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Novi, MI, United States

Lewis K.M.,Virginia Polytechnic Institute and State University | Byrd D.A.,South University | Ollendick T.H.,Virginia Polytechnic Institute and State University
Journal of Anxiety Disorders

The purpose of the present study was to determine the relations among negative life events, social support, coping and anxiety symptoms in 709 Caucasian and African-American youth between 11 and 14 years of age. Results indicated that more negative life events, less social support, more coping efforts, and African-American status were related to more anxiety symptoms. Additionally, although active coping moderated the relationship between negative life events and anxiety, these relations were qualified in separate analyses for the African-American and Caucasian youth. Negative life events were related to anxiety symptoms only for the African-American participants. When these findings were explored further for males and females of each racial group, negative life events remained significant for African-American males but not African-American females. Implications of these findings are examined and future directions for research to understand the processes underlying these relations with both Caucasian and African-American youth are addressed. © 2011 Elsevier Ltd. Source

Maxwell C.B.,Jackson Madison County General Hospital | Crouch M.A.,South University
American Journal of Health-System Pharmacy

Purpose. The use of intrapericardial triamcinolone for acute pericarditis after electro-physiologic procedures in three patients is described. Summary. Treatment for idiopathic pericarditis and viral pericarditis, which account for about 85% of cases, focuses on pain management and decreasing pericardial inflammation. This is oftentimes achieved with nonsteroidal antiinflammatory drugs (NSAIDs). Colchicine may be used in combination with NSAIDs, specifically in postmyocardial infarction pericarditis and recurrent pericarditis. Because oral corticosteroid use has been shown to be an independent risk factor in pericarditis recurrence, their use in patients with refractory pericarditis is reserved as a last-resort option. Intrapericardial triamcinolone is an uncommon treatment approach, although it is recommended in select situations of pericarditis according to guidelines developed by the European Society of Cardiology. In this retrospective case series, three patients with pericarditis, tamponade, or both as a complication of radiofrequency ablation or implantable cardioverter defibrillator implantation received triamcinolone. The drug was instilled intrapericardially, with doses ranging from 50 to 200 mg. In two patients, the need for pain medication and the perceived pain score decreased dramatically after triamcinolone administration. In the third patient, triamcinolone administration decreased the need for supportive therapy but was not deemed a complete clinical success. Additional study is necessary to better define the use of intrapericardial triamcinolone and determine long-term outcomes associated with this therapy. Other factors, including past medical history and renal function, also need to be taken into account when choosing the proper dosing regimen. Conclusion. Intrapericardial administration of triamcinolone acetonide may be an effective treatment for patients with acute pericarditis after electrophysiologic procedures. Copyright © 2010, American Society of Health-System Pharmacists, Inc. All rights reserved. Source

Blissit K.T.,William Jennings Bryan Dorn Veterans Affairs Medical Center | Tillery E.,South University | Latham C.,Pharmacy Services | Pacheco-Perez J.,G. Werber Bryan Psychiatric HospitalBC
American Journal of Health-System Pharmacy

Purpose: Four cases in which glycopyrrolate was used to treat clozapine-induced sialorrhea (CIS) are reported.Summary: Glycopyrrolate is an antimuscarinic agent that can be used preoperatively to inhibit drooling and excessive secretions of the respiratory tract. The outcomes of four patients who received glycopyrrolate for the treatment of CIS are described. The Thomas-Stonell and Greenberg Drooling Severity and Frequency Scale (DSFS) was used retrospectively to rate patients' drooling. Glycopyrrolate was effective in alleviating CIS in cases 1-3. Two patients (cases 1 and 4) exhibited severe drooling, which caused their clothing, hands, and objects to consistently become wet. One patient (case 1) responded well to glycopyrrolate and was restarted on the medication when CIS returned after discontinuation of the drug. While another patient (case 3) displayed a similar response to therapy for CIS as the patient described in case 1, this patient did not experience the psychosocial complications as did the patient in case 1, possibly due to the use of glycopyrrolate as the initial treatment of choice. The patient in case 2 experienced moderate but frequent drooling. Thioridazine's high anticholinergic potential may have contributed to this patient's lower baseline DSFS score compared with the scores of the other three patients, or it could have augmented initial symptom improvement. CIS continued in the patient described in case 4 despite treatment with glycopyrrolate, with only mild improvement in the severity and frequency of drooling.Conclusion: Glycopyrrolate was effective in alleviating symptoms in three of four patients with CIS. In a fourth patient, the degree of improvement was unknown due to documentation discrepancies; however, mild improvement was noted initially. © 2014, American Society of Health-System Pharmacists, Inc. Source

