Ulhasnagar, India
Ulhasnagar, India

Time filter

Source Type

Waghela B.N.,Indian Institute of Advanced Research | Sharma A.,Indian Institute of Advanced Research | Dhumale S.,Indian Institute of Advanced Research | Pandey S.M.,Smt Chm College | Pathak C.,Indian Institute of Advanced Research
PLoS ONE | Year: 2015

Curcumin, an ingredient of turmeric, exhibits a variety of biological activities such as anti-inflammatory, anti-atherosclerotic, anti-proliferative, anti-oxidant, anti-cancer and anti-metastatic. It is a highly pleiotropic molecule that inhibits cell proliferation and induces apoptosis in cancer cells. Despite its imperative biological activities, chemical instability, photo-instability and poor bioavailability limits its utilization as an effective therapeutic agent. Therefore, enhancing the bioavailability of curcumin may improve its therapeutic index for clinical setting. In the present study, we have conjugated curcumin with a biodegradable polymer Poly (D, L-lactic-co-glycolic acid) and evaluated its apoptotic potential in human colon carcinoma cells (HCT 116). The results show that curcumin-PLGA conjugate efficiently inhibits cell proliferation and cell survival in human colon carcinoma cells as compared to native curcumin. Additionally, curcumin conjugated with PLGA shows improved cellular uptake and exhibits controlled release at physiological pH as compared to native curcumin. The curcumin-PLGA conjugate efficiently activates the cascade of caspases and promotes intrinsic apoptotic signaling. Thus, the results suggest that conjugation potentiates the sustainability, anti-proliferative and apoptotic activity of curcumin. This approach could be a promising strategy to improve the therapeutic index of cancer therapy. © 2015 Waghela et al.


Verandani S.,Smt Chm College | Vardhan D.,Ramnarain Ruia College
Research Journal of Chemistry and Environment | Year: 2012

Water samples were collected from 25 sampling sites during the pre-monsoon season in Ulhasnagar city, Thane district in Mumbai. Different physicochemical parameters were measured and the samples were also analyzed for dissolved metal concentrations. The surface water physicochemical parameters included pH, temperature, turbidity, hardness, total alkalinity, dissolved oxygen (DO), total dissolved solids (TDS), electrical conductance (EC) and turbidity while the dissolved metals were Cd, Cu, Pb and Cr. The ranges for the physicochemical parameters were 28-32 degrees C for temperature, 6.8-8.5 for pH, 0.4-12.8 mg/l for DO, 0-100 NTU for turbidity, 22-580 ppm (as CaCO3) for hardness, 44-61 ppm. for total alkalinity, 250-520 mg/l for TDS and 554-1040 mhos/cm while the dissolved metals (mg/l) were 0.001-0.008 for Cd, 0.002-0.012 for Cu, 0.04-1.30 for Pb and 0.000-0.15 for Cr. Based on multivariate analysis and correlation studies, lead was identified as major dissolved metal contaminant in most of the analyzed samples. Microbial analysis was also carried out by testing the samples for E. coli and thermo tolerant bacteria and ranges for these were from 2-18 ppm for E. Coli and 2-19 ppm for the thermo tolerant bacteria.


Bajpai S.K.,P.A. College | Das P.,Smt Chm College | Sharma L.,P.A. College
Journal of Macromolecular Science, Part A: Pure and Applied Chemistry | Year: 2013

In this work, cotton cellulose/polyacrylic (CC/PAAc) composite fibers are produced by soaking plain cotton cellulose (CC) fibers in a reaction mixture containing monomer acrylic acid, crosslinker N,N-methylene-bis acrylamide (MB) and initiator potassium persulphate (KPS), followed by microwave induced in-situ formation of polyacrylic acid within cotton fibers. The fibers are characterized by TGA, FTIR and SEM analysis. The mechanical strength of CC/PAAc fibers was comparable to that of CC fibers, indicating marginal loss in mechanical strength. The antibacterial drug Gentamicin Sulphate (GS) was added to the reaction mixture before soaking the CC fibers in the reaction solution. This yielded GS loaded CC/PAAc fibers. The release of drug GS was investigated as a function of the amount of crosslinker in the soaking solution. It was found that the quantity of crosslinker MB in the soaking solution influenced the release mechanism. Fiber samples with relatively lower and higher amount of crosslinker followed Second order model and the Higuchi diffusion model, respectively. The CC fibers showed lower release as compared to the CC/PAAc fibers. Finally, the biocidal action of fibers was tested using a zone of inhibition method using E. Coli as model bacteria. The fibers demonstrated biocidal action by exhibiting zones of inhibition of diameter 1.3 and 2.2cm, respectively for fibers prepared by soaking in the reaction solutions containing 0.2 and 0.4 percent (w/v) drug. Finally, the killing kinetics was investigated to show time dependent bacterial killings for the fiber samples GSLCC/PAAc (0.2) and GSLCC/PAAc (1.2). © 2013 Copyright Taylor and Francis Group, LLC.


Patil A.G.,Smt Chm College | Patil A.G.,Birla College | Koli S.P.,Birla College | Patil D.A.,Smt Chm College | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2012

Curculigo orchioides Gaertn. (Family: Hypoxidaceae) commonly known as Kali musli, the rhizomes of which are extensively utilized as nutritive tonic for strength and for treatment of asthma, skin diseases, bronchitis, diarrhoea, dyspepsia, etc. It also possesses anticancer and antipyretic activity. It is one of the important Rasayana drugs of Ayurvedic Materia Medica for vigor and vitality. It is also used in many Ayurvedic and Unani compound formulations as an important ingredient. Hence, the present work has been undertaken to establish the requisite pharmacognostic standards for evaluating the Curculigo orchioides Gaertn rhizome. In addition, HPTLC is also performed to detect the presence of β- sitosterol as the marker compound. The anatomical markers observed were bundles of acicular calcium oxalate crystals, lysigenous cavities, starch grains and vessel with spiral thickening. Preliminary phytochemical analysis showed presence of glycosides, mucilage, tannins, steroids, flavonoids, saponins and essential oils. Phytochemical analysis using HPTLC showed presence of arbutin, bitter principles, cardiac glycosides, coumarins, essential oils, lignans, pungent - tasting principles, saponins, triterpenes and valepotraites.


