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Ravindranath L.K.,Sk University Anantapur Andrapradesh | Srikanth K.,Sk University Anantapur Andrapradesh | Ishrath Begum D.,Sk University Anantapur Andrapradesh
International Journal of Applied Chemistry | Year: 2010

Several thiazoles and pyrazolone carrying heterocyclic nucleus were synthesized and tested as antimicrobial agents. All compounds and some of the nitro substituted derivatives have effective antibacterial properties against Gram positive bacteria (Staphylococcus aureus NCCS 2079 and Bacillus cereus NCCS 2106), Gram negative bacteria (Escherichia coli NCCS 265 and Pseudomonas aeruginosa NCCS2200). The antifungal activity of synthesized compounds were studied by disc diffusion method against the organisms of Aspergillus niger NCCS 1196 and Candida albicans NCCS 3471. The chemical structures of these newly synthesized compounds were characterized by 1H-NMR, Mass, and IR spectral data. © Research India Publications.


Ravindranath L.K.,Sk University Anantapur Andrapradesh | Rangaraju K.,Sk University Anantapur Andrapradesh | Srikanth K.,Sk University Anantapur Andrapradesh | Radhakrishana S.,Sk University Anantapur Andrapradesh
Heterocyclic Communications | Year: 2010

Several 2,4-thiazolidindiones were prepared from corresponding aryl aldehydes by Knovengel condensation between Aldehydes and 2,4-thiazolidindione which shows anti-hyperglycemic potency such as Pioglitazone and Rosiglitazone. In our attempt we have prepared 4-[2-(methyl-2-pyridin-2yl-amino)-ethoxy]- benzaldehyde derivatives. Condensation of aryl Aldehydes with aryl ketones by Aldol condensation and the derivatives may have comparable biological importance.

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