Schweiger T.A.,Lake Erie College | Zdanowicz M.,South University
American Journal of Health-System Pharmacy

Purpose. The literature was reviewed to determine whether data support current treatment guideline recommendations regarding the use of systemic corticosteroids in the treatment of chronic obstructive pulmonary disease (COPD) exacerbations. Summary. Exacerbations of COPD are common and can be detrimental to both patient health and health care costs. Corticosteroids are recommended by consensus guidelines for patients during exacerbations of COPD. Although guidelines make very specific recommendations, clinical data are conflicting and inconsistent. A search of the English-language medical literature was performed, and all randomized, double-blind, placebo-controlled trials or meta-analyses that examined the use of systemic corticosteroids in COPD exacerbations were included. Trials that included nebulized corticosteroids were also included as long as they were compared to a systemic corticosteroid and a placebo. Recommendations regarding the use of systemic corticosteroids are not optimal or completely supported. Data support recommendations if patients are treated on an outpatient basis. However, hospitalized patients might also benefit from higher doses of systemic steroids initially, followed by an oral taper dose. Conclusion. In the treatment of COPD exacerbations, systemic corticosteroids improve airflow limitations, decrease treatment failure rates, decrease the risk of relapse, and may improve symptoms and decrease the length of hospital stay. Because of the risks of adverse effects, the lowest dose and shortest duration of corticosteroid therapy that will provide therapeutic benefit should be chosen. The literature suggests that hospitalized patients should benefit from a higher initial dosage of systemic corticosteroids than the 30-40 mg of i.v. or oral prednisolone for 7-10 days recommended in current guidelines. Copyright © 2010, American Society of Health-System Pharmacists, Inc. All rights reserved. Source

Home > Press > Quantum computing closer as RMIT drives towards first quantum data bus: RMIT researchers trialling a quantum processor capable of routing information from different locations have found a pathway towards the quantum data bus Abstract: RMIT University researchers have trialled a quantum processor capable of routing quantum information from different locations in a critical breakthrough for quantum computing. The work opens a pathway towards the "quantum data bus", a vital component of future quantum technologies. The research team from the Quantum Photonics Laboratory at RMIT in Melbourne, Australia, the Institute for Photonics and Nanotechnologies of the CNR in Italy and the South University of Science and Technology of China, have demonstrated for the first time the perfect state transfer of an entangled quantum bit (qubit) on an integrated photonic device. Quantum Photonics Laboratory Director Dr Alberto Peruzzo said after more than a decade of global research in the specialised area, the RMIT results were highly anticipated. "The perfect state transfer has emerged as a promising technique for data routing in large-scale quantum computers," Peruzzo said. "The last 10 years has seen a wealth of theoretical proposals but until now it has never been experimentally realised. "Our device uses highly optimised quantum tunnelling to relocate qubits between distant sites. "It's a breakthrough that has the potential to open up quantum computing in the near future." The difference between standard computing and quantum computing is comparable to solving problems over an eternity compared to a short time. "Quantum computers promise to solve vital tasks that are currently unmanageable on today's standard computers and the need to delve deeper in this area has motivated a worldwide scientific and engineering effort to develop quantum technologies," Peruzzo said. "It could make the critical difference for discovering new drugs, developing a perfectly secure quantum Internet and even improving facial recognition.'' Peruzzo said a key requirement for any information technology, along with processors and memories, is the ability to relocate data between locations. Full scale quantum computers will contain millions, if not billions, of quantum bits (qubits) all interconnected, to achieve computational power undreamed of today. While today's microprocessors use data buses that route single bits of information, transferring quantum information is a far greater challenge due to the intrinsic fragility of quantum states. "Great progress has been made in the past decade, increasing the power and complexity of quantum processors," Peruzzo said. Robert Chapman, an RMIT PhD student working on the experiment, said the protocol they developed could be implemented in large scale quantum computing architectures, where interconnection between qubits will be essential. "We experimentally relocate qubits, encoded in single particles of light, between distant locations," Chapman said. "During the protocol, the fragile quantum state is maintained and, critically, entanglement is preserved, which is key for quantum computing." The research, Experimental Perfect State Transfer of an Entangled Photonic Qubit, will be published in Nature Communications on April 18. For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

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