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Siddaiah B.,Sree Mookambika Institute of Medical science
Journal of the Indian Medical Association | Year: 2013

The complete androgen insensitivity syndrome is a rare case of practical interest to the clinicians and students. It is an insight into the social, medical and psychological aspects of intersex. Herein, such a case of this extremely rare chromosomal anomaly of a phenotypic female but genotypic male, a male pseudohermaphrodite has been described. Source


Palappallil D.S.,Government TD Medical College | Gangadhar R.,Sree Mookambika Institute of Medical science
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: The goal of teaching medical undergraduates Pharmacology is to form a sound foundation of therapeutics. The pharmacology record books are maintained as a part of the curriculum. The purpose of this study was to obtain feedback of the medical students about the new record adopted in the institution after major revision Materials and Methods: This was a questionnaire based study done in a Government Medical College of Kerala in February 2013. The data was analysed using SPSS. The feedback on clinical pharmacology exercises was given positive and negative scores. Results: Majority (64.5%) opined that the content in pharmacology record was good. A total of 78.1% completed the record during discussions in practical classes. Majority wrote the records for understanding pharmacology. For 79.8% General Pharmacology exercises were most relevant, 33.8% considered Clinical Pharmacology exercises to be the most thought provoking. Drug use in special groups received the maximum positive score. Conclusion: The new improved pharmacology record is an effective teaching-learning method. Inclusion of more clinically oriented exercises has increased the interest of the students in the subject. © 2015, Journal of Clinical and Diagnostic Research. All rights Reserved. Source


Bhatia M.,Post Graduate Institute of Medical Education and Research | Umapathy B.,Sree Mookambika Institute of Medical science | Navaneeth B.,Employees State Insurance Corporation Medical College
Indian Journal of Medical Microbiology | Year: 2015

Context: This study was conducted to analyze the clinical utility of various leptospira diagnostic modalities. Aims: To evaluate the role of dark field microscopy (DFM), culture, immunochromatography (IgM Leptocheck), IgM enzyme-linked immunosorbent assay (IgM ELISA), macroscopic slide agglutination test (MSAT) and microscopic agglutination test (MAT) in diagnosing leptospirosis in febrile patients. Settings and Design: Descriptive study conducted in a tertiary care hospital from January 2011 to April 2012. Subjects and Methods: Blood, urine and paired sera from 100 patients with clinical suspicion of leptospirosis (study group) were collected and subjected to DFM, culture, IgM Leptocheck, IgM ELISA and MSAT. Fifty randomly selected sera from febrile patients tested positive for infections other than leptospirosis (control sera) were also subjected to the aforementioned serological assays. All the leptospira seropositive samples were subjected to MAT. Statistical Analysis Used: Positive predictive values (PPV) and coefficient of agreement (kappa). Results: None of the clinical samples showed positivity by DFM. Leptospira inadai was isolated from a urine sample. The seropositivity of IgM Leptocheck, IgM ELISA and MSAT was 16%, 46% and 47%, respectively. The PPV of these assays was 14.3%, 8.7% and 6.5%, respectively. Poor agreement was obtained among these assays. Only four study group leptospira seropositive samples were confirmed by MAT with Australis being the predominant serovar. None of the leptospira-positive control sera were confirmed by MAT. Conclusions: DFM and culture have limited utility in diagnosing leptospirosis with serology being the mainstay. The present study shows discordant results with the commercially available serological kits. Further studies should be done to evaluate the various diagnostic modalities. © 2015, Medknow Publications. All rights reserved. Source


Sajitha G.R.,Sree Mookambika Institute of Medical science | Jose R.,Dr Smcsi Medical College | Andrews A.,University Center | Ajantha K.G.,University Center | Augustine P.,The Surgical Center
Indian Journal of Clinical Biochemistry | Year: 2010

Daily feeding of drinking water containing lead acetate (160 mg/l) or 10% alcohol by volume or a combination of both to rats for a month produced certain deleterious effects through oxidative stress. Both heavy metal lead and alcohol are capable of doing such damages. The deleterious alterations observed were in the parameters of blood, serum and tissues, viz; Hb, Pb, proteins, lipids, lipid per oxidation, Vitamins C and E levels and enzyme activities of AST, ALT, and catalase. Simultaneous feeding of either of the two antioxidants garlic oil (GO) and vitamin E at equal doses of 100 mg/kg/day, to the rats counteracted the deleterious effects of the above two chemicals significantly. The maximum damage was brought about by feeding of drinking water containing both lead acetate and alcohol. The protective effects of GO and Vitamin E were not significantly different. The mechanism of actions of the Vitamin E and GO is probably due to their efficiency as detoxifying agents and antioxidants, to scavenging free radicals as well as an independent action of GO on the removal of lead salt as lead sulfide. © 2010 Association of Clinical Biochemists of India. Source


Prabhakar P.,Sree Mookambika Institute of Medical science | Meena Kumari P.,Government Hospital
Indian Journal of Public Health Research and Development | Year: 2014

The study was done to determine the prevalence of metabolic syndrome in 100 newly diagnosed patients with essential hypertension in a tertiary care hospital, from South Tamilnadu, India. Hypertension, diabetes, insulin resistance and metabolic syndrome are all risk factors for coronary heart disease. Many patients with essential hypertension have associated metabolic abnormalities at the time of diagnosis. The results obtained show that 10% of hypertensives had diabetes and 32% had impaired glucose tolerance. 54% cases had any one form of dyslipidemia. Females (65%) were more dyslipidemic than males (46.67%). 48%patients fulfilled the criteria for metabolic syndrome. 46% of hypertensives had abnormal waist circumference; 30% had raised fasting glucose; 38% had low HDL and those with raised triglyceride were also 38%. Low HDL was predominant in males whereas abnormal waist circumference, raised TGL and glucose abnormalities were predominant in females This indicates that metabolic syndrome is very common in essential hypertension and signals the need for proper laboratory investigations to initiate early treatment. © 2014 Indian Journal of Public Health Research and Development. All rights reserved. Source

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