Chittagong, Bangladesh

Southern University Bangladesh

southern.edu.bd/
Chittagong, Bangladesh

Southern University Bangladesh or is a private university in Chittagong, Bangladesh. Southern was established as an Institute in 1998. Under the Private University Act.The University founded in the year 2003 got approval from Ministry of Education. Southern University is accredited by the University Grants Commission Bangladeshis the highest controlling authority for Government and Non-Government Universities in Bangladesh. Wikipedia.

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Islam M.T.,Federal University of Piauí | Islam M.T.,Southern University Bangladesh
International Journal of Radiation Biology | Year: 2017

Purpose: The use of radiation, especially ionizing radiation (IR), is currently attracting great attention in the field of medical sciences. However, it should be mentioned that IR has both beneficial and harmful effects in biological systems. This review aims to focus on IR-mediated physiological events in a mechanistic way. Materials and methods: Evidence from the databases, mainly from PUBMED and SCIENCE DIRECT were considered. Results: IR directly and/or with their lyses products (indirect) causes oxidative stresses to biological systems. These activities may be localized and systematic. Otherwise, IR-induced non-/multi-targeted effects are also evident. IR in diagnosis and cancer radiotherapy is well-known. Reactive species produced by IR are not only beneficial, but also can exert harmful effects in a biological system such as aging, genetic instability and mutagenicity, membrane lysis and cell death, alteration of enzymatic activity and metabolic events, mitochondrial dysfunction, and even cancer. Additionally, DNA adducts formation, after IR-induced DNA breakage, is a cause of blockage of DNA repair capability with an increase in cellular radiosensitivity. These may allow cellular ruin even at low IR levels. Conclusion: Dependent on the dose, duration of action and quality, IR plays diverse roles in biological systems. © 2017 Informa UK Limited, trading as Taylor & Francis Group.


Islam M.T.,Southern University Bangladesh | Islam M.T.,Federal University of Piauí
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2016

Cancer, the group of diseases, is characterized by an abnormal cell growth and function, thus the complications in physiological homeostasis. Although, not all tumors are cancerous, but after a certain time/biological events they may turn into cancer. That means, it is always a risk to continue with any type of tumor. Over 100 cancers are affecting human are detected till date. Treatments belong to the types and stages of cancers along with the areas (physiological). However, there is no single cancer therapy, which is free from side effects. Additionally, complications in cellular targeting and therapy-induced second cancer are also evident. Combination treatments are also used in some cases, despite the possibility of immunosuppression and a bundle of unavoidable events. Otherwise, cancer treatment in advanced stages and metastasize are yet being considered. Therefore, scientists are always in search for a new and effective mode of cancer treatment, so that they may ensure less or even no side effects with a promising survival rate. In fact, the economy, safety, and effectiveness are the deemed query of both the patients and physicians. Among the others, the markers coming from the changed cell membrane of a cancerous cell may be good sources to ligand targeting, as these are the basic differentiating matter between a normal and cancer cell. In this hypothesis, the membrane marker sensory strategy is going to be introduced theoretically for the first time may be an alternative and effective mode of cancer treatment. © 2016 The Authors.


Islam M.T.,Southern University Bangladesh | Islam M.T.,Federal University of Piauí
Frontiers in Pharmacology | Year: 2017

Recently, the use of plant-derived medicines is increasing interest in the prevention and treatment of a variety of disorders including metabolic syndromes. Metabolic syndrome is one of the major risk factors for cardiovascular diseases (CVDs) and incidence of mortality worldwide. Scientific evidence suggests that Andrographis paniculata and its derived components, especially andrographolide (AGL) and its analogs/derivatives have a broad spectrum of biological activities. This review aims to sketch the activity of AGL and its analogs/derivatives against the components of metabolic syndromes such as diabetes, hyperlipidemia, hypertension, and obesity. Additionally, AGL activity against CVDs is also summarized. The finding suggests that AGL and its analogs/derivatives have a potential role in the management of metabolic syndrome; however, more studies should be conducted to evaluate their effectiveness. © 2017 Islam.


Sultana J.,Chittagong University of Engineering and Technology | Ahmed T.,Southern University Bangladesh
ECCE 2017 - International Conference on Electrical, Computer and Communication Engineering | Year: 2017

Mobile Adhoc Network (MANET) is comprised of mobile nodes where each mobile node acts as both router and terminal. While acting as a router a reliable routing protocol is chosen ensuring the packet to reach its destination and an agent is responsible for the transmission of packet while acting as a terminal. In this paper, we implemented secure packet transmission in mobile adhoc network (MANET) through Adhoc On Demand Multipath Distance Vector (AOMDV) routing protocol. AOMDV, a multipath extension of AODV (Adhoc On Demand Distance Vector) routing protocol, is more reliable than its parent protocol, though not completely restraint from attacks. To keep the packets secure in an adversary environment with multiple attackers is the main objective. Elliptic Curve Cryptography (ECC) has been chosen to secure the packets against blackhole attack. Elliptic Curve Cryptography provides security with smaller key size compared to other public-key encryption. We configured three different types of environment using NS-2.35 which is a discrete event network simulator; a secure environment without malicious activity, a hostile environment with blackhole attackers and with ECC implementation by the agent and analyzed their performance. © 2017 IEEE.


