Sree Dattha Institute of Pharmacy

Ibrahimpatnam, India

Sree Dattha Institute of Pharmacy

Ibrahimpatnam, India
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Ganesh Kumar Y.,Sree Dattha Institute of Pharmacy | Sreekanth J.,MSN Laboratories Pvt. Ltd | Satyavati D.,Sree Dattha Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Methods: Bosentan SR Matrix tablets were prepared by Wet granulation method. The tablets were evaluated for Hardness, Thickness, Friability and Drug content and were subjected to a 12 hours in vitro drug release studies.Objective: Bosentan is an endothelin receptor antagonist (ERA) indicated for the treatment of Pulmonary arterial hypertension (PAH). The aim of the present study involves the development of sustained release matrix tablets of bosentan in order to release the drug in sustained and predictable manner.Results: The amount of Bosentan released from the tablet formulations at different time intervals was estimated using a UV Spectroscopy method. Among all the formulations are prepared by using different polymers like HPMC K 4 M, HPMC K15 M at different ratios.Conclusion: We Can Conclude that Among the Ten formulations, F-2 formulation containing drug to HPMC K 4 M in ratio 1:0.5 is optimized based on its ability to sustain drug release till 12 hours of dissolution study, The results of the study clearly demonstrated that HPMC matrix tablet formulation is an effective and promising drug delivery system for once daily administration of Bosentan. © 2014, International Journal of Pharmacy and Pharmaceutical Sciences. All right reserved.


Venkata Ramana Reddy K.,Sree Dattha Institute of Pharmacy | Patra P.K.,Sree Dattha Institute of Pharmacy | Divakar K.,Sree Dattha Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: Carvedilol is a non-selective beta blocker was formulated as microspheres by using Ethyl cellulose as a carrier. Methods: These ethyl cellulose microspheres were prepared by the solvent evaporation method. The prepared microspheres were subjected to various evaluation parameters and in vitro release studies. Highest percentage of entrapment was obtained by increasing the amount of polymer with respect to uniformity of drug. The particle sizes of the prepared microspheres were determined by optical microscopy method and morphology by SEM analysis. Results: The prepared microspheres have gained good spherical geometry with smooth surface as evidence by SEM studies. The entrapment efficiency for f3 was found to be 97.5±0.1527 % with maximum drug loading of 45.26 around. The best-fit release kinetics was achieved with Korsmeyer-Peppas plot followed by zero order and first order kinetics. The release of drug was influenced by the drug to polymer ratio and particle size and was found to be both diffusion and dissolution controlled. Conclusion: The study showed that Carvedilol microspheres of 1:2 (F3 batch) ratios got better sustained effect over a period of 12 hours. Finding of all this investigation conclusively demonstrate prolongation of drug release at a constant and controlled rate.


Patra P.K.,Sree Dattha Institute of Pharmacy | Debata J.,Guru Nanak Institutions | Sravanthi Reddy E.,Guru Nanak Institutions | Samal H.B.,Guru Nanak Institutions
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: The objective of the present investigation is to study the antioxidant power of different extracts of Scoparia dulcis. Scoparia dulcis Linn belongs to the family Scrophulariaceae and have speculated medicinal properties. Materials and Methods: The different extract of this plant were obtained by successive extraction with petroleum ether, chloroform and ethanol. These extracts (PEESD, CESD and EESD) were then taken for phytochemical screening using different chemical reagents. An in-vitro antioxidant study is carried out by using various antioxidant screening methods like estimation of total Phenolic compounds, reducing power, nitric oxide scavenging and superoxide ion scavenging activity. The antioxidant activity of the extracts was related to their phytochemical composition in terms of polyphenol and carotenoid contents. Results: The chloroform extract was found rich in phytochemical constituents and had the highest antioxidant activity in the different antioxidant systems. Conclusion: Result shows PEESD, CESD and EESD have significant antioxidant activity. The antioxidant potential may be attributed to the presence of polyphenolic compound.


