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Izumi, Japan

Iwamoto T.,Kinki University | Terada T.,Kinki University | Kogai Y.,SofSera Corporation | Okada M.,Osaka Dental University | And 2 more authors.
Functional Materials Letters

We prepared poly(L-lactide-co-glycolide) cell scaffolds coated with hydroxyapatite (HAp) nanocrystals with 50100 nm in diameter via the Pickering emulsion method. Our cell scaffolds were composed of biodegradable polymers and HAp nanocrystals as a core and shell, respectively. The scaffolds were spherical but displayed uneven shapes when altering a shear speed of homogenization during syntheses. The surface coverage of HAp nanocrystals was examined because the HAp-coating ratio for the scaffolds was an important factor as cell scaffolds in order to enhance cell adhesion. On the basis of scanning electron microscopy observations and thermogravimetric analyses, it was found that the cell scaffolds showed distorted morphologies, and the HAp-coating ratio decreased with increasing the shear speed in the synthesis because shear stress influenced shapes of the scaffolds. © 2012 World Scientific Publishing Company. Source

Furuzono T.,Kinki University | Furuzono T.,Osaka University | Azuma Y.,Kinki University | Niigawa Y.,Kinki University | And 2 more authors.
ASAIO Journal

To develop a nanoscaled coating material for medical devices possessing weak antibacterial activity, dispersible and crystalline fluorinated hydroxyapatite (F-HAp) nanoparticles were prepared using antisintering agent to avoid calcinationinduced sintering. The product was identical to fluorapatite, as determined by X-ray diffraction and Fourier transform infrared spectroscopy. The primary particles generally showed rodshaped morphology with a length of 367 ± 67 nm and a width of 223 ± 21 nm measured by scanning electron microscopy (SEM). The dispersed average particle size (313 ± 51 nm) in ethanol analyzed by dynamic light scattering was almost the same as that obtained from the SEM images. In the evaluation of solubility in acidic aqueous solution, F-HAp and original hydroxyapatite (HAp) nanoparticles started to dissolve at around pH 3.4 and 4.2, respectively. Thus, the stability of F-HAp in a living body increased compared with original HAp. The antibacterial activity of F-HAp nanoparticles was higher than that of fluoride in sodium fluoride alone or the original HAp nanoparticles. However, it was estimated that the effect of F-HAp was much lower compared with that of silver, one of the popular antibacterial materials. Thus, the dispersed F-HAp nanoparticles possessing weak antimicrobial activity can be useful without severe damage to the living tissue. © Copyright American Society of Artificial Internal Organs. Source

Silver particles are prepared by aggregating silver ions in accordance with a method including steps of (a), in preparing a mixed solution by adding a thiol compound to a solution containing silver ions, adjusting an amount of the thiol compound added to the solution and (b) adding a reducing agent to the mixed solution. This allows a particle size and antibacterial activity of the silver particles to be easily adjusted.

Sofsera Corporation | Date: 2011-12-01

A method for enlarging a breast includes the step of administering to a subject in need thereof a composition that includes a fine particle of calcium phosphate. The fine particle of calcium phosphate may be a fine particle of hydroxyapatite. An average particle size of the fine particle of calcium phosphate is 10 to 1,000 nm. The fine particle of calcium phosphate may be a sintered body. The sintered body may be manufactured by a method including: a mixing step in which a primary particle containing calcium phosphate is mixed with a fusion inhibitor, and a sintering step in which the mixed particle obtained by the mixing step defined above is exposed to a sintering temperature.

Japan Vilene Company and Sofsera Corporation | Date: 2013-12-06

Provided is a functional nonwoven fabric that has good feeling upon use, such as hand feeling (softness) or texture, and is capable of stably exhibiting the characteristics of hydroxyapatite (for example, microbe adsorption property). Disclosed is a functional nonwoven fabric in which sintered hydroxyapatite particles are fixed by thermal fusion bonding to a surface of a nonwoven fabric containing fibers, at least surfaces of the fibers being mainly composed of a thermoplastic resin, wherein a shearing rigidity of the functional nonwoven fabric is 8.5 gf/cm/degree or less.

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