Boise, ID, United States
Boise, ID, United States
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Grueneberger J.M.,Smart Surgical | Fritz T.,Smart Surgical | Zhou C.,Smart Surgical | Zhou C.,Wuhan No 1 Hospital | And 7 more authors.
Wideochirurgia I Inne Techniki Maloinwazyjne | Year: 2013

Introduction: Fast delivery of food to the terminal ileum is thought to be pathophysiologically responsible for type 2 diabetes remission after obesity surgery. Imitating this effect, ileal transposition (IT) is designed as initiating diabetes remission for non-obese patients. Aim: To date, it is not clear which length of the transposed segment achieves the best glucose lowering results. As previous rodent data mostly rely on a 10 cm IT, the current study evaluated a long segment IT (20 cm) in the diabetic obese Zucker rat. Material and methods: Twenty male diabetic obese Zucker rats (Crl:ZUC-Leprfa) were randomly assigned to undergo either a long segment (20 cm; ~ 50% of ileum) IT or sham surgery. Glucose control was determined by an oral glucose tolerance test (OGTT) on day -7, 0, 14 and 20. Analysis of the incretin hormones glucagon-like peptide 1 (GLP-1), peptide YY (PYY) and insulin was included in the first and third OGTT. Results: Ileal transposition animals showed an early improvement of glucose control after 14 days (area under the curve: IT vs. baseline 314.7 ±229.0 mmol/l × min vs. 564.6 ±268.5 mmol/l × min; p < 0.05). Compared to sham animals, glucose-stimulated GLP-1 and PYY levels were raised (5.75 ±3.73 pmol/l vs. 18.52 ±14.22 pmol/l, p < 0.05; 129.7 ±64.62 pmol/l vs. 164.0 ±62.26 pmol/l, p < 0.05). Body weight gain from postoperative day 5 was greater for sham animals (50.22 ±20.93 g vs. 16.4 ±25.93 g; p < 0.01). Conclusions: Long segment IT shows a rapid rise in GLP-1 and PYY levels, thus leading to early amelioration of glucose control. © 2013 Termedia Sp. z o.o.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Smart - Proof of Concept | Award Amount: 99.99K | Year: 2012

Minimally invasive surgery (MIS) or ‘keyhole surgery’ is one of the most significant developments in the field of medicine in recent history, gaining widespread acceptance across many surgical disciplines. However, surgeons learning and performing MIS procedures are faced with a unique set of challenges. The main challenge in MIS is the use of a video image to view the patients internal anatomy or operative field. Drawbacks associated with the use of video imaging include loss of depth vision due to the image being 2-D. The loss of depth vision has been shown to lead to impaired performance in surgical tasks. Generally, there is always a demand for surgery to become safer and reducing these vision constraints would help significantly. Improving depth perception, facilitating instrument navigation, and manoeuvring in MIS should be a priority. Although advances in camera technology aim to improve depth perception, such systems have limitations with respect to their use, as they tend to be expensive and not widely available. For these reasons, it is useful to investigate other alternatives for conveying depth information in MIS. It is well known that monocular cues i.e. perspective, relative size, can provide adequate depth information for the performance of most MIS tasks. One of the primary monocular cues is shadow but due to the arrangement of the camera (endoscope) and light source used, shadow is missing in MIS rendering the operative scene shadowless. We are proposing to further the development of our ‘SmartShadow’ system that introduces a faint secondary light source into the operative field that casts a weak shadow of the surgical instruments that is invisible to the human eye but detectable by a computer. The computer detects the faint shadow then enhances it to create a digital shadow, which it then introduces into the video image to be viewed by the surgeon to aid depth perception to facilitate and enhance performance of surgical tasks.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Smart - Development of Prototype | Award Amount: 207.13K | Year: 2015

We are proposing to advance the development of our key-hole medical device, the SmartShadow, by building upon the successful completion of our Innovate UK proof-ofmarket and proof-of-concept projects to date (http://www.mynewsdesk.com/uk/innovateuk/ news/smart-shadow-making-keyhole-surgery-safer-101184). The goal over the next 18 months is focused on the development of an engineering prototype, which is the vital next stage for Smart Surgical to expand its development programme with UK surgeons and to advance into in-man clinical investigations in 3 UK hospitals. This in turn will build the business case to progress the device into main stream surgical practice in 2017. Currently, surgeons learning and performing minimally invasive surgery (MIS) or keyhole surgery are faced with a unique set of challenges. The main challenge is the use of a video image to view the patients’ internal anatomy or operative field. The major drawback with the use of video imaging includes loss of depth vision due to the image being 2-D. It is well understood in MIS that loss of depth vision leads to impaired surgical performance. Generally, there is demand for MIS to become safer and reducing vision constraints is essential. Improving depth vision, facilitating instrument navigation, and manoeuvring should be a priority. Although advances in camera technology aims to improve matters, such systems have a range of practical limitations with respect to their widespread adoption and are expensive. The SmartShadow is a truly unique, cost effective device that comprises a disposable secondary light source that is inserted like a needle through a patient’s abdominal wall. The light casts a shadow of the surgical instruments in the cavity but is invisible to the human eye but detectable by a computer. The computer detects the shadow then enhances it to create a digital shadow, which is introduced into the video image viewed by the surgeon as a depth aid to facilitate instrument navigation.


Smart Surgical | Entity website

SMART MARKETING is a marketing company that optimizes various avenues of medical marketing such as website, social media, print materials, and internet strategy


Smart Surgical | Entity website


Smart Surgical | Entity website

Business Relations SMART SURGICAL's business development team designs anddevelops strategies for companies to achieve market share in the medical device and biotech space. Our team of experienced executives and business professionals have extensive experience in the finance, marketing, operational management and finally the development and implementation of sales objectives ...


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