Societe Hitex

Vannes, France

Societe Hitex

Vannes, France
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Grant
Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-IAPP-2008 | Award Amount: 1.06M | Year: 2009

OLITEC is a collaborative research project between academic community (Universities of Athens-Greece and Paris Descartes-France) and industry (Hitex-France, Lavipharm-Greece and Frutarom-Switzerland) focusing in the advance of new technologies and the development of new products from the olive tree with therapeutic or preventive potential (phytomedicines, food supplement). The main scientific and technological objectives of this project are: a) to develop extraction methods based on the combination of emerging new technologies (Supercritical Fluid Extraction, Adsorption Resin Technology, Accelerated Solvent Extraction and Microwave Associated Extraction) for the preparation of enriched extracts from olive tree leaves, b) to study the chemical composition of the extracts and their variation, depending on the extraction processes, the botanical origin c) to identify bioactive small molecules from the highly complex extract matrix with modern techniques , d) To investigate the preparation of oleocanthal (and analogues) using chemical and/or biotechnological transformations, e) to evaluate the biological activity of the pure isolated compounds and of the extracts, in terms of anti-inflammatory and cancer chemopreventive activity, by direct effect or through anti-angiogenic or neo-vascular disrupting processes, f) to study the transdermal formulation of the bioactive compounds and extracts and to scale up the best process for the preparation of transdermal products, and g) to study the feasibility of the development of a new commercial product and design the next steps of OLITEC results exploitation.. The final outcome of OLITEC project will be The optimized production in pilot scale of extracts enriched in oleuropein (>50%), the optimized production of oleocanthal (or its analogues) the development of new transdermal pharmaceutical forms based on the active compounds and Documentation on the anticancer and anti-inflammatory activity of the products


Becerra M.,Pharmacognosy | Boutefnouchet S.,University of Paris Descartes | Cordoba O.,Biological Chemistry II | Vitorino G.P.,Medicinal Chemistry II | And 9 more authors.
Phytochemistry Letters | Year: 2015

Fucosterol, a triterpene derivative encountered in several alga species, provides a wide range of biological activities, such as protection against metabolic syndrome, or against UV-induced skin damage. We describe here the comparison of extraction by supercritical fluid (SFE) and pressurized solvent (PSE) of the brown alga Lessonia vadosa mainly abundant in the coastal water of Patagonia, followed by the isolation of fucosterol, using centrifugal partition chromatography (CPC), in association with HPLC-UV quantification. After collection, the seaweed was dried, ground and extracted either by PSE or by SFE under various conditions. The yield and the content in fucosterol of each extract were determined by HPLC-UV. Optimization of a biphasic solvent system and KD calculation led to the isolation of pure fucosterol with high recovery rate. Extraction by SFE using CO2 at 180 bar and 50 C with 20 to 30 % of cellulose as modifier and CPC purification by cyclohexane/acetone/methanol/water 10/1/10/1 with lower layer as mobile phase led to the best results in terms of yield, purity, time and solvent consumption. Natural and semisynthetic steroid derivatives have been previously shown to be potential drug candidates against parasitic diseases including leishmaniasis. In this context fucosterol was evaluated and demonstrated noticeable antileishmanial activity (IC50 < 10 μM) against intracellular amastigotes with limited or no cytotoxicity in host cell macrophages. These results make this compound a valuable starting scaffold for pharmacomodulation. Adaptation of the procedure by slight modifications of the extraction and/or isolation conditions could permit the exploitation of other alga species as raw material. Since SFE and CPC are available for pilot and batch production, this work may serve as a model for further scale-up and industrial development. © 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.


News Article | December 7, 2016
Site: www.prlog.org

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