Time filter

Source Type

Kauppi P.,University of Helsinki | Linna M.,Aalto University | Jantunen J.,South Karelia Allergy and Environment Institute | Martikainen J.E.,Social Insurance Institution | And 3 more authors.
Mediators of Inflammation | Year: 2015

Background. We aimed to study the prevalence of chronic comorbidities in asthma patients and the costs of health care use associated with asthma with comorbidities. Material and Methods. We analysed the prevalence of the four most common chronic diseases in asthma patients in 2008-2014 in Finland. Prevalence of coronary artery disease, diabetes and dyslipidaemia, hypertension, epilepsy, inflammatory bowel disease, rheumatic diseases, and severe psychiatric disease was studied by register of the Social Insurance Institution of Finland. The costs of health care services were collected from the registries maintained by the National Institute for Health and Welfare (THL). Results. Prevalence of asthma was 4.6% in 2014. Diabetes was among the four most common comorbidities in all the age groups. The other common comorbidities were hypertension (≥46 years; 12.9-37.6%), severe psychiatric disorders (age groups of 16-59 years; 1.4-3.5%), and ischaemic heart disease (≥60 years; 10-25%). In patients with both asthma and diabetes, the costs of hospitalization were approximately 169% compared with patients with asthma alone. Conclusions. Prevalence of asthma increases by tenfold when aging. The comorbidity diversity and rate are age-dependent. Prevalence of diabetes as comorbidity in asthma has increased. Costs of hospitalizations in asthma approximately double with chronic comorbidities. © 2015 Paula Kauppi et al.


Gonneau C.,CNRS Center of Evolutionary and Functional Ecology | Gonneau C.,University of Lorraine | Gonneau C.,French National Institute for Agricultural Research | Jersakova J.,University of South Bohemia | And 9 more authors.
Journal of Ecology | Year: 2014

Summary: Some forest understorey plants recover carbon (C) not only from their own photosynthesis, but also from mycorrhizal fungi colonizing their roots. How these mixotrophic plants use the resources obtained from mycorrhizal and photosynthetic sources remains unknown. We investigated C sources and allocation in mixotrophic perennial orchids from the genus Epipactis. Based on the assumption that fungal biomass has high δ13C and N content, while photosynthetic biomass has lower δ13C and N content, we indirectly estimated the respective contributions of these two resources to various organs, at various times over the growth season. Fully heterotrophic and fully autotrophic plants from the same sites were used as references for δ13C and N content of biomass purely issuing from fungi and photosynthesis, respectively. In four investigated populations, the biomass shifted from fully heterotrophic in young spring shoots to 80-100% autotrophic in leaves and fruits at fruiting time, suggesting that photosynthesis supported mostly fruiting costs. In addition, fungal colonization decreased in roots over this period. Based on δ13C and N content, below-ground organs and young spring shoots from green (mixotrophic) individuals and spontaneous achlorophyllous variants (fully heterotrophic) displayed similar fungal C contributions. Similar fungal contributions were also found in shoots of individuals that were either sprouting (and thus partially photosynthetic) or dormant (and thus fully heterotrophic) in the previous years. Therefore, fungal C supported mostly young spring shoots and below-ground organs. Although experimentally shaded plants had decreased contributions of photosynthetic C in shoots, experimentally defoliated plants showed no increase in fungal C contribution as compared with non-defoliated controls. Strikingly, these defoliated plants maintained the same seed production: they likely compensated defoliation by increasing stem and fruit photosynthesis. Synthesis. We propose a falsifiable model of C resource allocation in mixotrophic orchids, where mycorrhizal fungi mostly support below-ground organs and survival, while photosynthesis mostly supports above-ground sexual reproduction, but not below-ground reserves. We discuss how this allocation pattern, where seed production depends on photosynthesis, complicates the evolutionary route to full heterotrophy in mixotrophic orchids. © 2014 British Ecological Society.


PubMed | Social Insurance Institution, University of Helsinki, South Karelia Allergy and Environment Institute and Aalto University
Type: | Journal: Mediators of inflammation | Year: 2016

We aimed to study the prevalence of chronic comorbidities in asthma patients and the costs of health care use associated with asthma with comorbidities.We analysed the prevalence of the four most common chronic diseases in asthma patients in 2008-2014 in Finland. Prevalence of coronary artery disease, diabetes and dyslipidaemia, hypertension, epilepsy, inflammatory bowel disease, rheumatic diseases, and severe psychiatric disease was studied by register of the Social Insurance Institution of Finland. The costs of health care services were collected from the registries maintained by the National Institute for Health and Welfare (THL).Prevalence of asthma was 4.6% in 2014. Diabetes was among the four most common comorbidities in all the age groups. The other common comorbidities were hypertension (46 years; 12.9-37.6%), severe psychiatric disorders (age groups of 16-59 years; 1.4-3.5%), and ischaemic heart disease (60 years; 10-25%). In patients with both asthma and diabetes, the costs of hospitalization were approximately 169% compared with patients with asthma alone.Prevalence of asthma increases by tenfold when aging. The comorbidity diversity and rate are age-dependent. Prevalence of diabetes as comorbidity in asthma has increased. Costs of hospitalizations in asthma approximately double with chronic comorbidities.


