Southwest Comprehensive Center for Drug Discovery and Development

Discovery Bay, United States

Southwest Comprehensive Center for Drug Discovery and Development

Discovery Bay, United States
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Dietrich J.,University of Arizona | Kaiser C.,The Translational Genomics Research Institute TGen | Meurice N.,Southwest Comprehensive Center for Drug Discovery and Development | Meurice N.,The Translational Genomics Research Institute TGen | Hulme C.,University of Arizona
Tetrahedron Letters | Year: 2010

Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation.

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