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PubMed | Vivekanandha Dental College for Women, Madha Dental College and Hospital, Sree Mookambika Institute of Dental Science and Annamalai University
Type: Review | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

Early detection of cancer greatly decreases the morbidity and mortality rates and thereby increases the 5-year survival rates. In developing countries like India where the disease is highly prevalent focus is mainly on decreasing the mortality rates which can be easily achieved by detection at an asymptomatic stage. Visual examination has been the standard screening method for screening oral cancer through several decades, and it is well known that conventional visual examination is limited to subjective interpretation and cannot be easily achieved in certain anatomical sites. As a solution to all these adjunctive techniques have emerged, and it has been widely used. An effort is made through this paper to review the most commonly used adjunctive aids for the detection of premalignancy and cancer.

Ganesh C.,Srm Kattankulathur Dental College | Sangeetha G.,Sree Mookambika Institute of Dental Science | Narayanan V.,Saveetha Dental College | Umamaheswari T.,Srm Kattankulathur Dental College
Journal of Clinical Imaging Science | Year: 2013

Lymphangioma is a benign hamartomatous tumor of lymphatic vessels. This lymphatic malformation is characterized by an abnormal proliferation of lymphatic vessels. Extra-oral lymphangiomas occur more frequently in the neck region predominantly in the posterior triangle, while intra-oral lymphangiomas are commonly seen in the tongue mainly on the dorsum surface. Various imaging modalities such as ultrasound and color Doppler are very useful in viewing the extent of the lesion. In most of the cases, surgical excision is the treatment of choice. The prognosis is good for most patients, but recurrence has also been reported in some cases, presumably because the lesion is interwoven between muscle fibers, preventing complete removal. This case report discusses the clinical features, color Doppler imaging, histopathology, and treatment of lymphangioma.

PubMed | Sumukha Orofacial and Dental Care, Sree Mookambika Institute of Dental science and Sri Hasanamba Dental College and Hospital
Type: Journal Article | Journal: Journal of International Society of Preventive & Community Dentistry | Year: 2016

To evaluate the efficacy of platelet rich fibrin (PRF) with or without bone graft [demineralized bone matrix (DBM) graft] in the treatment of intrabony defects based on clinical and radiographic parameters.Thirty six intrabony defects in 36 patients were randomly divided into three different groups and were treated with group A (PRF with DBM) or group B (PRF alone) or group C [open flap debridement (OFD)]. Clinical parameters such as plaque index (PI), gingival index (GI), probing depth (PD), relative attachment level (RAL), and gingival recession (GR) were assessed at baseline and 9 months postoperatively; radiographic parameters such as linear bone growth (LBG) and percentage in bone fill (%BF) were calculated by using the image analysis software. Comparisons of groups were analyzed using Kruskal-Wallis analysis of variance test. Pair-wise comparison of groups was done by Mann-Whitney U test.Mean PD reduction and RAL gain were greater in group A (4.25 1.48, 3.92 0.90) and group B (3.82 0.75, 3.27 0.65) than control (3.00 1.21, 2.25 0.62). Furthermore, statistically significant improvement in LBG and %BF was found in group A (3.47 0.53, 61.53 4.54) compared to group B (2.55 0.61, 49.60 14.08) and group C (1.21 0.80, 24.69 15.59).The study demonstrated that PRF improves clinical and radiological parameters compared to OFD alone in intrabony defects. Addition of DBM enhances the effects of PRF in RAL gain and radiographic defect fill.

