Sree Gokulam Medical College

Thiruvananthapuram, India

Sree Gokulam Medical College

Thiruvananthapuram, India
Time filter
Source Type

Sajitha G.R.,Kannur University | Augusti K.T.,Kannur University | Jose R.,Sree Gokulam Medical College
Indian Journal of Clinical Biochemistry | Year: 2016

Heavy metal pollution is a global public health challenge due to its stable and persistent environmental contamination. Of these lead is considered to be one of the most common ubiquitous and industrial pollutants and at low concentration it exerts extensive damages to the tissues. Daily feeding of lead acetate solution (Dose: 10 mg/kg/day) to normal rats for a month adversely altered the parameters of blood, serum and tissues, viz; RBC, WBC, Hb, ɗ- ALAD (Delta amino levulinic acid dehydratase), Pb content, lipids, oxidized lipids (TBARS), vitamins C and E and GSH levels and activities of AST, ALT and antioxidant enzymes viz; catalase, GR, Gpx and SOD. In order to study whether antioxidants have any effect to counteract the toxicity of lead we have selected comparatively better active allium fractions for the study viz: polar fraction of garlic (PFG) and polar fraction of onion (PFO). On feeding of these active fractions of garlic and onion oils i.e. their polar fractions and vitamin E (Dose 100 mg/kg/day) separately for a month along with or without lead acetate to rats each nutraceutical and vitamin E counteracted the adverse effects of Pb significantly (p ≤ 0.05). Their effects are in the order of PFG > PFO > Vitamin E. All these results point out that garlic and onion oils contain natural disulfoxide compounds which act as antioxidant and anti toxic to lead compounds. Their comparative differences in action may be due to the presence and position of double bonds and disulfide oxide bonds in their molecules. i.e., in PFG the allyl disulfide oxide group is present and in PFO saturated methyl and propyl groups and unsaturated propenyl group are present in place of allyl groups. The former group confers a better antioxidant activity on PFG, while the latter groups confer a lesser activity on PFO. © 2016 Association of Clinical Biochemists of India

Patil A.,Karnataka Institute of Medical science | Chandramohan K.,Karnataka Institute of Medical science | Shivaprakash M.,Sree Gokulam Medical College | Nadgir S.,Karnataka Institute of Medical science | Lakshminarayana S.,Collaborating Center
Indian Journal of Medical Microbiology | Year: 2013

Rhizomucor variabilis is a rare cause of human infections. We report a case of primary cutaneous zygomycosis in an immunocompetent host. Although microscopy reveals the fungal aetiology, the need for species identification is highlighted to better understand the species and establish an epidemiological pattern as it is reported from restricted geographical locations.

Simi S.M.,Sree Gokulam Medical College | Nandakumar G.,Government Medical College | Anish T.S.,Government Medical College
Indian Journal of Dermatology | Year: 2013

Context: White lesions in the oral cavity may be benign, pre-malignant or malignant. There are no signs and symptoms which can reliably predict whether a leukoplakia will undergo malignant change or not. Many systemic conditions appear initially in the oral cavity and prompt diagnosis and management can help in minimizing disease progression and organ destruction. Aim : The aim of the paper was to study the clinical and histopathological patterns of white lesions in the oral cavity presented at the study setting and to study the factors associated with the histopathological patterns of the lesions. Settings and Design: A hospital based cross-sectional study of patients with white lesions in the oral cavity attending the Department of Dermatology and Venereology, Medical College, Thiruvananthapuram was done. Materials and Methods: After taking a detailed history, microscopic examination of Potassium hydroxide smear and an oral biopsy with histopathologial examination was done. Results : Out of the 50 patients in the study, clinically the diagnoses made were Lichen planus (32 patients; 64%), Frictional Keratosis (4;8%), Dysplasia (2;4%), Oral Hairy Leukoplakia (1;2%), Pemphigus Vulgaris (2;4%), Cutaneous Lupus Erythematosus (1;2%), Oral Submucous fibrosis (3;6%) and Oral Candidiasis alone (5;10%). Out of the 45 patients who had undergone biopsy, 25 (55.6%) had Lichen planus, 9 (20%) had Frictional Keratosis and mild Dysplasia was found in 4 (8.9%) patients. Conclusion : The measure of agreement between the clinical and pathological diagnosis was only 32%. Older age, difficulty in opening the mouth, consumption of non-smoked tobacco, site of the lesion (gingival, floor of mouth or lingual vestibule) and presence of tenderness on the lesion were significantly associated with Dysplasia.

