Bhavani Aiswarya K.S.,Skuniversity |
Jagadeeswara Rao P.,Skuniversity |
Spoorthy Y.N.,Skuniversity |
Ishrath Begum D.,Skuniversity |
Journal of Chemical and Pharmaceutical Research | Year: 2012
New mannich bases of 2-phenoxy-1,3,2-dioxaphospholanes derivatives (4R, 5R) - N'4, N'5-bis-(2-oxo-1-(piperidin-1-ylmethyl)/(morpholino methyl)/(4-methyl piperazin-1-ylmethyl) indolin-3-ylidene) - 2-(4-substituted phenoxy)-1, 3, 2-dioxa phospholane-4, 5-dicarbohydrazide-2-oxide 6(a-g) were prepared by the condensation reaction between (4R, 5R) -2-(4-substituted phenoxy)-1, 3, 2-dioxa phospholane-4, 5-dicarbohydrazide-2-oxide 3(a-e) with Isatin (4) yielded the corresponding (4R, 5R) - N'4, N'5-bis-(2-oxo indolin-3-ylidene) - 2-(4-substituted phenoxy)-1, 3, 2- Dioxaphospholane-4, 5-dicarbohydrazide-2-oxide 5(a-e). This was allowed to undergo the Mannich reaction with different Secondary Amines namely: piperidine, morpholine and N-methyl piperazine in the presence of formaldehyde in DMF to give corresponding hydrazides 6(a-g). The structure of these newly synthesized compounds was characterized by 1H-NMR, Mass, IR, C 13-NMR and P 31-NMR Spectral data.These newly synthesized compounds 6(a-g) were screened for their antibacterial and antifungal activity.
Kranthi Kumar K.,Skuniversity |
Swathi M.,Skuniversity |
Srinivas L.,Gitam Institute of Pharmacy
Der Pharmacia Lettre | Year: 2015
The present investigation deals with the formulation and evaluation of sodium alginate and pectin based In situ gel of Losartan Potassium. Sodium alginate and guar gum were used as a polymer and CaCO3 was used as a crosslinking agent. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultra-violet irradiation, from which drug gets released in sustained and controlled manner. The objective of this study was to develop a novel in-situ gel. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific Physico-chemical parameters. In-situ gel was formed at a biological pH. In vitro release studies were conducted in simulated gastric fluid and cumulative amount of drug release was analyzed by spectrophotometry. From designed set of experiments, it was evident that formulation containing 2% of sodium alginate and 1.5% of Guar gum control the release of drug for longer duration. The in-situ gel exhibited the expected, viscosity, drug content, pH, in vitro gelling capacity, in vitro floating ability and sustained drug release. The drug release from the in situ gels follows the Fickian diffusion type of release.
Sivaiah K.,Sri Venkateswara University |
Rudramadevi H.,Sri Venkateswara University |
Buddhudu S.,Sri Venkateswara University |
Kumar G.B.,Indian Institute of Technology Madras |
Indian Journal of Pure and Applied Physics | Year: 2010
Spectral characterization of Cu2+ and Co2+: PVP polymer films has been carried out from the measurement of their absorption, excitation and emission spectra in order to understand their optical performance as the visible colour displaying luminescent materials. Transparent and very clear natured reference PVP polymer film has also been developed by employing a solution cast method to measure the profiles of XRD, FTIR and Raman spectra in exploring its structural details. Besides, we have also reported its thermal properties based on the measurement of TG-DTA profiles.
Rajesh Kumar B.,Sri Venkateswara University |
Rajesh Kumar B.,Skuniversity |
Subba Rao T.,Sri Venkateswara University
Digest Journal of Nanomaterials and Biostructures | Year: 2012
In the present work Zinc Aluminum Oxide (ZAO) thin films have been deposited on glass substrates by DC reactive magnetron sputtering technique at different sputtering powers of Zn varied from 85 W - 125 W. XRD patterns exhibits ZAO thin films had a diffraction peak corresponding to (0 0 2) preferred orientation with c-axis perpendicular to the substrate surface. The preferred orientation is due to the lowest surface free energy for (0 0 2) plane. The minimum resistivity of 1.67 X 10 -4 Ω.cm is found for the thin film deposited at sputtering power of 115 W. Optical absorption edge of nanostructured ZAO thin films has a significant blue shift to the region of higher photon energy. Such a shift is attributed to the Burstein-Moss effect. The optical band gap of nanostructured ZAO thin films is found to be in the range of 3.43 - 3.60 eV. The carrier concentration of ZAO thin films is found to be in the range of 3.95 X 10 20 cm -3 - 1.38 X 10 21 cm -3.