Islam M.T.,Southern University Bangladesh
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2016

Cancer is considered by both genetic and epigenetic pathways. Although, genetic pathways are straightforward, but the reversibility and numerous unclear talks make epigenetic pathway complicated. DNA methylation, histone modifications and non-coding RNA (ncRNA) mediated gene silencing are the three known consequences in epigenetic alterations. In this context, small ncRNAs such as microRNA are known to regulate various components of cellular epigenetic machinery by up or down-regulating in pathogenesis; those are already known in a number of pathophysiological states. These types of biomarkers can be used in the diagnosis and therapeutic interventions in some instances. Although some epigenetic therapies have been introduced, but a number of challenges in each case are remarkable, encouraging more researchers in this field of novel strategy. This paper will discuss a short note on epigenetics and epigenetic therapeutic interventions along with crucial challenges yet to be resolved. © 2016 The Authors.


Islam M.T.,Federal University of Piauí | Islam M.T.,Southern University Bangladesh | Da Silva C.B.,Federal University of Piauí | De Alencar M.V.O.B.,Federal University of Piauí | And 3 more authors.
Phytotherapy Research | Year: 2016

A significant number of studies have been performed with diterpene effect on the brain. Our study aims to make a systematic revision on them. The initial purpose of this review was to screen diterpenes with neurological activity, in particular those that have already been studied and published in different journals (databases until August 2015). The second purpose was to make an action-wise discussion as results viewed on them by taking into drug discovery and development account. Diterpenes considered in this review were selected on the basis of updated information on them and having sufficient information on their screenings. We identified several examples of diterpenes having an interest in further study. We have included the possible sources of them as observed in evidence, their known molecular neurobiological mechanisms, and the active constituents responsible for such activities with the doses and test systems. Results suggest diterpenes to have neurobiological activities like neuro-protection, anti-epileptic, anxiolytic, anti-Alzheimer's disease, anti-Parkinson's disease, anti-cerebral ischemia, anti-neuropathic pain, anti-neuro-inflammatory, and many more. In conclusion, diterpenes may be the prominent candidates in neurobiological drug research. © 2016 John Wiley & Sons, Ltd.


Costa J.P.,Federal University of Piauí | De Oliveira G.A.L.,Federal University of Piauí | De Almeida A.A.C.,Federal University of Piauí | Islam M.T.,Federal University of Piauí | And 3 more authors.
Brain Research | Year: 2014

Phytol, a branched chain unsaturated alcohol, is particularly interesting because it is an isolated compound from essential oils of different medicinal plants. The aim of this study was to evaluate the anxiolytic-like effects of phytol in animal models to clarify their possible action mechanism. After acute intraperitoneal treatment with phytol at doses of 25, 50 and 75 mg/kg behavioral models of open-field, elevated-plus-maze, rota-rod, light-dark, marble-burying and pentobarbital sleeping time tests were utilized. In open field test, phytol (25, 50 and 75 mg/kg) [p<0.01] increased the number of crossings and rearings. However, the number of groomings [p<0.01] was reduced. Likewise, the number of entries and the time spent in light space were increased [p<0.01] while the number of marble-burying was decreased [p<0.001], in elevated-plus-maze, light-dark and marble-burying tests, respectively. In motor activity test, phytol (75 mg/kg) impaired the rota-rod performance of mice [p<0.01]. In pentobarbital sleeping time test, phytol 75 mg/kg decreased for latency of sleeping and phytol (25, 50 and 75 mg/kg) increased the sleep time when compared to negative control [p<0.05]. All these effects were reversed by pre-treatment with flumazenil (2.5 mg/kg, i.p.), similarly to those observed with diazepam (2 mg/kg, i.p.; positive control) suggesting that the phytol presents mechanism of action by interaction with the GABAergic system. These findings suggest that acute administration of phytol exerts an anxiolytic-like effect on mice. Furthermore, suppose that phytol interacts with GABAA receptor, probably at the receptor subtypes that mediate benzodiazepines effects, to produce sedative and anxiolytic activities. © 2013 Published by Elsevier B.V.