Jantunen J.,South Karelia Allergy and Environment Institute | Saarinen K.,South Karelia Allergy and Environment Institute | Rantio-Lehtimaki A.,University of Turku
Aerobiologia | Year: 2012

In order to study allergic people responding to daily changes in pollen concentrations, we compared personal diary data on allergic symptoms and the use of allergy medicines to daily pollen counts during the two unequal alder and birch pollen seasons of 2009 and 2010. Almost 90% of the 61 subjects with physician-diagnosed birch pollinosis developed con-junctival, nasal or other symptoms during the peak birch pollination. Most subjects (95%) also reported symptoms during the alder pollination. Despite a delay between the most severe symptoms and the pollen peaks and the increased risk of allergy symptoms between the alder and birch pollen peaks at much lower pollen concentrations, the number of subjects with allergy symptoms correlated with the daily pollen concentrations in both years (r 09 = 0.35, r 10 = 0.36, p < 0.01). The positive correlation was even stronger (r 09 = 0.69, r 10 = 0.74, p < 0.001) in relation to the cumulative sum of daily concentrations. The use of allergy medicines precisely followed the abundance of allergy symptoms in both years (r 09 = 0.96, r 10 = 0.70, p < 0.001). We conclude that there is a fair correlation between the daily allergy symptoms and the particular pollen concentrations, but the risk of developing symptoms at low, moderate and high concentrations is affected by the progression of the pollen season. © Springer Science+Business Media B.V. 2011.


Gorbach V.V.,Petrozavodsk State University | Saarinen K.,South Karelia Allergy and Environment Institute | Reznichenko E.S.,Petrozavodsk State University
Zoologicheskii Zhurnal | Year: 2010

Ecology of the poplar admiral was studied in periphery of its range over 19 years (1990-2008), including seasonal phenomena, spatial distribution, and dynamics of abundance and settling of the species. The spatial organization of territorial grouping of the species was studied in one of the local areas. The flying period of butterflies in Eastern Fennoscandia is divided into three phases: observed flight of males, latent activity, and observed flight of females. Males emerge more than 10 days before females. The difference is likely to be one of the reasons for strong reduction in the butterfly abundance. The asynchrony observed in the abundance of the butterflies in different areas was explained by the influence of local factors. In the years of high abundance, the proportion of occupied areas increased. The analysis of the curves of the settling and abundance showed a trend of colonization of vacant areas. Within the occupied area, the butterflies are irregularly distributed. The presence of areas with constantly moistened soils and aspen trees in the forest stands are the main factors responsible for butterfly aggregations. Observations of the marked individuals showed that the maximum distance covered by a butterfly was 4.8 km. The butterfly moved freely across all the study area, and no single accumulation of butterflies isolated from the others was registered. All the movements are shown to be local. The distance of these movements, according to the exponential model, reached 6-7 km; the grouping itself is classified as subpopulation - a structural unit of large spatially differentiated population. The high mobility of poplar admiral ensures migration of individuals between the populations and colonization of vacant habitats as well.


Sandell J.,South Karelia Allergy and Environment Institute | Hedman J.,Central Finland Central Hospital | Saarinen K.,South Karelia Allergy and Environment Institute | Haahtela T.,University of Helsinki
Allergy: European Journal of Allergy and Clinical Immunology | Year: 2013

Background We have shown that salt chamber treatment reduces airway hyper-responsiveness as an add-on therapy in adult asthmatics on inhaled corticosteroids. Methods We assessed whether this effect is due to the suppression of eosinophilic airway inflammation. Thirty-nine adult asthmatics on inhaled corticosteroids were randomized to receive active salt chamber treatment with low-salt treatment 6.6 mg/m3 (n = 14), high-salt treatment 10.8 mg/m3 (n = 15) or placebo 0.3 mg/m3 (n = 10) 10 times in a 2 weeks' period in a double-blind manner. Results The level of induced sputum eosinophilic cationic protein μg/l, was 3070 before and 4651 after the low-salt treatment period, on average. In the high-salt treatment group, it was 12 192 μg/l vs 11 803 and in the placebo group 3942 vs 4144, respectively. Salt chamber treatment had no effect on sputum eosinophil or neutrophil cell numbers. Conclusions The reduction in hyper-responsiveness observed in the previous study is probably not due to the effect on eosinophilic inflammation. © 2012 John Wiley & Sons A/S.


