Brookings, SD, United States

South Dakota State University
Brookings, SD, United States

South Dakota State University is a public research university located in Brookings, South Dakota. It is the state's largest and second oldest university. A land-grant university and sun grant university, founded under the provisions of the 1862 Morrill Act, SDSU offers programs of study required by, or harmonious to, this Act. In step with this land-grant heritage and mission, SDSU has a special focus on academic programs in agriculture, engineering, nursing, and pharmacy, as well as the liberal arts. The Carnegie Foundation for the Advancement of Teaching classifies SDSU as a Research University with high research activity. The graduate program is classified as Doctoral/Science, Technology, Engineering, Math dominant. SDSU is governed by the South Dakota Board of Regents, which governs the state's six public universities and two special schools. Wikipedia.

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Guan X.,South Dakota State University
Acta Pharmaceutica Sinica B | Year: 2015

Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths. Although cancer survival rate has been significantly improved over the years, the improvement is primarily due to early diagnosis and cancer growth inhibition. Limited progress has been made in the treatment of cancer metastasis due to various factors. Current treatments for cancer metastasis are mainly chemotherapy and radiotherapy, though the new generation anti-cancer drugs (predominantly neutralizing antibodies for growth factors and small molecule kinase inhibitors) do have the effects on cancer metastasis in addition to their effects on cancer growth. Cancer metastasis begins with detachment of metastatic cells from the primary tumor, travel of the cells to different sites through blood/lymphatic vessels, settlement and growth of the cells at a distal site. During the process, metastatic cells go through detachment, migration, invasion and adhesion. These four essential, metastatic steps are inter-related and affected by multi-biochemical events and parameters. Additionally, it is known that tumor microenvironment (such as extracellular matrix structure, growth factors, chemokines, matrix metalloproteinases) plays a significant role in cancer metastasis. The biochemical events and parameters involved in the metastatic process and tumor microenvironment have been targeted or can be potential targets for metastasis prevention and inhibition. This review provides an overview of these metastasis essential steps, related biochemical factors, and targets for intervention. © 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Idaho Milk Products and South Dakota State University | Date: 2016-02-03

In one embodiment, the disclosure relates to milk permeate powders, methods of production thereof, and uses of the milk permeate powders. In another embodiment, the disclosure relates to the use of carbon dioxide for the production of milk permeate powders.

Different versions of heat stable whey protein ingredients can be produced by subjecting whey protein solutions to specific heat treatments in the presence of a specific concentration of hydrogen peroxide. The whey protein ingredients including heat stable liquid retentate of WPI, WPC or any other form of whey protein ingredients, and heat stable powders of WPI or WPC or any other whey protein powders can be prepared by heat treatment of a whey protein solution mixed with a hydrogen peroxide solution. The heat stable whey proteins have the starting whey protein cystine converted to cystine sulfonic acid, such that the free sulfhydral groups of major whey protein (-lactoglobulin) being converted into non-reactive compounds, such as cysteine sulphonic acid and/or cysteic acid, which not only minimizes or eliminates undesirable gelling but also is a precursor for taurine group of compounds.

Agency: NSF | Branch: Standard Grant | Program: | Phase: RSCH EXPER FOR UNDERGRAD SITES | Award Amount: 356.29K | Year: 2016

Part 1:
The health of our nations economy depends on the continued growth of a STEM workforce. The effective application of high performance computing (HPC) is a skill increasingly demanded in a widening variety of fields including engineering, biology, plant science, biochemistry, and many others. This REU program will equip underrepresented students to pursue STEM careers by training them to use HPC in mathematics and statistics, engineering, and biological sciences. Participating undergraduate students will engage in cutting-edge research to learn how high fidelity models represent physical phenomena; how these models are implemented within HPC; and how results are analyzed, interpreted, and used to resolve theoretical and applied problems. In addition, a variety of personal, interpersonal, and leadership skills (including technical communication, time management, networking, and continuous improvement) will be cultivated through complementary hands-on/minds-on activities. This project serves the national interest, as stated by NSFs mission: to promote the progress of science by engaging undergraduate students in state-of-the art research in engineering applications and computation; and to advance the national health, prosperity, and welfare by strengthening the STEM workforce and increasing the participation of underrepresented groups and veterans returning from active duty.

