mediterranean Journal of Nutrition and Metabolism | Year: 2012

The objective of this study was to investigate the effect of arginine-rich coconut kernel protein (CKP) on alloxan-induced diabetes in comparison with L-arginine and an antidiabetic drug, glibenclamide. 1-month-old 24 male Sprague-Dawley rats, weighing 130-150 g, were randomly divided into five groups: group I-normal control, group II-diabetic control, group III-diabetic + CKP, group IV-diabetic + L-arginine, group V-diabetic + glibenclamide (0.6 mg/100 g body weight). The rats were induced diabetes by injecting a single dose of alloxan (150 mg/ 100 g body weight) intraperitoneally. After the experimental period, various parameters were analyzed. The results showed that diabetic rats treated with CKP, arginine, and glibenclamide reduced the serum glucose and had no significant effect on total serum protein content compared to diabetic control. Serum urea level was found to be comparatively reduced in arginine-, CKP-, and glibenclamide- treated rats. Toxicological analysis showed that arginine, CKP, and glibenclamide delivered to diabetic rats significantly reduced the SGOT, SGPT and ALP activities to the basal level. Histopathological analysis also showed a comparable reversible effect of CKP on alloxan-induced pancreatic damage with respect to arginine and glibenclamide- treated rats. These results clearly indicate the nontoxic and antidiabetic properties of CKP, possibly mediated through arginine. © Springer-Verlag 2012. Source


Salil G.,Kerala University | Salil G.,Mar Baselios Dental College | Nevin K.G.,Kerala University | Nevin K.G.,Sree Narayana Guru Institute of Science and Technology | Rajamohan T.,Kerala University
International Journal of Food Sciences and Nutrition | Year: 2013

Impaired lipid levels and oxidative stress are indicative of malfunction of endogenous antioxidant capacity. The aim of this study was to determine the effect of coconut kernel protein (CKP) on the lipid peroxides and antioxidant enzyme activities in diabetic rats. Diabetes was induced prior to feeding by injecting a single dose of alloxan (150 mg/kg body weight) intraperitoneally. CKP (8% w/w) was administered to these rats along with a semi-synthetic diet for 45 days. After the experimental period, peroxide products and antioxidant enzyme activities were determined. Results show that CKP maintained the antioxidant enzyme activities and levels of peroxides to the normal levels in treated group compared to diabetic rats. This study clearly show that CKP has potential effect in lowering oxidative stress associated with diabetes. This beneficial effect of CKP may be due to the high amount of biologically potent arginine present in it. © 2012 Informa UK, Ltd. Source


Varsha G.,Cochin University of Science and Technology | Arun V.,Cochin University of Science and Technology | Robinson P.P.,Cochin University of Science and Technology | Sebastian M.,Cochin University of Science and Technology | And 4 more authors.
Tetrahedron Letters | Year: 2010

An efficient one-pot synthesis of two new heterocyclic perimidines 4-(2,3-dihydro-1H-perimidin-2-yl)-2-methoxyphenol and 2-(quinoxalin-2-yl)-2,3-dihydro-1H-perimidine in good yields is presented. This methodology provides a simple, straightforward synthetic route to these interesting classes of heterocycles. Crystal structure, solvatochromism, and antibacterial activity of these organic compounds are discussed. © 2010 Elsevier Ltd. All rights reserved. Source

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