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Kryukov A.I.,Li Sverzhevsky Research Clinical Institute Of Otorhinolaryngology | Kunel'skaya N.L.,Li Sverzhevsky Research Clinical Institute Of Otorhinolaryngology | Krylov V.V.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Vinokurov A.G.,Nv Sklifosovsky Research Institute Of Emergency Medicine | And 2 more authors.
Vestnik otorinolaringologii | Year: 2015

The objective of the present work was to study syntopy of the artery of labyrinth using block-preparations of the posterior cranial fossa, variants of its branching-off from the vertebro-basiliar basin (VBB), and peculiar features of its anatomical structure. A total of 12 block-preparations of the posterior cranial fossa were available for the investigation. They were preliminarily stained with red latex and fixed in a three-point system. These procedures were followed by retrosigmoid craniotomy, opening of dura mater in the supero-lateral part of the cerebellomedulllary cistern, traction of the cerebellum, and blunt separation of the basiliar artery (BA). Variants of branching of the antero-inferior cerebellar artery (AICA) and branching of the artery of labyrinth from AICA were studied. It was shown that the artery of labyrinth branches off from the antero-inferior cerebellar artery in 100% of the cases. The latter artery formed a loop in 14% of the cases (3 ears). The average diameter of the labyrinth artery was 0.32 mm and its mean area 0.06 sq.cm. The artery of labyrinth branched off from the posterior para-stem segment of the antero-inferior cerebellar artery in 42.6% of the cases (9 ears), and from the anterior para-stem segment of AICA in 14.2% of the cases (3 ears). Within the conventional «rhombus», the artery of labyrinth was straight in 76.2% of the cases (16 ears) and arc-shaped in 23.8% (4 ears).Abstract available from the publisher.


PubMed | Nv Sklifosovsky Research Institute Of Emergency Medicine and Li Sverzhevsky Research Clinical Institute Of Otorhinolaryngology
Type: Journal Article | Journal: Vestnik otorinolaringologii | Year: 2015

The objective of the present work was to study syntopy of the artery of labyrinth using block-preparations of the posterior cranial fossa, variants of its branching-off from the vertebro-basiliar basin (VBB), and peculiar features of its anatomical structure. A total of 12 block-preparations of the posterior cranial fossa were available for the investigation. They were preliminarily stained with red latex and fixed in a three-point system. These procedures were followed by retrosigmoid craniotomy, opening of dura mater in the supero-lateral part of the cerebellomedulllary cistern, traction of the cerebellum, and blunt separation of the basiliar artery (BA). Variants of branching of the antero-inferior cerebellar artery (AICA) and branching of the artery of labyrinth from AICA were studied. It was shown that the artery of labyrinth branches off from the antero-inferior cerebellar artery in 100% of the cases. The latter artery formed a loop in 14% of the cases (3 ears). The average diameter of the labyrinth artery was 0.32 mm and its mean area 0.06 sq.cm. The artery of labyrinth branched off from the posterior para-stem segment of the antero-inferior cerebellar artery in 42.6% of the cases (9 ears), and from the anterior para-stem segment of AICA in 14.2% of the cases (3 ears). Within the conventional rhombus, the artery of labyrinth was straight in 76.2% of the cases (16 ears) and arc-shaped in 23.8% (4 ears).


Khubutiya M.S.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Grafov B.M.,RAS Frumkin Institute of Physical Chemistry and Electrochemistry | Goldin M.M.,Liberty University | Garaeva G.R.,Nv Sklifosovsky Research Institute Of Emergency Medicine | And 2 more authors.
Journal of Solid State Electrochemistry | Year: 2012

An investigation of electroless electrochemical detoxification processes occurring on porous hemosorbent electrodes was performed. Cupric ions, isopropanol, t-buta-nol, and free hemoglobin were used as model toxicants. The elementary act of electrochemical adsorption detoxification was shown to nearly always be accompanied by partial transfer of charge. It was concluded that the method of experimental determination of effective numbers of electrons that correspond to the elementary act of detoxification is a robust tool for the selection and evaluation of relative effectiveness of hemosorbent electrodes. © 2012 Springer-Verlag Berlin Heidelberg.