Ullah H.M.A.,Gyeongsang National University | Zaman S.,North South University | Juhara F.,North South University | Akter L.,North South University | And 3 more authors.
BMC Complementary and Alternative Medicine | Year: 2014

Background: The present study was aimed to investigate the antinociceptive and anti-inflammatory activity of the Curcuma zedoaria (family Zingiberaceae) ethanolic rhizome extract in laboratory using both in vitro and in vivo methods so as to justify its traditional use in the above mentioned pathological conditions. Methods: Phytochemical screening was done to find the presence of various secondary metabolites of the plant. In vivo antinociceptive activity was performed employing the hot plate method, acidic acid induced writhing test and formalin induced writhing test on Swiss albino mice at doses of 250 and 500 mg/kg body weight. Anti-inflammatory activity test was done on Long Evans rats at two different doses (250 and 500 mg/kg body weight) by using carrageenan induced paw edema test. Finally in vitro anti-inflammatory test by protein-denaturation method was followed. Data were analyzed by one-way analysis of variance (ANOVA) and Dunnett's t-test was used as the test of significance. P value <0.05 was considered as the minimum level of significance. Results: Phytochemical screening revealed presence of tannins, saponins, flavonoids, gums & carbohydrates, steroids, alkaloids, reducing sugars and terpenoids in the extract. In the hot plate method, the extract increased the reaction time of heat sensation significantly to 61.99% and 78.22% at the doses of 250 and 500 mg/kg BW respectively. In acetic acid induced writhing test, the percent inhibition of writhing response by the extract was 48.28% and 54.02% at 250 and 500 mg/kg doses respectively (p < 0.001). The extract also significantly inhibited the licking response in both the early phase (64.49%, p < 0.01) and the late phase (62.37%, p < 0.01) in formalin induced writhing test. The extract significantly (p < 0.05, p < 0.01 and p < 0.001) inhibited carrageenan induced inflammatory response in rats in a dose related manner. In in-vitro anti-inflammatory test, the extract significantly inhibited protein denaturation of 77.15, 64.43, 53.04, 36.78 and 23.70% for doses of 500, 400, 300, 200 and 100 μg/mL respectively. Conclusions: The results obtained from the tests indicate that the plant might have one or more secondary metabolite(s) having central and peripheral analgesic and anti-inflammatory activity. © 2014 Ullah et al.; licensee BioMed Central Ltd.


Khan M.A.A.,Southern University Bangladesh | Islam M.T.,Southern University Bangladesh
Journal of Pharmacy and Bioallied Sciences | Year: 2012

Objectives: The aim of the study was to evaluate analgesic and cytotoxic activity of Acorus calamus L., Kigelia pinnata L., Mangifera indica L., Tabernaemontana divaricata L. extracts by using acetic acid-induced writhing method in mice and brine shrimp lethality assay. Materials and Methods: The ethanolic extracts of the plants were obtained by simple maceration method and were subjected to standardization by using pharmacognostical and phytochemical screening methods, which were followed by acetic acid writhing and brine shrimp lethality test methods. Dose selection was made on the basis of acute oral toxicity study (10-1000 mg/kg body weight). Results and Conclusion: In analgesic test, M. indica L. extract produced 28.16% and 22.02% writhing protection at the doses of 250 and 500 mg/kg body weight in mice, respectively. While the T. divaricata L. extract produced 22.02% and 33.93%, K. pinnata L. extract produced 11.55% and 47.29% and A. calamus L. extract produced 15.16% and 54.51% of writhing protection at the same doses. The percent mortality (mean ± SD) was found to be 58.7 ± 25.22, 56.25 ± 22.88, 52.50 ± 24.37, and 61.25 ± 26.66 with M. indica L., T. divaricata L., K. pinnata L., and A. calamus L., respectively. And the LC 50 and LC 90 values were found to be 100 and 300 μg/mL for M. indica L. and that were (200 and 350 μg/mL), (100 and 350 μg/mL) and (50 and 300 μg/mL) for T. divaricata L., K. pinnata L., and A. calamus L., respectively. Thus it can be concluded that bark of M. indica L., leaves of T. divaricata L., bark of K. pinnata L., and roots of A. calamus L. have significant analgesic and cytotoxic activity and can be preferred in the treatment of pain and tumor.


Daiyan G.M.,Southern University Bangladesh | Mottalib M.A.,Islamic University of Technology | Rahman M.M.,Islamic University of Technology
Proceeding of the 15th International Conference on Computer and Information Technology, ICCIT 2012 | Year: 2012

A high performance decision based median filter is proposed for removal of salt and pepper in images. It is an enhanced Adaptive Switching Median filter which initially detects noise pixels iteratively through several phases and replaces the noisy pixels with median value. It calculates median value without considering noisy pixels to improve the performance of median filter for high density noise. Detection of noise is done by expanding the mask until 7×7 to maintain local information extraction. Moreover, the processing pixel is replaced by last processed pixel if the algorithm fails to detect noise free pixel at 7×7. If the noise free median value is not available at 7×7 processing window, the last processed pixel take into consideration if it is noise free. If the last processed pixel is noisy, the algorithm select a window size with 15×15 dimension and calculate the number of 0's and 255's in the processing window. Then replace the processing pixel with 0 or 255 which is more in number in the selected window. Experiment result shows that it can provide very high quality restored images for images that are contaminated by 'salt & pepper' noise, especially when the noise density is large. © 2012 IEEE.

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