Arunprasad B.,Sree Dattha Institute of Pharmacy | Krishna Teja G.,Sree Dattha Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

The aim of the present investigation was to develop bilayer tablets for treating respiratory tract infections. In present study Levofloxacin is selected as antibiotic to treat upper and lower respiratory tract infections, but antibiotic taking along with a mucolytic drug shows reduction of acute exacerbation and days of illness. So we selected Ambroxol hydrochloride as mucolytic drug along with antibiotic Levofloxacin. Bi-layered tablets were formulated consisting of Levofloxacin as immediate release layer and Ambroxol HCL as sustain release layer because its half life is only 4 hours so it will not produce pharmacological effect along with Levofloxacin, so Ambroxol layer is sustained by using polymers. Levofloxacin IR layer was prepared, by using starch as disintegrant which shows sufficient hardness and friability and released the drug within one hour. Ambroxol HCL SR layer was prepared, by using HPMC K4M (11%) and HPMC K100M (12.5%) mixture, sustained the drug release upto 12th hour. Bilayer tablets prepared by wet granulation method were evaluated for thickness, hardness, weight variation, friability and drug content. FT-IR studies clearly indicated that there was no drug-polymer interaction. In total 12 formulations F11 batch releases the Ambroxol HCL in sustained manner similar to the release given by marketed sample and same batch releases the Levofloxacin immediately within an hour. The optimized batch was selected for stability studies and confirmed that there was no significant difference over a stability testing period.


Raju T.,Sree Dattha Institute of Pharmacy | Santhosh Kumar J.,Sree Dattha Institute of Pharmacy | Ravindra Babu D.S.,Sree Dattha Institute of Pharmacy | Arvind G.,Sree Dattha Institute of Pharmacy | Pradeep Reddy T.,Sree Dattha Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

The present investigation was aimed at developing cytarabine-loaded poly (L-lactide) (PLA) based biodegradable microspheres by a double emulsion solvent evaporation technique which would have sustained release of the drug. The poly (L-lactide) (PLA) microspheres containing Cytarabine as a drug and evaluate the various physicochemical characteristics of the formulations, namely morphology, particle size, FTIR, Cytarabine encapsulation efficiency and in-vitro Cytarabine release profile. Cytarabine-loaded microspheres were prepared by double emulsion solvent evaporation method with different Cytarabine, PLA ratios and at different speeds of homogenization keeping the amount of Cytarabine constant in all the formulations and different amount of salt (NaCl) concentrations Accelerated stability testing was performed with the optimized formulations for a period of two months. The mean particle size and encapsulation efficiency of the microspheres were found to decrease as the speed of homogenization increased and the encapsulation efficiency was increased with increase in salt (NaCl) concentration. The in vitro release study showed a slow and steady release pattern of Cytarabine. Thus a sustained release formulation of Cytarabine loaded PLA microspheres were developed.


Tejasvi P.R.,P.A. College | Satyavati D.,Sree Dattha Institute of Pharmacy | Begum S.A.,Sree Dattha Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: To study the anxiolytic activity of Jessica- a polyherbal formulation, in rats. Methods and Material: Swiss albino rats of either sex weighing between 180g-210g were used. The standard anxiolytic, diazepam (1mg and 2mg/kg) standard polyherbal drug, Streswin (100 and 200mg/kg) and the test drug, Jessica (100mg and 200mg/kg) were suspended in 2% gum acacia and administered orally. In acute study the vehicle and test drug were given 40 min prior to experiment, while in chronic study they were given daily once for 10 days. The anxiolytic effect of Jessica (100 and 200mg/kg) was evaluated by using Despair swim test (DST), Elevated Plus maze (EPM), Actophotometer and Rota rod apparatus the animals were explored on the above models on 1st, 5th, 10th day of the treatment plan. Results: It was observed that Jessica (100 and 200mg/kg) has increased the immobility time in DST, increased the total no of entries and time spent in open arm in EPM, increased the percentage reduction in locomotion in Actophotometer and decreased the time spent on revolving rod in Rota rod on 5 th day and 10 th day. All the results were significant when compared to control group and the effect was similar to that of standard drug diazepam (1 and 2mg/kg) and standard polyherbal formulation Streswin (100 and 200mg/Kg). Conclusion: Jessica has exhibited anxiolytic activity comparable to diazepam and streswin. So, it can be used as a novel therapeutic strategy for anxiety.


