Sree Balaji Medical College And Hospitals
Sree Balaji Medical College And Hospitals
Shanthi B.,Sree Balaji Medical College and Hospitals |
Rajini Samuel T.,Sree Balaji Medical College and Hospitals |
Devi M.,Sree Balaji Medical College and Hospitals
International Journal of Pharmaceutical Sciences Review and Research | Year: 2015
Factor v leiden thrombophilia is a genetically inherited disorder of blood clotting. Factor v leiden is a variant (mutated form) of human factor v that causes an increase in blood clotting. In this disorder, the leiden variant (form) of factor v cannot be inactivated (switched off) by activated protein c, and so clotting is encouraged. Here we present a case report of a 23 year male patient who was admitted on 8th june 2014 in Sree Balaji Medical college and hospital with the complaints of two episodes of generalized tonic clonic seizures as noticed by attenders that morning. Patient had no significant past history and family history. Patient was examined thoroughly and detailed investigation was done to find out the cause for young stroke and seizure disorder. His ct scan–brain revealed a case of dural venous and cortical venous thrombosis. He had highly elevated aPTT with slightly increased PT. Then tests for bleeding and clotting disorders are done which revealed he had decreased anti-thrombin and factor v leiden homozygous mutant detected. The condition is less common in latin americans and african-americans and is extremely rare in people of asian descent. © 2015, Global Research Online. All rights reserved.
Menon V.,Jawaharlal Institute Of Pg Medical Education And Research |
Kattimani S.,Jawaharlal Institute Of Pg Medical Education And Research |
Sarkar S.,Sree Balaji Medical College and Hospitals |
Mathan K.,Jawaharlal Institute Of Pg Medical Education And Research
Journal of Neurosciences in Rural Practice | Year: 2016
Background: Evidence indicates that repeat suicide attempters, as a group, may differ from 1st time attempters. The identification of repeat attempters is a powerful but underutilized clinical variable. Aims: In this research, we aimed to compare individuals with lifetime histories of multiple attempts with 1st time attempters to identify factors predictive of repeat attempts. Setting and Design: This was a retrospective record based study carried out at a teaching cum Tertiary Care Hospital in South India. Methods: Relevant data was extracted from the clinical records of 1st time attempters (n = 362) and repeat attempters (n = 61) presenting to a single Tertiary Care Center over a 4 half year period. They were compared on various sociodemographic and clinical parameters. The clinical measures included Presumptive Stressful Life Events Scale, Beck Hopelessness Scale, Coping Strategies Inventory - Short Form, and the Global Assessment of Functioning Scale. Statistical Analysis Used: First time attempters and repeaters were compared using appropriate inferential statistics. Logistic regression was used to identify independent predictors of repeat attempts. Results: The two groups did not significantly differ on sociodemographic characteristics. Repeat attempters were more likely to have given prior hints about their act (χ2 = 4.500, P = 0.034). In the final regression model, beck hopelessness score emerged as a significant predictor of repeat suicide attempts (odds ratio = 1.064, P = 0.020). Conclusion: Among suicide attempters presenting to the hospital, the presence of hopelessness is a predictor of repeat suicide attempts, independent of clinical depression. This highlights the importance of considering hopelessness in the assessment of suicidality with a view to minimize the risk of future attempts.
Subramanian S.,Sree Balaji Medical College And Hospitals |
Rajendran S.M.,Sree Balaji Medical College And Hospitals |
Anand N.N.,Sree Balaji Medical College And Hospitals
World Journal of Medical Sciences | Year: 2014
Aim of the study: Estimation of Serum Melatonin and Serum C-Peptide levels in Uncontrolled Type 2 Diabetes Mellitus-Correlation with normal people.Objectives: To investigate whether there is a correlation between Serum Melatonin and Serum C-Peptide levels in Uncontrolled Type 2 Diabetes Mellitus.To compare Serum Melatonin and Serum C-Peptide values between the diabetic and non-diabetic population.Materials and Methods: This study was conducted in Sree Balaji Medical College, Chennai, Tamil Nadu during the period of May 2012 to May 2013. Total number of people included in this study were 50. Out of 50, 26 were patients with type 2 diabetes mellitus and 24 were age & sex matched controls. There were 21 male and 29 female patients ranging from 35 years to 85 years.Conclusion:Comparison between patients and controls show that the serum melatonin levels are low in uncontrolled type 2 diabetes mellitus patients and high in the control population. The correlation between Mean fasting blood sugar levels and c-peptide levels with serum melatonin levels is an inverse relationship. © IDOSI Publications, 2014.