Mathew M.,Government Medical College | Abish A.,Sree Gokulam Medical College | Kuriakose A.,Government Medical College | Isaiah J.R.,Government Medical College | And 2 more authors.
Asian Journal of Psychiatry | Year: 2013

Objective: Diabetes mellitus and depression are major public health problems and are significantly linked with each other. This research study intends to assess for undiagnosed depression and its predictors among adult diabetic patients. Methods: A cross-sectional study was done among 100 patients with type 2 diabetes mellitus attending the diabetic clinic of a tertiary care hospital. Depression was assessed using Patient Health Questionnaire-9 (PHQ-9). Chi-square test was performed and odds ratios (OR) with 95% confidence interval (95% CI) were obtained. Mann Whitney U and Pearson correlation tests were done. Logistic regression was carried out to determine the predictors of depression and adjusted odds ratios with 95% confidence intervals were obtained. Results: The prevalence of depression was 49% (95% CI 39.1-58.9%). The predictors of depression were female gender, elevated fasting blood sugar (FBS) level, physical disability and lack of physician's advice about lifestyle modifications. FBS values were significantly higher in depressed individuals as compared to the non-depressed (p value 0.002). A positive correlation (r= 0.38, p value 0.01) was obtained between PHQ-9 scores and the FBS values of the diabetic subjects. Conclusions: Subjects with diabetes are highly prone for comorbid depression. Physicians should be sensitive towards the need for assessing for possible depression and its risk factors in diabetic patients. © 2013 Elsevier B.V.

Simi S.,Sree Gokulam Medical College | Narayanan B.,Government Medical College | Nandakumar G.,Government Medical College
Indian Journal of Dermatology | Year: 2012

Multiple endrocrine neoplasia (MEN) type 1 is characterized by mainly a triad of pancreatic, pituitary and parathyroid involvement. This is a case report of a 41-year-old male in whom recognition of collagenoma and gingival papule led to the identification of MEN type 1. Often the recognition of such dermatological manifestations help in the presymptomatic diagnosis of complex syndromes.

Vijayakumar K.,Government Medical College | George B.,Government Medical College | Anish T.S.,Government Medical College | Rajasi R.S.,Sree Gokulam Medical College | And 2 more authors.
Southeast Asian Journal of Tropical Medicine and Public Health | Year: 2013

The southern state of Kerala, India was seriously affected by a chikungunya epidemic in 2007. As this outbreak was the first of its kind, the morbidity incurred by the epidemic was a challenge to the state's public health system. A cross sectional survey was conducted in five districts of Kerala that were seriously affected by the epidemic, using a two-stage cluster sampling technique to select households, and the patients were identified using a syndromic case definition. We calculated the direct health expenditure of families and checked whether it exceed the margins of catastrophic health expenditure (CHE). The median (IQR) total out-of-pocket (OOP) health expenditure in the study population was USD7.4 (16.7). The OOP health expenditure did not show any significant association with increasing per-capita monthly income.The major share (47.4%) of the costs was utilized for buying medicines, but costs for transportation (17.2%), consultations (16.6%), and diagnoses (9.9%) also contributed significantly to the total OOP health expenditure. The OOP health expenditure was high in private sector facilities, especially in tertiary care hospitals. For more than 15% of the respondents, the OOP was more than double their average monthly family income.The chikungunya outbreak of 2007 had significantly contributed to the OOP expenditure of the affected community in Kerala.The OOP health expenditure incurred was high, irrespective of the level of income. Governments should attempt to ensure comprehensive financial protection by covering the costs of care, along with loss of productivity.

Patil A.B.,Karnataka Institute of Medical science | Nadagir S.D.,Karnataka Institute of Medical science | Lakshminarayana S.A.,Sree Gokulam Medical College | Syeda F.M.,Karnataka Institute of Medical science
Journal of Neurosciences in Rural Practice | Year: 2012

Morganella morganii is a gram negative aerobe , found often as intestinal commensal. It is commonly implicated in Urinary tract infections and pyogenic infections, but rarely causes CNS infections especially brain abscess. There are very few published reports of Morganella morganii as a causative pathogen in brain abscess. High index of suspicion of this pathogen is important in cases of brain abscess secondary to otogenic infections. This paper reports an unusual case of Morganella morganii, subspecies morganii, biogroup A Brain abscess. The paper also reviews other infections caused by Morganell morganii.

