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Kozlova L.S.,Mendeleev University of Chemical Technology | Novikov V.T.,Mendeleev University of Chemical Technology | Garaeva G.R.,Sklifosovskii Research Institute of Emergency Medicine | Gol'din M.M.,Sklifosovskii Research Institute of Emergency Medicine | Kolesnikov V.A.,Mendeleev University of Chemical Technology
Protection of Metals and Physical Chemistry of Surfaces | Year: 2015

Modification of an electrode surface with carbon nanomaterials leads to the increase in the current efficiency of H2O2 during the reduction of oxygen. The modifying layer composed of carbon nanotubes on the basis of a Nafion® emulsion remains stable under the synthesis conditions. The current efficiency of H2O2 in the reduction of air oxygen attains 85–99%. The product obtained via synthesis is compatible with the blood and is effective for the decomposition of exotoxicants such as chlorprothixene. © 2015, Pleiades Publishing, Ltd. Source


Goldin M.M.,Liberty University | Grafov B.M.,RAS Frumkin Institute of Physical Chemistry and Electrochemistry | Garaeva G.R.,Mendeleev University of Chemical Technology | Davydov A.D.,RAS Frumkin Institute of Physical Chemistry and Electrochemistry | And 2 more authors.
Russian Journal of Electrochemistry | Year: 2013

The hemosorbents made of carbon materials, which are used for hemosorption detoxication, should be indifferent toward blood. Therefore, in the course of hemosorption, it is important to avoid the Faradaic processes, which can change the blood composition. The probability of Faradaic processes depends on the open-circuit potential of activated carbon. This dependence is studied by simulating the detoxication processes. In order to obtain various open-circuit potentials, which are reached after switching-off polarization, the adsorption of cupric ions and t-butanol on the preliminarily polarized hemosorbent (AG-3 activated carbon) is studied. The effective number of electrons, which are transferred in an elementary adsorption act, is determined. The conditions, under which the Faradaic process does or does not proceed, are found. © 2013 Pleiades Publishing, Ltd. Source


Berezina I.Y.,Sklifosovskii Research Institute of Emergency Medicine | Sumsky L.I.,Sklifosovskii Research Institute of Emergency Medicine | Kudryashova N.E.,Sklifosovskii Research Institute of Emergency Medicine
Human Physiology | Year: 2013

The study examines correlation between the degree of stenosis of the internal carotid artery (ICA) and the night sleep parameters. The possible neurophysiological mechanisms of sleep disorder in blood flow disturbances in the carotid system are also discussed. Twenty-four patients (19 men and 5 women) were examined, including 6 cases of 50% ICA stenosis, 7 cases of 50-70% ICA stenosis; and 11 cases of ICA occlusion. A polygraphic study of night sleep was conducted and the sleep stages were analyzed. The patients filled in the quality of sleep questionnaire with the presence of the somnolence scoring system. In order to assess brain perfusion, single-photon emission CT imaging of the brain was performed. The results of the study showed that the night sleep structure in the cases of 50% ICA stenosis was unchanged: all the sleep phases and stages whose quantitative parameters corresponded to the reference normal data were recorded, or only stage II sleep representation declined; in the cases of 50-70% ICA stenosis, predominantly stage II sleep and slow-wave sleep were compromised; in patients with ICA occlusion, slow-wave sleep and REM-sleep (45% of cases) were disturbed. © 2013 Pleiades Publishing, Inc. Source


Klychnikova E.V.,Sklifosovskii Research Institute of Emergency Medicine | Tazina E.V.,Sklifosovskii Research Institute of Emergency Medicine | Kordonskii A.Y.,Sklifosovskii Research Institute of Emergency Medicine | Trifonov I.S.,Sklifosovskii Research Institute of Emergency Medicine | And 2 more authors.
Neurochemical Journal | Year: 2014

The pathophysiological mechanisms of brain lesions after craniocerebral trauma (CCT) are associated with the effects of primary and secondary damaging factors. Here, we studied the changes in the indices of oxidative stress, including the content of malondialdehyde (MDA), the total antioxidant activity (TAA), the MDA/TAA coefficient, albumin, and the levels of the markers of secondary damage, such as nitric oxide (NOx) and glucose in the blood serum of patients with CCT of moderate severity. A total of 29 patients with CCT were examined on days 1, 3, and 5 of their stay in a hospital. On day 5 of the posttraumatic period, we observed the exhaustion of the antioxidant system expressed in the increased MDA/TAA coefficient and decreased TAA in patients with CCT of moderate severity. The NOx level was decreased on day 1 and on days 3 and 5 it was similar to the norm. The glucose level was normal during the entire observation period. A significant positive correlation between the MDA/TAA index and traumatic subarachnoid hemorrhage was revealed on day 5, which reflected the relationship between oxidative stress and the lesion volume. This should be taken into account for the selection of a therapeutic approach. © 2014 Pleiades Publishing, Ltd. Source


Klychnikova E.V.,Sklifosovskii Research Institute of Emergency Medicine | Tazina E.V.,Sklifosovskii Research Institute of Emergency Medicine | Solodov A.A.,Sklifosovskii Research Institute of Emergency Medicine | Petrikov S.S.,Sklifosovskii Research Institute of Emergency Medicine | And 2 more authors.
Neurochemical Journal | Year: 2013

The development of cerebral vasoconstriction in subarachnoid hemorrhage (SAH) induced by the rupture of an aneurism of brain vessels impairs cerebral circulation. Treatment with normobaric hyperoxia may be used as an effective approach to oxygen delivery to the injured brain tissue. The purpose of the present study was to evaluate the effects of normobaric hyperoxia on oxidative stress and factors of endogenous vascular regulation in eight patients who suffered from non-traumatic SAH and remained in critical condition. The intensity of oxidative stress was assayed by measuring malonic dialdehyde and the total antioxidant activity in the blood serum. Endothelium functions were evaluated using the content of the stable metabolites of nitric oxide and the activity of angiotensin-converting enzyme in the blood serum. The data from eight patients who suffered from non-traumatic SAH showed an enhancement of oxidative stress, which influenced the functions of the vascular endothelium and resulted in an imbalance in the endogenous regulation of vascular tone. Treatment with normobaric hyperoxia was not associated with intensification of free-radical processes in patients who suffered from non-traumatic SAH and did not influence intracranial and arterial pressure. © 2013 Pleiades Publishing, Ltd. Source

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