Part 2:
The goals of this REU program are to enhance student capacity to: 1) conduct innovative and meaningful research using HPC, 2) learn and think independently within an interdisciplinary collaborative environment, 3) conduct research with the utmost integrity, 4) prepare for professional careers, and 5) pursue graduate degrees in STEM programs. This program will recruit ten students per year from a diverse pool of first- and second-year students from smaller colleges, tribal colleges, and community colleges, with an emphasis on both minority and traditionally underrepresented students, as well as returning veterans. These students will participate in an intensive ten-week summer program and will work closely with faculty mentors on research projects that involve 1) simulation tools in the context of engineering design and analysis; 2) state-of-the-art research tools in engineering applications and computation; 3) statistical analysis based on real datasets and simulations; and 4) advanced numerical methods including parallel algorithms in HPC. The tangible outcomes will include student-authored journal articles, conference proceedings, and technical presentations. Program success will be assessed by an external evaluator through formative and summative evaluations, daily student reflections, student interviews, and student enrollment in STEM graduate programs.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ENERGY,POWER,ADAPTIVE SYS | Award Amount: 153.69K | Year: 2016

The research project addresses energy efficiency and sustainability issues of electricity production and consumption in the United States. When the demand on the electric power system peaks, such as on hot summer days, the increased electricity is supplied by inefficient and polluting generators called peaking units. If the demand can be shifted or removed from this peak time, then electricity can be generated and consumed in a sustainable, energy-efficient manner. In this project, we introduce new methods for a coordinated multi-voltage-level energy management system to reduce peak electricity demand, which contributes to a sustainable energy future for the U.S. The projects scope is expected to significantly and positively impact several areas of vital importance to the future electric power system, including the integration, coordination, and deployment of distributed resources in the end-user realm; end-to-end interaction across the electric power system; full deregulation of electricity markets and control centers; and development of the engineering workforce. Additionally, the research will encourage, facilitate, and accelerate the deployment of new technologies in the electric grid and help achieve energy independence, low carbon footprint, reduced peak loads, and full-scale electric deregulation. The proposed intelligent energy management systems and new sustainability metrics may impact other critical energy delivery infrastructures, such as gas and oil delivery systems, transportation, hydroelectric dams (and associated irrigation contracts), deregulated markets, and telecommunications. The research will be disseminated to specific as well as broad audiences and through targeted K-12 STEM education. The success of the project outreach efforts will be evaluated by an independent educator.

To achieve the technical goals of the research project, a unique infrastructural framework is proposed for a coordinated multi-voltage-level multi-aggregation-scale energy management system, extending from the individual end-user asset to the bulk transmission grid, with the goal of optimizing environmental and economic sustainability. This transformational new method utilizes aggregator entities to perform demand response via the aggregation and control of end-user assets (e.g., electric vehicles). Customer incentive pricing, a unique time-varying pricing method for demand response that coexists with bulk power pricing and retail electricity pricing, is introduced and its effectiveness is evaluated under different market and system conditions. To realize the new holistic aggregator-based demand response energy management system, new coordinated stochastic control algorithms will be designed and their applicability for the existing bulk and retail power markets will be evaluated. These algorithms will be assessed using high-fidelity modeling and co-simulation, with respect to newly developed sustainability metrics, market and power system efficiency, and algorithm scalability to a realistic-size power system on a unique test bed.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ENG DIVERSITY ACTIVITIES | Award Amount: 495.00K | Year: 2016

A goal of the Tribal Colleges and Universities Program (TCUP) is to increase the science, technology, engineering and mathematics (STEM) instructional and research capacities of specific institutions of higher education that serve the Nations indigenous students. The PEEC-II track provides support for studies or educational research conducted by institutions that have had earlier Pre-Engineering Education Collaborative (PEEC) awards. The intent of PEEC-II is to capture, analyze, and disseminate the impact of these awards on the participating institutions, faculty, or students, and their communities. PEEC and PEEC-II are partnerships between TCUP and the Directorate for Engineering.

During PEEC-I, Oglala Lakota College (OLC) in conjunction with collaborators the College of Engineering at the South Dakota State University (SDSU) and the South Dakota School of Mines and Technology (SDSMT), referred to as OLC/SDSU/SDSMT PEEC (OSSPEEC), established infrastructure and capacity for students entering OLC to graduate from SDSU or SDSMT with engineering degrees. In PEEC-II, they will investigate the impact of the OSSPEEC model, which emphasizes the importance of experiential learning, incorporation of the Lakota world view and cultural perspective in engineering learning and decision making, and development of self-confidence in solving engineering problems.

The intellectual merit of this project lies in understanding the value of the OSSPEEC model and what factors lead to American Indian success in pre-engineering and engineering programs. The integrated research and experiential learning aspects of the project have the potential to generate knowledge related to water resources and geological engineering on the Pine Ridge Reservation in South Dakota. The broader impacts of this project will be 1) increased diversity in a globally engaged engineering workforce, 2) expanded tribal ability to address issues related to land use, drinking water, and sustainable housing and food production, and 3) a model of culturally centered classroom activities and relevant co-curricular research, project and maker activities.

Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 749.87K | Year: 2015

The NSF Partnerships for Learning and Adaptation Networks: Institutions of Higher Education (PLAN-IHE) funding track is designed to expand the application of proven-successful gender-equity initiatives for STEM faculty through networked adaptation of a specific program or initiative. Careful evaluation is expected to expand understanding of such initiatives across institutions and institution types.

This project will focus on producing policy changes to support gender equity and create culture change within the South Dakota state university system. This project will include six institutions: South Dakota State University (SDSU), the University of South Dakota, South Dakota School of Mines and Technology, Northern State University, Dakota State University, and Black Hills State University. This project has system wide leadership commitment and involves teams of science, technology, engineering, and mathematics (STEM) faculty in the policy review and development. The model, if successful, could be adapted to other higher education systems. It is expected that this project will result in: evidence of effective top-down change mechanisms in higher education; amended or new policies that promote gender equity in STEM; and contributions to the research on processes for systemic change in higher education.

This project will test the proposition that the central establishment of equity policy and indicators at the system level is required not only to demonstrate improvement in diversity but to actualize it (Blackmore, 2011; Castilla, 2008; Kalev, Kelly and Dobbin, 2006). Research from industry indicates the effectiveness of top-down change for increased gender equity. By implementing and assessing this process in academia, new evidence and subsequent models for centralized change will be produced for use beyond this state system. In this project, Scotts model (1987) of change is used to demonstrate that change is most effectively implemented through policy driven by a central authority. The project will expand and assess understanding of the probability of gender equity improvement in higher education state systems through policy implementation by a centralized authority. This work will also establish evidence for how centralized policies can change individual faculty assessment practices across a higher education system, linking the system and institutional level in Scotts theory of change. In addition, this project will contribute to the knowledge base on how centralized policies can change individual norms in career planning and aspirations, linking the system, institutional, and individual level in Scotts theory of change. This project builds on previous ADVANCE work at the University of Maryland in policy analysis, and work completed at Montana State University to solicit policy innovation.

The ADVANCE PLAN program track supports projects that promote the adaptation and implementation of previously effective ADVANCE programs in new contexts and the testing of innovative strategies to promote the participation, success, and advancement of women in STEM academic careers. PLAN projects also contribute to the knowledge base on gender equity in STEM academic careers.

Agency: NSF | Branch: Cooperative Agreement | Program: | Phase: RESEARCH INFRASTRUCTURE IMPROV | Award Amount: 12.00M | Year: 2014

Non-technical Description

The South Dakota Biochemical Spatiotemporal NeTwork Resource (BioSNTR) project will develop ways to increase agricultural productivity through scientific advances in bioscience and informatics. The BioSNTR will use imaging and molecular biology to map the biochemical architecture of plant and animal cells. Technologies to improve crop yields will be developed by applying new knowledge about the ways that molecular circuits signal plant cells to grow and function. Results from BioSNTR activities are likely to have positive economic outcomes for South Dakotas agriculture.

The project involves all of the colleges and universities in South Dakota, and is broadening the participation of women, Native Americans and persons with disabilities in science, technology, engineering, and mathematics. The BioSNTR will develop a skilled, diverse technical workforce with expertise in bioscience and informatics. South Dakota students will gain entrepreneurial and industrial experience through internship opportunities. BioSNTR is implementing a new PhD program in biochemistry at South Dakota State University and strengthening the computational science programs in several South Dakota universities.

Technical Description

The South Dakota Experimental Program to Stimulate Competitive Research (EPSCoR) is creating the Biochemical Spatiotemporal NeTwork Resource (BioSNTR), a transdisciplinary, multi-institutional program for systems bioscience research and education. BioSNTR advances imaging and molecular biology to investigate the sophisticated molecular circuit involved in cell signaling. Understanding this process is essential for rational manipulation of the cell-biomaterial interface in plant and animal systems. The vision of BioSNTR is to map the biochemical architecture of this molecular circuit with sufficient resolution that quantitative predictions can be made for effective control and manipulation of cell function. Technological advances from BioSNTR will lead to improvements in crop yields, animal welfare, and human health. Through BioSNTR, South Dakota EPSCoR is improving the state?s physical infrastructure and human workforce in the areas of bioscience and informatics, two scientific growth fields for South Dakota and the nation.

