Ballerup, Denmark

Sophion Bioscience

www.sophion.dk
Ballerup, Denmark

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Patent
Sophion Bioscience | Date: 2017-01-04

The invention describes a foil of polymeric material comprising a plurality of patch portions and a grid portion arranged between said patches. Each patch portion is connected to the grid portion by means of one or more connecting elements. Each patch portion is separated from the grid portion in the X-Y plane by means of a release portion, said release portion having a tensile strength in the X-Y plane which is lower than the tensile strength of both said patch portions and said grid portion, such that - upon exertion of a tensile force between said patch portions and said grid portion - said foil ruptures preferentially at said release portion. The invention relates to a method for the production of cell-capture chips using said foil, and a cell capture chip produced by said method.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: FoF.NMP.2012-5 | Award Amount: 5.19M | Year: 2012

The Hi-Micro project intends to realise an innovative approach for the design, manufacturing and quality control of tool inserts to achieve significant breakthrough in mass production of precision 3D micro-parts, through further developing both enabling manufacturing technologies, including additive manufacturing (AM), micro electrical discharge machining (micro-EDM), micro electro-chemical machining (micro-ECM) and micro-milling, and unique metrology and quality control methods such as computer-tomography (CT) metrology and digital holography. Together with industrial technology providers, the Hi-Micro project will further bolster the performance of industrial equipment for mass production of precision 3D micro-parts, through modular design of tool insert units with improved thermal management capability, development of on-machine handling system and in-line quality control device. Activities will run over the entire value chain of mass production of precision 3D micro-parts, from product and tool insert design, manufacturing of tool inserts, micro injection moulding processes, to the production equipment and quality control in the whole production chain. In order to tackle the identified challenges and critical problems, the Hi-Micro project will provide radical innovations and major breakthroughs as follows: Development of design and tolerance guidelines for advanced micro manufacturing of components (nominal size <1mm) Reliable capability of manufacturing tool inserts with complex internal features for conformal thermal management in micro-injection moulding (IM) and micro powder injection moulding (PIM) Processing technologies and equipment for manufacturing of 3D micro-parts with increased precision and accuracy to ensure smaller tolerances for the products, Metrology methods for complex internal structure and high-speed inline quality control with improved measurement efficiency and without loss of resolution or accuracy.


Grant
Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.40M | Year: 2013

This project is focused on development of technologies for separation and manipulation of single biological cells for life science research and medical applications. The research plan is built upon the results of the FP7 project PASCA (GA 257073, started 01.09.2010). The single cell manipulation technology (SCM technology) developed there is based on inkjet-like printing of single biological cells confined in free flying micro droplets. It constitutes a universal platform for single cell analysis that has been proven to have high potential for many life science applications. The objective of this project is to support the participating SMEs and companies to take up the SCM technology, to realize their own applications and to develop them into innovative products for the medical, biomedical and pharmaceutical markets. Central element of the research is the SCM prototype instrument as presented in numerous publications (see www.pasca.eu). The actual project will provide validation and extension of the use of this prototype instrument and deal with necessary improvements and modifications of pre-production prototypes towards the specific needs and applications of the SME partners. In particular also topics affecting commercial exploitation like e.g. application development, design for manufacturability, reliability issues, cost and throughput optimization, extension of technical specifications, and preparation of CE IVD labeling will be investigated. Applications targeted by the individual SMEs are considering fast pathogen detection for clinical use by combining the SCM technology with MALDI TOF mass spectroscopy of single bacteria, instruments for single cell cancer and stem cell research, methods for monoclonal cell line development and in-vitro medical diagnostic applications. The anticipated innovations stemming from this research will be exploited by the involved SMEs individually as well as jointly through several innovative products targeted for different markets and applications.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.9 | Award Amount: 3.94M | Year: 2010

