Tokyo, Japan
Tokyo, Japan

Sophia University is a private Jesuit research university in Japan, with its main campus located near Yotsuya station, in an area of Tokyo's Chiyoda Ward. It is ranked as one of the top private universities in Japan with the most selective admission and is known for its international academic climate. It takes its name from the Greek Sophia meaning "wisdom". The Japanese name, Jōchi Daigaku literally means "University of Higher Wisdom". It has an exchange program with many universities throughout the world, including Yale University, Sogang University and the University of Hong Kong. The university was a men’s university in the past, but at present admits women; the proportion of men to women is now more or less equal. Sophia’s alumni are referred to as "Sophians"; they include the 79th Japanese Prime Minister of Japan, Morihiro Hosokawa, a number of politicians represented in the Diet of Japan and professors at institutions such as the University of Tokyo and Yale University. Wikipedia.

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Canon Kabushiki Kaisha, Kyoto University, Tokyo Institute of Technology, Tokyo University of Science, Yamanashi University, Japan National Institute of Advanced Industrial Science, Technology and Sophia University | Date: 2013-08-05

Provided is a piezoelectric material excellent in piezoelectricity. The piezoelectric material includes a perovskite-type complex oxide represented by the following General Formula (1). A(Zn_(x)Ti_((1-x)))_(y)M_((1-y))O_(3)(1) wherein A represents at least one kind of element containing at least a Bi element and selected from a trivalent metal element; M represents at least one kind of element of Fe, Al, Sc, Mn, Y, Ga, and Yb; x represents a numerical value satisfying 0.4x0.6; and y represents a numerical value satisfying 0.1y0.9.

Kondo J.,Sophia University | Westhof E.,University of Strasbourg
Nucleic Acids Research | Year: 2011

Nucleotide bases are recognized by amino acid residues in a variety of DNA/RNA binding and nucleotide binding proteins. In this study, a total of 446 crystal structures of nucleotide-protein complexes are analyzed manually and pseudo pairs together with single and bifurcated hydrogen bonds observed between bases and amino acids are classified and annotated. Only 5 of the 20 usual amino acid residues, Asn, Gln, Asp, Glu and Arg, are able to orient in a coplanar fashion in order to form pseudo pairs with nucleotide bases through two hydrogen bonds. The peptide backbone can also form pseudo pairs with nucleotide bases and presents a strong bias for binding to the adenine base. The Watson-Crick side of the nucleotide bases is the major interaction edge participating in such pseudo pairs. Pseudo pairs between the Watson-Crick edge of guanine and Asp are frequently observed. The Hoogsteen edge of the purine bases is a good discriminatory element in recognition of nucleotide bases by protein side chains through the pseudo pairing: the Hoogsteen edge of adenine is recognized by various amino acids while the Hoogsteen edge of guanine is only recognized by Arg. The sugar edge is rarely recognized by either the side-chain or peptide backbone of amino acid residues. © The Author(s) 2011. Published by Oxford University Press.

Takayanagi K.,Sophia University
Nuclear Physics A | Year: 2011

The extended Krenciglowa-Kuo (EKK) method allows us to calculate the effective Hamiltonian in a non-degenerate model space. We show that the EKK method can be implemented numerically in two iterative schemes, which are explained in detail with emphasis on convergence conditions. Using test calculations in a simple model, we clarify how and on what conditions we can calculate the effective Hamiltonian. © 2011 Elsevier B.V.

Takayanagi K.,Sophia University
Annals of Physics | Year: 2016

We present a unified description of the Bloch and Rayleigh-Schrödinger perturbation theories of the effective interaction in both algebraic and graphic representations. © 2015 Elsevier Inc.

Resistance explained: The crystal structures of the ribosomal decoding Asite with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Takayanagi K.,Sophia University
Annals of Physics | Year: 2014

We present a unified description of the effective interaction v in the Rayleigh-Schrödinger perturbation theory. First, we generalize the well-known bracketing expression for the energy shift δ. E in a one-dimensional model space to express the effective interaction v in a multi-dimensional model space. Second, we show that the generalized bracketing representation has a natural graphic expression in terms of folded diagrams. The present work thus gives a unified understanding of the effective interaction (i)in one- and multi-dimensional model spaces and (ii)in algebraic (bracketing) and graphic (folded diagram) representations. © 2014 Elsevier Inc.

Slevin K.,Osaka University | Ohtsuki T.,Sophia University
New Journal of Physics | Year: 2014

We report a careful finite size scaling study of the metal-insulator transition in Anderson's model of localization. We focus on the estimation of the critical exponent ν that describes the divergence of the localization length. We verify the universality of this critical exponent for three different distributions of the random potential: box, normal and Cauchy. Our results for the critical exponent are consistent with the measured values obtained in experiments on the dynamical localization transition in the quantum kicked rotor realized in a cold atomic gas. © 2014 IOP Publishing and Deutsche Physikalische Gesellschaft.

Takayanagi K.,Sophia University
Nuclear Physics A | Year: 2013

The effective Hamiltonian in a model space has been derived from the decoupling equation. We present a rigorous proof of the proposition that the decoupling equation is a necessary and sufficient condition to give an effective Hamiltonian, establishing a robust one-to-one correspondence between a solution to the decoupling equation and an effective Hamiltonian. We then present discussions based on this result, emphasizing (i) that the current situation of the theory is far from being satisfactory, and (ii) that the proposition gives a rigorous mathematical foundation to any effort to improve the theory of the effective Hamiltonian on the basis of the decoupling equation. © 2013 Elsevier B.V.

Suzuki N.,Sophia University | Hashizume D.,RIKEN
Coordination Chemistry Reviews | Year: 2010

In this account [3]- and [5]cumulene complexes of group 4 metallocenes that form five-membered metallacycles are described. These complexes have a "triple bond" despite their five-membered ring structure, showing that they are regarded as 1-metallacyclopent-3-ynes. The molecular structures show their strained alkyne character. These complexes react with transition metals to form alkyne-coordinated bimetallic complexes. They also receive electrophilic attack by protons and boranes resulting in M-C bond cleavage. When a [3]cumulene couples with an alkyne on the metal, the reaction produces seven-membered metallacycloalkynes that have a strained structure showing an interaction between the "triple bond" and the metal center. Hexapentaenes, [5]cumulenes, form conjugated 1-metallacyclopent-3-ynes. The aryl-substituted [5]cumulene complex was reduced by alkali metal to give dianionic species that reacted with protons to give 1-metallacyclopent-3-ene, a cycloalkene, and with iodomethane to give 1-metallacyclopenta-2,3-diene, a cycloallene. The hexapentaene with tert-butyl groups reacts with zirconocene to form an η2-π-coordinated complex in the presence of trimethylphosphine, although it gave a 1-metallacyclopent-3-yne in the absence of the phosphine. The former was transformed into the latter by addition of a phosphine, and vice versa by removing the phosphine, showing a "haptotropic" shift. © 2009 Elsevier B.V. All rights reserved.

French National Center for Scientific Research and Sophia University | Date: 2013-09-16

The present invention relates to an in vitro or ex vivo method for producing a population of pancreatic beta-cells, comprising the step of inhibiting the expression or the activity of Arx in a population of pancreatic alpha-cells. The present invention also relates to method for inducing the conversion of pancreatic alpha-cells in pancreatic beta-cells in a patient in need thereof.

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