Agency: NSF | Branch: Standard Grant | Program: | Phase: HUMAN RESOURCES DEVELOPMENT | Award Amount: 91.94K | Year: 2016

The South Dakota School of Mines and Technology, along with its partner organizations, the University of South Dakota and South Dakota State University, will offer an innovative Research Experiences for Undergraduate (REU) Site focused on interdisciplinary research dedicated to Security Printing and Anti-Counterfeiting Technology (SPACT), for a diverse group of undergraduate students, targeting Tribal Colleges and other institutions with limited STEM research opportunities. The SPACT research theme is of great societal importance. Counterfeiting is a growing issue in the U.S., posing serious economic, safety and national security concerns and impacting a wide variety of industries (e.g. pharmaceutics, semiconductors). In this REU Site students will conduct research on transformative anti-counterfeiting technology. SPACT is a field which demands development in four key areas: advanced materials, advanced manufacturing/patterning technologies, detection and encryption technology, and software and database infrastructure. The SPACT REU will implement a unique undergraduate research program to curb the economic losses and health and safety risks associated with counterfeiting.

The key objectives of this 10-week summer REU Site are to: 1) conduct transformative research in a collaborative, interdisciplinary environment, and 2) provide STEM professional development opportunities to a diverse group of 10 undergraduate students, each year for three years. A team of faculty mentors from the three partner institutions, all with demonstrated experience in mentoring undergraduate researchers, will implement a program in SPACT by applying research methods from various fields of science and engineering. Participants will develop collaborative research skills via carefully designed research projects and training seminars. Students will participate in a highly integrated professional development and technical communications program. The faculty, alongside industry leaders, will deliver training seminars to broaden the students existing academic training in the necessary SPACT areas. The long-term goal of this REU Site is to provide a diverse group of STEM researchers with the training and skills needed to pursue graduate studies at the highest levels and to advance the developing field of SPACT.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ARCTIC SYSTEM SCIENCE PROGRAM | Award Amount: 362.93K | Year: 2017

Terrestrial Arctic systems are the result of complex interactions between climate, vegetation, herbivores, and humans that must be studied together to understand their functional
traits. While low temperatures and short-growing seasons limit plant growth, enough plant biomass exists to support herds of migratory caribou, on which Alaska Natives depend. Any changes in the plants at the base of the food web can have cascading consequences for herbivores and human consumers and their interactions. Today, the Arctic system is in the midst of change resulting in new vegetation assemblages, changes in the nutritive value of plant tissues, and ultimately in the diets of migratory caribou and the humans that depend on them. This project examines the nutritional landscape of the Central Arctic Caribou Herd as a unifying concept, describing the nutritional landscape as caribou available protein (CAP) and caribou available energy
(CAE), integrative forage quantity measures that reflect biomass, species composition, plant
C and N content, digestibility, and secondary compounds. The core objectives are gaining understanding of the drivers of spatial and temporal patterns in the amounts of CAP and CAE across the tundra; caribou use of this nutritional landscape; how the amounts of CAP and CAE will differ in the future under likely climate scenarios and long-term experiments, and the interactions between caribou and Native communities.

The broader impacts of this study involve several groups of Alaskan stakeholders, including: harvesters of the North Slope community of Nuiqsut, the worldwide caribou community, and students at multiple stages of education. The project will embed a team member with hunters in Nuiqsut,
and develop an educational scientific documentary on the caribou - Alaska Native interactions for
high school students. The group plans to employ village students and undergraduates affiliated with the Alaska Native Science
and Engineering Program to assist with experimental work and vegetation collection at Toolik Lake. This research is significant to ecologists from the Circumarctic Rangifer Monitoring
and Assessment Network, dedicated
to caribou conservation and sustainable management in the US, Canada, and Scandinavia, who will use the data to consider how a suite of climate change scenarios affect herd fecundity and population dynamics.

The intellectual merit of this project stems from the merging of five elements to understand Arctic
System function and response to climate change: (1) A landscape-scale assessment of plant species, soil and plant C and N, digestibility, and secondary compounds that will be used
to calculate the amounts of CAP (kg m-2) and CAE (kJ m-2); (2) analysis of how closely caribou foraging is tied to the nutritional landscape throughout the year; (3) analysis of samples
from an existing long-term winter - summer climate change experiment to provide data on how
CAP and CAE will differ in the future; (4) prediction of future nutritional landscapes and
caribou foraging interactions; and (5) observations of Alaska Native hunter harvesting and attributes
of the system that determine their spatial and temporal patterns. These project components will enable an integrative understanding of how an important herbivore, caribou, interact with a landscape that is rapidly changing. This research: (1) examines the Arctic System from primary production to secondary consumers and the
influence of climate change across multiple trophic levels; (2) applies broadly by examining
the most abundant large herbivore and its food sources, both of which are distributed throughout
the Arctic; and (3) integrates experimental, observational, and modeling approaches to understanding ecological systems and climate change. The integration of observation, experimental data
and modeling to describe current and forecast future nutritional landscapes is intended to provide a
mechanistic understanding of Arctic System function and transform the understanding
of climate-vegetation-caribou-subsistence hunter interactions.

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