Spectrix Analytical Services LLC

Middletown, CT, United States

Spectrix Analytical Services LLC

Middletown, CT, United States
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Denhart D.J.,Bristol Myers Squibb | Zuev D.,Bristol Myers Squibb | Ditta J.L.,Bristol Myers Squibb | Hartz R.A.,Bristol Myers Squibb | And 10 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

A series of pyrazinones were prepared and evaluated as potential CRF 1R PET imaging agents. Optimization of their CRF1R binding potencies and octanol-phosphate buffer phase distribution coefficients are discussed herein. © 2013 Elsevier Ltd. All rights reserved.


Deskus J.A.,Bristol Myers Squibb | Dischino D.D.,Bristol Myers Squibb | Mattson R.J.,Bristol Myers Squibb | Ditta J.L.,Bristol Myers Squibb | And 23 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Based on a favorable balance between CRF-R1 affinity, lipophilicity and metabolic stability, compound 10 was evaluated for potential development as PET radioligand. Compound [ 18F]10 was prepared with high radiochemical purity and showed promising binding properties in rat brain imaging experiments. © 2012 Elsevier Ltd. All rights reserved.


Zuev D.,Bristol Myers Squibb | Mattson R.J.,Bristol Myers Squibb | Huang H.,Bristol Myers Squibb | Mattson G.K.,Bristol Myers Squibb | And 9 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

A series of N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl- N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines were prepared and evaluated as potential CRF 1R PET imaging agents. Optimization of their CRF 1R binding potencies and octanol-phosphate buffer phase distribution coefficients resulted in discovery of analog 7e (IC 50 = 6.5 nM, log D = 3.5). © 2011 Elsevier Ltd. All rights reserved.

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