Time filter

Source Type

Sorgun, Turkey

Yeslyurt M.,Tekirdag State Hospital | Kilic S.,Public Health Institution of Turkey | Celeb B.,Public Health Institution of Turkey | Gul S.,Sorgun State Hospital
Scandinavian Journal of Infectious Diseases

Tularemia during pregnancy is exceedingly rare and has been reported infrequently in Europe. A review of the literature identified only 3 documented cases. Herein we report 4 tularemia cases occurring early in the second and third trimesters, which were successfully managed without any adverse pregnancy outcomes. © 2013 Informa Healthcare. Source

Ayhan A.,Baskent University | Basaran A.,Kulu State Hospital | Guler T.O.,Sorgun State Hospital
International Journal of Gynecological Cancer

The role of oxidized regenerated methylcellulose (ORC) in the lymphocyst formation after systematic lymphadenectomy Methods and Study Design: This was a retrospective case-control study Patients with gynecologic cancer who underwent systematic lymphadenectomy from May 2000 to April 2006 were considered Retroperitoneal Bno closure[ method was performed in all patients Two groups were identified according to ORC use The lymphocysts were evaluated via ultrasonography/computed tomography/magnetic resonance imaging between the third and sixth months after surgery Results: The overall lymphocyst incidence was found to be 75 (29.8%) of 252, and lymphocyst incidence in the ORC and control groups was 45 (30%) of 150 and 30 (29.4%) of 102, respectively The mean (SD) total number of extracted lymph nodes in the ORC group was 27.5 (10.6), which was significantly higher than that in the control group (22.1 [10.8]; P = 0.001) Duration of drain was significantly longer in the ORC group (P = 0.028) However, when confounding variables were included into the binary logistic regression analysis for the prediction of the duration of drains, only the stage of disease predicted the duration of drains Conclusions: Use of ORC does not seem to affect lymphocyst formation Oxidized regenerated methylcellulose use does not affect the duration of drains, hence ORC does not seem to pose a stimulatory effect on the peritoneum. Copyright © 2010 by IGCS and ESGO. Source

Yapca O.E.,Sorgun State Hospital | Turan M.I.,Ataturk University | Cetin N.,Ataturk University | Borekci B.,Ataturk University | Gul M.A.,Ataturk University
European Journal of Obstetrics Gynecology and Reproductive Biology

Objective: To investigate whether thiamine pyrophosphate can prevent infertility developing in rats undergoing unilateral ovariectomy and with ischemia reperfusion induced in the contralateral ovary. Biochemical examinations of the ovaries were also performed. Study design: Rats were divided into two main groups of three subgroups each. An ischemia reperfusion model was established in the first main group, while surgical unilateral ovariectomy was performed in the second. Thiamine pyrophosphate and melatonin were administered to the subgroups. No additional procedure was performed in the control groups. The rats were then left in laboratory environments and their fertility levels were determined. Malondialdehyde, total glutathione and DNA damage products were measured in those rats from which ovarian tissue was collected. Results: The results showed that thiamine pyrophosphate prevented ischemia/reperfusion injury-related infertility, but melatonin did not provide adequate prevention. However, reproduction in healthy animals receiving melatonin began earlier compared to those receiving thiamine pyrophosphate. Melatonin suppressed oxidative stress caused by ischemia/reperfusion in ovarian tissue significantly better than did thiamine pyrophosphate. Conclusions: We think that different mechanisms, in addition to antioxidant activity, are involved in the prevention of reperfusion-associated infertility after ischemia. © 2013 Elsevier Ireland Ltd. All rights reserved. Source

Yapca O.E.,Sorgun State Hospital | Turan M.I.,Research and Educational Hospital | Borekci B.,Ataturk University | Akcay F.,Ataturk University | Suleyman H.,Recep Tayyip Erdogan University
Iranian Journal of Basic Medical Sciences

Objective(s): This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury. Materials and Methods: Diabetic rats were divided into a control group (IRC) to be exposed to I/R, an ovarian I/R + 2.2 mg/kg melatonin (IRML) group, an ovarian I/R + famotidine (IRFA) group, an ovarian I/R + 20 mg/kg mirtazapine (IRMR) group, an ovarian I/R + 20 mg/kg thiamine pyrophosphate (IRTP) group, and a sham operation (SO) group. Results: In the control group exposed to I/R, the levels of the oxidant parameters Malondialdehyde (MDA) and Myeloperoxidase (MPO) were significantly higher compared with the SO group, while the levels of the antioxidant parameters glutathione (GSH), Glutathione peroxidase (GPO), Glutathione reductase (GSHRd), Glutathione S - transferase (GST), and Superoxide dismutase (SOD) were significantly lower. Melatonin, famotidine, mirtazapine, and thiamin pyrophosphate prevented a rise in oxidant parameters and a decrease in antioxidants in ovarian tissue exposed to I/R. However, apart from thiamin pyrophosphate, none of the drugs were able to prevent infertility caused by I/R injury. Conclusion: Prevention of ovarian I/R injury-related infertility in rats with induced diabetes is not through antioxidant activity. Thiamine pyrophosphate prevents infertility through an as yet unknown mechanism. This study suggests that thiamine pyrophosphate may be useful in the prevention of I/R-related infertility in diabetics. Source

Kisaoglu A.,Ataturk University | Borekci B.,Ataturk University | Yapca O.E.,Sorgun State Hospital | Bilen H.,Ataturk University | Suleyman H.,Ataturk University
Eurasian Journal of Medicine

The oxidant/antioxidant balance in healthy tissues is maintained with a predominance of antioxidants. Various factors that can lead to tissue damage disrupt the oxidant/antioxidant balance in favor of oxidants. In this study, disruptions of the oxidant/antioxidant balance in favor of oxidants were found to be a consequence of the over-consumption of antioxidants. For this reason, antioxidants are considered to be of importance in the prevention and treatment of various types of tissue damage that are aggravated by stress. Source

Discover hidden collaborations