Naveen Kumar H.M.P.,k-Technology |
Prabhakar M.N.,k-Technology |
Venkata Prasad C.,k-Technology |
Madhusudhan Rao K.,k-Technology |
And 3 more authors.
Carbohydrate Polymers | Year: 2010
The miscibility of chitosan (CS) and poly(vinyl alcohol) (PVA) blends in aqueous acetic acid solution was studied using viscosity, ultrasonic velocity and refractive index techniques at 30 °C. From the viscosity data by using Sun and Chee et al., approaches, the interaction parameters ΔB, μ and α are also calculated to predict the blend compatibility of the blend solutions. The results of these blends data suggest that CS/PVA blends were completely miscible in all proportions. The results pertaining to variation of ultrasonic velocity (v) and their derived parameters such as adiabatic compressibility, acoustic impedance, relaxation strength and Rao number also supports the miscibility nature of these blends. This is further confirmed by refractive index results also. Differential scanning calorimetry (DSC), XRD and FT-IR were also used to confirm the compatibility of the CS/PVA blends in the solid state (thin films). Experimental results showed that the blends of CS and PVA are miscible at all the compositions due to the strong intermolecular hydrogen bonding interactions between CS and PVA. © 2010 Elsevier Ltd. All rights reserved.
Rani V.E.,Skuniversity |
Praveena C.L.,Skuniversity |
Spoorthi Y.N.,Skuniversity |
Der Pharma Chemica | Year: 2013
New novelnderivatives of 1-( ( 1 (piperidine-1-yl-methyl) /(morpholinomethyl) / (4-methylpiperazin-1-yl-methyl )-6-nitro- 1H-benzo [d] imidazol-2-yl ) methyl -6-(4-substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-d] imidazole-6-oxide (9a-h) were prepared by condensation of 4-substituted of phenyl phosphorodichloridates (8a-f) with 1-((1- (piperidin-1-ylmethyl) / (morpholinomethyl) / (4-methylpiperazin-1-ylmethyl)-6-nitro-1H-benzo[d]imidazol-2-yl)methyl) 1H-imidazole-4,5-diyl)dimethanol(7a-c). The synthons (7a-c) was obtained by deprotection of isopropylidene of 6,6-dimethyl-1-((6-nitro-1-((1-(piperidin-1-ylmethyl) / (morpholinomethyl) / (4-methylpiperazin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)methyl)-4,8-dihy dro-1H-[1,3]-dioxepino [5,6-d] imidazole (6a-c). The synthons (6a-c) was obtained by the reaction of mannich reaction of 6,6-dimethyl-1-( ( 6-nitro-1H-benzo [d] imidazol-2-yl ) methyl ) -4,8-dihydro-1H-[1,3]-dioxepino[5,6-d] imidazole (5) with secondary heterocyclic amines and formaldehyde in DMF. The synthon (5) was obtained by the condensation of 2-(6,6-dimethyl-4,8-dihydro-1H-[1,3] dioxepino [5,6-d] imidazole-1-yl) acetic acid (3) with 4-nitro benzene 1,2-diamine(4).
Kumar K.K.,Skuniversity |
Kumar K.S.,Sri Lakshmivenkateseara Pharmacy College |
Satheesh G.,Krishnateja Pharmacy College
International Journal of Pharmacy and Technology | Year: 2013
The present study relates to formulations comprising Clopidogrel, including pharmaceutically acceptable salts thereof, which provide desired bioavailability. The aim of this study is to develop and evaluate pharmaceutically equivalent, stable, cost effective and quality improved formulation of Clopidogrel bisulfate immediate release tablets (at least 85% of the drug is dissolved in 30 min in each of three different aqueous media (i.e., PH ranging from 1 to 6.8) using US pharmacopeia (USP) apparatus II at 100 rpm) and comparison of dissolution rate of optimized formula with innovator's product and estimation of similarity and difference factors. In order to obtain acceptable product several trials were conducted. Various pharmacopeia evaluations of the formulations were conducted including weight variation, hardness, disintegration time, friability, invitro dissolution. Final selection of formulation was done based on invitro drug release of development formulation to that of marketed one. The optimized formulation was kept under stability conditions at 40°C ± 2°C / 75% RH conditions for 3 months as per ICH guidelines in HDPE containers and the product is to be stable throughout the period.