Khubutiya M.Sh.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Goldin M.M.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Stepanov A.A.,Mendeleev University of Chemical Technology | Hall P.J.,University of Strathclyde | And 2 more authors.
ECS Transactions | Year: 2010

Prospects of development of an electrochemically controlled hemosorption detoxification method are very promising because this method combines biocompatibility of activated carbon with high adsorptivity towards toxic compounds. The present work is an attempt to develop controlled detoxification processes on carbon adsorbents modified by electroconductive polypyrrole. Electropolymerization of pyrrole on activated carbon AG-3 had added biocompatibility to a material that is aggressive towards blood. The magnitude and direction of open circuit potential (OCP) shifts for the carbon materials studied depend on the conditions of electropolymerization. Adsorptivity of AG-3 covered by polypyrrole was increased compared with untreated carbon. ©The Electrochemical Society.


Abakumov M.M.,Nv Sklifosovsky Research Institute Of Emergency Medicine
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2010

Peculiar features of surgical treatment of gunshot, non-lethal arm, and cold steel wounds are formulated based on the 20-year experience with managing 20,000 injured subjects having multiple and combined injuries to neck, chest, and abdomen of suicidal and criminal character. The growth in the number of patients with suicidal wounds and hemocontact viral infections (hepatitis, HIV) is emphasized. It is concluded that assessment of the state of gas exchange, lipid peroxidation, antioxidative, and immune systems does not give full idea of pathogenetic mechanisms of traumatic diseases.


Goldin M.M.,Liberty University | Khubutia M.S.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Evseev A.K.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Goldin M.M.,Nv Sklifosovsky Research Institute Of Emergency Medicine | And 4 more authors.
Transplantation | Year: 2015

Background. The problem of noninvasive diagnosis of transplant dysfunction in patients is one of the most complex problems in transplantology at the present time. Because transplanted organs can be ischemic, the measurement of redox potential (RP) in blood serum reflects the prooxidant-antioxidant balance in the organism. It was hypothesized that certain dysfunctions and postoperative complications in transplant patients may be accompanied by a change in the RP of blood plasma. Methods. Monitoring of the RP in the blood serum of patients was performed as a noninvasive method of diagnosis of transplant dysfunctions. The RP values were measured in blood serum of 63 apparently healthy subjects. Monitoring of blood serum RP was performed in 64 liver transplant patients, 59 kidney allotransplantation patients and six lung transplant patients. A total of 1,759 measurements were performed in 192 total subjects. Statistical analysis of RP values was performed using the Statistica 6.0 software package. Results. and Conclusion. The proposed method is based on the electrochemical measurement of the open-circuit potential of the platinum electrode immersed in blood serum because the measured value reflects the state of equilibrium between prooxidant and antioxidant systems of the organism. Shifts in values of the RPs (open circuit potentials) observed in the course of monitoring are significantly different in patients with transplant dysfunction compared to patients with unremarkable recoveries. The analysis of monitoring allows for the development of certain diagnostic and prognostic criteria of transplant dysfunction. It is important that the proposed method is noninvasive, simple, and inexpensive. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.


Khubutiya M.S.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Goldin M.M.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Stepanov A.A.,Nv Sklifosovsky Research Institute Of Emergency Medicine | Kolesnikov V.A.,Mendeleev University of Chemical Technology | Kruglikov S.S.,Mendeleev University of Chemical Technology
Carbon | Year: 2012

Many of the vital processes in the human body are electrochemical in nature. Therefore, medical applications of electrochemistry show great promise. Particularly, detoxification by electrochemically controlled hemosorption combines biocompatibility of activated carbon with high adsorption activity toward toxic compounds. The present work involved the development of a controlled detoxification process using carbon adsorbents modified with polypyrrole. The electropolymerization of pyrrole on AG-3 activated carbon, which was initially quite aggressive towards erythrocytes, made it biocompatible. Glassy carbon and activated carbon were used to study the effect of polypyrrole on the physicochemical and biological activity of carbon materials. The magnitude and direction of open circuit potential shifts for these carbon materials depended on the conditions of electropolymerization. Adsorption activity of AG-3 activated carbon modified with polypyrrole was increased, as compared with untreated carbon. © 2011 Elsevier Ltd. All rights reserved.

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