Sweety L.M.,Sree Balaji Medical College and Hospitals |
Chandra Selvi E.,Sree Balaji Medical College and Hospitals |
Sai Kumar P.,Sree Balaji Medical College and Hospitals
Biomedicine (India) | Year: 2012
Background: Diabetes mellitus is a common health problem whose prevalence is increasing worldwide and its long term complication of various organs includes lungs. The magnitude of the complicationsof this disease is related to the lung function abnormalities. Objective: To asses the effect of phrenic neuropathy on forced expiratory flow rates in type 2 diabetic patients. Methods: We recruited 45 type 2 diabetic patients (males -15; females - 30) of age group 35 to55 years from the Diabetology Department of Sree Balaji Medical College & Hospital. Patients were divided into three groups based on duration of disease as < 5 years, 5-10 years and > 10 years. Questionnaire was provided to all the subjects in order to register their diabetic history and a written informed consent was obtained from all the subjects. All the patients were subjected to do Pulmonary Function Test using computerized spirometer and Phrenic Nerve conduction using Digital Polyrite. Results were statistically analyzed by Pearson Correlation co efficient test, student t test and ANOVA. Results: The FEF25% was reduced among all the patients of varying duration. The FEF 50% and FEF 25-75% were reduced only among patients < 5 years duration. The PEFR values were reduced in all the diabetic patients, however it increased as duration of disease progressed. The phrenic nerve latency showed positive correlation whereas amplitude showed negative correlation with the duration of disease. The phrenic nerve conduction time increased as disease progresses. Conclusion: we concluded that phrenic neuropathy is the reason for restrictive pattern of lung disorder as the disease progresses.
Kumar S.S.S.,Sree balaji medical college and hospitals |
Socrates,Sree balaji medical college and hospitals
International Journal of Pharma and Bio Sciences | Year: 2016
Various physical and psychological insults can cause acute and rapidly reversible left ventricular dysfunction .This is called stress cardiomyopathy or Takotsubo cardiomyopathy. The act of Suicidal hanging involves intense physical stress and distressing emotional outburst. We report a case of rapidly reversible left ventricular dysfunction following attempted suicide by hanging. The pathogenesis of left ventricular dysfunction in hanging is multifactorial but the main mechanism is due to catecholamine surge causing myocardial stunning.
Subramanian S.,Sree Balaji Medical College and Hospitals |
Anand N.N.,Sree Balaji Medical College and Hospitals
International Journal of Pharma and Bio Sciences | Year: 2013
Chloroma is a rare tumor of immature granulocytic cells. It is also called as granulocytic sarcoma or myeloid sarcoma. Chloromas are reported in 2.5%-9.1% of patients with acute myeloid leukemia (AML) and occur concomitantly, following, or rarely antedating the onset of leukemia. The presence of an extramedullary relapse of leukemia is often associated with a poor prognosis. Chloromas' clinical manifestations are diverse given their various sites of occurrence. Involvement of isolated peripheral nerves by chloromas is exceedingly rare and is documented only in limited reports preceding more widespread relapse in the majority of cases [1-4]Special staining and histochemistry studies are required for accurate diagnosis. No prognostic significance exists between acute leukemic patients with granulocytic sarcomas and those without. These sarcomas are very sensitive to focal irradiation or chemotherapy; they generally resolve completely in less than 3 months, although they recur in approximately 23% of patients . This particular case is presented because the patient initially presented with features of peripheral neuropathy and was later diagnosed with chloroma as the etiology of his neuropathic signs.
Chandraselvi E.,Sree Balaji Medical College and Hospitals |
Saikumar P.,Sree Balaji Medical College and Hospitals |
Kumar N.,Sree Balaji Medical College and Hospitals
Biomedicine (India) | Year: 2013
Introduction: In recent years, many studies have been proved that patients with COPD are not exclusively limited to respiratory functional abnormalities, they also suffer with many non-respiratory manifestations that go beyond the lungs involvement. Aim: To assess whether steroid intake COPD patients having increased blood glucose level with no evidence of visual abnormality orperipheral neuropathy have visual evoked potential abnormalities. Materials and Methods: In the present study ten subjects (both male and female) with no peripheral neuropathy or visual abnormality were included. Smoking history, duration of disease, nutritional status, calorie intake was assessed by questionnaire and skinfold thickness was measured by skinfold thickness calipers. Blood glucose level, and pulmonary function tests were examined. Latency and amplitude of Visual evoked potential was carried out on RMS polyrite. Results: Calotrie intake, Total body fat, Body mass index were decreased in COPD patients when compared to controls. Duration of disease was negatively correlated with total body fat but positively correlated with blood glucose level and latency of VEP P100 Significant VEP difference was observed between steroid intake as tablet and inhalers. Conclusion: This study concluded that hypoxia may not be the only cause for abnormal VEP in corticosteroid treated COPD patients. The long term effects of steroid intake as well as increased blood glucose levels on VEP need to be evaluated.