Sherubin E.J.,Sree Mookambika Institute of Dental science | Kannan K.S.,Sree Mookambika Institute of Dental science | Kumar D.N.,Sree Mookambika Institute of Dental science | Joseph I.,Sree Mookambika Institute of Dental science
Journal of Oral and Maxillofacial Pathology | Year: 2013

Background Objectives: Alterations in the lipid profile have long been associated with various cancers because lipids play a key role in maintenance of cell integrity. This study was to estimate the plasma lipid levels in patients with oral cancer and to correlate the values with the histopathological grades. Materials and Methods: The study group included 50 patients with oral cancer aged between 20 and 60 years who had visited the Department of Oral Medicine and Radiology during the period of September 2005 to July 2007. After the histotopathological confirmation, their plasma lipid levels were estimated using auto analyzer and the data was statistically analyzed. Results: The study revealed a significant decrease in the total plasma lipid levels in patients with oral cancer in comparison with the standard values. Comparing the plasma lipid levels with the histopathological grades, we observed a significant variation in the levels of total cholesterol, very low density lipoprotein, low-density lipoprotein, high-density lipoprotein and triglycerides Conclusion: The variation in the levels of plasma cholesterol and other lipid constituents in patients with cancer might be due to their increased utilization by neoplastic cells for new membrane biosynthesis. This study was an attempt to estimate the plasma lipids in oral cancer patients and its significance on histopathological grades. We observed a relationship between lower plasma lipids and oral cancer. The result of our study strongly warrants an in-depth research with larger samples and a longer follow-up to consider the low plasma lipid status in oral cancer patients as a useful indicator to assess the course and prognosis of the disease.

Isaac Joseph T.,Sree Mookambika Institute of Dental science | Vargheese G.,Sree Mookambika Institute of Dental science | George D.,Sree Mookambika Institute of Dental science | Sathyan P.,Sree Mookambika Institute of Dental science
Journal of Oral and Maxillofacial Pathology | Year: 2012

Oral erythema multiforme (EM) is considered as a third category of EM other than EM minor and major. Patients present with oral and lip ulcerations typical of EM but without any skin target lesions. It has been reported that primary attacks of oral EM is confined to the oral mucosa but the subsequent attacks can produce more severe forms of EM involving the skin. Hence, it is important to identify and distinguish them from other ulcerative disorders involving oral cavity for early management. This article reports two cases of oral EM that presented with oral and lip ulcerations typical of EM without any skin lesions and highlights the importance of early diagnosis and proper management.

PubMed | Sree Mookambika Institute of Dental science
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

The aim and objective is to evaluate the level of awareness and attitude about radiation hazards and safety practices among general dental practitioners in Trivandrum District, Kerala, India.A questionnaire-based cross-sectional study was conducted among 300 general dental practitioners in Trivandrum District, Kerala, India. Postanswering the questions, a handout regarding radiation safety and related preventive measures was distributed to encourage radiation understanding and protection.Statistical analysis were done by assessing the results using Chi-square statistical test, Among 300 general practitioners (247 females and 53 males), 80.3% of the practitioners were found to have a separate section for radiographic examination in their clinics. Intraoral radiographic machines were found to be the most commonly (63.3%) used radiographic equipment while osteoprotegerin was the least (2%). Regarding the practitioners safety measures, only 11.7% of them were following all the necessary steps while 6.7% clinicians were not using any safety measure in their clinic, and with respect to patient safety, only 9.7% of practitioners were following the protocol.The level of awareness of practitioners regarding radiation hazards and safety was found to be acceptable. However, implementation of their knowledge with respect to patient and personnel safety was found wanting. Insisting that they follow the protocols and take necessary safety measures by means of continuing medical education programs, pamphlets, articles, and workshops is strongly recommended.

PubMed | Sree Mookambika Institute of Medical science, Sree Mookambika Institute of Dental science and University of Technology Malaysia
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

Bronchial asthma constitutes important problem worldwide. This chronic lung disease has detrimental effect in the oral cavity like reduction of salivary secretion, change in salivary composition and pH.This study was conducted to compare the prevalence of dental caries in asthmatic children and healthy children, and also to evaluate the correlation between the In this study, the mean decayed, missing, filled teeth score of children in the study group was (4.53 3.38) higher than the control group (1.51 1.58) (The dental caries prevalence increases with the usage of