Vijayanand P.,Jawaharlal Nehru Technological University Kakinada | Reddy M.V.,Sree Dattha Institute of Pharmacy
Brazilian Journal of Pharmaceutical Sciences | Year: 2016

The objective of this investigation was to develop a novel oral edible gel dosage form for nebivolol hydrochloride, with suitable rheological characteristics that can provide a means of administering the drug to dysphagic and geriatric patients. Edible gels were prepared using low acetylated gellan gum and sodium citrate in different concentrations. The effect of concentration of the solution on gelation time, viscosity, and drug release was studied. Optimized formulation had “spoon thick” consistency that is considered suitable for dysphagic patients as suggested by National Dysphagia Diet Task Force. The optimized formulation containing gellan gum (0.4 % w/v) and sodium citrate (0.3 % w/v) showed more than 95% drug release in 20 minutes. This formulation also showed significantly better pharmacokinetic profile when compared to marketed conventional tablets in New Zealand white rabbits (n = 3). Optimized formulation was found stable for 6 months when stored at 25 °C ± 0.2 °C/60 ± 5% RH. From this study, it can be concluded that the novel edible gel dosage form containing nebivolol hydrochloride may prove to be more efficacious in the treatment of hypertension in dysphagic patients. © 2016, Faculdade de Ciencias Farmaceuticas (Biblioteca). All rights reserved.


Ganesh Kumar Y.,Jawaharlal Nehru Technological University | Satyavati D.,Satavahana University | Anil kumar C.,Sree Dattha Institute of Pharmacy | Soujanya N.,Kingston University
Der Pharmacia Lettre | Year: 2014

Olanzapine is an atypical antipsychotic, FDA for the treatment of schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine and quetiapine. The present research workis aimed at developing a Formulate and Evaluated of a Rapid disintegrating tablet dosage form of Olanzapine. Who have little or no access to water are also good candidates for Rapid disintegratingtablets of Direct Compression method was employed for blending of drug with polymers in the given ratio as a nine formulations. The prepared powder blends were then compressed into tablets using the necessary Superdisintegrants like CCS, CP, and SSG and Excipients. The tablets were evaluated for Weight variation, thickness, hardness, friability, Drug Content and Disintegrating Time (Sec) were subjected to a 40 minutes in vitro drug release studies (USP dissolution rate test apparatus II, 50 rpm, 370C ±0.50C) using phosphate buffer, pH 6.8 as a dissolution medium (900ml). The amountof Olanzapine released from the tablet formulations at different time intervals was estimated using a UV spectroscopy method. The formulations that showed a considerable retardation of the drug release are considered promising. Among the nine formulations, F5 formulation containing Drug to Crospovidone (CP) in ratio 1:0.25 is optimized based on its ability to till 40 mins of invitro dissolution time, and its % Cumulative Drug Release Of The 96.09% of dissolution study.


Rajani A.,Sree Dattha Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

The aim of this study was to evaluate the behavioural, muscle coordination and anxiolytic activities of methanolic extracts of Tabebuiarosea(Bignoniaceae) in mice. The behavioural, muscle coordination and anxiolytic activities were evaluated by using various models of CNS using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 500 mg/kg. The results of the present study indicates that the methanolic extract of Tabebuiarosealeaves are effective in inducing a significant protection against behavioural, muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the behavioural, muscle coordination and anxiolytic activities of this plant as it is used in traditional medicine.


Rajani A.,Sree Dattha Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

The aim of this study was to evaluate the muscle coordination and anxiolytic activities of methanolic extracts of Anogeissus latifolaWall (combretaceae) in mice. The muscle coordination and anxiolytic activities were evaluated by using various models of using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 300,400 mg/kg. The results of the present study indicates that the methanolic extract of Anogeissus latifola leaves are effective in inducing a significant protection against muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the muscle coordination and anxiolytic activities of this plant as it is used in traditional medicine.

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