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The Uab Research Foundation and Southern Research Institute | Date: 2015-05-21
In one embodiment, a hinged microfracture awl includes a handle, and a shaft that extends through and from the handle, the shaft being pivotally mounted to the handle with a hinge, wherein a distal end of the shaft includes a sharp tip adapted to pierce bone and a proximal end of the shaft includes an impact head adapted to be struck by a striking tool.
Southern Research Institute | Date: 2016-07-08
In one aspect, the invention relates to pharmaceutical compositions and methods for treating a cancer comprising administration of an EGFR inhibitor and a MEK or MET inhibitor. In various aspects, the methods can comprise determination of increased levels of HGF, e.g., determining if a patient has an increased level of serum HGF. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Southern Research Institute | Date: 2016-04-26
Disclosed herein is a method and apparatus that uses a brine from a well that is used to both generate electricity and recover valuable minerals present in the brine. The method and apparatus uses a hydrophobic membrane to separate water vapor from the brine to concentrate the brine that is then used to recover the minerals.
The Uab Research Foundation and Southern Research Institute | Date: 2017-04-05
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(-D-arabinofuranosyl)-2-fluoroadenine (F-araA).
Southern Research Institute | Date: 2017-01-11
The disclosure provides catalyst composition for converting propylene glycol and glycerol to acrolein comprising a catalyst having the formula:M1M2_(x)M3_(y)O_(z)wherein M1 is a metal promoting dehydrogenation and C-O cleavage,wherein M2 is a metal with acid sites promoting dehydration,wherein M3 is an amphoteric catalyst support, with acid and base sites, promoting both dehydration and dehydrogenation in conjunction with M1,wherein x is a molar ratio from about 0.25 to about 4,wherein y is a molar ratio from about 0.25 to about 4,wherein z is the total amount of oxygen bound to M1, M2, and M3, and corresponds to the sum of the oxidation states of M1, M2, and M3. The catalyst composition may be used in a method for converting propylene glycol into acrolein. Subsequently, the acrolein may be converted into acrylonitrile.Also disclosed is a method for producing a first product comprising ethylene glycol, propylene glycol, and glycerol by converting C5 and/or C6 sugars.
University of North Carolina at Chapel Hill and Southern Research Institute | Date: 2015-06-26
Methods of administering an oligonucleotide of interest into a cell in vitro or in vivo are described. In the methods, a small organic compound active agent is concurrently administered to the cell in an amount effective to increase the delivery of the oligonucleotide into the cell, and/or increase the activity of said oligonucleotide in the cell. Compositions useful for carrying out the method are also described.
Southern Research Institute and Sanford Burnham Institute for Medical Research | Date: 2017-02-06
Provided is a method for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus, as well as novel compounds that are useful in the method.
University of Kansas, University of Louisville and Southern Research Institute | Date: 2017-02-27
The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).
Southern Research Institute | Date: 2016-12-16
The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinsons disease; precancerous conditions and cancer; autoimmune disorders such as Crohns disease, rheumatoid arthritis and psoriasis; and leprosy (Hansens disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Southern Research Institute | Date: 2016-06-07
Nickel based catalyst structures are described herein that include a plurality of metal oxides formed as crystalline phases within the catalyst structures. Each metal oxide of a catalyst structure includes nickel and/or aluminum, where one or more metal oxides includes a nickel aluminum oxide, and the one or more nickel aluminum oxides is greater than 50% by weight of the catalyst structure. The catalyst structures further have surface areas of at least 13 m^(2)/g. The catalyst structures are resistant to high concentrations of sulfur and are effective in reforming operations for converting methane and other light hydrocarbons to hydrogen and one or more other components. For example, the catalyst structures are effective in coal and biomass gasification systems for the forming and cleanup of synthetic gas.