Dallas, TX, United States
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Certain aspects relate to apparatuses and techniques for non-invasive optical imaging that acquires a plurality of images corresponding to both different times and different frequencies. Additionally, alternatives described herein are used with a variety of tissue classification applications, including assessing the presence and severity of tissue conditions, such as burns and other wounds.


Moza R.,University of Texas Southwestern Medical Center | Dimaio J.M.,Cardiovascular and Thoracic Surgery Research | Melendez J.,Spectral MD Inc
IEEE Engineering in Medicine and Biology Magazine | Year: 2010

The use of deep-tissue multiwavelength imaging is of paramount importance in clinical settings as a noninvasive solution to identify andmonitor the progression of decubitus ulcers. A point-of-care multiwavelength imager is being developed, whose utility results from the provision of important physiological characteristics and blood flow metrics via analysis of deep-tissue response to light. The noninvasive real-time monitoring and analysis of tissue focusing on wound imaging is integral, because it allows for quantitative in situ measurements that characterize tissue to assess the progress of either tissue healing or necrosis. © 2006 IEEE.


Trademark
Spectral MD Inc | Date: 2014-11-13

Medical imaging apparatus for imaging blood flow, tissue perfusion, wound healing, viable/nonviable tissue, and wound, burn, sore, skin, and sub-skin conditions; Medical imaging diagnostic apparatus for detecting viable skin; Medical imaging diagnostic apparatus for detecting viable/nonviable tissue and skin; Medical imaging apparatus for detecting sub-skin conditions; Medical imaging apparatus for use to observe and/or analyze changes in tissue perfusion and blood flow and diagnosing viable/nonviable tissue and skin; Medical imaging apparatus for screening and imaging the skin and tissue for medical purposes.


Trademark
Spectral MD Inc | Date: 2014-11-13

Medical imaging apparatus for imaging blood flow, tissue perfusion, wound healing, viable/nonviable tissue, and wound, burn, sore, skin, and sub-skin conditions; Medical imaging diagnostic apparatus for detecting viable skin; Medical imaging diagnostic apparatus for detecting viable/nonviable tissue and skin; Medical imaging apparatus for detecting sub-skin conditions; Medical imaging apparatus for use to observe and/or analyze changes in tissue perfusion and blood flow and diagnosing viable/nonviable tissue and skin; Medical imaging apparatus for screening and imaging the skin and tissue for medical purposes.


Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 452.91K | Year: 2011

This Small Business Innovation Research (SBIR) Phase II project has as its main objective the development of a mobile physiological optical imaging hardware and software system to empower clinicians with the ability to deploy, capture, assess and distribute standards compliant image data characterizing deep wounds and cardiovascular conditions. The mobile system will allow clinicians to rapidly identify the presence of hidden wound conditions or problematic blood flow patterns thus allowing care facilities to provide more cost effective and informed care to their patients, while minimizing financial losses associated with wound related hospital acquired conditions. The intellectual merit of this project lies in its scientific pursuit to define, develop, and distribute a comprehensive systems platform that will significantly accelerate the deployment of suitable physiological optical imaging solutions into the market. The research includes linking illumination patterns to physiological conditions while implementing mapping transfer functions by way of digital signal processing. The research objectives include system definition, integration, algorithmic optimization, and clinical validations. The broader impact/commercial potential of this project is to provide substantially affordable noninvasive imaging tools that may be used to assist in treatments that are more accessible to persons in remote areas or those having economic disadvantages. The portable device increases the ability of qualified clinicians to access patient wound care imaging diagnostics remotely, improving quality of care and accessibility to society. Broader commercial benefits include reductions in hospital visits and stays due to more thorough wound assessments and greater accessibility. The mobile system will enable care decisions that are more closely coupled with the state of the underlying tissue and related hemodynamics. It will also allow clinicians and patients to more effectively monitor the benefits of care decisions. The development of the novel and cost-effective optical system to facilitate the imaging of clinically and physiologically meaningful information will fill a void in the medical imaging industry for a point of care solution capable of providing quantitative visualization of physiological processes critical to wound care. The development of the mobile imaging technology will enhance scientific and technological understanding in the areas of optical-tissue image mapping, optoelectronic illumination systems, image processing, clinical applicability and real-time imaging scenarios.


Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 200.00K | Year: 2010

This Small Business Innovation Research (SBIR) Phase I project will lead to methodologies and systems that extract deep tissue physiological images utilizing novel optical illumination and capture technology. The problem addressed is the challenge of effective and timely analysis of deep tissue physiological processes and their corresponding impact upon human health, wound formation and healing. The opportunity is to provide an affordable and accessible means of identifying critical tissue characteristics in a quantitative fashion thus leading to better clinical guidance and more informed care decisions. The research will identify a set of digital illumination conditions, define model-based transfer functions, and then combine these to construct depth resolved physiological image maps. Illumination patterns will be modeled and evaluated representing a variety of combinations of pattern density, symmetry, geometry and coverage cycles. The resulting image maps and use cases will be compared with established clinical metrics for validation. The project shall lead to a definitive means for extracting depth resolved physiological images. The broader impact/commercial potential of this project is to establish affordable and accessible point of use diagnostic tools utilizing a novel non-contact, optical illumination and imaging modality to gain insights into otherwise non-accessible physiological processes. The innovation will enhance the scientific and technological understanding of the inter-relationships between underlying physiology, hemodynamics, diffuse tissue optics, signal processing, clinical understanding and care. Products to be enabled by variable tissue depth physiological imaging include tools for the effective diagnosis and treatment of the millions of Americans that are impacted annually by debilitating skin conditions caused by cancers, burns, pressure sores or skin transfers. At the same time care providers will realize reduced labor costs and liabilities through more effective identification of wounds. The project's technology advances in real-time, non-invasive optical imaging systems will provide particular benefits to elderly and economically disadvantaged patients who would otherwise suffer from reduced access to adequate diagnosis. Resulting products shall provide greater accessibility to all segments of society to better clinical information that can be used to prevent debilitating wounds and enable more effective wound healing.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 1.26M | Year: 2011

