Seoul, South Korea
Seoul, South Korea

Sookmyung Women’s University ) is a private university in Yongsan-gu, Seoul, South Korea. Founded in 1906, Sookmyung is Korea’s first royal private educational institution for women Wikipedia.


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The present invention relates to a pharmaceutical composition for treating STK11-mutation cancer, containing, as an active ingredient, a material inhibiting a sodium-potassium transport function of Na^(+)-K^(+) ATPase (ATP1A1); an anticancer drug containing the composition as an active ingredient; and a method for screening STK11-mutation cancer therapeutic agent. It was first established that, of cancer cells in which various gene mutations are confirmed, an STK11-mutation cancer cell line, which is confirmed at high frequency, was treated with cardiac glycosides as a material inhibiting a sodium-potassium transport function of Na^(+)-K^(+) ATPase (ATP1A1), to significantly inhibit the growth of cancer cells. Therefore, the material inhibiting a sodium-potassium transport function of Na^(+)-K^(+) ATPase (ATP1A1) can be a target for treating STK11-mutation-derived cancer.


Yang M.,Sookmyung Womens University
Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews | Year: 2011

This review is focused on current information of avoidable environmental pollution and occupational exposure as causes of cancer. Approximately 2% to 8% of all cancers are thought to be due to occupation. In addition, occupational and environmental cancers have their own characteristics, e.g., specific chemicals and cancers, multiple factors, multiple causation and interaction, or latency period. Concerning carcinogens, asbestos/silica/wood dust, soot/polycyclic aromatic hydrocarbons [benzo(a) pyrene], heavy metals (arsenic, chromium, nickel), aromatic amines (4-aminobiphenyl, benzidine), organic solvents (benzene or vinyl chloride), radiation/radon, or indoor pollutants (formaldehyde, tobacco smoking) are mentioned with their specific cancers, e.g., lung, skin, and bladder cancers, mesothelioma or leukemia, and exposure routes, rubber or pigment manufacturing, textile, painting, insulation, mining, and so on. In addition, nanoparticles, electromagnetic waves, and climate changes are suspected as future carcinogenic sources. Moreover, the aspects of environmental and occupational cancers are quite different between developing and developed countries. The recent follow-up of occupational cancers in Nordic countries shows a good example for developed countries. On the other hand, newly industrializing countries face an increased burden of occupational and environmental cancers. Developing countries are particularly suffering from preventable cancers in mining, agriculture, or industries without proper implication of safety regulations. Therefore, industrialized countries are expected to educate and provide support for developing countries. In addition, citizens can encounter new environmental and occupational carcinogen nominators such as nanomaterials, electromagnetic wave, and climate exchanges. As their carcinogenicity or involvement in carcinogenesis is not clearly unknown, proper consideration for them should be taken into account. For these purposes, new technologies with a balance of environment and gene are required. Currently, various approaches with advanced technologiesgenomics, exposomics, etc.have accelerated development of new biomarkers for biological monitoring of occupational and environmental carcinogens. These advanced approaches are promising to improve quality of life and to prevent occupational and environmental cancers. Copyright © Taylor & Francis Group, LLC.


Baek S.H.,Seoul National University | Kim K.I.,Sookmyung Womens University
Annual Review of Physiology | Year: 2014

A growing body of evidence suggests that a subset of orphan nuclear receptors are amplified and prognostic for some human cancers. However, the specific roles of these orphan nuclear receptors in tumor progression and their utility as drug targets are not fully understood. In this review, we summarize recent progress in elucidating the direct and indirect involvement of orphan nuclear receptors in cancer as well as their therapeutic potential in a variety of human cancers. Furthermore, we contrast the role of orphan nuclear receptors in cancer with the known roles of estrogen receptor and androgen receptor in hormone-dependent cancers. © Copyright ©2014 by Annual Reviews. All rights reserved.


