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The IL-6 inhibitors may have a harder time penetrating the RA EU market, where Roche's RoActemra (tocilizumab) is the third most commonly prescribed biologic behind AbbVie's Humira and Pfizer's Enbrel with use far surpassing that of Actemra in the US.  Though over one-quarter of the respondents believe the new IL-6 inhibitors will be completely interchangeable with RoActemra, they also note that the greatest barriers for displacing RoActemra are it's length of time on the market, well understood safety profile, rheumatologist comfort in prescribing, and RoActemra's strong supporting clinical data. Further changes impacting the RA treatment paradigm across the EU include the continued acceptance and adoption of biosimilars.  Indeed, 41% of rheumatologists noted that biosimilars have been the single most significant change with regard to RA management over the past year.  Additionally, the biosimilar versions of Remicade now account for nearly 40% of all infliximab use and Biogen/Samsung's Benepali accounts for 25% of all etanercept use. About Spherix Global Insights Spherix Global Insights is a business intelligence and market research company, specializing in renal, autoimmune, neurologic and rare disease markets.  Our aim is to apply our commercial experience and unique relationships within core specialty markets to translate data into insight, enabling our clients to make smarter business decisions. All company, brand or product names in this document may be trademarks of their respective holders. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/eu-rheumatoid-arthritis-landscape-poised-for-big-changes-as-rheumatologists-plan-for-the-adoption-of-eli-lillyincytes-olumiant-pfizers-xeljanz-and-regeneronsanofis-kevzara-300451672.html


News Article | November 28, 2016
Site: www.prnewswire.com

NEW YORK, Nov. 28, 2016 /PRNewswire/ -- Spherix Incorporated (Nasdaq: SPEX)  a company committed to the fostering of technology and monetization of intellectual property, today announced that it executed a Consulting Services Agreement with LawCash ®(www.lawcash.com), ("LawCash") one of th...


