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Jivani R.R.,Smt Rbpatel Mahila Pharmacy College | Patel C.N.,Shari Sarvajanik Pharmacy College | Patel D.M.,Shari Sarvajanik Pharmacy College | Jivani N.P.,Smt Rbpatel Mahila Pharmacy College
Iranian Journal of Pharmaceutical Research

The present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) were used to check the presence of any interaction between the drug and the excipients. A 3 2 full factorial design was used for optimization. The concentrations of sodium alginate (X 1) and calcium bicarbonate (X 2) were selected as the independent variables. The amount of the drug released after 1 h (Q 1) and 10 h (Q 10) and the viscosity of the solution were selected as the dependent variables. The gels were studied for their viscosity, in-vitro buoyancy and drug release. Contour plots were drawn for each dependent variable and check-point batches were prepared in order to get desirable release profiles. The drug release profiles were fitted into different kinetic models. The floating lag time and floating time found to be 2 min and 12 h respectively. A decreasing trend in drug release was observed with increasing concentrations of CaCO 3. The computed values of Q 1 and Q 10 for the check-point batch were 25% and 86% respectively, compared to the experimental values of 27.1% and 88.34%. The similarity factor (f 2) for the check-point batch being 80.25 showed that the two dissolution profiles were similar. The drug release from the in-situ gel follows the Higuchi model, which indicates a diffusion-controlled release. A stomach specific in-situ gel of baclofen could be prepared using floating mechanism to increase the residence time of the drug in stomach and thereby increase the absorption. © 2010 by School of Pharmacy. Source

Devmurari V.P.,Smt Rbpatel Mahila Pharmacy College | Shivanand P.,Smt Rbpatel Mahila Pharmacy College | Goyani M.B.,Smt Rbpatel Mahila Pharmacy College | Nandanwar R.R.,JKK Nataraja Dental College and Hospital | And 2 more authors.
International Journal of ChemTech Research

The series of seven substituted 2-phenyl-benzothiazole and substituted 1, 3-benzothiazole-2-yl-4-carbothiaote derivatives were synthesized. Substituted 2-phenyl-benzothiazole were synthesised by condensing substituted benzoic acid with 2-amino thiophenol in the presence of phosphoric acid and 3-benzothiazole-2-yl-4-substituted carbothiaote derivatives were prepared by condensing 2-mercaptobenzothiazole with substituted acid chloride. Structures of all the compounds were characterized by spectral and elemental analysis. All the synthesised novel compounds were screened for anticancer activity. It was also found that compounds 1 ,2 ,6 and 7 showed very good anticancer activity whereas all the other comp have showed mild to moderate anticancer activity as compared to standard drug. Source

Devmurari V.P.,Smt Rbpatel Mahila Pharmacy College | Shivanand P.,Smt Rbpatel Mahila Pharmacy College | Goyani M.B.,Smt Rbpatel Mahila Pharmacy College | Jivani N.P.,Smt Rbpatel Mahila Pharmacy College
International Journal of ChemTech Research

A series of methyl 2-substituted benzimidazole-1-carbodithioates were successfully synthesized. Benzimidazoles were prepared by condensation of o-phenylenediamine with substituted Carboxylic acid and by condensation of substituted benzaldehyde, Sodium metabisulphate and o-phenylenediamine. Methyl Carbodithioate derivative of the benzimidazole were prepared by reaction with carbon disulfide. In vitro antibacterial activity of the synthesized compounds was analyzed against three gram-positive bacterial species and gram negative microorganism by agar well-diffusion method (Cup plate method). Source

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