Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research

San Antonio, TX, United States

Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research

San Antonio, TX, United States

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Slingluff J.L.,Western University of Health Sciences | Williams J.T.,Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research | Blau L.,University of Texas Health Science Center at San Antonio | Blau A.,University of Texas Health Science Center at San Antonio | And 2 more authors.
Journal of Medical Primatology | Year: 2010

Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans. © 2009 John Wiley & Sons A/S.


Bommineni Y.R.,Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research | Dick Jr E.J.,Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research | Malapati A.R.,Texas AgriLife Research Center | Owston M.A.,Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research | And 2 more authors.
Journal of Medical Primatology | Year: 2011

Background Baboons are useful animal models for biomedical research, but the natural pathology of the baboon is not as well defined as other non-human primates. Methods A computer search for all morphologic diagnoses from baboon necropsies at the Southwest National Primate Research Center was performed and included all the natural deaths and animals euthanized for natural causes. Results A total of 10,883 macroscopic or microscopic morphologic diagnoses in 4297 baboons were documented and are presented by total incidence, relative incidence by sex and age-group, and mean age of occurrence. The most common diagnoses in descending order of occurrence were hemorrhage, stillborn, amyloidosis, colitis, spondylosis, and pneumonia. The systems with the most diagnoses were the digestive, urogenital, musculoskeletal, and respiratory. Conclusion This extensive evaluation of the natural pathology of the baboon should be an invaluable biomedical research resource. © 2011 John Wiley & Sons A/S.


PubMed | Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research
Type: Journal Article | Journal: Anticancer research | Year: 2011

Chewing of regurgitated food elicits in baboons life-long gastro-esophageal reflux (GER). The acid reflux transforms the multilayered squamous cell epithelium of the esophagus into columnar-lined mucosa with mucus-producing accessory glands. The function of this mucous gland metaplasia (MGM), which mimics Barretts mucosa with MGM in humans, is to buffer the gastric acid entering the esophagus during regurgitation. In a previous study of entire esophagi, the majority of baboons showed MGM. The gastric mucosa was not investigated.Hematoxylin-eosin-stained sections from the esophagus, from the lesser gastric curvature and from the greater gastric curvature were collected separately from 50 adult baboons. The presence of MGM was assessed in each one of these locations.MGM was demonstrated in 92% (46/50) of blocks from the esophagus, in 98% (49/50) of blocks from the lesser curvature and in 90% (45/50) of those of the greater curvature (fundus).The majority of the animals had MGM, not only in the esophagus but also in the proximal gastric mucosa. Rationally, MGM in baboons starts in the distal esophagus and proceeds downwards, towards the proximal stomach. The histogenesis of the MGM in Barretts mucosa in humans (that is Barretts mucosa type 2) remains elusive. Therefore the baboon might be an important animal model for studying the histogenesis of Barretts mucosa with MGM in humans, a recognized pre-cancerous lesion.


PubMed | Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research
Type: Journal Article | Journal: Journal of medical primatology | Year: 2011

Baboons are useful animal models for biomedical research, but the natural pathology of the baboon is not as well defined as other non-human primates.A computer search for all morphologic diagnoses from baboon necropsies at the Southwest National Primate Research Center was performed and included all the natural deaths and animals euthanized for natural causes.A total of 10,883 macroscopic or microscopic morphologic diagnoses in 4297 baboons were documented and are presented by total incidence, relative incidence by sex and age-group, and mean age of occurrence. The most common diagnoses in descending order of occurrence were hemorrhage, stillborn, amyloidosis, colitis, spondylosis, and pneumonia. The systems with the most diagnoses were the digestive, urogenital, musculoskeletal, and respiratory.This extensive evaluation of the natural pathology of the baboon should be an invaluable biomedical research resource.

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