News Article | November 7, 2016
Site: globenewswire.com

IRVINE, Calif., Nov. 07, 2016 (GLOBE NEWSWIRE) -- ChromaDex Corp. (NASDAQ:CDXC), an innovator of proprietary health, wellness and nutritional ingredients that creates science-based solutions to dietary supplement, food and beverage, skin care, sports nutrition, and pharmaceutical products, announced today it has appointed Dr. Matthew Roberts, Ph.D. to the Company’s Scientific Advisory Board (“SAB”). Dr. Roberts is an accomplished innovation executive with over 25 years of success at the industry’s major companies.  Currently he is managing, growing and advising startup companies across the food, nutrition, and digital health industries.  Dr. Roberts will add further operational, development, and discovery experience to the SAB. He has achieved outstanding results in both the commercial and research sides of business, leading to successful introduction of hundreds of new food products, ingredients, and science & technology resulting in material improvements in business performance. He has launched concentrated, sterile, and clear protein beverages that have grown both share and margin on major human nutrition brands in both retail and healthcare institutions. His work has also contributed to advances in infant nutrition and care. In the companion animal sector, his work has shaped veterinary and retail animal diets with new approaches to improving the lives of pets. Through his business development work, he has participated or led acquisitions and equity investments, which have resulted in significant structural shifts in the human and companion animal nutrition industry. Operationally, he has worked with global supply chains, procurement, pilot production scale up of innovations, stage gate evaluations, and development of strategic corporate partnerships. As a scientist, Dr. Roberts managed a variety of teams and projects with significant annual budgetary responsibilities. He is the author or editor of numerous peer-reviewed scientific publications, professional publications, and patents. He has presented at hundreds of international life and food science conferences over his career. He has mentored Ph.D. students as an industrial advisor and thesis committee member as well as taught graduate level courses at the ETH and EPFL (Switzerland). The ChromaDex SAB is chaired by Roger Kornberg, a Professor at Stanford Medical School, who was awarded the Nobel Prize in Chemistry in 2006 for his research on the molecular basis of eukaryotic transcription.  Dr. Kornberg earned his bachelor's degree in chemistry from Harvard University in 1967 and his Ph.D. in chemical physics from Stanford in 1972. He became a postdoctoral fellow at the Laboratory of Molecular Biology in Cambridge, England and then an Assistant Professor of Biological Chemistry at Harvard Medical School in 1976, before moving to his present position as Professor of Structural Biology at Stanford Medical School in 1978. Kornberg’s father, the late Arthur Kornberg, was a professor of biochemistry at Stanford and was awarded the Nobel Prize for Physiology or Medicine in 1959.  He was among the first to investigate nicotinamide riboside more than 60 years ago while at the National Institute of Health (NIH). The SAB’s mission is to assist the Company’s management team in maximizing the value of the Company’s portfolio of patented ingredients by advising on such matters as scientific and research focus, clinical studies, safety and regulatory, commercialization opportunities, and assessing new potential ingredient technologies. ChromaDex leverages its complementary business units to discover, acquire, develop and commercialize patented and proprietary ingredient technologies that address the dietary supplement, food, beverage, skin care and pharmaceutical markets. In addition to our ingredient technologies unit, we also have business units focused on natural product fine chemicals (known as "phytochemicals"), chemistry and analytical testing services, and product regulatory and safety consulting (known as Spherix Consulting). As a result of our relationships with leading universities and research institutions, we are able to discover and license early stage, IP-backed ingredient technologies. We then utilize our in-house chemistry, regulatory and safety consulting business units to develop commercially viable ingredients. Our ingredient portfolio is backed with clinical and scientific research, as well as extensive IP protection. Our portfolio of patented ingredient technologies includes NIAGEN® nicotinamide riboside; pTeroPure® pterostilbene; PURENERGY®, a caffeine-pTeroPure® co-crystal; IMMULINA™, a spirulina extract; and AnthOrigin™, anthocyanins derived from a domestically-produced, water-extracted purple corn. To learn more about ChromaDex, please visit www.ChromaDex.com. This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended., Statements that are not a description of historical facts constitute forward-looking statements and may often, but not always, be identified by the use of such words as "expects", "anticipates", "intends", "estimates", "plans", "potential", "possible", "probable", "believes", "seeks", "may", "will", "should", "could" or the negative of such terms or other similar expressions. More detailed information about ChromaDex and the risk factors that may affect the realization of forward-looking statements is set forth in ChromaDex's Annual Report on Form 10-K for the fiscal year ended January 2, 2016, ChromaDex's Quarterly Reports on Form 10-Q and other filings submitted by ChromaDex to the SEC, copies of which may be obtained from the SEC's website at www.sec.gov. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and actual results may differ materially from those suggested by these forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement and ChromaDex undertakes no obligation to revise or update this release to reflect events or circumstances after the date hereof.


