SpectraFluidics Inc.

Hollister, CA, United States

SpectraFluidics Inc.

Hollister, CA, United States
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Piorek B.D.,SpectraFluidics Inc. | Lee S.J.,SpectraFluidics Inc. | Judy N.,University of California at Santa Barbara | Meinhart C.D.,University of California at Santa Barbara | And 4 more authors.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2010

A novel microfluidic/SERS platform has been developed for real time sensing of 2,4-DNT. The fundamental research is being conducted at UCSB, commercialized by SpectraFluidics, and validated at ECBC. The system leverages phenomena at multiple length scales, ranging from tens of micrometers to several nanometers. The key enabling technology is a newly developed invention termed Free-Surface Fluidics (FSF), where one or more fluidic surfaces are confined by surface tension forces, and exposed to the surrounding atmosphere. The free-surface fluidic architecture is combined with surface-enhanced Raman spectroscopy (SERS) for detection of 2,4-DNT. Once 2,4-DNT analyte molecules are absorbed into the flow, they can interact with gold or silver colloidal particles. This architecture allows for analysis and deterministic control of SERS 'hot spot' aggregation, which can increase Raman scattering signal strength by up to 10 orders in magnitude. We have successfully measured DNT vapor at concentrations as low as ∼1 ppb. This sensitivity value is confirmed by orthogonal measurements using GC-mass spectroscopy at ECBC. © 2010 Copyright SPIE - The International Society for Optical Engineering.


Piorek B.D.,University of California at Santa Barbara | Piorek B.D.,SpectraFluidics Inc. | Lee S.J.,University of California at Santa Barbara | Lee S.J.,SpectraFluidics Inc. | And 3 more authors.
Analytical Chemistry | Year: 2012

The dominant physical transport processes are analyzed in a free-surface microfluidic and surface-enhanced Raman spectroscopy (SERS) chemical detection system. The analysis describes the characteristic fluid dynamics and mass transport effects occurring in a microfluidic detection system whose analyte absorption and concentration capability is designed to operate on principles inspired by canine olfaction. The detection system provides continuous, real-time monitoring of particular vapor-phase analytes at concentrations of 1 ppb. The system is designed with a large free-surface-to-volume ratio microfluidic channel which allows for polar or hydrophilic airborne analytes to readily be partitioned from the surrounding gas phase into the aqueous phase for detection. The microfluidic stream can concentrate certain molecules by up to 6 orders of magnitude, and SERS can enhance the Raman signal by 9-10 orders of magnitude for molecules residing in the so-called SERS "hot spots", providing extremely high detection sensitivity. The resulting vibrational spectra are sufficiently specific to identify the detected analyte unambiguously. Detection performance was demonstrated using a nominal 1 ppb, 2,4-dinitrotoluene (2,4-DNT) vapor stream entrained within N2 gas. Applications to homeland security arise from the system's high sensitivity and its ability to provide highly reproducible, continuous chemical detection monitoring with minimal sampling requirements. © 2012 American Chemical Society.


Ding C.,University of California at Santa Barbara | Soni G.,University of California at Santa Barbara | Bozorgi P.,University of California at Santa Barbara | Piorek B.D.,SpectraFluidics Inc. | And 3 more authors.
Journal of Microelectromechanical Systems | Year: 2010

A novel 3 cm ×3 cm × 600μm-thick Ti-based flat heat pipe is developed for Thermal Ground Plane (TGP) applications. The Ti-based heat pipe architecture is constructed by laser welding two microfabricated titanium substrates to form a hermetically sealed vapor chamber. The scalable heat pipes' flat geometry facilitates contact with planar heat sources, such as microprocessor chip surfaces, thereby reducing thermal contact resistance and improving system packaging. Fluid transport is driven by the wicking structure in the TGP, which consists of an array of Ti pillars that are microfabricated from a titanium substrate using recently developed high-aspect-ratio Ti processing techniques. The hydrophilic nature of the Ti pillars is increased further by growing ∼200-nm hairlike nanostructured titania of the pillar surfaces. The resulting super hydrophilic wick offers the potential to generate high wicking velocities of ∼27.5 mm/s over distances of 2 mm. The experimental wetting results show a diffusive spreading behavior that is predicted by Washburn dynamics. The maximum effective thermal conductivity of a heat pipe is directly related to the speed of capillary flow of the working fluid through the wick and is measured experimentally in the first-generation device to be k = 350W/mċK. A dummy TGP with a cavity volume of ∼170μL was used to test the hermiticity level of the laser packaging technique. The device gave a 0.067% of water loss based on ∼60μL of charged water at 100 °C in air for over a year. © 2010 IEEE.