PubMed | Sree Mookambika Institute of Dental science
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

oral cancer is a result of disordered cellular behavior initiated by various stimuli which is characterized by the alteration of serum glycoproteins consisting of different monosaccharides. One of these is levo-fucose (L-fucose), a methyl pentose. Elevated levels of protein-bound fucose have been reported in various malignancies.The present study attempted to correlate levels of serum L-fucose as a biomarker with the various tumor node metastasis (TNM) stages of oral cancer.The study was carried out on 90 subjects consisting of 30 healthy controls and 60 histopathologically proven oral squamous cell carcinoma (OSCC) cases. The serum fucose level estimation was done based on the method adopted by Winzler. Statistical analysis included independent samples Significant elevation in serum fucose levels was noticed among OSCC patients when compared with the controls and a progressive ascent of L-fucose levels were noted as the stage of severity increased. Serum fucose levels were independent of histopathological grading, age, and sex.Serum L-fucose levels were increased in OSCC patients, and a positive correlation was observed between serum L-fucose levels and TNM staging of OSCC. Thus, serum L-fucose can be used as an effective diagnostic and prognostic biomarker in OSCC patients.

PubMed | Mar Baselios Dental College, Sree Mookambika Institute of Dental science and Malabar Dental College and Research Center
Type: Journal Article | Journal: Journal of Indian Prosthodontic Society | Year: 2016

Cone beam computed tomography (CBCT) is a medical imaging technique of X-ray computed tomography where the X-rays are divergent, forming a cone. CBCT systems have been designed for imaging hard tissues of the maxillofacial region. The increasing availability of this technology provides the dental clinician with an imaging modality capable of providing a three-dimensional representation of the maxillofacial skeleton with minimal distortion. This article is intended to elaborate and enunciate on the various applications and benefits of CBCT, in the realm of maxillofacial prosthodontics, over and beyond its obvious benefits in the rehabilitation of patients with implants. With the onus of meticulous reconstruction of near ideal occlusion resting on the prosthodontist, CBCT provides a unique imaging option, which can be a boon in various aspects of prosthodontic practice - from imaging of the temporomandibular joint for accurate movement simulation, to template assisted maxillofacial reconstruction or even over denture therapy. CBCT could play a crucial role in lessening the burden of a hectic prosthodontic routine for the clinician and critically contribute to accurate and effective treatment for the patient. Apart from the authors clinical experiences shared here, a web-based search for relevant articles in this specific area of interest was also conducted. The selected articles were critically reviewed and the data acquired were systematically compiled.

PubMed | Sree Mookambika Institute of Dental science
Type: Journal Article | Journal: Journal of conservative dentistry : JCD | Year: 2016

The effect of 10% ascorbic acid, 10% tannic acid, and 10% gallic acid on the dentinal tubular penetration of Resilon and Real Seal SE on sodium hypochlorite-treated root canal dentin was evaluated.Fifty human premolars were decoronated to attain 14-mm root length and divided into five groups of 10 teeth each. Biomechanical preparation was done with rotary instruments. Group I specimens were irrigated with saline and 17% ethylenediaminetetraacetic acid (EDTA). Specimens from groups II, III, IV, and V were irrigated with 5.25% sodium hypochlorite and 17% EDTA. Specimens from groups III, IV, and V underwent additional irrigation with antioxidants-10% ascorbic acid, 10% tannic acid, and 10% gallic acid, respectively. Following obturation with Resilon and Real Seal SE, scanning electron microscope (SEM) analysis was done to note the maximum dentinal tubular penetration at the cervical, middle, and apical thirds of each specimen. The data were statistically analyzed using one-way analysis of variance (ANOVA), Post hoc and Dunnetts test.Maximum dentinal tubular penetration of Resilon and Real Seal SE was obtained following irrigation with 10% gallic acid.10% gallic acid was superior among the antioxidant irrigants that enabled the increased dentinal tubular penetration of Resilon and Real Seal SE.

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