Chong S.-H.,Sookmyung Womens University | Ham S.,Sookmyung Womens University
Angewandte Chemie - International Edition | Year: 2014

Understanding the molecular determinants of the relative propensities of proteins to aggregate in a cellular environment is a central issue for treating protein-aggregation diseases and developing peptide-based therapeutics. Despite the expectation that protein aggregation can largely be attributed to direct protein-protein interactions, a crucial role the surrounding water in determining the aggregation propensity of proteins both in vitro and in vivo was identified. The overall protein hydrophobicity, defined solely by the hydration free energy of a protein in its monomeric state sampling its equilibrium structures, was shown to be the predominant determinant of protein aggregation propensity in aqueous solution. Striking discrimination of positively and negatively charged residues by the surrounding water was also found. This effect depends on the protein net charge and plays a crucial role in regulating the solubility of the protein. These results pave the way for the design of aggregation-resistant proteins as biotherapeutics. Water, water, everywhere: Understanding the causes of protein aggregation is a central issue for understanding and preventing protein-aggregation diseases. Most studies to date have focused on the protein sequences without fully addressing the role of the surrounding water molecules. In fact, the interaction of a protein with the water surrounding it was found to play a pivotal role in determining its hydrophobicity and thus its aggregation propensity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Patent
Sookmyung Womens University, Il Yang Pharm. Co. and Samsung | Date: 2016-01-06

The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on promoting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial-skin and preparation of blood vessels for transplantation.


Patent
Il Yang Pharm. Co., Sookmyung Womens University and Samsung | Date: 2013-07-03

The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide encoding the peptide, a pharmaceutical composition comprising the peptide or polynucleotide for preventing or treating inflammatory diseases, an anti-inflammatory drug, an over-the-counter (OTC) drug composition comprising the peptide for preventing or ameliorating inflammation, a health food composition for alleviating or ameliorating inflammation, a cosmetic composition for preventing or ameliorating inflammation, a method for treating inflammatory diseases, comprising administrating the pharmaceutical composition to the subject suspected of having inflammatory disease, a method for preparing a mimetic of the peptide and a method for designing the same.


Patent
Sookmyung Womens University, Il Yang Pharm. Co. and Samsung | Date: 2016-11-02

The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on prompting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial skin and preparation of blood vessels for transplantation.


Patent
Sookmyung Womens University | Date: 2016-05-13

A method of producing silica nanostructures, and more particularly, to a method of producing silica nanostructures is described to easily control shapes of the nanostructures produced with even using liquid phase deposition(LPD), so that the nanostructures can be applied to a circuit or a transistor using a dielectric material and can be applied to a large area, resulting in promising applicability to industries. The method includes method of producing silica nanostructures, the method comprising performing low-temperature liquid phase deposition (LPD) including adding silica to a liquid phase deposition (LPD) solution and impregnating silica beads in the silica-added LPD solution, wherein shapes of the silica nanostructures are controlled by adjusting the concentration of silica based on the following expression: 0


Patent
Sookmyung Womens University, Il Yang Pharm. Co. and Samsung | Date: 2016-10-26

The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on prompting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial skin and preparation of blood vessels for transplantation.


Yu S.J.,Sookmyung Womens University
Information Sciences | Year: 2012

As the number of Twitter users exceeds 175 million and the scale of social network increases, it is facing with a challenge to how to help people find right people and information conveniently. For this purpose, current social network services are adopting personalized recommender systems. Existing recommendation algorithms largely depend on one of content-based algorithm, collaborative filtering, or influential ranking analysis. However, these algorithms tend to suffer from the performance fluctuation phenomenon in common whenever an active user changes, and it is due to the diversities of personal characteristics such as the local social graph size, the number of followers, or sparsity of profile content. To overcome this limitation and to provide consistent and stable recommendation in social networks, this study proposes the dynamic competitive recommendation algorithm based on the competition of multiple component algorithms. This study shows that it outperforms previous approaches through performance evaluation on actual Twitter dataset. © 2011 Elsevier Inc. All rights reserved.

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