This Small Business Innovation Research (SBIR) Phase II project has as its main objective the development of a mobile physiological optical imaging hardware and software system to empower clinicians with the ability to deploy, capture, assess and distribute standards compliant image data characterizing deep wounds and cardiovascular conditions. The mobile system will allow clinicians to rapidly identify the presence of hidden wound conditions or problematic blood flow patterns thus allowing care facilities to provide more cost effective and informed care to their patients, while minimizing financial losses associated with wound related hospital acquired conditions. The intellectual merit of this project lies in its scientific pursuit to define, develop, and distribute a comprehensive systems platform that will significantly accelerate the deployment of suitable physiological optical imaging solutions into the market. The research includes linking illumination patterns to physiological conditions while implementing mapping transfer functions by way of digital signal processing. The research objectives include system definition, integration, algorithmic optimization, and clinical validations.

The broader impact/commercial potential of this project is to provide substantially affordable noninvasive imaging tools that may be used to assist in treatments that are more accessible to persons in remote areas or those having economic disadvantages. The portable device increases the ability of qualified clinicians to access patient wound care imaging diagnostics remotely, improving quality of care and accessibility to society. Broader commercial benefits include reductions in hospital visits and stays due to more thorough wound assessments and greater accessibility. The mobile system will enable care decisions that are more closely coupled with the state of the underlying tissue and related hemodynamics. It will also allow clinicians and patients to more effectively monitor the benefits of care decisions. The development of the novel and cost-effective optical system to facilitate the imaging of clinically and physiologically meaningful information will fill a void in the medical imaging industry for a point of care solution capable of providing quantitative visualization of physiological processes critical to wound care. The development of the mobile imaging technology will enhance scientific and technological understanding in the areas of optical-tissue image mapping, optoelectronic illumination systems, image processing, clinical applicability and real-time imaging scenarios.


Trademark
Spectral MD Inc | Date: 2016-04-08

Computer software for medical imaging apparatus; computer software for 3D medical imaging; Computer software for imaging blood flow, tissue perfusion, wound healing, viable/nonviable tissue, and wound, burn, sore, skin, and sub-skin conditions; Computer software for detecting viable skin; Computer software for detecting viable and nonviable tissue and skin; Computer software for detecting sub-skin conditions; Computer software for use to observe and analyze changes in tissue perfusion and blood flow and diagnosing viable and nonviable tissue and skin; Computer software for screening and imaging the skin and tissue for medical purposes; Computer software for processing, analyzing, and displaying images from medical imaging apparatus; Computer software system for measuring and displaying thermal tissue damage. Medical imagers for imaging blood flow, tissue perfusion, wound healing, viable and nonviable tissue, and wound, burn, sore, skin, and sub-skin conditions; Medical imaging apparatus; Medical imaging apparatus for imaging blood flow, tissue perfusion, wound healing, viable and nonviable tissue, and wound, burn, sore, skin, and sub-skin conditions; Medical imaging diagnostic apparatus for detecting viable skin; Medical imaging diagnostic apparatus for detecting viable and nonviable tissue and skin; Medical imaging apparatus for detecting sub-skin conditions; Medical imaging apparatus for use to observe and analyze changes in tissue perfusion and blood flow and diagnosing viable and nonviable tissue and skin; Medical imaging apparatus for screening and imaging the skin and tissue for medical purposes.


Trademark
Spectral MD Inc | Date: 2016-07-01

Medical imaging apparatus for imaging blood flow, tissue perfusion, wound healing, viable and nonviable tissue, and wound, burn, sore, skin, and sub-skin conditions; Medical imaging diagnostic apparatus for detecting viable skin; Medical imaging diagnostic apparatus for detecting viable and nonviable tissue and skin; Medical imaging apparatus for detecting sub-skin conditions; Medical imaging apparatus for use to observe and analyze changes in tissue perfusion and blood flow and diagnosing viable and nonviable tissue and skin; Medical imaging apparatus for screening and imaging the skin and tissue for medical purposes.


Trademark
Spectral MD Inc | Date: 2014-11-13

Medical imaging apparatus for imaging blood flow, tissue perfusion, wound healing, viable and nonviable tissue, and wound, burn, sore, skin, and sub-skin conditions; Medical imaging diagnostic apparatus for detecting viable skin; Medical imaging diagnostic apparatus for detecting viable and nonviable tissue and skin; Medical imaging apparatus for detecting sub-skin conditions; Medical imaging apparatus for use to observe and analyze changes in tissue perfusion and blood flow and diagnosing viable and nonviable tissue and skin; Medical imaging apparatus for screening and imaging the skin and tissue for medical purposes.

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