South China Agricultural University
Wushan, China

South China Agricultural University commonly referred to as SCAU, is a public university in Guangzhou, China.Founded in 1909. Main campus settles in Wushan, Guangzhou, People's Republic of China. It is a national comprehensive university with long history. The university has 24 colleges/department and more than 40,000 students, including international students from 33 countries. The main feature of the university is biology science. Wikipedia.

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South China Agricultural University | Date: 2015-04-02

The invention belongs to the field of biomass energy utilization, and a continuous pyrolysis and carbonization method of agricultural and forestry biomass is disclosed. The method comprises the following steps: feeding biomass feedstock to a dryer for drying, then transporting to a continuous pyrolysis apparatus for pyrolyzing to obtain pyrolysis semicoke and pyrolysis volatiles; and transporting the pyrolysis semicoke to a carbonization apparatus for carbonization to obtain biomass charcoal and semi-coke carbonized volatiles; then discharging the pyrolysis volatiles and the semi-coke carbonized volatiles, and cooling to obtain tar, wood vinegar and pyrolysis gas; introducing the pyrolysis gas into a combustion apparatus for combustion to obtain a high temperature flue gas; and finally transporting the high temperature flue gas into pyrolysis apparatus and carbonization apparatus for supplying heat, then the flue gas after supplying heat is delivered to the dryer and discharging tail gas. In the method, continuous and stable pyrolysis and carbonization of biomasses is realized, the pyrolysis step and the carbonization step are finished in the same system with separate step, transport efficiency is significantly increased, reaction conditions are steady and controllable, and the energy utilization efficiency is high.

News Article | May 9, 2017

Trap-jaw ants, with their spring-loaded jaws and powerful stings, are among the fiercest insect predators, but they begin their lives as spiny, hairy, fleshy blobs hanging from the ceiling and walls of an underground nest. New research provides the first detailed descriptions of the larval developmental stages of three species of Odontomachus trap-jaw ants. "This research provides foundational knowledge which enables future research questions on developmental trajectories, such as when an individual might switch from developing into a worker to developing into a queen," says Adrian Smith, a research assistant professor at NC State University and head of the Evolutionary Biology & Behavior Research Lab at the North Carolina Museum of Natural Sciences. "Beyond furthering our understanding of these social insects, the work also offers us a little more insight into how the natural world works," says Smith, who co-authored a paper on the research. "We think that's inherently valuable and, as the images associated with this research show, nature can be visually fascinating." While there are nearly 16,000 described species of ants, less than half of one percent of those have had their developmental stages, from egg to adult, described. The number of larval stages in insects can be variable, however the new study finds that trap-jaw ant workers go through three stages of larval development. This research determined the number of larval developmental stages, or instars, by measuring hundreds of larval head widths and body lengths and by identifying stage-specific anatomical features through scanning electron microscopy. These images revealed an amazing complexity of body parts such as four "sticky doorknobs" on the backs of first and second instars, used to adhere the larvae to nest walls and ceilings, complex "frustrum with spire" hairs of second and third instars, and silk-spinning "pseudopalps" of third instar larva. Beyond providing the first categorization of larval stages for these ants, surprising results from the work include discovery of the "sticky doorknobs" which were previously studied in only one other ant species, developmental anomalies such as the appearance of additional doorknob protuberances, and the discovery of a larval parasite found in the gut of a third instar larva. The journal article, "Larvae of trap-jaw ants, Odontomachus Latreille, 1804 (Hymenoptera: Formicidae): morphology and biological notes," is published in the journal Myrmecological News. Lead author of the paper is Eduardo G.P. Fox, of South China Agricultural University. Other co-authors were Joshua C. Gibson of the University of Illinois and Daniel R. Solis of Sao Paulo State University. A slide show of select images from the research is also available at https:/ . All original electron microscope images are freely available through CC BY 4.0 license here: http://dx. . A related video can be seen at https:/ .

South China Agricultural University | Date: 2015-08-28

The present invention disclosed a Nosema bombycis HMG1 gene, a specific primer set used for rapidly detecting Nosema bombycis, a group of microsporidium universal detection primers, and uses thereof. The primer set comprises a primer HMG1-sF and a primer HMG1-sR, and nucleotide sequences of the primers are shown in SEQ ID No. 5-6 respectively. The universal detection primers comprise a primer HMG1F and a primer HMG1R, and nucleotide sequences of the primers are shown in SEQ ID No. 3-4 respectively.

