Ibrahimpatnam, India
Ibrahimpatnam, India

Time filter

Source Type

Rajani A.,Sree Dattha Institute of Pharmacy | Swathi M.,Sree Dattha Institute of Pharmacy | Madhuri M.,Sree Dattha Institute of Pharmacy | Arifa Begum S.K.,Sree Dattha Institute of Pharmacy | Vishnu Vardhan Reddy M.,Sree Dattha Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2014

Picrorrhiza kurroa (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate and compare antipyretic activity of Picrorrhiza kurroa royle ex. Benth by using 2, 4-Dinitro Phenol (DNP), D-Amphetamine and brewer's Yeast induced pyrexia models. Paracetamol was used as the standard drug to compare the test results. The test extract showed significant antipyretic activity (p<0.05) which justify its use in ethnomedicine.


Rajani A.,Sree Dattha Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

The aim of this study was to evaluate the behavioural, muscle coordination and anxiolytic activities of methanolic extracts of Tabebuiarosea(Bignoniaceae) in mice. The behavioural, muscle coordination and anxiolytic activities were evaluated by using various models of CNS using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 500 mg/kg. The results of the present study indicates that the methanolic extract of Tabebuiarosealeaves are effective in inducing a significant protection against behavioural, muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the behavioural, muscle coordination and anxiolytic activities of this plant as it is used in traditional medicine.


Rajani A.,Sree Dattha Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

The aim of this study was to evaluate the muscle coordination and anxiolytic activities of methanolic extracts of Anogeissus latifolaWall (combretaceae) in mice. The muscle coordination and anxiolytic activities were evaluated by using various models of using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 300,400 mg/kg. The results of the present study indicates that the methanolic extract of Anogeissus latifola leaves are effective in inducing a significant protection against muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the muscle coordination and anxiolytic activities of this plant as it is used in traditional medicine.


Rajani A.,Sree Dattha Institute of Pharmacy | Vishnu Vardhan Reddy M.,Sree Dattha Institute of Pharmacy | Arifa Begum S.K.,Sree Dattha Institute of Pharmacy | Swathi M.,Sree Dattha Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Picrorrhiza kurroa (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate and compare anti-diarrhoeal activity of Picrorrhiza kurroa royle ex. Benth on magnesium su;phate induced enteropooling and gastro intestinal motility test using charcoal meal methods. The results suggested that there was a significant reduction in the peristaltic movemets in charcoal meal test and reduction in the intestinal fluid secretions in magnesium sulphate induced enteropooling method indicating its anti-diarrhoeal activity. Two doses of the test extract i.e. 250mg/kg, 500mg/kg were used to evaluate the anti-diarrhoeal activity. Atropine sulphate was used as the standard in the gastro intestinal motility test to compare the test results. Loperamide was used as the standard drug in magnesium sulfate induced enteropooling method to compare the test results. The study concluded that the methanolic rhizome extract of Picrorrhiza kurroa showed significant Anti-diarrhoeal action.


Arifa Begum S.K.,Sree Dattha Institute of Pharmacy | Rajani A.,Sree Dattha Institute of Pharmacy | Satyavati D.,Sree Dattha Institute of Pharmacy | Saradhi N.D.V.R.,Sree Dattha Institute of Pharmacy | And 2 more authors.
Rasayan Journal of Chemistry | Year: 2013

A series of Azetidinone analogues were synthesized characterized and screened for the presence of anti-microbial activity. The final test compounds were characterized by UV, IR and NMR. The purity of the compounds was ascertained by TLC technique. The test compounds were tested on four bacterial species i.e., E.coli, S.aureus, P.aeruginosa, B.subtilis. Amoxicillin was used as a standard drug for comparing the test results. © 2013 RASĀYAN. All rights reserved.


Rajani A.,Sree Dattha Institute of Pharmacy | Vasireddy U.,IPA Treasurer
International Journal of Pharma and Bio Sciences | Year: 2013

Tabebuia rosea is one of the medicinally important plant belonging to the family Bignoniaceae. Tabebuia species are native to tropical rain forests throughout central and South America. The objective of the present study was to evaluate and compare the Anthelmintic activity of methanolic extract of leaves of Tabebuia rosea Bertol DC. (Bignoniaceae). Albendazole was used as a standard drug to compare the test results. Indian Adult earth worms (Pheretima posthuma) were used for the study. The results were interpreted as time taken for paralysis and death of the earth worms. The study concluded that the methanolic leaf extract of Tabebuia rosea showed significant Anthelmintic activity.


