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Sima P.,Mikrobiologicky Ustav V. V. I. | Turek B.,Spolecnost Pro Vyzivu | Bencko V.,Ustav Hygieny A Epidemiologie 1. LF UK A VFN
Prakticky Lekar | Year: 2014

A growing number of in vitro/ in vivo experimental and clinical studies documents that the products of nonenzymatic reactions formed during technological and culinary processing of food may play a major role in the emergence and global spreading of chronic non-infectious diseases. Evidence mainly points towards a pathogenic role for advanced glycation end products (AGE), advanced lipoxidation end products (ALE), and advanced oxidation protein products (AOPP), which represent the most important dietary compounds that accumulate within the internal milieu of an organism during the whole life span. Currently, they are often regarded as one of a row of causations having strong negative influence on the health and causative agents of chronic diseases burden in all countries, which adopt the westernized lifestyle.


Turek B.,Spolecnost Pro Vyzivu | Sima P.,Mikrobiologicky Ustav V. V. I. | Bencko V.,Ustav Hygieny A Epidemiologie 1. LF UK A VFN
Hygiena | Year: 2014

The recent results of research in the field of nutritional immunology have a wide impact on health protection and promotion-related activities. There is a great deal of evidence showing that the inadequate or lowered nutritional intake is reflected in both protein-energetic malnutrition and immune system disorders. A growing number of in vitro/in vivo experimental and clinical studies documents that the products of non-enzymatic reactions formed during technological and culinary processing of food may play a major role in the emergence and global spread of chronic non-communicable diseases. Evidence mainly points to the pathogenic role of advanced glycation end products (AGE), advanced lipoxidation end products (ALE), and advanced oxidation protein products (AOPP), which represent the most important dietary compounds that accumulate within the internal milieu of an organism over a whole life span. Currently, these factors are regarded as one of a row of causations with strong negative influence on health and the most frequent causative agents of increasing chronic disease burden in all countries which adopt a 'westernized lifestyle'.


Sima P.,Mikrobiologicky ustav v. v. i. | Turek B.,Spolecnost pro vyzivu | Bencko V.,Ustav hygieny a epidemiologie 1. LF UK a VFN
Prakticky Lekar | Year: 2013

Nutritional imunology: modulation of immunity by components of nutrition Nutritional immunology often termed immunonutritology is a relatively new branch of medical sciences connecting two at first glance quite different fields, immunology and nutrition. In spite of this dissimilarity, immunonutritology has a wide impact on public health. There is a great deal of evidence that the nonadequate or lowered intake of nutrition is reflected in both protein-energetic malnutrition (wasting disorder, kwashiorkor etc.) and immune system disorders.


The aim of nutritional toxicology is to reduce to the utmost the incidence of toxic, mutagenic and carcinogenic substances in foodstuffs, and to ensure an adequate supply of protective factors. Limitation of the intake of undesirable health-damaging substances can be achieved in two ways: by strict supervision of the composition and the quality of food raw materials, and by the choice of friendly technologies for their manufacturing and culinary preparation. This primarily concerns the use of processing techniques that allow regulation of the heating (temperature) of foodstuffs so as to avoid as much as possible the formation of compounds that directly affect health. The authors mention the formation and occurrence of key health risk factors in foodstuffs, which cause chronic non-communicable diseases. They point out that from the nutritionally toxicological point of view it is possible to implement effective preventive measures which would lead to the restriction of currently still growing incidence of these diseases.


Turek B.,Spolecnost Pro Vyzivu | Sima P.,Mikrobiologicky Ustav AV CR | Sevcik J.,Spolecnost Pro Vyzivu
Hygiena | Year: 2010

Intestinal microflora greatly influences metabolic processes. Correct nutrition enables an adequate ratio of individual microorganisms in intestinal flora which, as probiotics, play a role in the biochemical and immune mechanisms of prevention in cardiovascular diseases, carcinogenesis, diabetes, and allergies.


Sima P.,Mikrobiologicky ustav V.V.I. | Turek B.,Spolecnost pro vyzivu | Bencko V.,UStav Hygieny a Epidemiologie 1
Prakticky Lekar | Year: 2015

The history of the use of polysaccharides in the role of immunomodulators is relatively long. As the first, the so- -called Shear's polysaccharide, for these reasons was applied at the beginning of 40 s of the last century. Then, the interests in immunomodulation partially faded but it appeared again about twenty years later in connection with evidence of a strong effect of the yeast Saccharomyces cerevisiae cell wall crude extracts for the activation of the complement system. Research of betaglucan biomodulation properties focused initially on infectious immunity and later on the field of anticancer immunity. After successful demonstration of their positive impact on this branch of immunity, in Japan were in the mid-eighties of the last century firstly allowed two types of betaglucans, lentinan and schizophyllan, for supportive treatment of certain types of malignant neoplasms. Important milestones in discovering and defining the immunomodulatory properties of betaglucans, their sources and mechanism of action, are the subject of this communication..

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