Qiu H.,South China Agricultural University
Nonlinear Analysis: Real World Applications | Year: 2017

In this paper, we study the Cauchy problem for a regularized viscoelastic fluid model in space dimension two, the Bardina–Oldroyd model, which is inspired by the simplified Bardina model for the turbulent flows of fluids, introduced by Cao et al. (2006). In particular, we obtain the local existence of smooth solutions to this model via the contraction mapping principle. Furthermore, we prove the global existence of smooth solutions to this system. © 2016 Elsevier Ltd

Human drug transporters often play key roles in determining drug accumulation within cells. Their activities are often directly related to therapeutic efficacy, drug toxicity as well as drug-drug interactions. However, the progress for interpretation of their crystal structures is relatively slow. Hence, conventional biochemical studies together with computer modeling became useful manners to reveal essential structures of these membrane proteins. Over the years, quite a few structure-function relationship information had been obtained for members of the two major transporter families: the ATP-binding cassette family and the solute carrier family. Critical structural features of drug transporters include transmembrane domains, post-translational modification sites and domains for cell surface assembly and protein-protein interactions. Alterations at these important sites may affect protein stability, trafficking to the plasma membrane and/or ability of transporters to interact with substrates. © 2016 Elsevier B.V.

Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: ENV.2007.;ENV.2007. | Award Amount: 1.91M | Year: 2009

Project partner will complete a detailed multidisciplinary situation analysis of highland aquatic resources, focused on values, livelihoods, conservation issues and wise-use options at five sites in Asia (Guangdong, China; Uttrakhand and West Bengal, India and northern and central Vietnam). Factors assessed will include biodiversity and ecosystem services, including provisioning, regulating, supporting and cultural services. Livelihood strategies of households dependent on ecosystem services derived from highland aquatic resources, in particular poor, food-insecure and vulnerable people, will be assessed within a sustainable livelihoods framework and opportunities to enhance such livelihoods assessed. Institutional features, including local, national and international policy and legislation, trajectories of change, stakeholder values associated with highland aquatic resources and areas of conflict will be assessed. Stakeholder participation will be critical to ensure new knowledge is accessible for collective decision-making and development of policies for the equitable use and conservation; methods and indicators for participatory monitoring and evaluation of ecosystem services and biodiversity will be developed. Action plans will then be formulated with stakeholders to: monitor the health of highland aquatic resources; develop and promote wise-use, and where necessary livelihoods diversification, to enhance poor livelihoods and conservation; integrate sustainable and wise-use, livelihoods diversification and conservation with watershed management priorities throughout the region. Action plans will be implemented by stakeholders at four sites displaying high biodiversity in Asia and the ecosystem, livelihoods and institutional impacts assessed through participatory monitoring and evaluation. Best practices aimed at conserving biodiversity and sustaining ecosystem services will be communicated to potential users to promote uptake and enhanced policy formulation.

News Article | February 21, 2017

Anyone who has ever been to a farm knows there’s no shortage of drool dangling from the mouths of barnyard animals. Those super-active salivary glands could someday be put to good use, according to a new study. Zhenfang Wu and colleagues at the South China Agricultural University transformed the salivary glands of mice into miniature bioreactors for producing human nerve growth factor (NGF) proteins in their spit (Sci. Rep. 2017, DOI: 10.1038/srep41270). “This is the first paper that reports production of therapeutic protein from transgenic animals’ saliva,” Wu says. Protein drugs, such as blood clotting factors and insulin, are often produced in large vats of genetically engineered cells. Sometimes yields are low, and if bacterial or yeast cells are used, the protein drugs may lack the appropriate chemical modifications that occur in mammalian cells, such as glycosylation. To get around that limitation, some scientists have turned to harvesting the proteins from transgenic animals. Two therapeutic proteins produced in in the milk of genetically modified animals, ATryn and Ruconest, have been approved for use in Europe and the U.S. In the new study, Wu’s team looked to produce NGF. Scientists have studied human NGF because of its therapeutic implications in a number of neurological diseases, including Alzheimer’s, Parkinson’s, spinal cord injury, and glaucoma. Surprisingly, NGF is produced in both mouse and human saliva, but Wu and colleagues engineered mice to produce human NGF protein in their salivary glands instead of the mouse version. To collect the NGF protein, the researchers anesthetized the mice and administered pilocarpine hydrochloride, a known salivary stimulant. After purifying NGF from the saliva, the team showed that the protein was functional, triggering rat adrenal gland cells to become neuronlike. “Currently we are working on using this process in pigs,” Wu says, adding that his team has already developed methods for “repeated, long-term and large-volume collection of saliva from pigs.” “The production of pharmaceutical proteins from transgenic animals is developing slowly. This is the case even for the production from milk, which is likely the best system,” says Louis-Marie Houdebine, an expert on producing drugs in transgenic animals at the French National Institute for Agricultural Research. Enqi Liu of the Laboratory Animal Center at Xi’an Jiaotong University School of Medicine says that compared with milk, saliva would be especially “susceptible to microbial contamination,” posing a further complication for purifying the proteins. But could scientists produce a high enough concentration of a protein and collect a large enough volume of saliva to make spit a viable option? “In theory, I think it could work,” says Karen Beauchemin, a ruminant nutrition scientist at Agriculture & Agri-Food Canada. Beauchemin says that dairy cows produce more than 200 L of saliva in a single day to buffer fermentation in the rumen, the cow’s first of four stomachs. Like humans, pigs have only one stomach. Wu says that swine produce about 15 L of saliva per day, and his team has been able to collect 3 L of spit per day from pigs, for 40 days straight, without any apparent harm to the animals. Houbedine points out that salivary glands are not the first unusual tissue researchers have attempted to tap for protein production. Other researchers have proposed to engineer bladder epithelium and male epididymis tissues for collecting therapeutic proteins in animal urine and semen, respectively. “These two systems were soon abandoned,” he says, perhaps because of low yield, and also the foreseeable difficultly in marketing such a product.

