Suzhou, China

The original Soochow University was established in 1900 in Suzhou, Jiangsu in Qing dynasty China. The original Soochow University and the university currently in Taiwan are named Dōngwú Dàxué , after the general region in which Suzhou is located. The university in the People's Republic of China is named Sūzhōu Dàxué after the city of Suzhou. Wikipedia.

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Soochow University of China and SILK PLUG BEIJING BIOMEDICINE TECHNOLOGY COMPANY Ltd | Date: 2016-03-09

A high-strength biological scaffold and preparation method thereof. The biological scaffold is comprised of a framework of boiled-off silk woven material, the form of the framework is determined by actual needs; the framework surface is coated with a layer of silk protein scaffold material, fibroin protein/gelatin biological scaffold material or fibroin protein/collagen biological scaffold material having a thickness of 100 micrometers to 5 centimeters. The high-strength biological scaffold material has high tear resistance strength and mechanical strength and good biocompatibility, has a porous structure suitable for tissue regeneration, and can be used for preparing anal fistula repair plugs.

Xu L.,Soochow University of China | Chen H.,Soochow University of China
Nature Photonics | Year: 2014

The field of transformation optics shows that media containing gradients in optical properties are equivalent to curved geometries of spacetime for the propagation of light. Conformal transformation optics-a particular variant of this feature-can be used to design devices with novel functionalities from inhomogeneous, isotropic dielectric media. © 2014 Macmillan Publishers Limited. All rights reserved.

Metal-Insulator-Metal (MIM) structures have raised as the most promising configuration for next generation information storage, leading to great performance and fabrication-friendly Resistive Random Access Memories (RRAM). In these cells, the memory concept is no more based on the charge storage, but on tuning the electrical resistance of the insulating layer by applying electrical stresses to reach a high resistive state (HRS or "0") and a low resistive state (LRS or "1"), which makes the memory point. Some high-k dielectrics show this unusual property and in the last years high-k based RRAM have been extensively analyzed, especially at the device level. However, as resistance switching (in the most promising cells) is a local phenomenon that takes place in areas of ~100 nm2, the use of characterization tools with high lateral spatial resolution is necessary. In this paper the status of resistive switching in high-k materials is reviewed from a nanoscale point of view by means of conductive atomic force microscope analyses. © 2014 by the authors.

Li Y.,Soochow University of China | Dai H.,Stanford University
Chemical Society Reviews | Year: 2014

Zinc-air is a century-old battery technology but has attracted revived interest recently. With larger storage capacity at a fraction of the cost compared to lithium-ion, zinc-air batteries clearly represent one of the most viable future options to powering electric vehicles. However, some technical problems associated with them have yet to be resolved. In this review, we present the fundamentals, challenges and latest exciting advances related to zinc-air research. Detailed discussion will be organized around the individual components of the system-from zinc electrodes, electrolytes, and separators to air electrodes and oxygen electrocatalysts in sequential order for both primary and electrically/mechanically rechargeable types. The detrimental effect of CO2 on battery performance is also emphasized, and possible solutions summarized. Finally, other metal-air batteries are briefly overviewed and compared in favor of zinc-air. This journal is © the Partner Organisations 2014.

Ze Y.,Soochow University of China
PloS one | Year: 2014

Titanium dioxide nanoparticles (TiO2 NPs) have been used in various medical and industrial areas. However, the impacts of these nanoparticles on neuroinflammation in the brain are poorly understood. In this study, mice were exposed to 2.5, 5, or 10 mg/kg body weight TiO2 NPs for 90 consecutive days, and the TLRs/TNF-α/NF-κB signaling pathway associated with the hippocampal neuroinflammation was investigated. Our findings showed titanium accumulation in the hippocampus, neuroinflammation and impairment of spatial memory in mice following exposure to TiO2 NPs. Furthermore, TiO2 NPs significantly activated the expression of Toll-like receptors (TLR2, TLR4), tumor necrosis factor-α, nucleic IκB kinase, NF-κB-inducible kinase, nucleic factor-κB, NF-κB2(p52), RelA(p65), and significantly suppressed the expression of IκB and interleukin-2. These findings suggest that neuroinflammation may be involved in TiO2 NP-induced alterations of cytokine expression in mouse hippocampus. Therefore, more attention should be focused on the application of TiO2 NPs in the food industry and their long-term exposure effects, especially in the human central nervous system.

Dong J.Y.,Soochow University of China
Atherosclerosis | Year: 2013

Previous studies suggest obstructive sleep apnea (OSA) may increase cardiovascular risk, but the results are inconclusive due to various limitations. We aimed to systematically evaluate the effect of OSA on the incidence of cardiovascular events by a meta-analysis of prospective cohort studies. We searched multiple electronic databases for studies that examined the prospective relationship between OSA and incidence of coronary heart disease (CHD), stroke, or total cardiovascular diseases (CVD) among adults. Either fixed- or random-effects models were used to calculate the pooled risk estimates. Sensitivity analysis was conducted to examine the robustness of pooled outcomes. Of 17 studies included, 9 reported results on total CVD, 7 reported on fatal or non-fatal CHD, and 10 reported on fatal or non-fatal stroke. The pooled relative risks (95% confidence interval) for individuals with moderate-severe OSA compared with the reference group were 2.48 (1.98-3.10) for total CVD, 1.37 (0.95-1.98) for CHD, and 2.02 (1.40-2.90) for stroke. These results did not materially change in the sensitivity analyses according to various inclusion criteria. In conclusion, findings from this meta-analysis supported that moderate-severe OSA significantly increased cardiovascular risk, in particular stroke risk. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Deng K.,Soochow University of China | Li L.,Soochow University of China
Advanced Materials | Year: 2014

