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Madurai, India

Rajesh M.,Sourashtra College
Journal of Pure and Applied Microbiology | Year: 2010

Aquatic systems are very sensitive to heavy metal pollutants and the gradual increase in the levels of such metals in aquatic environment, mainly due to anthropogenic sources, became a problem of primary concern. This is due to their persistence as they are not usually eliminated either by biodegradation or by chemical means, in contrast to most organic pollutants. Moreover, the decay of organic materials in aquatic systems together with detritus formed by natural weathering processes, provides a rich source of nutrients in both the bottom sediments and overlying water body. Microorganisms, microflora and algae are capable of incorporating and accumulating metal species into their living cells from various supply sources. Consequently, small fish become enriched with the accumulated substances. Eventually man, consuming the fish, inevitably suffers from the results of an enrichment taken place at each trophic level, where less is extracted than ingested (Forstner and Wittmann, 1983). In the present study, effect of Aluminium toxicity on carbohydrate, protein and lipid of Oreochromis mossambicus was seen. Our experiments demonstrate that increasing concentrations of aluminium decreases the carbohydrate, protein and lipid content of muscles and liver in the tilapia fish. Source


Rajasekaran M.,Sourashtra College | Annaraj J.,Madurai Kamaraj University
Journal of Nanoscience and Nanotechnology | Year: 2014

Nanostructured phyto-drugs such as curcumin and quercetin were prepared by simple sonochemical method and studied for their bio-activities. FT-IR spectra indicate that the chemical structures of these nanostructured drugs are identical with their commercially available microcrystalline counterparts. Scanning Electron Microscopic (SEM) analysis reveals that the curcumin and quercetin, form as nanocube and nanoneedle like structures respectively. These nanocrystalline drugs have enhanced solubility in neutral aqueous medium at room temperature and thus exhibit better bioavailability than their commercially available microcrystalline form. Their DNA interactions and the observed binding constants were investigated through UV-vis spectral technique. Nanocurcumin, due to its small size, exhibits significantly high DNA binding constant (1.2×106 M-1). The voltammetric and CD spectral changes observed for the nanocurcumin reveal its deep penetration into the core of the DNA through the minor grooves, where it forms H-bonds with the floor nitrogen/oxygen atoms of the DNA bases. Copyright © 2014 American Scientific Publishers All rights reserved. Source


Thirunarayanan G.,Annamalai University | Vanangamudi G.,Government Arts College | Sathiyendran V.,Sourashtra College | Ravi K.,Proventus Life Science Private Ltd
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2011

A series of 6-substituted ω-bromo-2-naphthyl ketones and 6-substituted 2-naphthacyl esters have been synthesized by greener synthetic method using fly-ash:water catalyzed aqueous phase reaction. These ketones and esters have been characterized by their physical constants, GC-MS, IR and NMR spectral data. These compounds exist as two rotomers and the carbonyl frequencies of these rotomers have been assigned and correlated with Hammett substituent constants, F, R and Swain-Lupton's parameters. The antioxidant activities of the synthesized esters have been evaluated. Source


Arumugam G.,Madurai Kamaraj University | Vijayakumar V.K.,Sourashtra College
Lecture Notes in Business Information Processing | Year: 2015

Association rule mining(ARM) techniques search for groups of frequently co-occurring items (i.e., frequent itemset) in a market-basket transaction database and convert these groups into business-oriented rules. The problem of ARM will gain momentum when it is attached with the time of transaction. High utility itemset mining is a research area of utility based data mining, aimed at finding itemsets that contribute most to the total utility. The association of time and utility on frequent itemsets gives a novel approach to efficiently capture the transactions for getting better predictions and planning for an enterprise. Previous research has focused mainly on how to obtain exhaustive lists of association rules. However, users often prefer a quick response to targeted queries. To accelerate the processing of such queries, a query-driven system called TD-FVAUFM (Time-Dependent Fast Value Added Utility Frequent Mining) is proposed in this paper. It performs data preprocessing steps on the given database and the resultant database is converted in the form of an itemset tree, a compact data structure suitable for query response. The proposed system is applied on a medical database containing patient’s records. It generates association rules that predict possible diseases with risk factor and frequency with respect to time. Experiments indicate that the targeted queries are answered in a time that is roughly linear in the number of transactions. © Springer International Publishing Switzerland 2015. Source


Raman N.,VHNSN College | Jeyamurugan R.,VHNSN College | Subbulakshmi M.,VHNSN College | Boominathan R.,VHNSN College | Yuvarajan C.R.,Sourashtra College
Chemical Papers | Year: 2010

A novel series of Co(II), Ni(II), Cu(II), Zn(II), and VO(IV) complexes has been synthesized from the Schiff base derived from 4-[(3,4-dimethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one and 1,2-diaminobenzene. Structural features were determined by analytical and spectral techniques. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods and viscosity measurements. Experimental results indicate that the complexes are able to form adducts with DNA and to distort the double helix by changing the base stacking. Lower DNA affinity of the VO(IV) complex is caused by the change of coordination geometry by the vanadyl ion resulting in a somewhat unfavorable configuration for the DNA binding. Oxidative DNA cleavage activities of the complexes were studied with supercoiled (SC) pUC19 DNA using gel electrophoresis; the mechanism studies revealed that the hydroxyl radical is likely to be the reactive species responsible for the cleavage of pUC19 DNA by the synthesized complexes. The in vitro antimicrobial screening effects of the investigated compounds were monitored by the disc diffusion method. The synthesized Schiff base complexes exhibit higher antimicrobial activity than the respective free Schiff base. © 2009 Institute of Chemistry, Slovak Academy of Sciences. Source

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