Dietrich J.,University of Arizona |
Kaiser C.,The Translational Genomics Research Institute TGen |
Meurice N.,Southwest Comprehensive Center for Drug Discovery and Development |
Meurice N.,The Translational Genomics Research Institute TGen |
Hulme C.,University of Arizona
Tetrahedron Letters | Year: 2010
Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation.