Society for Womens Health Research

Washington, DC, United States

Society for Womens Health Research

Washington, DC, United States
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McLean M.H.,U.S. National Cancer Institute | Dieguez D.,Society for Womens Health Research | Miller L.M.,Society for Womens Health Research | Young H.A.,U.S. National Cancer Institute
Gut | Year: 2015

The microbiota of the human metaorganism is not a mere bystander. These microbes have coevolved with us and are pivotal to normal development and homoeostasis. Dysbiosis of the GI microbiota is associated with many disease susceptibilities, including obesity, malignancy, liver disease and GI pathology such as IBD. It is clear that there is direct and indirect crosstalk between this microbial community and host immune response. However, the precise mechanism of this microbial influence in disease pathogenesis remains elusive and is now a major research focus. There is emerging literature on the role of the microbiota in the pathogenesis of autoimmune disease, with clear and increasing evidence that changes in the microbiota are associated with some of these diseases. Examples include type 1 diabetes, coeliac disease and rheumatoid arthritis, and these contribute significantly to global morbidity and mortality. Understanding the role of the microbiota in autoimmune diseases may offer novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies. This review summarises the current status on the role of the microbiota in autoimmune diseases.


Nolan M.,Society for Womens Health Research
Journal of Population Therapeutics and Clinical Pharmacology | Year: 2013

The Society for Women's Health Research (SWHR) has been a driving force in the U.S. for ensuring that biomedical research is conducted on women and for raising awareness about the biological and physiological differences between men and women. SWHR is a Washington, DC-based patient/research advocacy organization that has successfully advocated for the inclusion of women in clinical trials for more than two decades. It has lobbied successfully for research into women's health and sex differences and continues to recommend a number of actions to government, lawmakers and organizations as part of a comprehensive effort to transform science and improve the quality of medical care. © 2013 Canadian Society of Pharmacology and Therapeutics. All rights reserved.


Mallampalli M.P.,Society for Womens Health Research | Davies E.,Society for Womens Health Research | Wood D.,Society for Womens Health Research | Robertson H.,George Washington University | And 2 more authors.
Journal of Women's Health | Year: 2013

Autoimmune diseases (ADs) impose substantial health and financial burdens in the United States and in many parts of the world. Women are disproportionately affected by many of these disorders, which often contribute to lifelong disabilities. While the number of patients with some ADs appears to be rising, the complexities of conducting epidemiological studies prevent a thorough understanding of the prevalence and incidence of these various conditions. Research on environmental influences of these illnesses is limited, although they are generally hypothesized to result from the interaction of environmental agents in genetically susceptible individuals. Further, there is little known regarding the role of sex and gender in the environmentally influenced mechanisms leading to the development of AD. To address these issues, particularly the roles of environment and sex and gender in ADs and the factors that contribute to the rise in ADs, the Society for Women's Health Research convened an interdisciplinary roundtable of experts from academia, medicine, and government agencies to share their expertise, address knowledge gaps in research, and propose future research recommendations. © Copyright 2013, Mary Ann Liebert, Inc. 2013.


Ritter L.,Society for Womens Health Research
Journal of Women's Health | Year: 2014

The Society for Women's Health Research has long advocated that research studies on diseases that impact men and women should consider sex as a fundamental variable. Thankfully, this attitude seems to be evolving. Recently, the National Institutes of Health (NIH) reported that it will issue new policies on the inclusion of female animals and cells in preclinical medical research. We look forward to working with the NIH and the Office of Research on Women's Health as they develop new policies that require grant applicants to report their plans for including a balance of male and female animals and cells in preclinical studies as appropriate. © Copyright 2014, Mary Ann Liebert, Inc. 2014.


Nolan M.R.,Society for Womens Health Research | Nguyen T.-L.,Society for Womens Health Research
Journal of Women's Health | Year: 2013

Over the past decade, the scientific community has begun to recognize the importance of biological sex differences in disease pathology, diagnosis, prevention, and treatment; however, the practice of sex-specific analysis and reporting is not integrated as standard practice by either our federal health agencies or by major medical journals. Despite the reforms of 20 years ago and the general inclusion of women in drug clinical trials, we have yet to see data routinely analyzed and reported by sex. Major journals are not requiring it, and large, publicly available datasets, such as ClinicalTrials.gov, are not systematically collecting and pointing to it. However, federal health databases and medical journals have the potential to impact progress in sex-specific analysis and reporting. We conducted a search on ClinicalTrials.gov for phase III device clinical trials and assessed their practice of sex differences evaluation. Reporting of clinical trial results by sex will maximize scientific value of research investments, significantly impact clinical decision-making, and transform medical care. © Mary Ann Liebert, Inc.