Analysis of biological cells down to single cell resolution is a prospective technique in nearly all fields of life science research. In particular manipulation and analysis of single cells can open up a new dimension in cell biology, tissue engineering, drug development and diagnostics. The advancement of single cell technology as a whole requires tools and instrumentation to sort, transport and manipulate single living cells. Micro system technology with its sophistications can provide in this context capabilities far beyond todays methods.\n\nTherefore, this project aims to develop a single cell manipulator (SCM) micro instrument for inkjet like printing of single living cells confined in micro droplets of only 50m size. Such a device can serve as a universal tool for manipulating cells in a non-invasive flexible manner. Within the project the SCM device will be applied to cell biological applications in cancer research and drug development to demonstrate and validate the performance of the device, as well as to establish a flexible platform for advanced single cell-manipulation and analysis (PASCA).\n\nIn order to achieve these objectives crosscutting technological challenges have to be faced which can be overcome by integrating and interfacing multiple core technologies, only. Cutting edge bio-sensing technology like impedance spectroscopy and state of the art micro dispensing methods will be applied and combined with latest cell biological methods to establish the SCM instrument as multifunctional microsystem for cell manipulation. Through the highly innovative integrated approach and the validation within the PASCA platform the SCM instrument has excellent exploitation perspectives in multiple application sectors.\n\nAlso the project structure as a whole supports the objectives of the work program:By intensively involving SMEs to feed the innovation cycle and by bringing the user into research cycles through the open access partner structure.


Patent
Sophion Bioscience | Date: 2016-07-25

A chip assembly for use in a microfluidic analysis system, such as a patch clamp apparatus, comprises a chip having an outer wall, a carrier structure comprising an aperture for receiving the chip, the aperture defining an inner wall, wherein the chip is arranged in the aperture with a liquid tight seal between the outer wall of the chip and the inner wall of the aperture. The chip may be sealed and bonded to the carrier structure by means of a bonding material, such as an UV curing adhesive. A through hole in the chip is aligned with the aperture in the carrier structure. A method for manufacturing the chip assembly is further disclosed.


Patent
Sophion Bioscience | Date: 2015-02-25

The invention describes a foil of polymeric material comprising a plurality of patch portions and a grid portion arranged between said patches. Each patch portion is connected to the grid portion by means of one or more connecting elements. Each patch portion is separated from the grid portion in the X-Y plane by means of a release portion, said release portion having a tensile strength in the X-Y plane which is lower than the tensile strength of both said patch portions and said grid portion, such thatupon exertion of a tensile force between said patch portions and said grid portionsaid foil ruptures preferentially at said release portion. The invention relates to a method for the production of cell-capture chips using said foil, and a cell capture chip produced by said method.


Patent
Sophion Bioscience | Date: 2013-01-08

The invention provides a chip for use in a microfluidic analysis system, for example a patch-clamp system, said chip having improved cell adhesion through a predetermined pattern of hydrophobic and hydrophilic regions. A method for manufacture of the chips, and a method for improving the adhesion of a cell to a chip are also disclosed.


Patent
Sophion Bioscience | Date: 2014-06-23

The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.


Patent
Sophion Bioscience | Date: 2013-09-27

A single-step method for applying a coating to a polymeric substrate comprising: exposing a photoreactive compound and a polymeric compound in an aqueous solvent to ultraviolet radiation in the presence of said polymeric substrate to obtain a covalently bound coating thereon comprising a reaction product of the photoreactive compound and the polymeric compound. More particularly, the present invention relates to a method of applying a coating to a polymeric substrate in order to reduce the adsorption of analytes in solution to said substrate by imparting properties to the substrate similar to the properties of the coating applied.


Patent
Sophion Bioscience | Date: 2012-02-29

A handheld device for analysis of electro-physiological properties of a cellular membrane ion channel in an ion channel containing lipid cellular membrane comprises a handheld body with a pump and an electronic controller, and a disposable pipette tip comprising a pathway for fluid, said pathway connecting an open end of the pipette tip to an analysis substrate comprised in the pipette tip. The substrate is adapted to transmit an electrical current through the ion channel in said ion channel-containing lipid cellular membrane, when said lipid cellular membrane is held at a predetermined site of the substrate, e.g. for patch clamp analysis. The handheld body and the disposable pipette tip are configured to releasably attach the pipette tip to the body, to provide a hydraulic connection between the pump of the handheld body and said pathway, and to provide an electric connection between the electronic controller and at least one of said electrodes of the substrate. The electronic controller of the handheld body is configured to operate the assembled device for micfofluidic analysis of aspirated fluid.

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