Methods and apparatus for detection and/or analysis of gas phase analytes and chemical compounds. The apparatus can be formed with microfluidic cells containing a selected fluid that interacts with the analyte(s), wherein the fluid can selectively transition between a vapor phase and a liquid phase. During condensation of the fluid, the population of analytes present within the vapor phase region of the fluid can be transported into the liquid phase region of the fluid within the microfluidic cells. During evaporation of the fluid, the analytes can be substantially retained within liquid phase region of the fluid and within the cells. Repetitive cycling of this vapor/liquid exchange can provide a build-up of the analytes within the microfluidic cells where they can be detected/analyzed.


Patent
SpectraFluidics Inc. | Date: 2010-11-29

SERS-active materials are delivered to a remote zone, then optically interrogated to detect and analyze from a safe distance the presence of explosives or other materials which may or may not be hazardous. Delivery methods include deploying projectiles comprising SERS-active material(s) which distribute their contents upon deployment to a target zone.


A series of electronic-chemometric control processes to enhance the selectivity, concentration, analysis, and detec tion of chemical species (analytes) in the gas phase, such as when using SERS-based techniques. Controls consist variously of: 1) feedback of electronic signals corresponding to changes of static and variable parameters in targeted chemical species that vary according to a reduction, increase, maximization, linearization, or improved confidence in one or more chemometric output parameters; 2) methods for spatially locating the source of an analyte species; and, 3) variable duty cycling to save power and materials according to altered physical and environmental conditions within a monitored zone.


Trademark
SpectraFluidics Inc. | Date: 2012-08-01

(Based on Use in Commerce) Portable devices for the detection, measurement, identification and analysis of chemicals, explosive materials, biomarkers and bioharzardous materials, namely, chemical vapor detection cartridges and cartridge readers and processing units therefor, not for medical use; portable devices for the detection, measurement, identification and analysis of chemicals for the purpose of drug and narcotic detection; portable devices for the detection, measurement, identification and analysis of the levels of pesticide, herbicide, and decay in food products; portable devices for the detection, measurement, identification and analysis of explosive material, for use in the field of security; portable devices for the detection, measurement, identification and analysis of chemicals, explosive materials, biomarkers and bioharzardous materials, for use in the field of scientific research. (Based on Intent to Use) Custom manufacture of chemical preparations, chemical reagents, and portable devices used for the detection, measurement, analysis and identification of chemicals, vapor trace chemicals, bio-chemicals, biological materials, bacterial materials, explosive materials, biomarkers, and biohazardous materials. (Based on Intent to Use) Chemical research; research and development of chemical preparations and chemical reagents used in the detection, measurement, analysis and identification of chemicals, bio-chemicals, biological materials, bacterial materials, explosive materials, biomarkers and bioharzardous materials; research and development of portable devices for the detection, measurement, identification and analysis of vapor trace chemicals, bio-chemicals, biological materials, bacterial materials, explosive materials, biomarkers and bioharzardous materials; chemical, bio-chemical, biological and bacterial analysis services, namely, analysis, detection, measurement, and identification of chemical, bio-chemical, biological, and bacterial materials; chemical, bio-chemical, biological and bacterial analysis, detection, measurement, and identification services, for food safety testing purposes; chemical, bio-chemical, biological, and bacterial analysis services, namely, analysis, detection, measurement, and identification of chemicals, bio-chemicals, biological materials, bacterial materials, biomarkers and bioharzardous material for security purposes. (Based on Intent to Use) Bomb detection services, namely, detection and identification of explosive materials for airport screening, homeland security, and anti-terrorism purposes; airline passenger screening and baggage security inspections to detect the presence of explosives, illegal drugs, and hazardous materials.


Patent
SpectraFluidics Inc. | Date: 2011-11-04

For a rapid and real-time SERS detection of organic chemicals in the air and the interfaces of air/solids, colloidal silver and/or gold nanoparticles solution is sprayed, in the form of nano-/micro-sized droplets, at the desired target area where the analytes of interest are present, e.g., in the air or onto certain organic/inorganic interfaces.

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