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Suryaprabha P.,Sree Balaji Medical College | Divya Rani M.,Sree Balaji Medical College | Illamani V.,Sree Balaji Medical College | Lakshmipriya R.,ESIC Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Oral infections i.e., dental caries, gingivitis and periodontitis are the most common chronic oral diseases encountered worldwide. Diabetes has already reached the epidemic status and is characterised by increased susceptibility to infection, poor wound healing and increased morbidity and mortality associated with disease progression. Diabetes alters the response of periodontal tissues to local factors. Hence diabetes as such is not the reason for higher rate of infection. Poor hygiene of oral cavity, irrational use of antibiotics in diabetics, immuno suppression and other infections in the body enhances the growth of bacterial flora[2-3]. This study was done to know the relation between diabetes and the spectrum of bacteria in three common dental infections i.e., dental caries, gingivitis and periodontitis and to compare its prevalence in diabetic and nondiabetic patients. A total of 60 patients including 30 diabetic and 30 non-diabetics were taken in the study. Samples were collected from each patient using a sterile cotton swab at the site of lesion in the oral cavity. They were then inoculated in appropriate medias. A total of 50 strains were isolated from diabetics and 42 from non-diabetics. The isolated flora in diabetic was high in peridontitis (54%) as compared to non-diabetics which had higher isolated flora in dental caries (42%) followed by gingivitis (33.3%). Thus the study reemphasizes that perodontitis is higher in diabetic patients as compared to non-diabetic patients. Also dental caries and gingivitis were higher in non-diabetic patients.

Sindhuja M.,Sree Balaji Medical College | Mohanraj K.,Bharath University
International Journal of Pharmacy and Technology | Year: 2016

Gelatin has unique functional properties. Hence it is widely used in pharmaceutical, food, cosmetic, and photographic applications. Gelatin is a mixture of peptides and proteins. It is produced by partial hydrolysis of collagen extracted from the connective tissues, skins and bones of animals such as cattle, chicken, pigs, and fish. In this study, gelatin was extracted from skin, arms and visceral organ of marine source (Octpus areolatus) using alkaline pretreatment method and their phsico-chemical properties were characterized. FTIR confirmed the presence of characteristics bonds of gelatin. © 2016, International Journal of Pharmacy and Technology. All rights reserved.

Rajam Krishna S.,Sree Balaji Medical College | Devaki P.R.,Bharath University
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Heart rate variability is a measure of modulation in autonomic input to the heart and is one of the markers of autonomic functions. Though there are many studies on the long term influence of breathing on HRV (heart rate variability) there are only a few studies on the immediate effect of breathing especially alternate nostril breathing on HRV. This study focuses on the immediate effects of alternate nostril breathing and the influence of different breathing rates on HRV. Materials and Methods: The study was done on 25 subjects in the age group of 17-35 years. ECG and respiration were recorded before intervention and immediately after the subjects were asked to perform alternate nostril breathing for five minutes. Results: Low frequency (LF) which is a marker of sympathetic activity increased, high frequency (HF) which is a marker of parasympathetic activity decreased and their ratio LF/HF which is a marker of sympatho/vagal balance increased immediately after 6 and 12 minutes in comparison to baseline values whereas there was no significant difference in the means of these components when both 6 and 12 minutes were compared. Conclusion: Immediate effects of alternate nostril breathing on HRV in non practitioners of yogic breathing are very different from the long term influence of yogic breathing on HRV which show a predominant parasympathetic influence on the heart. © 2015, Journal of Clinical and Diagnostic Research. All rights Reserved.

Cheekavolu C.,Bharath University | Muniappan M.,Sree Balaji Medical College
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: The inflammatory response is closely intertwined with the process of repair. However in some diseases the inflammatory response may be exaggerated and sustained without apparent benefit and even with severe adverse complications. For decades, we have been primarily relying upon Nonsteroidal (NSAID) and Steroidal Anti-Inflammatory agents for management of various inflammatory conditions. However, adverse effects of these drugs are severe which often leads to patient’s non-compliance with inadequate relief. Therefore, there has been a constant pursuit to develop newer anti - inflammatory treatment with fewer side effects. Aim: The study was designed to investigate the possible anti-inflammatory activity of indazole, its derivatives and to further investigate the possible cellular mechanisms underlying the anti-inflammatory effect. Materials and Methods: Carrageenan induced hind paw oedema in rats was employed to study the acute anti-inflammatory activity of indazole and its derivatives. Further, the role of cyclooxygenase – 2, pro-inflammatory cytokines like Tumour Necrosis Factor – α, Interleukin – 1β and free radical scavenging activity (LPO, DPPH and NO) in the action of indazole and its derivatives was investigated using in vitro assays. Results: SPSS version 16.0 software was used for analyse the anti-inflamatory data. The IC50values of indazole and its derivatives obtained in in vitro experiments were calculated by linear regression analysis. Indazole and its derivatives significantly, dose dependently and time dependently inhibited carrageenan induced hind paw oedema. In addition, the test compounds inhibited cyclooxygenase–2, pro-inflammatory cytokines and free radicals in a concentration dependent manner. Conclusion: The results of the present study revealed the potential anti-inflammatory action of investigated indazoles. The inhibition of cyclooxygenase -2, cytokines and free radicals may contribute to the anti-inflammatory effect of the test compounds. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.

