Sree Mookambika Institute of Medical science

Kulasekharam, India

Sree Mookambika Institute of Medical science

Kulasekharam, India
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Palappallil D.S.,Government TD Medical College | Ramnath S.N.,Government TD Medical College | Gangadhar R.,Sree Mookambika Institute of Medical Science
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2017

Background: Adverse drug reactions (ADRs) have become a major clinical problem causing additional burden on the total cost of a patient’s treatment. Aims and Objectives: To determine the characteristics of ADRs reported in a tertiary care center. Materials and Methods: Descriptive analysis of ADRs reported to the Department of Pharmacology over a period of 2 years from July 2012 to June 2014 was done. ADR reports were analyzed on the basis of patient characteristics, drug characteristics, predictability, preventability, severity, causality, and seriousness of the ADR. The continuous variables were expressed as mean ± standard deviation. Categorical variables were expressed as frequencies and percentages. Odds ratio (OR) was calculated to assess the risk factors for severe ADRs using SPSS 16. Results: From the 359 ADR reports, 377 ADRs were identified with mean age 43 ± 19 years. 95.3% affected single organ system, the most common being skin and appendages. The most common ADR reported was maculopapular rash. Antibiotics accounted for the maximum ADRs of which beta-lactams were the most common. 30.1% (108) ADRs occurred within 1 h of administration of the drug. In 12.73% (48) drug interactions (DIs) were cause of ADRs. Risk analysis showed that DIs (OR = 2.25, 95% confidence interval [CI] = 1.1-1.53), concomitant use of more than one drug (OR = 1.75, 95% CI = 1.97-3.18) and delayed onset ADRs (OR = 1.89, 95% CI = 1.22-3.51) were risk factors for development of severe ADRs. Conclusions: Skin and integumentary system was the most commonly affected system and beta-lactams were the most common drug class implicated to cause ADR. © 2016 Dhanya Sasidharan Palappallil et al.


Augusti K.T.,Kerala University | Jose R.,Dr Somervell Memorial Csi Medical College Karakonam | Sajitha G.R.,Sree Mookambika Institute of Medical science | Augustine P.,The Surgical Center
Indian Journal of Clinical Biochemistry | Year: 2012

This review article on the beneficial uses of Allium antioxidants tries to give some answers to the recent doubts raised by Singh et al. (Ind J Clin Biochem 25(3):225-243, 2010) against the claim of some researchers that Antioxidants (AOs) are miraculous molecules. Many people still believe that vitamins like A, C and E are the only true AOs that play important role in the corrections of metabolic derangements in life style diseases and hence all their faults are attributed to the failures of AOs as a class. This is quite unfair as there are many other natural AOs that do equal or even better AO action than the vitamins. Such is the case with the Allium S-alkyl sulfoxide aminoacids and their breakdown products viz, the various poly sulfides and their oxides e.g. allicin and ajoene type compounds which trap electrons mainly. It is true that antioxidant vitamins and β-carotene a precursor of Vitamin A bring about problems as prooxidant or as agents that block some metabolic pathways and gene expression. Again the argument that AOs cannot improve the level of antioxidant enzymes like SOD, catalase and glutathione Px is also not universal. Actually allium AOs can even spare the use of antioxidant vitamins in the body and enhance the action of antioxidant enzymes and supply of ATP and other nutrients to the tissues as the former are good vasodialators and promoters of membrane permeability. The use of AOs should be selective and moderate. Allium AOs satisfy the role of ideal AOs based on many of their invivo and invitro actions reported by the author and others. Their metabolits can regenerate them and recycle them for a sufficient time in the body. They have non antioxidant effects also such as antiplatelet, fibrinolytic, antiinflammatory, immunomodulatory, antiageing actions etc. Plant derived AOs may be more beneficial and better tolerated in their partially purified forms rather than in their absolutely purified forms as the accompanying principles have some protective and regulatory effects in general. This and other aspects of allium AOs are discussed in the paper. © 2011 Association of Clinical Biochemists of India.