Carter C.L.,Society for Womens Health Research | Mallampalli M.,Society for Womens Health Research
Journal of Women's Health | Year: 2012

Alzheimer's disease (AD) disproportionately affects women in both prevalence and severity; however, the biologic mechanisms underlying these sex differences are not fully understood. Sex differences in the brain, such as in brain anatomy, age-related declines in brain volume, and brain glucose metabolism, have been documented and may be important in understanding AD etiology. The full impact of sex as a basic biologic variable on this neurodegenerative disease remains elusive. To address the evidence for sex differences in AD, the Society for Women's Health Research (SWHR) convened an interdisciplinary roundtable of experts from academia, clinical medicine, industry, and the government to discuss the state-of-the-science in sex and gender differences in AD. Roundtable participants were asked to address gaps in our knowledge and identify specific sex-based research questions for future areas of study. © 2012 Mary Ann Liebert, Inc.


Resnick E.M.,Society for Womens Health Research | Mallampalli M.,Society for Womens Health Research | Carter C.L.,Society for Womens Health Research
Journal of Women's Health | Year: 2012

Women in the U.S. military are technically barred from serving in combat specialties, positions, or units; however, since Operation Desert Storm, women have served in forward positions in greater numbers. This increased involvement in combat zones has resulted in exposures to trauma, injury, and a myriad of environmental hazards associated with modern war. Some of these hazards present new health risks specifically relevant to women who have been deployed to or recently returned from Iraq or Afghanistan or both. To address this evolving public health concern, the Society for Women's Health Research (SWHR) convened a 1-day interdisciplinary scientific conference, with speakers and attendees from civilian, military, and veteran settings. The purpose of the conference was to reveal the state-of-the-science on the health of the female veteran and to focus attention on recent advances in biomedical research related to female veterans' health. The following topics were discussed: mental health (posttraumatic stress disorder [PTSD] and depression), urogenital health, musculoskeletal health, and traumatic brain injury (TBI). © Copyright 2012, Mary Ann Liebert, Inc. 2012.


Trademark
Society For Womens Health Research | Date: 2013-06-05

Downloadable electronic newsletters in the field of womens health and sex differences; downloadable videos in the field of womens health and sex differences. Newsletters in the field of womens health and sex differences; brochures about womens health; printed reports in the field of womens health and sex differences. Association services, namely promoting the need for womens health research and sex differences. Education services, namely, providing conferences and seminars in the field of womens health and sex differences; book publishing. Providing scientific and research information in the field of womens health and sex differences; providing a Web site featuring information in the field of womens health and sex differences.


Trademark
Society For Womens Health Research | Date: 2013-10-18

Downloadable electronic newsletters in the field of womens health and sex differences; downloadable videos in the field of womens health and sex differences. Newsletters in the field of womens health and sex differences; brochures about womens health; printed reports in the field of womens health and sex differences. Association services, namely, promoting the need for womens health research and sex differences. Education services, namely, providing conferences and seminars in the field of womens health and sex differences; book publishing. Providing scientific and research information in the field of womens health and sex differences.


Manteuffel M.,Society for Womens Health Research | Williams S.,Express Scripts | Chen W.,Express Scripts | Verbrugge R.R.,Express Scripts | And 2 more authors.
Journal of Women's Health | Year: 2014

Background: This study evaluates the differences between women and men in medication use, medication adherence, and prescribing alignment with clinical guidelines. Methods: We conducted an analysis of pharmacy and medical claims for 29.5 million adults with prescription benefits administered by a pharmacy benefits manager in the United States, age 18 and older, between January 1, 2010, and December 31, 2010. Prevalence and intensity of medication use were evaluated by sex, age group, and medication type (acute vs. chronic). Medication adherence was measured by the percentage of patients with a medication possession ratio (MPR) ≥80%. The percentage of patients receiving guideline-based treatment was measured for diabetes and select cardiovascular conditions. Results: The study population comprised 16.0 million women and 13.5 million men with continuous pharmacy benefit eligibility. Women were significantly more likely than men to use one or more medications during the analysis period (68% vs. 59%, respectively, p<0.001), and women used more unique medications, on average, than men (5.0 vs. 3.7 medications per year, respectively, p<0.001). Differences in drug utilization were observed for all age groups and medication types. For all clinical metrics evaluated, women were less likely than men to be adherent in their use of chronic medications, and they were less likely to receive the medication treatment and monitoring recommended by clinical guidelines. Conclusions: There are significant disparities between women and men in their intensity of medication use, their adherence to medications, and their likelihood of receiving guideline-based drug therapy. These differences may indicate a need for more personalized drug selection and therapeutic management to improve clinical outcomes. © Mary Ann Liebert, Inc.

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