Croker D.M.,Solid State Pharmaceutical Cluster |
Croker D.M.,University of Limerick |
Foreman M.E.,Solid State Pharmaceutical Cluster |
Foreman M.E.,University College Cork |
And 14 more authors.
Crystal Growth and Design | Year: 2012
A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state. The ternary phase diagram for the two coformers was constructed in two different solvents: Acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system. © 2011 American Chemical Society.