CdS nanostructures have received much attention in recent years as building blocks for optoelectronic devices due to their unique physical and chemical properties. This progress report provides an overview of recent research about rational design of CdS nanoscale photodetectors. Three kinds of photodetectors according to the metal-semiconductor contact types are discussed in detail: Ohmic contact, Schottky contact, and field enhanced transistor configuration. The focus is on the tuning of optical and electrical properties CdS nanostructures by element doping, composition and bandgap engineering, and heterojunction integration, along with thus modified device performances generated during these tuning processes. Latest concepts of photodetector design such as flexible, self-powered, plasmonic, and piezophototronic photodetectors with novel properties are introduced to demonstrate the future directions of such an exciting research field. Recent advances of CdS nanoscale photodetectors with Ohmic contact, Schottky contact and MESFET configuration are summarized. Element doping, composition and bandgap engineering, heterojunction integration, and new design concepts in photodetectors are discussed. Future development directions are also discussed. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Semaphorin 4D (Sema4D) is a transmembrane protein that supports contact-dependent amplification of platelet activation by collagen before being gradually cleaved by the metalloprotease ADAM17, as we have previously shown. Cleavage releases a soluble 120-kDa exodomain fragment for which receptors exist on platelets and endothelial cells. Here we have examined the mechanism that regulates Sema4D exodomain cleavage. The results show that the membrane-proximal cytoplasmic domain of Sema4D contains a binding site for calmodulin within the polybasic region Arg762-Lys779. Coprecipitation studies show that Sema4D and calmodulin are associated in resting platelets, forming a complex that dissociates upon platelet activation by the agonists that trigger Sema4D cleavage. Inhibiting calmodulin with W7 or introducing a membrane-permeable peptide corresponding to the calmodulin-binding site is sufficient to trigger the dissociation of Sema4D from calmodulin and initiate cleavage. Conversely, deletion of the calmodulin-binding site causes constitutive shedding of Sema4D. These results show that (1) Sema4D is a calmodulin-binding protein with a site of interaction in its membrane-proximal cytoplasmic domain, (2) platelet agonists cause dissociation of the calmodulin-Sema4D complex, and (3) dissociation of the complex is sufficient to trigger ADAM17-dependent cleavage of Sema4D, releasing a bioactive fragment.

Mao S.,Soochow University of China
Biosensors & bioelectronics | Year: 2013

Ag@C core-shell nano-composites have been prepared by a simple one-step hydrothermal method and are further explored for protein immobilization and bio-sensing. The electrochemical behavior of immobilized horseradish peroxidase (HRP) on Ag@C modified indium-tin-oxide (ITO) electrode and its application as H2O2 sensor are investigated. Electrochemical and UV-vis spectroscopic measurements demonstrated that Ag@C nano-composites provide excellent matrixes for the adsorption of HRP and the entrapped HRP retains its bioactivities. It is found that on the HRP-Ag@C/ITO electrode, HRP exhibited a fast electron transfer process and good electrocatalytic reduction toward H2O2. Under optimum experimental conditions the biosensor linearly responds to H2O2 concentration in the range of 5.0×10-7-1.4×10-4 M with a detection limit of 2.0×10-7 M (S/N=3). The apparent Michaelis-Menten constant (K(app)(M)) of the biosensor is calculated to be 3.75×10-5 M, suggesting high enzymatic activity and affinity toward H2O2. In addition, the HRP-Ag@C/ITO bio-electrode shows good reproducibility and long-term stability. Thus, the core-shell structured Ag@C is an attractive material for application in the fabrication of biosensors due to its direct electrochemistry and functionalized surface for efficient immobilization of bio-molecules. Copyright © 2013 Elsevier B.V. All rights reserved.

Super absorbent resin with a high solution absorbing rate and a preparation method therefor. In the method, by mass percent, 2%-10% polyvinyl alcohol whose polymerization degree is 1700-2400, 18%-26% sodium polyacrylate whose molecular weight is 2-510^(3), 3%-9% 2-acrylamide-2-methylpro panesulfonic acid, and 55%-77% water are first mixed, to obtain a polymer and a monomeric aqueous mixture solution; and then, the polymer and the solution are irradiated and crosslinked by an electron beam and are then grafted to synthesize polymer gel, the gel is swelled and immersed by preferably using a dipping solution, and is frozen and lyophilized, to obtain super absorbent resin. The super absorbent resin reaches the international level in the pH value, the normal saline solution swallow, and the centrifugal solution preserving capability, and especially, has significant advantages in the solution absorbing rate and swallow of water distilled three times; in addition, has a simple process, is desirable in biocompatibility, and can be safely used. Therefore, the super absorbent resin can be applied in the fields of medical and hygienical products such as diapers and women sanitary towels, petrochemical engineering, and water and moisture preserving in agriculture and forestry, and therefore has great application and development values.

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