IRVINE, Calif., Feb. 22, 2017 (GLOBE NEWSWIRE) -- ChromaDex Corporation (NASDAQ:CDXC) an innovator of proprietary health, wellness and nutritional ingredients that creates science-based solutions for dietary supplement, food and beverage, skin care, sports nutrition, and pharmaceutical products, announced today that University of Iowa researchers have published a study in the prestigious Journal of the International Association for the Study of Pain (PAIN) showing that NIAGEN® Nicotinamide Riboside (NR) ameliorates chemotherapy-induced peripheral neuropathy (CIPN) in an animal model. Results from this study suggest that NR may be an effective therapy in relieving chemotherapy induced peripheral neuropathy (CIPN) in humans.  Access to the study was made available online on February 11, 2017. Currently, the American Society for Clinical Oncology considers the development of adjunctive therapy for the prevention and relief of CIPN as essential for patient care. This study provides an important proof of concept for the use of NR as a novel therapeutic approach in filling the unmet need for treatments that alleviate CIPN. ChromaDex CEO and co-founder, Frank Jaksch, Jr. stated, “This is another well-designed study that reinforces the role of NR in neuronal protection.  These results are particularly important given that this research may contribute to the discovery of a new therapeutic option for a significantly underserved patient population.” Led by Dr. Donna Hammond, Ph.D., the research team at the University of Iowa demonstrated that treatment with NR increased blood levels of nicotinamide adenine dinucleotide (NAD+) by 50 percent after three weeks of daily administration.  NR was able to prevent the development of tactile hypersensitivity induced by the chemotherapeutic paclitaxel and reverse well-established tactile hypersensitivity, while also blunting escape/avoidance behaviors. Furthermore, the prophylactic effect was sustained for at least two weeks after treatment with NR ceased. Dr. Marta Hamity, Ph.D., the lead study author, indicated that the team embarked on the study based on evidence that suggested that increasing levels of NAD+ in the cells may protect against neuronal injury. The study used female Sprague-Dawley rats, clinically relevant doses of paclitaxel and incorporated measures that quantify the impact of CIPN on quality of life. “This is significant because the pain associated with CIPN can increase as the [chemotherapy] dose escalates, and at times it reaches a point where the patient is no longer able to tolerate the effective doses,” explained Hammond. “The American Society of Clinical Oncology has issued a position paper that there is an unmet need for treatments that can alleviate CIPN,” stated Hammond. “This study has provided positive data which is particularly exciting considering the unmet need for therapies in this area. We believe that further development of NR as a therapy for CIPN is warranted.” NR has been the subject of nearly 200 peer-reviewed journal publications and is currently at the center of over 100 collaborative studies between ChromaDex and leading universities and research institutions around the world such as the National Institute of Aging, MIT and the Scripps Research Institute representing an estimated $40-50 million in NR research. In November, 2016 ChromaDex announced that it met with FDA to gain Agency guidance on the requirements needed to successfully file an Investigational New Drug (IND) application to initiate a Phase I/II clinical trial in patients with Cockayne Syndrome. Jaksch commented, “ChromaDex is working towards completing IND-enabling preclinical studies for Cockayne Syndrome and filing that IND sometime in 2017.” ChromaDex, being publicly traded on NASDAQ, gives the public an opportunity for investing in the business of science-based technologies for healthy aging and longevity. To date, ChromaDex has invested millions in safety, toxicology and human clinical trials on NR. Most of ChromaDex’s recent revenue growth has come from its proprietary ingredients, in particular NIAGEN®. ChromaDex’s NIAGEN® is the only commercially available form of NR and is supported by five patents issued and several pending, with patents rights acquired from Cornell University, Dartmouth College and Washington University. In addition to human clinical studies, ChromaDex is actively collaborating with numerous leading universities and research institutes studying the health benefits of NIAGEN®. For additional information about ChromaDex and NIAGEN®, visit www.Chromadex.com. Additional research and news about NR and NAD+ can be found at www.AboutNR.com. About ChromaDex: ChromaDex leverages its complementary business units to discover, acquire, develop and commercialize patented and proprietary ingredient technologies that address the dietary supplement, food, beverage, skin care and pharmaceutical markets. In addition to our ingredient technologies unit, we also have business units focused on natural product fine chemicals (known as "phytochemicals"), chemistry and analytical testing services, and product regulatory and safety consulting (known as Spherix Consulting). As a result of our relationships with leading universities and research institutions, we are able to discover and license early stage, IP-backed ingredient technologies. We then utilize our in-house chemistry, regulatory and safety consulting business units to develop commercially viable ingredients. Our ingredient portfolio is backed with clinical and scientific research, as well as extensive IP protection. Our portfolio of patented ingredient technologies includes NIAGEN® nicotinamide riboside; pTeroPure® pterostilbene; PURENERGY®, a caffeine-pTeroPure® co-crystal; IMMULINA™, a spirulina extract; and AnthOrigin™, anthocyanins derived from a domestically-produced, water-extracted purple corn. To learn more about ChromaDex, please visit www.ChromaDex.com. Forward-Looking Statements: This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended, including statements related to results and significance of the NIAGEN® study  and the likelihood that NR will be an effective tool in relieving chemotherapy-induced peripheral neuropathy, whether NIAGEN® may be used in a therapeutic approach in filling the unmet need for treatments that alleviate CIPN and the likelihood of ChromaDex initiating a Phase I/II clinical trial in patients with Cockayne Syndrome. Statements that are not a description of historical facts constitute forward-looking statements and may often, but not always, be identified by the use of such words as "expects", "anticipates", "intends", "estimates", "plans", "potential", "possible", "probable", "believes", "seeks", "may", "will", "should", "could" or the negative of such terms or other similar expressions. More detailed information about ChromaDex and the risk factors that may affect the realization of forward-looking statements is set forth in ChromaDex's Annual Report on Form 10-K for the fiscal year ended January 2, 2016, ChromaDex's Quarterly Reports on Form 10-Q and other filings submitted by ChromaDex to the SEC, copies of which may be obtained from the SEC's website at www.sec.gov. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and actual results may differ materially from those suggested by these forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement and ChromaDex undertakes no obligation to revise or update this release to reflect events or circumstances after the date hereof. ChromaDex provided research materials and a portion of the grant funding as a collaborator for the study.


