Time filter

Source Type

Nastase-Melicovici D.,Spitalul Clinic Judetean De Urgenta Mures | Macarie C.,UMF TG | Coman S.,Spitalul Clinic Judetean De Urgenta Mures | Tilinca M.,UMF TG
Annals of the Romanian Society for Cell Biology

The main objective was to establish some prognostic corelations between echographic evaluation, clinical characteristics and clinical simptomatology (NYHA class) and between exercise capacity (measured by Naughton protocol) and ejection fraction of left ventricol. For these objectives we made a transversal,prospective study, which include two groups of patients with dilatative cardiomiopathy confirmated by echography, with ischemic(confirmed by coronarography who revealed coronarian stenosis and diagnosed with acute myocardial infarction) and nonischemic etiology (without coronary artery disease). As a result of statistical methods we considered that evaluation of the factors presented in our study (age,gender,diabetes mellitus, NYHA class,EF,serum sodium,potassium and hemoglobin, GFR) useful, mandatory, relatively easy to obtain and important to improve therapeutical ways in contrast with the determination of natriuretic peptides, troponines or dosing of neurohormonal markers (norepinephrine, renin, aldosteron, endotelyn) useful in evaluation of neuroendocrine activation, but less useful in diagnosis or prognosis of each patient. From 9 factors studied we found only 4 to be significant for exercise capacity of patient with heart failure: ejection fraction, hemoglobin, sodium levels and glomerular filtration rate. Decreased renal function and hiponatremia represent powerful negative predictors on mortality, superior to NYHA class. Source

Nastase-Melicovici D.,Spitalul Clinic Judetean De Urgenta Mures | Macarie C.,UMF | Coman S.,Spitalul Clinic Judetean De Urgenta Mures | Mariana T.,UMF
Annals of the Romanian Society for Cell Biology

The purpose of our study was to determine left ventricular mass index with transthoracic echocardiography in patients with congestive heart failure, in stages (ussual upper) when renal dysfunction was or not asociated. Materials and Methods: we consider renal dysfunction when rate of glomerular filtration <60 ml/min.Glomerular filtation rate was measured in 47 patients with ischemic heart failure and an ejection fraction <40%. For each patient we registered clinical examination, laboratory tests (serum hemoglobin, creatinin, potassium and albumin), echocardiogram and echocardiography (left ventricular ejection fraction (EF), LV mass, and LV mass index), body mass index (BMI) and total body water (TBW). Results: number of patients with RD was 21 representing a prevalence of 44,68%. There was a greater prevalence for elder subjects. These patients has lower level of hemoglobin and serum albumin but potasium, serum creatinine levels, body mass index (BMI) and total body water (TBW) were higher. Left ventricular mass determined by echocardiography was greater in patients with RD (p= 0.06). Comparison of their drug therapy revealed significant statisticaly diferences only for use of beta blockers and amiodarone. Conclusions: Renal dysfunction is a frequent and seems inevitable asociation in patients with congestive heart failure with ejection fraction of left ventricle under 40 percentage, and is associated with distinctive features that may explain some major undesirable clinical aspects. Patients with CHF and renal dysfunction has left ventricular mass increased. Source

Discover hidden collaborations