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Iwasaki M.,Research Center for Cancer Prevention and Screening | Franke A.A.,University of Hawaii at Manoa | Hamada G.S.,Nikkei Disease Prevention Center | Miyajima N.T.,Sociedade Beneficente de Cotia Hospital | And 7 more authors.
European Journal of Cancer Prevention | Year: 2015

Previous studies of Japanese migrants have suggested that the increase in colorectal cancer rates occurring after migration is slower among Japanese Brazilians than among Japanese Americans. We hypothesized that this difference may partly reflect differences in vegetable and fruit intake between the populations. Using data from validation studies of food frequency questionnaires being used in comparative case-control studies of colorectal adenoma in Tokyo, São Paulo, and Hawaii, plasma carotenoid, retinol, tocopherol, and coenzyme Q10 levels were measured by highperformance liquid chromatography, and 25-hydroxy vitamin D levels were estimated by enzyme-linked immunosorbent assay. Plasma levels were compared by analysis of covariance between 142 Japanese in Tokyo, 79 Japanese Brazilians in São Paulo, and 78 Japanese Americans in Hawaii. Overall, we found significantly lower plasma carotenoid levels, except for lycopene levels, and retinol levels in Japanese Americans compared with Japanese in Tokyo and Japanese Brazilians. The plasma total carotenoid level was highest in Japanese Brazilians. Compared with the mean level among Japanese Brazilians (1741.2 ng/ml), P for difference was 0.03 among Japanese in Tokyo (1514.4 ng/ml) and less than 0.01 for Japanese Americans (1257.7 ng/ml). Plasma lycopene and tocopherol levels did not substantially differ between the three populations. We also found significantly lower plasma levels of 25-hydroxy vitamin D and total coenzyme Q10 in Japanese in Tokyo than in Japanese Americans and Japanese Brazilians. Higher levels of plasma carotenoids among Japanese Brazilians than among Japanese in Tokyo and Hawaii may have contributed to the slower pace of the increase in colorectal cancer rates observed in that population after migration. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.


Marchandc L.L.,University of Hawaii at Manoa | Frankec A.A.,Research Center for Cancer Prevention and Screening | Hamadad G.S.,Nikkei Disease Prevention Center | Miyajimae N.T.,Sociedade Beneficente de Cotia Hospital | And 2 more authors.
European Journal of Cancer Prevention | Year: 2016

Although Japanese in Japan and the USA are high-risk populations for colorectal cancer, the prevalence of obesity, one of the established risk factors for this disease, is low in these populations compared with other high-risk populations. To understand this inconsistency, we compared plasma obesity-related biomarkers in crosssectional studies carried out in Tokyo, São Paulo, and Hawaii. We measured plasma levels of insulin-like growth factor-I (IGF-I), insulin-like growth factor-binding protein (IGFBP)-1, IGFBP-3, C-peptide, adiponectin, leptin, tumor necrosis factor-?, and interleukin-6 by immunoassay and total C-reactive protein, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides using a clinical chemistry autoanalyzer. A total of 299 participants were included in the present analysis, comprising 142 Japanese in Tokyo, 79 Japanese Brazilians in Sao Paulo, and 78 Japanese Americans in Hawaii. We found significantly lower plasma levels of C-peptide and IGF-I in Japanese in Tokyo than in Japanese Americans, and lower levels of leptin and triglycerides and higher levels of adiponectin, IGFBP-3, and high-density lipoprotein cholesterol in Japanese in Tokyo than in the other two populations. We also observed a significantly higher plasma IGFBP-1 level in Japanese Brazilians, and lower plasma levels of total cholesterol and low-density lipoprotein in Japanese Americans than in the other two populations. We observed significant differences in obesity-related biomarkers between the three Japanese populations. If our results are confirmed, the risk of colorectal cancer predicted on the basis of these biomarkers would be lowest for Japanese in Tokyo, followed by Japanese Brazilians and Japanese Americans. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Pakseresht M.,University of Alberta | Miyajima N.T.,Sociedade Beneficente de Cotia Hospital | Shelton A.,University of North Carolina at Chapel Hill | Iwasaki M.,Research Center for Cancer Prevention and Screening | And 3 more authors.
Public Health Nutrition | Year: 2013

Objective To assess the validity of a 161-item quantitative FFQ (QFFQ) that was developed to evaluate dietary risk factors for a colorectal adenoma case-control study. Design A cross-sectional validation study of the QFFQ against 4 d food diary using Pearson correlation coefficients, cross-classification, weighted κ statistics and Bland-Altman plotting. Setting Two hospitals in São Paulo, Brazil. Subjects Ninety-seven healthy Japanese-Brazilian adults (40-75 years) were recruited. One participant was excluded from the analysis due to unusual energy intake report. Results Mean daily nutrient intakes from the QFFQ were higher than from the food diary. The mean Pearson correlation coefficient for nutrient intakes between the QFFQ and the average of the 4 d food diary was 0·43, and increased to 0·45 after correcting correlations for attenuation due to residual day-to-day variation in the food diary measurements. Adjustment for total energy and further adjustment for age and gender decreased the correlation; however, 77 % of observations remained in the same or adjacent quartiles with a mean weighted κ of 0·22. Bland-Altman plots on loge-transformed data showed no linear trend between the differences and means for energy, fat, protein, total folate and vitamin C. Compared with the food diary, the QFFQ showed consistently reasonable performance for dietary fibre, total folate, retinol, riboflavin and vitamin C. Conclusions This investigation supports the relative validity of the QFFQ as a method for assessing long-term dietary intake. The instrument will be a useful tool in the analysis of diet-adenoma associations in the case-control study. Copyright © 2012 The Authors.


Sharma S.,University of North Carolina at Chapel Hill | Brambilla A.,University of Hawaii at Manoa | Cao X.,University of North Carolina at Chapel Hill | Iwasaki M.,Research Center for Cancer Prevention and Screening | And 4 more authors.
International Journal of Food Sciences and Nutrition | Year: 2010

Primary objective: To calculate the nutritional composition of commonly consumed Brazilian foods and beverages to analyze dietary intake data obtained with a quantitative food frequency questionnaire in a colorectal adenoma casecontrol study in Japanese Brazilians. Methods and procedures: Weighed recipes were collected in São Paulo, Brazil and analyzed using NutriBase Clinical Nutrition Manager. Main outcomes and results: A total of 387 recipes for 76 dishes commonly consumed by Japanese Brazilians were collected: 30 composite main course dishes, 26 composite vegetable dishes, 19 snack foods and desserts, and one beverage. The nutritional composition (energy and 32 macronutrients and micronutrients) was calculated per 100 g for each dish. Conclusions: We provided, for the first time, complete and up-to-date calculated nutritional composition data for commonly consumed Brazilian food items, which are essential to assess the current dietary intake among Japanese Brazilians. © 2010 Informa UK, Ltd.

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