News Article | October 31, 2016
Site: www.prnewswire.com

NEW YORK, Oct. 31, 2016 /PRNewswire/ -- Spherix Incorporated (Nasdaq: SPEX) an intellectual property development company committed to the fostering of technology and monetization of intellectual property, today announced that two of the Company's Directors, Jeffrey Ballabon and Howard E....


News Article | February 21, 2017
Site: www.prnewswire.com

NEW YORK, Feb. 21, 2017 /PRNewswire/ -- Spherix Incorporated (Nasdaq: SPEX) an intellectual property development company committed to the fostering of technology and monetization of intellectual property, today announced that it has signed up a new client to its Patent Monetization and...


ZUG, Switzerland, Nov. 2, 2016 /PRNewswire/ -- A recent study of nearly 100 surveyed US rheumatologists reveals that after approximately nine months on the market, not only are current users of Novartis' Cosentyx reporting increased PsA initiations, but the brand has also made significant...


CAMBRIDGE, Mass., Nov. 29, 2016 /PRNewswire/ -- At just over six months post launch, US dermatologists report a significant increase in familiarity with Eli Lilly's IL-17 inhibitor, coupled with a significant increase in the Taltz user base from prior quarters.  Current users of Taltz expe...


News Article | November 8, 2016
Site: globenewswire.com

IRVINE, Calif., Nov. 08, 2016 (GLOBE NEWSWIRE) -- ChromaDex Corp. (NASDAQ:CDXC), an innovator of proprietary health, wellness and nutritional ingredients that creates science-based solutions to dietary supplement, food and beverage, skin care, sports nutrition, and pharmaceutical products, announced today that it has established a $5 million credit facility with Bridge Bank. The credit facility will provide ChromaDex non-dilutive working capital needed for future growth as the company continues to expand its proprietary ingredient business. “We are pleased to have a business-focused bank available to the Company as the next step in our evolution,” said Tom Varvaro, ChromaDex CFO. “We look forward to working with Bridge Bank, which has a strong record of corporate banking and credit facilities for companies our size.” About Bridge Bank Bridge Bank is a division of Western Alliance Bank, Member FDIC, the go-to bank for business in its growing markets. Bridge Bank was founded in 2001 in Silicon Valley to offer a better way to bank for small-market and middle-market businesses across many industries, as well as emerging technology companies and the private equity community. Geared to serving both venture-backed and non-venture-backed companies, Bridge Bank offers a broad scope of financial solutions including growth capital, equipment and working capital credit facilities, sustainable energy project finance, venture debt, treasury management, asset-based lending, SBA and commercial real estate loans, ESOP finance and a full line of international products and services. Based in San Jose, Bridge Bank has eight offices in major markets across the country along with Western Alliance Bank’s robust national platform of specialized financial services. Western Alliance Bank is the primary subsidiary of Phoenix-based Western Alliance Bancorporation. With $17 billion in assets, Western Alliance Bancorporation is one of the fastest-growing bank holding companies in the U.S. and recognized as #10 on the Forbes 2016 “Best Banks in America” list. For more information, visit www.bridgebank.com. About ChromaDex: ChromaDex leverages its complementary business units to discover, acquire, develop and commercialize patented and proprietary ingredient technologies that address the dietary supplement, food, beverage, skin care and pharmaceutical markets. In addition to our ingredient technologies unit, we also have business units focused on natural product fine chemicals (known as "phytochemicals"), chemistry and analytical testing services, and product regulatory and safety consulting (known as Spherix Consulting). As a result of our relationships with leading universities and research institutions, we are able to discover and license early stage, IP-backed ingredient technologies. We then utilize our in-house chemistry, regulatory and safety consulting business units to develop commercially viable ingredients. Our ingredient portfolio is backed with clinical and scientific research, as well as extensive IP protection. Our portfolio of patented ingredient technologies includes NIAGEN® nicotinamide riboside; pTeroPure® pterostilbene; PURENERGY®, a caffeine-pTeroPure® co-crystal; IMMULINA™, a spirulina extract; and AnthOrigin™, anthocyanins derived from a domestically-produced, water-extracted purple corn husk. To learn more about ChromaDex, please visit www.ChromaDex.com. Forward-Looking Statements: This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended, including statements related future growth and financial security. Statements that are not a description of historical facts constitute forward-looking statements and may often, but not always, be identified by the use of such words as "expects", "anticipates", "intends", "estimates", "plans", "potential", "possible", "probable", "believes", "seeks", "may", "will", "should", "could" or the negative of such terms or other similar expressions. More detailed information about ChromaDex and the risk factors that may affect the realization of forward-looking statements is set forth in ChromaDex's Annual Report on Form 10-K for the fiscal year ended January 2, 2016, ChromaDex's Quarterly Reports on Form 10-Q and other filings submitted by ChromaDex to the SEC, copies of which may be obtained from the SEC's website at www.sec.gov. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and actual results may differ materially from those suggested by these forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement and ChromaDex undertakes no obligation to revise or update this release to reflect events or circumstances after the date hereof.