Bajpai S.K.,P.A. College | Das P.,Smt Chm College | Soni B.,Polymer Research Laboratory
Journal of Industrial Textiles | Year: 2016

In this work, poly(acrylic acid) has been grafted onto cotton fibers through the free radical initiated polymerization and the resulting fibers have been characterized by Fourier transform infrared, thermogravimetric analysis, and scanning electron microscopy analysis. The grafted fibers have been loaded with copper nanoparticles using in situ approach. The Transmission Electron Microscopy (TEM) analysis of Cu nanoparticles revealed that almost 45% of the particles had a diameter range of 60–80 nm. The copper nanoparticles loaded fibers show slow release of Cu(II) ions, extended over a period of around 50 h. The release of Cu(II) ions followed a second-order kinetic model successfully. The fibers also exhibited an excellent antibacterial action against model bacteria Escherichia coli as tested by zone of inhibition method. © 2014, The Author(s) 2014.


Bajpai S.K.,Robertson College, Jabalpur | Das P.,Smt Chm College
Journal of Applied Polymer Science | Year: 2011

This study describes preparation of poly (acrylic acid)-grafted cotton fibers and release of antibiotic drug gentamicin sulfate from them under physiological conditions. Poly(acrylic acid) has been grafted onto cellulose backbone of cotton fibers via Ce(IV)-initiated polymerization in aqueous medium. The conditions obtained for optimum grafting were as follows: initiation time 30 min; initiation temperature 37°C; monomer concentration 27.8 mM; grafting temperature 30°C; nitric acid (catalyst) concentration 0.1M. The grafted fibers were characterized by FTIR, TGA, and SEM analysis. The antibiotic drug gentamicin sulfate (GS) was loaded into the grafted fibers by equilibration method and release was studied under physiological conditions. The kinetic release data was interpreted by first-order kinetic model. Finally, drug-loaded fibers showed fair antibacterial action against Escherichia coli. © 2011 Wiley Periodicals, Inc.


Patil A.,Birla College | Patil D.,Smt CHM College | Ansari A.,Birla College | Koli S.,Birla College
Indian Journal of Traditional Knowledge | Year: 2013

To obtain effective drug with proven efficacy, it is necessary to establish standards through modern scientific and technical procedures which would certainly enhance the reputation and acceptance of traditional medicines. Sufoof-e-mohazzil, a unani polyherbal formulation is used by Unani physicians for treatment of obesity. The present work involves standardization of Sufoof-e-mohazzil in order to assess the quality of In-house and marketed formulations. In-house and marketed formulations were subjected to pharmacognostic studies, physico-chemical properties, phytochemical analysis and HPTLC fingerprint profile to set the standards, which can be used as reference standard to evaluate the quality control in herbal industries and to overcome batch to batch variations in traditional preparation. In the present study, the anatomical markers fibro vascular tissue, endospermic cells, vittae, pitted vessels and group of sclereids from the mesocarp were observed. The extractive values were found to be more for alcohol than water. The preliminary phytochemical analysis indicated presence of alkaloids, fats and fixed oils, essential oils, glycosides, resins and saponins. HPTLC fingerprint profile of formulations showed a characteristic pinkish red band of Thymol at Rf of 0.43.


Kemkar S.D.,Government of India | Kemkar S.D.,Smt Chm College | Mahajan H.S.,Smt Chm College | Vaidya M.,Smt Chm College | Vaidya M.,Sices College
AIP Conference Proceedings | Year: 2012

The disordered structural pattern in ferrofluid occurs under external magnetic filed gives rise to significant optical properties such as birefringence, magnetochromatics and transmission. In this work transmission property has been utilized for making optical switch which can be electronically controlled with external TTL logic signal. © 2012 American Institute of Physics.


PubMed | Smt Chm College and Indian Institute of Advanced Research
Type: Journal Article | Journal: PloS one | Year: 2015

Curcumin, an ingredient of turmeric, exhibits a variety of biological activities such as anti-inflammatory, anti-atherosclerotic, anti-proliferative, anti-oxidant, anti-cancer and anti-metastatic. It is a highly pleiotropic molecule that inhibits cell proliferation and induces apoptosis in cancer cells. Despite its imperative biological activities, chemical instability, photo-instability and poor bioavailability limits its utilization as an effective therapeutic agent. Therefore, enhancing the bioavailability of curcumin may improve its therapeutic index for clinical setting. In the present study, we have conjugated curcumin with a biodegradable polymer Poly (D, L-lactic-co-glycolic acid) and evaluated its apoptotic potential in human colon carcinoma cells (HCT 116). The results show that curcumin-PLGA conjugate efficiently inhibits cell proliferation and cell survival in human colon carcinoma cells as compared to native curcumin. Additionally, curcumin conjugated with PLGA shows improved cellular uptake and exhibits controlled release at physiological pH as compared to native curcumin. The curcumin-PLGA conjugate efficiently activates the cascade of caspases and promotes intrinsic apoptotic signaling. Thus, the results suggest that conjugation potentiates the sustainability, anti-proliferative and apoptotic activity of curcumin. This approach could be a promising strategy to improve the therapeutic index of cancer therapy.

Loading Smt Chm College collaborators
Loading Smt Chm College collaborators