Soiken Inc

Ōsaka, Japan

Soiken Inc

Ōsaka, Japan
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Ueno H.M.,Brand Science Institute | Yoshise R.E.,Brand Science Institute | Sugino T.,Soiken Inc. | Kajimoto O.,Osaka City University | Kobayashi T.,Brand Science Institute
International journal of molecular sciences | Year: 2016

Dysmenorrhea is a highly prevalent complaint and highly undiagnosed gynecologic condition. Dairy products have a potential in the management of menstrual distress, and bovine lactoferrin can help the subjective dysphoria associated with dysmenorrhea. In the present study, we aimed to investigate the effects of a lactoferrin formulation isolated from cow's milk on menstrual symptoms in volunteers. A double-blind, randomized, placebo-controlled, crossover study of the iron-lactoferrin complex (FeLf) was performed in thirty-five healthy Japanese women. Participants received the 150 mg FeLf (per day) or placebo from day ten of the luteal phase to day four of the follicular phase. The Moos Menstrual Distress Questionnaire (MDQ) was measured for menstrual distress, and heart rate variability was measured as an index of autonomic nerve balance during menses. A visual analog scale for menstrual pain, and a verbal rating scale for quality of life during the first three days of menstruation were measured. The MDQ score for the automatic nervous system subscale was lower and the parasympathetic nervous system activity was greater in FeLf than in placebo for intention-to-treat or per-protocol populations. The other variables were not different between the groups. No treatment-related side effects were observed during the study. The results indicate that FeLf can provide a beneficial effect on the psychological symptoms in women affected by menstrual distress.


Sugino T.,Soiken Inc | Yasunaga G.,Institute of Cetacean Research | Fukuda M.,Fukuda Clinic
Japanese Pharmacology and Therapeutics | Year: 2013

Objectives: According to an epidemiological survey by the Fatigue Study Group of Ministry of Health, Labour and Welfare in 1999, about 60% (47.2 million) of Japanese working population complained of fatigue, moreover according to a survey in Aichi Prefecture by Health Labour Sciences Research in 2012, 51% of the population was aware of fatigue. These results show that the social environment related to fatigue has not changed in the last 10 years. However, there have been no established recommendations for fatigue, and few anti-fatigue medicines or foods have been developed. Oxidative stress is known to cause fatigue, so antioxidants are potential candidates for anti-fatigue agents. Imidazole dipeptides, which are abundant in whale meat, are reported to have strong antioxidative effects. We investigated the effect of whale meat extract on fatigue induced by physical load and by daily activities in humans. Methods: In this double-blind, placebo-controlled, crossover trial, 12 healthy volunteers were randomized to oral administration of whale meat extract (400 mg of imidazole dipeptides) or placebo for 29 days. The subjects took 12 capsules of whale meat extract or placebo twice a day for 29 days. As a fatigue-inducing physical load, the subjects performed workload trials on a cycle ergometer at fixed workloads for 4 hours and then rested for 4 hours. We evaluated subjective fatigue sensation using the visual analogue scale and autonomic nervous system by accelerated plethysmography. Moreover we evaluated fatigue induced by daily activities using the Chalder fatigue scale in the 4-week administration period. Results: The administration of oral whale meat extract administration attenuated fatigue sensation and modulated sympathetic dominance induced by physical load, and decreased the total score of Chalder fatigue scale in the 4th week. Conclusions: These results show that whale meat extract has an effect on attenuating fatigue induced by physical load and daily activities, so it is a promising candidate for anti-fatigue food.


Kuratsune H.,Kansai University of Welfare Sciences | Umigai N.,Chiyoda Corporation | Takeno R.,Soiken Inc. | Kajimoto Y.,Soiken Inc. | Nakano T.,Chiyoda Corporation
Phytomedicine | Year: 2010

Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo (p= 0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep. © 2010 Elsevier GmbH.


Ueno H.M.,Brand Science Institute | Yoshise R.E.,Brand Science Institute | Sugino T.,Soiken Inc | Kajimoto O.,Osaka City University | Kobayashi T.,Brand Science Institute
International Journal of Molecular Sciences | Year: 2016

Dysmenorrhea is a highly prevalent complaint and highly undiagnosed gynecologic condition. Dairy products have a potential in the management of menstrual distress, and bovine lactoferrin can help the subjective dysphoria associated with dysmenorrhea. In the present study, we aimed to investigate the effects of a lactoferrin formulation isolated from cow’s milk on menstrual symptoms in volunteers. A double-blind, randomized, placebo-controlled, crossover study of the iron-lactoferrin complex (FeLf) was performed in thirty-five healthy Japanese women. Participants received the 150 mg FeLf (per day) or placebo from day ten of the luteal phase to day four of the follicular phase. The Moos Menstrual Distress Questionnaire (MDQ) was measured for menstrual distress, and heart rate variability was measured as an index of autonomic nerve balance during menses. A visual analog scale for menstrual pain, and a verbal rating scale for quality of life during the first three days of menstruation were measured. The MDQ score for the automatic nervous system subscale was lower and the parasympathetic nervous system activity was greater in FeLf than in placebo for intention-to-treat or per-protocol populations. The other variables were not different between the groups. No treatment-related side effects were observed during the study. The results indicate that FeLf can provide a beneficial effect on the psychological symptoms in women affected by menstrual distress. © 2016 by the authors; licensee MDPI, Basel, Switzerland.