Zhaoqing Dahuanong Biological Medicine Co. and South China Agricultural University | Date: 2015-11-18

The invention discloses an avian infectious bronchitis virus purification method. The method uses ordinary avian embryo which was affected by avian bronchitis virus. Using the combination of centrifugation, ultrafiltration, concentration, molecular sieve chromatography and ultrafiltration method can effectively remove miscellaneous protein in embryo-derived infectious bronchitis virus antigen, high virus recovery, and have no effect on the activity of avian infectious bronchitis virus. The avian infectious bronchitis virus purified by this method can be directly used in the preparation of avian infectious bronchitis virus vaccine.

In order to elucidate the immune-protective mechanisms of inactivated Cryptocaryon irritans vaccine, different doses of C. irritans theronts were used to immunize orange-spotted grouper (Epinephelus coioides). We measured serum immobilization titer, blood leukocyte respiratory burst activity, serum alternative complement activity, and serum lysozyme activity weekly. In addition, the expression levels of immune-related genes such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), major histocompatibility complexes I and II (MHC I and II), and transforming growth factor-β1 (TGF-β1) were determined in spleen and gills. The results showed that the immobilization titer, respiratory burst activity, and alternative complement activity of immunized fish were significantly increased, and the levels of the last two immune parameters in the high-dose vaccine group were significantly higher than in the low-dose vaccine group. Serum lysozyme activity in the high-dose vaccine group was significantly higher than in the PBS control group. Vaccination also regulated host immune-related gene expression. For example, at 2- and 3- weeks post immunization, IL-1β expression in the high-dose vaccine group spleen was significantly increased. At 4-weeks post immunization, the fish were challenged with a lethal dose of parasite, and the survival rates of high-dose vaccine group, low-dose vaccine group, PBS control group, and adjuvant control group were 80%, 40%, 0%, and 10% respectively. These results demonstrate that inactivated C. irritans vaccination improves specific and nonspecific immune responses in fish, enhancing their anti-parasite ability. These effects are vaccine antigen dose-dependent. Copyright © 2013 Elsevier Ltd. All rights reserved.

Qi W.,South China Agricultural University
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin | Year: 2014

Human infection with a novel influenza A(H10N8) virus was first described in China in December 2013. However, the origin and genetic diversity of this virus is still poorly understood. We performed a phylogenetic analysis and coalescent analysis of two viruses from the first case of influenza A(H10N8) (A/Jiangxi-Donghu/346-1/2013 and A/Jiangxi-Donghu/346-2/2013 and a novel A(H10N8) virus (A/chicken/Jiangxi/102/2013) isolated from a live poultry market that the patient had visited. The haemagglutinin (HA), neuraminidase (NA), PA subunit of the virus polymerase complex, nucleoprotein (NP), M and nonstructural protein (NS) genes of the three virus strains shared the same genetic origins. The origins of their HA and NA genes were similar: originally from wild birds to ducks, and then to chickens. The PA, NP, M, and NS genes were similar to those of chicken influenza A(H9N2) viruses. Coalescent analyses showed that the reassortment of these genes from A(H9N2) to A(H10N8) might have occurred at least twice. However, the PB1 and PB2 genes of the chicken A(H10N8) virus most likely originated from H7-like viruses of ducks, while those of the viruses from the case most likely stemmed from A(H9N2) viruses circulating in chickens. The oseltamivir-resistance mutation, R292K (R291K in A(H10N8) numbering) in the NA protein, occurred after four days of oseltamivir treatment. It seems that A(H10N8) viruses might have become established among poultry and their genetic diversity might be much higher than what we have observed.

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