News Article | February 21, 2017
Site: globenewswire.com

IRVINE, Calif., Feb. 21, 2017 (GLOBE NEWSWIRE) -- ChromaDex Corp. (NASDAQ:CDXC), an innovator of proprietary health, wellness and nutritional ingredients that creates science-based solutions to dietary supplement, food and beverage, skin care, sports nutrition, and pharmaceutical products, announced today it is bringing some of its top industry-advancing health and wellness products and services to booth #868 at Engredea 2017, taking place March 9-12 in Anaheim, CA.  ChromaDex is confident that this year’s Engredea attendees will like what they see and hear at booth #868. In addition to showcasing exciting ingredient demonstrations, ChromaDex standards and services experts will be available to discuss how they can help assure your products are delivering on their brand promise. What’s in your product and how can you be sure it is delivering on promise? With today’s stringent focus on ingredient quality and efficacy, ChromaDex provides a comprehensive suite of analytical services such as contaminant testing, the ComplyID™ raw material testing program, and finished product testing. It is an industry-leading provider of phytochemical reference standards, botanical reference materials, and research grade materials for the natural products industry. To learn more about working with ChromaDex, visit www.ChromaDex.com. About ChromaDex: ChromaDex leverages its complementary business units to discover, acquire, develop and commercialize patented and proprietary ingredient technologies that address the dietary supplement, food, beverage, skin care and pharmaceutical markets. In addition to our ingredient technologies unit, we also have business units focused on natural product fine chemicals (known as "phytochemicals"), chemistry and analytical testing services, and product regulatory and safety consulting (known as Spherix Consulting). As a result of our relationships with leading universities and research institutions, we are able to discover and license early stage, IP-backed ingredient technologies. We then utilize our in-house chemistry, regulatory and safety consulting business units to develop commercially viable ingredients. Our ingredient portfolio is backed with clinical and scientific research, as well as extensive IP protection. Our portfolio of patented ingredient technologies includes NIAGEN® nicotinamide riboside; pTeroPure® pterostilbene; PURENERGY®, a caffeine-pTeroPure® co-crystal; IMMULINA™, a spirulina extract; and AnthOrigin™, anthocyanins derived from a domestically-produced, water-extracted purple corn. To learn more about ChromaDex, please visit www.ChromaDex.com. Forward-Looking Statements: This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended, including statements related ingredient claims. Statements that are not a description of historical facts constitute forward-looking statements and may often, but not always, be identified by the use of such words as "expects", "anticipates", "intends", "estimates", "plans", "potential", "possible", "probable", "believes", "seeks", "may", "will", "should", "could" or the negative of such terms or other similar expressions. More detailed information about ChromaDex and the risk factors that may affect the realization of forward-looking statements is set forth in ChromaDex's Annual Report on Form 10-K for the fiscal year ended January 2, 2016, ChromaDex's Quarterly Reports on Form 10-Q and other filings submitted by ChromaDex to the SEC, copies of which may be obtained from the SEC's website at www.sec.gov. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and actual results may differ materially from those suggested by these forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement and ChromaDex undertakes no obligation to revise or update this release to reflect events or circumstances after the date hereof. Statements in this press release have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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