Sruthi T.,P.A. College | Satyavati D.,Sree Dattha Institute of Pharmacy | Dasari R.,Mallareddy Institute of Pharmaceutical science | Jyothi V.,P.A. College | Roshan Ali P.,P.A. College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Objective: The present study was focused to evaluate the hypoglycemic activity of NIDDWIN, a polyherbal formulation in normal rats. Methods: Male Albino Wistar Rats (180-200gms) were divided into four groups of five animals each. Group-I was given aqueous suspension of 2% gum acacia, Group-II was given aqueous suspension of NIDDWIN 50mg/kg, Group-III was given aqueous suspension of NIDDWIN 100mg/kg, Group-IV was given aqueous suspension of Glibenclamide 10mg/kg were given orally for 10days. The blood samples were collected before and after administration drugs at 0hrs, 2hrs, 4hrs, 6hrs, and 8hrs on 1st, 5th, and 10th days from retro-orbital sinus and serum was separated and estimated for glucose, cholesterol and triglycerides by using analytical method[1,2]. Results: NIDDWIN showed significant hypoglycemic activity at 4hrs on 1st, 5th, and 10th days was found to be effect in comparable with standard Glibenclamide 10mg/kg. Conclusion: NIDDWIN a polyherbal formulation concluded that it possesses hypoglycemic activity in normal rats and should be evaluated for its antidiabetic activity.


Kumar N.S.,P.A. College | Ganesh Kumar Y.,Sree Dattha Institute of Pharmacy | Chandana C.H.,P.A. College | Kunalkumar J.,P.A. College
International Journal of Pharmacy and Technology | Year: 2014

The objective of present investigation was to formulate and evaluate hydrophilic matrix tablets of cefixime trihydrate to achieve sustained sdrug release with reduced frequency of drug administration, reduced side effects and patient compliance. Matrix tablets of cefixime trihydrate were prepared by using polymers like hydroxypropylmethylcellulose (HPMC K100, and HMC K4), and different diluents like microcrystalline cellulose, Ethyl cellulose, magnesium stearate, and talc as glidant. Cefixime is orally active third generation cephalosporin antibiotic. Cefixime is well absrobed from the Gut. The oral bioavailability is 40-50%. Cefixime sustained release tablets were prepared by direct compression method. The powder blend was subjected for pre-compressional parameters such as tapped density, bulk density,angle of repose, compressibilty index and hausner ratio. The prepared tablets are evaluated to post-compressional parameters such as hardness, friability, average weight, uniformity of weight and invitro dissolution studies. Drug compatability with excipients was checked FTIR studies. The values of pre-compressional parameters evaluated were within prescribed limits and indicated good free flowing property. The values of post-compressional parametres evaluated were within acceptable limits. The dissolution profiles of all the formulations were evaluated. Amongst all the formulations, the release profile of formula F7 gave optimum results., It was concluded that for Cefixime trihydrate sustained release matrix Tablets, F7 is successful formulation and can be manufactured with reproducible characteristics from batch to batch.


Santhosh Kumari C.H.,Sree Dattha Institute of Pharmacy | Prasad C.V.N.,Sree Dattha Institute of Pharmacy | Sree Ramulu J.,Krishna University
International Journal of Pharma and Bio Sciences | Year: 2010

Background: Antimicrobial and antiulcer activities of Aloe vera plant extract were evaluated against H. pylori strains. According to several studies, oral consumption of Aloe Vera works effectively to soothe conditions like heartburn, arthritis and rheumatism pain and asthma. Researchers are now investigating the new roles of antimicrobial and antiulcer activities of Aloe vera in acid peptic disorders. Therefore the current study is aimed to evaluate the anti-H. pylori and antiulcer properties of Aloe vera. Methods: The extracts of Aloe vera plants were harvested and stored for the in-vitro and in-vivo studies. The antimicrobial activity was detected by using disc diffusion method. In vivo activities were also studied in albino rats by ethanol induced ulcers and the treatment regimens. Results: The results showed that Aloe vera exhibited strong antimicrobial activity against H. pylori at two different concentrations of 250, 500μg/mL in comparison with standard Clarithromycin. In vivo studies showed a very good response in ulcer healing properties. Study found that use of Aloe vera may act as complementary and alternative medicine for gastrointestinal diseases.

Loading Sree Dattha Institute of Pharmacy collaborators
Loading Sree Dattha Institute of Pharmacy collaborators