Blue Peter Research Center Society

Hyderabad andhra Pradesh, India

Blue Peter Research Center Society

Hyderabad andhra Pradesh, India
SEARCH FILTERS
Time filter
Source Type

Bhat K.H.,DNA Diagnostics Center | Das A.,DNA Diagnostics Center | Srikantam A.,Blue Peter Research Center Society | Mukhopadhyay S.,DNA Diagnostics Center
Annals of the New York Academy of Sciences | Year: 2013

Although the pathophysiological role of PE/PPE proteins of Mycobacterium tuberculosis is yet to be fully understood, recent evidence shows that these proteins play important roles in antigenic diversity, as well as in host-pathogen interactions and mycobacterial pathogenesis. Most of the PE/PPE proteins are highly expressed in pathogenic bacteria, pointing to their role in the pathogenesis of mycobacteria. Here, we provide an overview of our work in progress on a specific PPE protein, PPE2 (Rv0256c), which may inhibit nitric oxide (NO) production in activated macrophages. As NO and its by-products are considered to be toxic to bacilli, it is possible that the bacilli recruit Rv0256c in order to inhibit higher production of NO during infection. © 2013 New York Academy of Sciences.

Loading Blue Peter Research Center Society collaborators
Loading Blue Peter Research Center Society collaborators