Mohammadi S.F.,Karnataka Institute of Medical science | Patil A.B.,Karnataka Institute of Medical science | Nadagir S.D.,Karnataka Institute of Medical science | Nandihal N.,Karnataka Institute of Medical science | Lakshminarayana S.A.,Sree Gokulam Medical College
Annals of Indian Academy of Neurology | Year: 2013

Objectives: To know the incidence of bacterial meningitis in children below five years of age. To compare conventional culture and antigen detection methods ( Latex agglutination test). Materials and Methods: 100 CSF samples of clinically suspected meningitis cases in children below 5 years of age were included. The samples were subjected to cell count, Gram stain, culture and LAT. The organisms isolated in the study were characterized according to standard procedures. Results: Of the 100 cases studied, 31 cases were diagnosed as ABM by Gram stain, culture and latex agglutination test as per WHO criteria. The hospital frequency of ABM was 1.7%. 15 (48.38) cases were culture positive. Gram stain was positive in 22(70.96) cases and LAT in 17(54.83) cases. Haemophilus influenzae was the most common causative agent of acute bacterial meningitis followed by S.pneumoniae. Case fatality rate was 45.16%.The sensitivity and specificity of LAT was 66.66% and 87.91% respectively. Conclusion : Bacterial meningitis is a medical emergency and early diagnosis and treatment is life saving and reduces chronic morbidity. LAT was more sensitive compared to conventional Gram stain and Culture technique in identifying the fastidious organisms like H.influenzae, S.pneumoniae and Group B Streptococcus. However, the combination of Gram stain, Culture and LAT proved to be more productive than any of the single tests alone.

Ashish J.,Sree Gokulam Medical College | Vinay H.,Navodaya Medical College
International Journal of Pharma and Bio Sciences | Year: 2013

Background Methicillin-resistant Staphylococcus aureus (MRSA) one of the most widespread causes of nosocomial infection's worldwide. Recently, they have been recovered from community. This study was undertaken to analyze the prevalence of methicillin resistance among isolates at Sree Gokulam Medical College, Trivandrum, and document the current resistance profile of MRSA and methicillinsensitiveStaphylococcus aureus (MSSA) to the commonly used anti-staphylococcal agents. Methods Over a 2-year period we analyzed 1215 isolates of S. aureus strains recovered from various clinical sources, from hospital and community practices. Antimicrobial susceptibility testing was done according to CLSI guidelines. Results The prevalence of MRSA from surgical/burn wounds/pus, urine and miscellaneous others were 60.1%, 15.5% and 6.6%, respectively. The major sources of MSSA were surgical/burn wounds, pus/abscess and upper respiratory tract specimens with rates of 32.9%, 17.1% and 14.3%, respectively. The greatest prevalence of resistance of MRSA along with beta lactams was seen for erythromycin (86.7%), and clindamycin (70%). Resistance rates among MSSA were highest for ampicillin (70%). Conclusion The prevalence of MRSA in the hospital increased from 12.5% in 2011 to 20.8% in 2013. Most isolates were associated with infected surgical/burn wounds which may have become infected via the hands of health care workers during dressing exercises. Infection control measures aimed at the proper hand hygiene procedures may interrupt the spread of MRSA. health care workers may also be carriers of MRSA in their anterior nares. Surveillance cultures of both patients and health care workers may help to identify carriers who would be offered antibiotics to eradicate the organisms. Most MRSA are resistant to several non-β-lactam antibiotics. Frequent monitoring of susceptibility patterns of MRSA and the formulation of a definite antibiotic policy may be helpful in decreasing the incidence of MRSA infection.

Amar C.S.,Chalmeda Anand Rao Institute of Medical science | Ashish J.,Sree Gokulam Medical College | Hajare V.,Navodaya Medical College | Sreekantha,Navodaya Medical College | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

Background and Objectives: The yeast like fungus candida is the most common fungal pathogen causing disease in the human beings. As the disease is usually chronic and treatment failure cases were commonly noted, so the study was conducted to know the prevalence and antifungal susceptibility pattern of various candida species isolated from clinical samples. Materials and Results: A total of 1702 subjects were selected, among which 60.2%were male and 39.8% were female. The identification of various candida species was done by saline wet mount, 10% KOH mount, Gram stain, germ tube test, culture on SDA, Chromagar, cornmeal agar, sugar fermentation tests and sugar assimilation tests. Antifungal susceptibility test was done by disc diffusion method.103 candida species were isolated from 1702 samples. Conclusion: Candida albicans is the most common species isolated from clinical specimen and the infection is almost same in both the sexes and predisposing factors like diabetes mellitus, prolonged contact it water were noted. They were advised correct treatment for diabetes mellitus, to limit the contact with water and maintenance of good personal hygiene.

Loading Sree Gokulam Medical College collaborators
Loading Sree Gokulam Medical College collaborators