Sajitha G.R.,Sree Mookambika Institute of Medical science | Jose R.,Dr Smcsi Medical College | Andrews A.,University Center | Ajantha K.G.,University Center | Augustine P.,The Surgical Center
Indian Journal of Clinical Biochemistry | Year: 2010

Daily feeding of drinking water containing lead acetate (160 mg/l) or 10% alcohol by volume or a combination of both to rats for a month produced certain deleterious effects through oxidative stress. Both heavy metal lead and alcohol are capable of doing such damages. The deleterious alterations observed were in the parameters of blood, serum and tissues, viz; Hb, Pb, proteins, lipids, lipid per oxidation, Vitamins C and E levels and enzyme activities of AST, ALT, and catalase. Simultaneous feeding of either of the two antioxidants garlic oil (GO) and vitamin E at equal doses of 100 mg/kg/day, to the rats counteracted the deleterious effects of the above two chemicals significantly. The maximum damage was brought about by feeding of drinking water containing both lead acetate and alcohol. The protective effects of GO and Vitamin E were not significantly different. The mechanism of actions of the Vitamin E and GO is probably due to their efficiency as detoxifying agents and antioxidants, to scavenging free radicals as well as an independent action of GO on the removal of lead salt as lead sulfide. © 2010 Association of Clinical Biochemists of India.


PubMed | Junior Resident and Sree Mookambika Institute of Medical Science
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Sodium valproate induced hyperammonaemic delirium with normal liver function tests is a relatively uncommon adverse effect. It may be mistaken for psychosis or worsening of mania leading to wrong diagnosis and improper management. Plasma ammonia levels should be monitored in all patients developing altered mental status after receiving valproate therapy. This is a case series of hyperammonaemic delirium due to valproate reported to the Department of Pharmacology from Department of Psychiatry over a period of one year.


PubMed | Sree Mookambika Institute of Medical science, Sree Mookambika Institute of Dental science and University of Technology Malaysia
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

Bronchial asthma constitutes important problem worldwide. This chronic lung disease has detrimental effect in the oral cavity like reduction of salivary secretion, change in salivary composition and pH.This study was conducted to compare the prevalence of dental caries in asthmatic children and healthy children, and also to evaluate the correlation between the In this study, the mean decayed, missing, filled teeth score of children in the study group was (4.53 3.38) higher than the control group (1.51 1.58) (The dental caries prevalence increases with the usage of


Bhatia M.,Post Graduate Institute of Medical Education and Research | Umapathy B.,Sree Mookambika Institute of Medical science | Navaneeth B.,Employees State Insurance Corporation Medical College
Indian Journal of Medical Microbiology | Year: 2015

Context: This study was conducted to analyze the clinical utility of various leptospira diagnostic modalities. Aims: To evaluate the role of dark field microscopy (DFM), culture, immunochromatography (IgM Leptocheck), IgM enzyme-linked immunosorbent assay (IgM ELISA), macroscopic slide agglutination test (MSAT) and microscopic agglutination test (MAT) in diagnosing leptospirosis in febrile patients. Settings and Design: Descriptive study conducted in a tertiary care hospital from January 2011 to April 2012. Subjects and Methods: Blood, urine and paired sera from 100 patients with clinical suspicion of leptospirosis (study group) were collected and subjected to DFM, culture, IgM Leptocheck, IgM ELISA and MSAT. Fifty randomly selected sera from febrile patients tested positive for infections other than leptospirosis (control sera) were also subjected to the aforementioned serological assays. All the leptospira seropositive samples were subjected to MAT. Statistical Analysis Used: Positive predictive values (PPV) and coefficient of agreement (kappa). Results: None of the clinical samples showed positivity by DFM. Leptospira inadai was isolated from a urine sample. The seropositivity of IgM Leptocheck, IgM ELISA and MSAT was 16%, 46% and 47%, respectively. The PPV of these assays was 14.3%, 8.7% and 6.5%, respectively. Poor agreement was obtained among these assays. Only four study group leptospira seropositive samples were confirmed by MAT with Australis being the predominant serovar. None of the leptospira-positive control sera were confirmed by MAT. Conclusions: DFM and culture have limited utility in diagnosing leptospirosis with serology being the mainstay. The present study shows discordant results with the commercially available serological kits. Further studies should be done to evaluate the various diagnostic modalities. © 2015, Medknow Publications. All rights reserved.


