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Anantapur, India

Sreedevi G.,Koneru Lakshmaiah College of Engineering | Raghavendra Rao R.,Koneru Lakshmaiah College of Engineering | Prasada Rao D.R.V.,Sk University | Chamkha A.J.,Prince Mohammad Bin Fahd University
Ain Shams Engineering Journal | Year: 2016

An analysis has been carried out on the influence of radiation absorption, variable viscosity, Hall current of a magnetohydrodynamic free-convective flow and heat and mass transfer over a stretching sheet in the presence of heat generation/absorption. The fluid viscosity is assumed to vary as an inverse linear function of temperature. The boundary-layer equations governing the fluid flow, heat and mass transfer under consideration have been reduced to a system of nonlinear ordinary differential equations by employing a similarity transformation. Using the finite difference scheme, numerical solutions to the transform ordinary differential equations have been obtained and the results are presented graphically. The numerical results obtained are in good agreement with the existing scientific literature. © 2016 Faculty of Engineering, Ain Shams University. Source

Hotha K.K.,Novel Laboratories Inc. | Roychowdhury S.,Novel Laboratories Inc. | Mullangi R.,Jubilant Biosys Ltd. | Ravindranath L.K.,Sk University
Biomedical Chromatography | Year: 2013

A rapid, simple, specific and sensitive LC-MS/MS method has been developed and validated for the enantiomeric quantification of amlodipine (AML) isomers [R-amlodipine (R-AML) and S-amlodipine (S-AML)] with 200 μL of human plasma using R-AML-d4 and S-AML-d4 as corresponding internal standards as per regulatory guidelines. A simple liquid-liquid extraction process was used to extract these analytes from human plasma. The total run time was 3.5min and the elution of R-AML, S-AML, R-AML-d4 and S-AML-d4 occurred at 1.62, 2.51, 1.63 and 2.53min, respectively. This was achieved with a mobile phase consisting of 0.2% ammonia-acetonitrile (20:80, v/v) at a flow rate of 1mL/min on a Chiralcel OJ RH column. A linear response function was established for the range of concentrations 0.1-10ng/mL (r >0.998) for each enantiomer. The intra- and inter-day precision values for both enantiomers met the acceptance criteria. Both enantiomers were stable in a set of stability studies, viz. bench-top, auto-sampler, freeze-thaw cycles and long-term. The current assay was successfully applied to a pharmacokinetic study to quantitate AML enantiomers following oral administration of 10mg AML tablet to humans. © 2013 John Wiley and Sons, Ltd. Source

Fareeza F.,Rayalaseema University | Murthy B.R.,Sk University
European Journal of Scientific Research | Year: 2012

Most of the real time processes are nonlinear with mutually interacting process variables having a vast amount of highly correlated data, and this good correlation need to be utilized in the design of an intelligent system algorithm. In this work, a unified approach towards using intelligent control strategies by integrating data from mutually interacting, independently designed, separately located sensors along with testing the algorithms on a real time nonlinear process is presented. A confidence band for the input-output data, obtained in the normal operating conditions of a system, is approximated using a fuzzy model with interval parameters. Applying low-pass filtering when obtaining the confidence band, makes it possible to use arbitrary sets of identification of system. © EuroJournals Publishing, Inc. 2012. Source

Rambabu C.,Rayalaseema University | Murthy B.R.,Sk University
European Journal of Scientific Research | Year: 2012

Visual Evoked Potentials originates from neurons in the cortex, outer layer of brain and are oscillating and event-related potentials in nature. These signals are responses to visual stimulants and extensively used in neuropsychological studies. With electroencephalogram as background, these signals have poor signal-to-noise ratio which is a major hurdle in its analysis. Averaging is the primitive scheme to reduce the EEG effects on VEP signals. In this work, a method to reduce electroencephalogram (EEG) artifacts from Visual-Evoked Potentials (VEP) in brain-computer interface (BCIs) design is presented. For the test composite signal, the frequency ranges corresponding to stimulusrelated VEP components were located using statistical coefficient selection (SCS). The resulting cyclic frequency spectrum provides VEP frequency band detection. Using this identified frequency ranges, evolved adaptive filters are employed for EEG artifacts reduction. Adaptive Noise Cancellation (ANC) scheme and Wavelet Denoising Algorithm (WDA) are used to distinguish VEP components and EEG artifacts. In this work, a reconfigurable adaptive noise cancellation filter that constitutes the backbone of a Adaptive Noise Cancellation (ANC) scheme is designed and applied to remove the EEG artifact effects that occur along with VEP signals. © 2012 EuroJournals Publishing, Inc. Source

Shameela S.,Sk University | Shamshad S.,Kvr Government Degree College | Indira Priyadarsini A.,Kvr Government Degree College | John Paul M.,P.A. College | Lakshmi Devi K.,Sk University
International Journal of Pharma and Bio Sciences | Year: 2015

Cardiovascular disease (CVD) or diseases of the circulatory system can be described as all diseases relating to the heart and blood vessels. The World Health Organization (WHO) estimates there will be about 20 million CVD deaths in 2015, accounting for 30 percent of all deaths worldwide. The present study was designed to evaluate the cardioprotective role of whole plant extract of Boerhaavia diffusa on isoproterenol induced myocardial infarction in wistar albino rats. The rats were divided into four groups of six animals each. Group I served as a normal control, Group II rats were administered isoproterenol (85mg/kg, i.p) at the end of experimental period on the45th and 46th days. Group III received an ethanolic extract of Boerhaavia diffusa 150mg/kg b.w for 45 days. Group IV rats were pretreated with Boerhaavia diffusa 150mg/kg b.w for a period of 45 days and received intraperitonial injection of isoproterenol (85 mg/kg, b.w) at the end of experimental period for 2 consecutive days. After the experimental period, blood was collected and serum was separated and used for the estimation of cholesterol, triglycerides, phospholipids, and lipoproteins and the assay lipid peroxidation and protein oxidation. The heart homogenate was used for the assay lipid profile, lipid peroxidation and protein oxidation. Isoproterenol induced rats showed a significant increase in the levels of triglycerides, total cholesterol and free fatty acids in both serum and heart homogenate. A rise in the levels of LDL, VLDL with a significant decrease in the level of HDL was also observed in the serum and heart tissues of isoproterenol treated rats. But the phospholipid content was found to be significantly increased in serum and decreased in heart tissue. The values of atherogenic index and C/P ratio were significantly increased in the ISPH treated group. The oral administration of ethanolic extract of Boerhaavia diffusa 150/kg b.w) to isoproterenol-induced rats daily for a period of 45 days proved the protective role of Boerhaavia diffusa. The levels of the biochemical parameters in the plant treated groups were nearly the same as that of the normal control. Source

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