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Anantapur, India

Naveen Kumar H.M.P.,k-Technology | Prabhakar M.N.,k-Technology | Venkata Prasad C.,k-Technology | Madhusudhan Rao K.,k-Technology | And 3 more authors.
Carbohydrate Polymers | Year: 2010

The miscibility of chitosan (CS) and poly(vinyl alcohol) (PVA) blends in aqueous acetic acid solution was studied using viscosity, ultrasonic velocity and refractive index techniques at 30 °C. From the viscosity data by using Sun and Chee et al., approaches, the interaction parameters ΔB, μ and α are also calculated to predict the blend compatibility of the blend solutions. The results of these blends data suggest that CS/PVA blends were completely miscible in all proportions. The results pertaining to variation of ultrasonic velocity (v) and their derived parameters such as adiabatic compressibility, acoustic impedance, relaxation strength and Rao number also supports the miscibility nature of these blends. This is further confirmed by refractive index results also. Differential scanning calorimetry (DSC), XRD and FT-IR were also used to confirm the compatibility of the CS/PVA blends in the solid state (thin films). Experimental results showed that the blends of CS and PVA are miscible at all the compositions due to the strong intermolecular hydrogen bonding interactions between CS and PVA. © 2010 Elsevier Ltd. All rights reserved. Source

Rajesh Kumar B.,Sri Venkateswara University | Rajesh Kumar B.,Skuniversity | Subba Rao T.,Sri Venkateswara University
Digest Journal of Nanomaterials and Biostructures | Year: 2012

In the present work Zinc Aluminum Oxide (ZAO) thin films have been deposited on glass substrates by DC reactive magnetron sputtering technique at different sputtering powers of Zn varied from 85 W - 125 W. XRD patterns exhibits ZAO thin films had a diffraction peak corresponding to (0 0 2) preferred orientation with c-axis perpendicular to the substrate surface. The preferred orientation is due to the lowest surface free energy for (0 0 2) plane. The minimum resistivity of 1.67 X 10 -4 Ω.cm is found for the thin film deposited at sputtering power of 115 W. Optical absorption edge of nanostructured ZAO thin films has a significant blue shift to the region of higher photon energy. Such a shift is attributed to the Burstein-Moss effect. The optical band gap of nanostructured ZAO thin films is found to be in the range of 3.43 - 3.60 eV. The carrier concentration of ZAO thin films is found to be in the range of 3.95 X 10 20 cm -3 - 1.38 X 10 21 cm -3. Source

Prasad C.V.,k-Technology | Prasad C.V.,Changwon National University | Swamy B.Y.,Skuniversity | Swamy B.Y.,Pusan National University | And 6 more authors.
Journal of Polymers and the Environment | Year: 2012

Novel type of highly swollen beads were prepared by grafting 2-hydroxyethylacrylate onto biodegradable Sodium alginate (SA) via free-radical polymerization using potassium persulphate as an initiator and Triprolidine hydrochloride as a model drug. Evidence of grafting was obtained by fourier transform infrared spectroscopic technique. Morphological properties of the beads were studied by SEM analysis. Thermal properties and crystallinity of the beads were characterized using differential scanning calorimetry and thermogravimetric analysis and X-ray diffraction techniques, respectively. Dissolution experiments were performed to study the release profiles at 37 °C in phosphate buffer solution (pH-7. 4). Effect of monomer content, crosslinking agent and drug/polymer ratio on swelling properties and release profiles were also comparatively studied. A dissolution result concludes that drug release decreases with increasing crosslinker content. The highest release (96%) was obtained for the beads prepared with 0. 5 mL crosslinking agent. Equilibrium swelling degree also supports the drug release profiles confirming SA-g-HEA beads showed better release profiles compare to plain SA beads. © 2012 Springer Science+Business Media, LLC. Source

Sivaiah K.,Sri Venkateswara University | Rudramadevi H.,Sri Venkateswara University | Buddhudu S.,Sri Venkateswara University | Kumar G.B.,Indian Institute of Technology Madras | Varadarajulu A.,Skuniversity
Indian Journal of Pure and Applied Physics | Year: 2010

Spectral characterization of Cu2+ and Co2+: PVP polymer films has been carried out from the measurement of their absorption, excitation and emission spectra in order to understand their optical performance as the visible colour displaying luminescent materials. Transparent and very clear natured reference PVP polymer film has also been developed by employing a solution cast method to measure the profiles of XRD, FTIR and Raman spectra in exploring its structural details. Besides, we have also reported its thermal properties based on the measurement of TG-DTA profiles. Source

Kumar K.K.,Skuniversity | Kumar K.S.,Sri Lakshmivenkateseara Pharmacy College | Satheesh G.,Krishnateja Pharmacy College
International Journal of Pharmacy and Technology | Year: 2013

The present study relates to formulations comprising Clopidogrel, including pharmaceutically acceptable salts thereof, which provide desired bioavailability. The aim of this study is to develop and evaluate pharmaceutically equivalent, stable, cost effective and quality improved formulation of Clopidogrel bisulfate immediate release tablets (at least 85% of the drug is dissolved in 30 min in each of three different aqueous media (i.e., PH ranging from 1 to 6.8) using US pharmacopeia (USP) apparatus II at 100 rpm) and comparison of dissolution rate of optimized formula with innovator's product and estimation of similarity and difference factors. In order to obtain acceptable product several trials were conducted. Various pharmacopeia evaluations of the formulations were conducted including weight variation, hardness, disintegration time, friability, invitro dissolution. Final selection of formulation was done based on invitro drug release of development formulation to that of marketed one. The optimized formulation was kept under stability conditions at 40°C ± 2°C / 75% RH conditions for 3 months as per ICH guidelines in HDPE containers and the product is to be stable throughout the period. Source

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