PubMed | Soiken Inc., Brand Science Institute and Osaka City University
Type: Journal Article | Journal: International journal of molecular sciences | Year: 2016

Dysmenorrhea is a highly prevalent complaint and highly undiagnosed gynecologic condition. Dairy products have a potential in the management of menstrual distress, and bovine lactoferrin can help the subjective dysphoria associated with dysmenorrhea. In the present study, we aimed to investigate the effects of a lactoferrin formulation isolated from cows milk on menstrual symptoms in volunteers. A double-blind, randomized, placebo-controlled, crossover study of the iron-lactoferrin complex (FeLf) was performed in thirty-five healthy Japanese women. Participants received the 150 mg FeLf (per day) or placebo from day ten of the luteal phase to day four of the follicular phase. The Moos Menstrual Distress Questionnaire (MDQ) was measured for menstrual distress, and heart rate variability was measured as an index of autonomic nerve balance during menses. A visual analog scale for menstrual pain, and a verbal rating scale for quality of life during the first three days of menstruation were measured. The MDQ score for the automatic nervous system subscale was lower and the parasympathetic nervous system activity was greater in FeLf than in placebo for intention-to-treat or per-protocol populations. The other variables were not different between the groups. No treatment-related side effects were observed during the study. The results indicate that FeLf can provide a beneficial effect on the psychological symptoms in women affected by menstrual distress.


Sugimoto K.,Nagaoka Perfumery Co. | Sugimoto K.,Osaka Prefecture University | Kawasaki T.,Teikyo University | Kawasaki T.,Kawakita General Hospital | And 6 more authors.
Food Science and Technology Research | Year: 2010

Excess intake of sucrose or fructose induces adiposity and insulin resistance syndrome, which subsequently lead to diabetes mellitus and hypertension. We evaluated the effects of Eucalyptus globulus leaf extract (ELE) on the postprandial changes in peripheral fructose concentrations during oral sucrose tolerance test in humans. When subjects (/i = 18) ingested 25 g of sucrose, both fructose and glucose concentrations in peripheral blood increased transiently and peaked at 30 min after ingestion. Administration of ELE (3 g) 5 min before sucrose ingestion resulted in a significant decrease in the rise in fructose concentration, although no significant effect on glucose concentration was observed. These results suggest that, in humans, ELE ingestion reduces acute hyperfructosemia after sucrose consumption by inhibiting intestinal fructose absorption (but not the sucrase reaction).


Matsumoto K.,Yakult Central Institute for Microbiological Research | Takada T.,Yakult Central Institute for Microbiological Research | Shimizu K.,Yakult Central Institute for Microbiological Research | Moriyama K.,Yakult Central Institute for Microbiological Research | And 5 more authors.
Journal of Bioscience and Bioengineering | Year: 2010

The effects of drinking a fermented milk beverage that contains Lactobacillus casei strain Shirota (LcS) at 40billion bacterial cells/bottle for 4weeks (probiotics, 1 bottle/day) on defecation frequency, intestinal microbiota and the intestinal environment of healthy individuals with soft stools were evaluated. Thirty-four healthy adults who had soft stools were randomised into 2 groups, and the effects of a regular 4-week intake of probiotics were evaluated by a placebo-controlled, double-blind, parallel-group comparative design. Defecation frequency significantly decreased after the 4-week intake period compared with before the probiotic treatment. The stool quality significantly improved (hardened) compared to the placebo. Also, the water content of the stools was lower in the probiotic group than in the placebo group. Live LcS was recovered at 6.9±1.3 and 7.2±0.8 log10 CFU per 1g of stool after 2 and 4weeks, respectively, of probiotic treatment. The number of bifidobacteria in the stools also increased significantly compared with the level before starting the probiotics. The organic acid levels (total, acetic acid, propionic acid, and butyric acid) significantly increased compared with the level before intake in both the probiotic and placebo groups, but they returned to the original levels after the end of the intake period. These results suggest that probiotic fermented milk beverage has an intestine-conditioning effect by improving the frequency of defecation and stool quality and increasing the intrinsic bifidobacteria in healthy individuals with soft stool. © 2010 The Society for Biotechnology, Japan.


Nakamura S.,DNA Chip Research Inc. | Kobayashi M.,DNA Chip Research Inc. | Sugino T.,Soiken Inc. | Kajimoto O.,Soiken Inc. | And 2 more authors.
Biochemical and Biophysical Research Communications | Year: 2010

A 4-h bout of exercise induces immunomodulatory effects. Peripheral blood was withdrawn before, and at 4, 8 and 24 h after the start of exercise. RNA from the unfractionated white blood cells was analyzed using Agilent human 44 K microarray. The expression profiles were sorted into seven clusters based on their unique time-dependent kinetics. In a separate experiment, cell-specific markers were collected and compared among the members in each cluster. Two clusters were assigned as representing neutrophils, one as NK cells, and another mostly as T cells. Three clusters seemed to be mixtures of several cell types. Extension of this approach to other systems is discussed. © 2009 Elsevier Inc. All rights reserved.

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