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Teramura M.,Tokyo Womens Medical University | Arai M.,Social Insurance General Omiya Hospital | Masuda A.,Tokyo Womens Medical University | Mizoguchi H.,Tokyo Womens Medical University | Motoji T.,Tokyo Womens Medical University
International Journal of Hematology

A 69-year-old man with blastic natural killer cell lymphoma (BNKL) was treated mainly with methotrexate (MTX). He presented with skin and bone marrow involvement at onset. Neoplastic cells were blastic in appearance with CD3-, CD4-, CD8-, CD7-, CD16-, CD56+ and HLA-DR+ phenotype. Molecular studies showed germline configuration of both immunoglobulin H and T cell receptor genes, and negative results for Epstein-Barr virus-encoded small RNA (EBER). He was treated with standard acute lymphoblastic leukemia (ALL) induction therapy, followed by 1 cycle of high-dose MTX (HD-MTX) as consolidation therapy. However, BNKL relapsed during standard ALL maintenance therapy. Three cycles of HD-MTX were effective in achieving a second complete remission and then he received low dose MTX as maintenance therapy. BNKL remained well controlled for 4 years. Chemotherapeutic toxicity was mild and manageable. Since BNKL reportedly has a poor prognosis, this encouraging result warrants further investigation of MTX as either a single agent or in a combination regimen as a first-line treatment for patients with BNKL. © 2010 The Japanese Society of Hematology. Source

Murakami M.,Machida Municipal Hospital | Sugaya S.,Machida Municipal Hospital | Kimura T.,Jikei University School of Medicine | Kato N.,Kanagawa Prefectural Shiomidai Hospital | And 11 more authors.
Tokyo Jikeikai Medical Journal

OBJECTIVE: To clarify the differences in clinical features and treatments of prostate cancer among 12 institutions, including The Jikei University Hospital and its affiliated hospitals, we examined the results of prostate needle biopsy and the therapeutic strategy for newly diagnosed cases of prostate cancer to standardize the method of diagnosis and treatment. METHODS: The results of prostate needle biopsy and the therapeutic strategy for newly diagnosed prostate cancer in 2007 were compared among the institutions. RESULTS: A total of 1590 transrectal prostate needle biopsies were performed and 682 cases (42.9%) of prostate cancer were diagnosed. A total of 819 patients with newly diagnosed prostate cancer were treated. Of these patients, 275 (33.6%) were treated with hormonal therapy, 243 (29.7%) were treated with radical prostatectomy;RP and 218 (26.6%) were treated with radiotherapy. CONCLUSION: The survey suggests that the patient characteristics and therapeutic strategies differ somewhat among 12 institutions. Further investigation is required regarding whether the difference in therapeutic strategy affects outcomes. Source

Shioya T.,Saitama Citizen Medical Center | Nomura S.,Saitama Citizen Medical Center | Watanabe Y.,Saitama Citizen Medical Center | Nanbu K.,Saitama Citizen Medical Center | And 6 more authors.
Japanese Journal of Gastroenterological Surgery

A 69-year-old man was seen for a lower right abdominal tumor 2 years after right inguinal hernia repair with a Kugel patch. He was operated right inguinal hernia and appendectomy in childhood. Computed tomography (CT) and barium enema examination found to have an abscess formation due to right side colonic diverticulitis. Operative findings showed the cecum strongly adhering to the abdominal wall, with the patch adhering to and penetrating the cecum and forming part of the tumor. The patch was removed and the ileocecum resected. Actinomyces infection was recognized pathologically in the abscess. Despite paralytic ileus and postoperative surgical site infection, the man recovered with conservative treatment. This is, to our knowledge, the first report to demonstrate that colonic penetration after Kugel patch inguinal hernia repair. © 2010 The Japanese Society of Gastroenterological Surgery. Source

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