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Chen E.M.,Tamkang University | Lu P.-J.,National Cheng Kung University | Shaw A.Y.,University of Arizona | Shaw A.Y.,Southwest Comprehensive Center for Drug Discovery and Development
Journal of Heterocyclic Chemistry | Year: 2012

A series of 2'-arenesulfonyloxy-5-benzylidene-thiazolidine-2,4-diones (TZDs) were synthesized and examined for their antiproliferative effects on a panel of carcinoma cell lines. Our results indicated that initial synthesis of 5-[2'-hydroxybenzylidene]-2,4-thiazolidinone (9) by Knoevenagel condensation followed by nucleophilic substitution with arylsulfonyl chlorides exhibited superior efficiency to the alternative synthetic route. Among tested compounds, only 8c and 8e showed significant antiproliferative activity against PC-3 and BT474 cells with GI 50 values of 8.4 and 20.6 μM, respectively. SKHep cells displayed interesting structure-activity relationships in response to TZD derivatives treatment. Alkyl group-substituted TZD analogs such as 8a (4-Me, GI 50, 9.4 μM) and 8k (4-iso-propyl, GI 50, 9.8 μM) revealed better antiproliferative activity than those with bulkier alkyl groups. On the other hand, halogen-substituted TZD analogs 8c, 8h, and 8i showed better antiproliferative activity against H460 cell line. Together, the new synthesized TZD derivatives 8a-8p exhibited appreciable antiproliferative activity worth for further study. © 2012 HeteroCorporation.

Dietrich J.,University of Arizona | Dietrich J.,Southwest Comprehensive Center for Drug Discovery and Development | Kaiser C.,The Translational Genomics Research Institute TGEN | Meurice N.,Southwest Comprehensive Center for Drug Discovery and Development | And 3 more authors.
Tetrahedron Letters | Year: 2010

Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation.

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