Kumar P.,Thanjavur Medical College | Thomas J.,Sree Balaji Medical College
Indian Journal of Dermatology | Year: 2014

Trigeminal trophic syndrome (TTS) is a rare cause of facial ulceration, consequent to damage to the trigeminal nerve or its central sensory connections. We reporta case of TTS in a 48-year-old woman with Bell's palsy following herpes zoster infection. The patient was treated and counseled. There hasnot been any recurrence for 1 year and the patient is being followed-up. The diagnosis of TTS should be suspected when there is unilateral facial ulceration, especially involving the ala nasi associated with sensory impairment.

Mythili S.V.,Sree Balaji Medical College | Jamunarani A.,Sree Balaji Medical College
International Journal of Pharmaceutical Sciences Review and Research | Year: 2015

Incretins, are the intestinal hormones and they are "Glucose dependant Insulinotropic Polypeptide" (GIP) and "Glucagon Like Polypeptide-1" (GLP-1). Their secretion is induced by the presence of food in the stomach and they in turn induce the secretion of Insulin from the pancreatic beta cells. A lot of studies have been undertaken on Incretins around the world. They convey interpretations on the characteristics of Incretins, the synthesis, their functions, the mechanism of action etc. Do they have effects on other tissues also? Incretins have been found to have significant effect on other tissues like liver, muscle, heart, bone etc. apart from the pancreas. Results of the Literature search of some such studies on the extrapancreatic effects of incretins are reviewed and presented here. © Copyright protected.

Vinod Kumar P.,Sree Balaji Medical College | Begum T.,Sree Balaji Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2016

Cardiac Tamponade also known as Pericardial Tamponade, is a life threatening condition causing slow or rapid compression of heart due to pericardial accumulation of fluid, blood, pus or gas, as a result of eff usion, trauma or rupture of heart. Postmortem examination of an 80 year old male with history of sudden death revealed tense hemopericardium and the rupture of left ventricle. Root of aorta, coronaries and their branches showed multiple raised atheromatous plaques. Coronary ostia were narrowed. Histopathological examination of ruptured ventricular wall showed features of “Acute Myocardial infarction”. © 2015, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Vinod Kumar P.,Sree Balaji Medical College | Begum T.,Sree Balaji Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2016

Cut throat injuries can be suicidal, homicidal or accidental. Suicidal and homicidal cut throat injuries are common. Cut throat injuries are generally caused by the sharp edged weapons or objects. It is not uncommon that kite flying ‘Manja’ strings also cause such cut throat injury. Kite flying is the common time pass activity of the children. In order to strengthen the kite’s string, a paste made of glass powder, glue and the grain flour named "MANJA" is applied on the kite string and dried, before using to fly the kites. While flying the kites, the children attempt cutting high flying kites by rubbing the opponent’s kite string with the help of their high flying kite’s string, to prove their supremacy in the sky. During such instances, both ends of the cut kite string may get entangled and become taut. When it gets positioned across the road, it would act as a sharp weapon and cause accidental cut throat injuries to the road users and birds. In this case report, a four year old child sitting on the petrol tank of the motor bike rode by her father, sustained cut throat injury, involving the left internal jugular vein, by the kite string coated with ‘Manja’ stretched across the road. © 2015, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Rekha P.,Sree Balaji Medical College | Ganapathy H.,Sree Balaji Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

Squamous cell carcinoma is the second most common type of cutaneous malignancy. Squamous cell carcinoma has the propensity to recur and metastasise to a distant site. A 59 yrs old female presented with an ulceroproliferative lesion over the anterior abdominal wall. A clinical diagnosis of Malignant Melanoma was made. However, histopathological examination proved it to be moderately differentiated squamous cell carcinoma. A panel of Immunohistochemistry markers were done to prove the primary nature and also to rule out a diagnosis of malignant melanoma.

Thomas J.,Sree Balaji Medical College
Expert Review of Dermatology | Year: 2013

4th World Congress on Teledermatology Tbilisi, Georgia, 4-6 October 2012 The 4th World Congress of Teledermatology was held from 4-6 October 2012 at Tbilisi, Georgia. George Galdava from the Tbilisi State University, Tbilisi, Georgia and Oleg Kvlividze from the Institute of Dermatology and Venereology, Tbilisi, Georgia, were the Congress President and Secretary, respectively. The Congress theme of 'dermatology conquering distance' was exemplified by the speaker delegates from across the globe. Stella Atkins from the University of British Columbia, Canada, started the scientific session with her sterling talk on 'Automated melanoma diagnosis using a dermoscope attached to a smart phone'. The role of NGOs in the establishing and promotion of telemedicine network today was stressed by Olga Litusi, from Ukraine. Saul Halpern of the British Teledermatology Society expressed that dermatologists in the UK appear to be gradually accepting Teledermatology. The American Academy of Dermatology, African Teledermatology Project was reviewed by Karen Mckoy Lahey Clinic, VT, USA. The concept of virtual hospital was elaborated by Leonard Witkamp from KSYOS TeleMedical Centre, the first virtual hospital in The Netherlands. In his presentation, he concluded that health management practice has been applied in the development, research and large scale implementation of teledermatology. The Indian delegates Jayakar Thomas from the Sree Balaji Medical College and Hospital (Chromepet, Chennai, India), Parimalam Kumar, Head of Dermatology (Thanjavur, India) and Dinesh Kumar from the KK CHILDS Trust Hospital (Nungambakkam, India) discussed the current status and the future directions of Teledermatology in India. © 2013 Expert Reviews Ltd.

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