Saarinen K.,South Karelia Allergy and Environment Institute | Jantunen J.,South Karelia Allergy and Environment Institute | Haahtela T.,University of Helsinki
International Archives of Allergy and Immunology | Year: 2011

Background: Only a few randomized controlled trials have been carried out to evaluate various complementary treatments for allergic disorders. This study assessed the effects of the preseasonal use of birch pollen honey (BPH; birch pollen added to honey) or regular honey (RH) on symptoms and medication during birch pollen season. Methods: Forty-four patients (59% female, mean age 33 years) with physician-diagnosed birch pollen allergy consumed either BPH or RH daily in incremental amounts from November 2008 to March 2009. Seventeen patients (53% female, mean age 36 years) on their usual allergy medication served as the control group. From April to May, patients recorded daily rhinoconjunctival and other symptoms and their use of medication. Fifty patients completed the study. Results: During birch pollen season in 2009, BPH patients reported a 60% lower total symptom score (p < 0.01), twice as many asymptomatic days (p < 0.01), and 70% fewer days with severe symptoms (p < 0.001), and they used 50% less antihistamines (p < 0.001) compared to the control group. The differences between the BPH and RH groups were not significant. However, the BPH patients used less antihistamines than did the RH patients (p < 0.05). Conclusions: Patients who preseasonally used BPH had significantly better control of their symptoms than did those on conventional medication only, and they had marginally better control compared to those on RH. The results should be regarded as preliminary, but they indicate that BPH could serve as a complementary therapy for birch pollen allergy. © 2010 S. Karger AG, Basel.


Jantunen J.,South Karelia Allergy and Environment Institute | Saarinen K.,South Karelia Allergy and Environment Institute
Aerobiologia | Year: 2011

Pollen transport into houses via clothing was studied on different types of fabrics after clothing was aired or worn outdoors. After walking through grassland, 68 pollen grains/cm 2 were found on clothes (tape samples). The amount of grass pollen, and especially pollen from insect-pollinated plants, increased from the shirt towards the shoes. The amount of pollen on clothes aired outdoors in a yard depended on the concentration in the ambient air and the texture of the fabrics. On vacuumed samples, 1.2 grains/cm 2/h adhered to the furry fabric of fleece and wool, whereas only 0.3 grains/cm 2/h adhered to a tight weave polyamide coat and a denim jacket. A moist cotton shirt gave slightly higher pollen counts in both the tape (8.6 grains/cm 2/h) and the vacuumed samples (1.0 grains/cm 2/h) compared to a dry shirt (5.6 and 0.6 grains/cm 2/h), but the difference was not significant. Tape samples gave tenfold higher pollen numbers compared to vacuumed samples, probably due to the more optimal location of the tape sampling area on top of the shoulders. We conclude that clothing constitutes an important route for carrying allergenic pollen into houses. Pollen transport can be decreased by shaking outdoor clothing before entering a residence. In our case, shaking removed 68% pollen grains from trousers. © 2011 Springer Science+Business Media B.V.


PubMed | South Karelia Allergy and Environment Institute
Type: Journal Article | Journal: Allergy | Year: 2012

We have shown that salt chamber treatment reduces airway hyper-responsiveness as an add-on therapy in adult asthmatics on inhaled corticosteroids.We assessed whether this effect is due to the suppression of eosinophilic airway inflammation. Thirty-nine adult asthmatics on inhaled corticosteroids were randomized to receive active salt chamber treatment with low-salt treatment 6.6mg/m(3) (n=14), high-salt treatment 10.8mg/m(3) (n=15) or placebo 0.3mg/m(3) (n=10) 10 times in a 2weeks period in a double-blind manner.The level of induced sputum eosinophilic cationic protein g/l, was 3070 before and 4651 after the low-salt treatment period, on average. In the high-salt treatment group, it was 12192g/l vs 11803 and in the placebo group 3942 vs 4144, respectively. Salt chamber treatment had no effect on sputum eosinophil or neutrophil cell numbers.The reduction in hyper-responsiveness observed in the previous study is probably not due to the effect on eosinophilic inflammation.


PubMed | South Karelia Allergy and Environment Institute
Type: Journal Article | Journal: International archives of allergy and immunology | Year: 2011

Only a few randomized controlled trials have been carried out to evaluate various complementary treatments for allergic disorders. This study assessed the effects of the preseasonal use of birch pollen honey (BPH; birch pollen added to honey) or regular honey (RH) on symptoms and medication during birch pollen season.Forty-four patients (59% female, mean age 33 years) with physician-diagnosed birch pollen allergy consumed either BPH or RH daily in incremental amounts from November 2008 to March 2009. Seventeen patients (53% female, mean age 36 years) on their usual allergy medication served as the control group. From April to May, patients recorded daily rhinoconjunctival and other symptoms and their use of medication. Fifty patients completed the study.During birch pollen season in 2009, BPH patients reported a 60% lower total symptom score (p < 0.01), twice as many asymptomatic days (p < 0.01), and 70% fewer days with severe symptoms (p < 0.001), and they used 50% less antihistamines (p < 0.001) compared to the control group. The differences between the BPH and RH groups were not significant. However, the BPH patients used less antihistamines than did the RH patients (p < 0.05).Patients who preseasonally used BPH had significantly better control of their symptoms than did those on conventional medication only, and they had marginally better control compared to those on RH. The results should be regarded as preliminary, but they indicate that BPH could serve as a complementary therapy for birch pollen allergy.

Loading South Karelia Allergy and Environment Institute collaborators
Loading South Karelia Allergy and Environment Institute collaborators