Prabhakar P.,Sree Mookambika Institute of Medical science | Meena Kumari P.,Government Hospital
Indian Journal of Public Health Research and Development | Year: 2014

The study was done to determine the prevalence of metabolic syndrome in 100 newly diagnosed patients with essential hypertension in a tertiary care hospital, from South Tamilnadu, India. Hypertension, diabetes, insulin resistance and metabolic syndrome are all risk factors for coronary heart disease. Many patients with essential hypertension have associated metabolic abnormalities at the time of diagnosis. The results obtained show that 10% of hypertensives had diabetes and 32% had impaired glucose tolerance. 54% cases had any one form of dyslipidemia. Females (65%) were more dyslipidemic than males (46.67%). 48%patients fulfilled the criteria for metabolic syndrome. 46% of hypertensives had abnormal waist circumference; 30% had raised fasting glucose; 38% had low HDL and those with raised triglyceride were also 38%. Low HDL was predominant in males whereas abnormal waist circumference, raised TGL and glucose abnormalities were predominant in females This indicates that metabolic syndrome is very common in essential hypertension and signals the need for proper laboratory investigations to initiate early treatment. © 2014 Indian Journal of Public Health Research and Development. All rights reserved.


Palappallil D.S.,Government TD Medical College | Gangadhar R.,Sree Mookambika Institute of Medical science
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: The goal of teaching medical undergraduates Pharmacology is to form a sound foundation of therapeutics. The pharmacology record books are maintained as a part of the curriculum. The purpose of this study was to obtain feedback of the medical students about the new record adopted in the institution after major revision Materials and Methods: This was a questionnaire based study done in a Government Medical College of Kerala in February 2013. The data was analysed using SPSS. The feedback on clinical pharmacology exercises was given positive and negative scores. Results: Majority (64.5%) opined that the content in pharmacology record was good. A total of 78.1% completed the record during discussions in practical classes. Majority wrote the records for understanding pharmacology. For 79.8% General Pharmacology exercises were most relevant, 33.8% considered Clinical Pharmacology exercises to be the most thought provoking. Drug use in special groups received the maximum positive score. Conclusion: The new improved pharmacology record is an effective teaching-learning method. Inclusion of more clinically oriented exercises has increased the interest of the students in the subject. © 2015, Journal of Clinical and Diagnostic Research. All rights Reserved.


PubMed | Government TD Medical College and Sree Mookambika Institute of Medical science
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

The goal of teaching medical undergraduates Pharmacology is to form a sound foundation of therapeutics. The pharmacology record books are maintained as a part of the curriculum. The purpose of this study was to obtain feedback of the medical students about the new record adopted in the institution after major revision.This was a questionnaire based study done in a Government Medical College of Kerala in February 2013. The data was analysed using SPSS. The feedback on clinical pharmacology exercises was given positive and negative scores.Majority (64.5%) opined that the content in pharmacology record was good. A total of 78.1% completed the record during discussions in practical classes. Majority wrote the records for understanding pharmacology. For 79.8% General Pharmacology exercises were most relevant, 33.8% considered Clinical Pharmacology exercises to be the most thought provoking. Drug use in special groups received the maximum positive score.The new improved pharmacology record is an effective teaching-learning method. Inclusion of more clinically oriented exercises has increased the interest of the students in the subject.


Siddaiah B.,Sree Mookambika Institute of Medical science
Journal of the Indian Medical Association | Year: 2013

The complete androgen insensitivity syndrome is a rare case of practical interest to the clinicians and students. It is an insight into the social, medical and psychological aspects of intersex. Herein, such a case of this extremely rare chromosomal anomaly of a phenotypic female but genotypic male, a male pseudohermaphrodite has been described.

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