Lakshmi Praveena C.H.,Skuniversity |
Rani V.E.,Skuniversity |
International Journal of ChemTech Research | Year: 2015
New novel derivatives of N-((5-((6-oxido-6-(4 substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-c]pyrazol-1-yl) methyl)-1,3,4-thiadiazol-2-yl)carbamoyl) substituted benzene sulfo namides (7a-o as depicted in scheme) were Synthesized by condensation reaction of 4- substituted Phenyl phosphorodichloridates (6a-c) and N-((5-((4,5-bis(hydroxymethyl)-1H-pyrazol-1-yi)methyl)- 1,3,4-thiadiazol- 2-yl)carbamoyl) substituted benzene sulfonamides (5a-e). synthons (5a-e) were obtained by deprotection of isopropilidine group of N-((5-((6,6-dimethyl-4,8-dihydro-1H-[1,3]dioxepino[5,6-c]pyrazol-1-yl)methyl)-1,3,4- thiadiazol-2-yl)carbamoyl) substituted benzene sulfonamides (4a-e).These synthons (4a-e) were obtained by condensation reaction between methyl (cyclopropyl/per fluoro phenyl /4-bromo phenyl/4-nitro phenyl) sulfonyl carbamates (3a-e).and 5-((6,6-dimethyl-4,8-dihydro-1H-[1,3]dioxepino[5,6-C]pyrazol-1-yl)methyl)-1,3,4-thia diazol-2-amine (2). © 2014, Sphinx Knowledge House. All rights reserved.
Kumar K.K.,Skuniversity |
Narasimha Reddy M.,Skuniversity |
Naga Kishore R.,Sri Lakshmivenkateseara pharmacy college
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013
The aim of present study was to design the concept of bilayered tablets containing Pioglitazone hydrochloride for immediate release using cross Povidone as super disintegrant and Metformin hydrochloride for sustained release using poly ethylene oxide (PEO-303) as matrix forming polymer. The tablets were evaluated for physicochemical properties. All the values are found to be satisfactory. In vitro release studies were carried out as per USP in pH 1.2 and phosphate buffer pH 6.8 using the USP apparatus II. The release kinetics of Metformin hydrochloride was evaluated using the regression coefficient analysis. The formulated tablets (F5) shows first order release and diffusion was the dominant mechanism of drug release. The polymer Polyethylene oxide (PEO- 303) had significant effect on the release of Metformin HCl matrix tablets (F5).Thus formulated bilayer tablets proved immediate release of Pioglitazone and Metformin HCl as sustained release over a period of 12 hours. The stability studies and FT-IR studies were also indicating the absence of strong interactions between the components and suggesting drug-excipient compatibility in all the formulations examined.
Sreeramulu J.,Skuniversity |
Oriental Journal of Chemistry | Year: 2014
New novel derivatives of 4-(3-(1-((4-acetyl-5-methyl-5-(p-substituted phenyl)-4,5-dihydro- 1,3,4-oxadiazol-2-yl)methyl)-5-chloro-1H-indol-3-yl)-1-(pyridin-4-yl)-1H-pyrazol-4-yl)-3-chloro-1- (4 substituted phenyl)azetidin-2-one (5a-g) were prepared by the condensation of acetohydrazide (4a-g) with acetic anhydride. The compound 4(a-g) was obtained by the reaction of (3) with 4- substituted acetophenone in the presence of glacial aceticacid. The synthon (3) was obtained by the reaction of compound(2) with hydrazine hydrate in ethanol. The compound (2) was obtained by the reaction of (1H-indol-1-yl)acetate(1) with monochloroacetyl chloride in the presence of triethylamine in dioxane. The structure of the newly synthesized compounds were charecterized by IR, NMR, Mass and elemental analysis.