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Unnikrishnan M.,Sree Chitra Tirunal Institute for Medical Science and Technology | Viswanathan S.,Sree Chitra Tirunal Institute for Medical Science and Technology | Balasubramaniam K.,South India Textile Research Association | Muraleedharan C.V.,Sree Chitra Tirunal Institute for Medical Science and Technology | And 4 more authors.
Indian Journal of Medical Research | Year: 2016

Background & objectives: Vascular illnesses are on the rise in India, due to increase in lifestyle diseases and demographic transition, requiring intervention to save life, organ or limbs using vascular prosthesis. The aim of this study was to develop indigenous large diameter vascular graft for treatment of patients with vascular pathologies. Methods: The South India Textile Research Association, at Coimbatore, Tamil Nadu, India, developed seamless woven polyester (Polyethylene terephthalate) graft at its research wing. Further characterization and testing followed by clinical trials were conducted at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. Fifteen in vivo experiments were carried out in 1992-1994 in pigs as animal model. Controlled (phase I) clinical trial in ten patients was performed along with control graft. Thereafter, phase II trial involved 22 patients who underwent multi-centre clinical trial in four centres across India. Results: Laboratory testing showed that polyester graft was non-toxic, non-leeching and non-haemolytic with preserved long-term quality, further confirming in pigs by implanting in thoracic aorta, comparable to control Dacron grafts. Perigraft incorporation and smooth neointima formation which are prime features of excellent healing characteristics, were noted at explantation at planned intervals. Subsequently in the phase I and II clinical trials, all patients had excellent recovery without mortality or device-related adverse events. Patients receiving the test graft were followed up for 10 and 5 years, respectively. Serial clinical, duplex scans and CT angiograms performed periodically confirmed excellent graft performance. Interpretation & conclusions: Indigenously developed Chitra vascular graft was comparable to commercially available Dacron graft, ready for clinical use at affordable cost to patients as against costly imported grafts. © 2016, Indian Council of Medical Research. All rights reserved.

Doraiswamy I.,South India Textile Research Association | Chellamani K.P.,South India Textile Research Association
Textile Magazine | Year: 2010

The textile industry is witnessing latest developments in the field of fiber research, product and machinery development, nanotechnology/plasma technology based fabric finishing. Fiber Innovation Technology Inc., (FTI) has launched Ingeo™ fibers that allow man-made fibers to be derived from 100% annually renewable resources. Fiber Visions has launched a new fiber called Fiber Visions Hy-Entangle WA for spun lace and wipes products. The nonwoven research group at the University of Leeds has developed a new three-dimensional spunlaced web forming technology called Hydrospace. Ciba Specialty Chemicals has modified fibers on the basis of nano microcapsules to provide controlled release of fragrances, biocides and antifungals on textiles. Sensory perception technology (SPT) microcapsule has been developed that can be applied to garments using exhaust, padding, spray or foam method which imparts utilitarian qualities to the fabric, enabling wearer to perceive and experience qualities such as moisturizing, fragrance, insect repellence, stress release and anti-bacterial.

Chellamani K.P.,South India Textile Research Association | Pasupathy R.,South India Textile Research Association | Vittopa M.K.,South India Textile Research Association
Journal of the Institution of Engineers (India), Part TX: Textile Engineering Division | Year: 2010

Seam pucker is one of the critical problems in garment manufacturing. In addition to process variables, low stress mechanical properties of the fabrics also have a considerable influence on seam pucker and hence a study has been carried out. A model for predicting seam pucker grades in knitted structures based on low stress mechanical properties of fabrics using artificial neural network has been developed. An empirical expression connecting low stress mechanical properties of weft knitted fabrics with seam pucker grades has also been developed.

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