SK Chemicals Co.

Seongnam, South Korea

SK Chemicals Co.

Seongnam, South Korea
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Patent
SK Chemicals Co. | Date: 2017-02-15

The present invention relates to a method for preparing polymeric microspheres to improve the drug encapsulating efficiency and, more specifically, to a method for preparing polymeric microspheres, the method comprising the steps of: preparing an internal water phase (w1) and an oil phase (0); mixing the internal water phase and the oil phase to prepare a W1/0 emulsion, followed by cooling; mixing the W1/0 emulsion with an external water phase (W2) to prepare a W1/0/W2 emulsion; and drying the prepared W1/0/W2 emulsion, followed by collection. The method of the present invention can increase the drug encapsulating efficiency and manufacture polymeric microspheres having high drug contents through a procedure of maintaining the step of solidifying the oil phase at a particular temperature for a particular period of time, and thus the method of the present invention is effective in the preparation of sustained release-type drugs.


The present invention relates to a method for preventing the precipitation of rotigotine crystals in a transdermal absorption preparation containing rotigotine as an active ingredient and, more specifically, to a method for preparing a transdermal absorption preparation, comprising a step of mixing rotigotine and an antioxidant at a weight ratio of 1:0.0001 to 0.1, and to a transdermal therapeutic system, comprising: a drug-containing adhesive layer containing the transdermal absorption preparation prepared by the method, and rotigotine and an antioxidant at a weight ratio of 1:0.0001 to 0.1; and a substrate for supporting the drug-containing adhesive layer. The method and system of the present invention suppress the crystallization of rotigotine as well as the generation of related substances, thereby increasing the long-term storage stability, and thus the present invention can be effectively applied to the preparation of a rotigotine-containing patching agent or the like.


The present invention relates to a composition comprising 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl]-2-thiophene carboxyamide as an active ingredient, manufactured by a melt extrusion method. The composition according to the present invention has a wide variety of advantages such as securing dissolution rate and bioavailability of the active ingredient, improving absorption deviation depending on whether a patient has a meal or not, and securing stability during the manufacturing process. The present invention further provides a method which can manufacture the said composition.


Patent
SK Chemicals Co. | Date: 2017-02-15

The present invention relates to a multilayer polyester sheet, comprising: a substrate layer including a thermoplastic resin; and a coating layer formed on at least one surface of the substrate layer and contains a polyester resin including a residue of a diol component including 51 mol% to 85 mol% of isosorbide and a residue of a dicarboxylic acid component, and a molded product of the same.


Patent
Sk Chemicals Co. | Date: 2017-01-04

Disclosed is a method for producing proteins having factor VIII procoagulant activity in serum-free medium by in vitro culturing of mammalian cells, wherein the serum-free medium contains an inhibitor against the protease released from cultured cells. In accordance with this invention, the inhibitor can protect the cleavage of a target protein during cultivation and increase homogeneity of a target molecule, wherein the inhibitor can be a dextran sulfate. This invention also relates to a method of purifying target molecules from the culture medium containing both a target molecule and selected inhibitors by affinity chromatography.


Patent
SK Chemicals Co. | Date: 2017-05-24

The present invention relates to a polyester resin composition capable of having an excellent shrinkage rate, being heat-shrunk at a low temperature, and improving adhesion properties, without impairing insulation properties in a state of heat-shrinkable films, and a method for preparing the same. The present polyester resin composition comprises: a copolymerized polyester resin including a dicarboxylic acid-derived residue including a residue derived from an aromatic dicarboxylic acid; and a diol-derived residue including a residue derived from 4-(hydroxymethyl)cyclohexylmethyl 4-(hydroxymethyl)cyclohexane carboxylate, and a residue derived from 4,4-(oxybis(methylene)bis) cyclohexane methanol, an alkali metal compound, and an alkaline earth metal compound, wherein the alkali metal compound and the alkaline earth metal compound are contained in an amount that the content ratio of the alkali metal element/the alkaline earth metal element derived therefrom is 0.01 to 1.


The present invention relates to a method for preparing poly(trimethylene terephthalate). According to the present invention, it is possible to prepare poly(trimethylene terephthalate) containing low levels of toxic by-products such as acrolein without separate additives.


The present invention relates to a pharmaceutical composition containing leuprolide acetate and having both immediate and sustained release properties and, more specifically, to a pharmaceutical composition in which, on the basis of the total weight of active ingredients, leuprolide as an immediate release preparation is contained in 0.001 wt% to 25 wt%; and leuprolide contained in microspheres of a sustained release preparation is contained in 75 wt% to 99.999 wt%. The pharmaceutical composition of the present invention is characterized by satisfying both a drug immediate release property so as to realize the prompt exposure to a sufficient amount of drug at the early stage for expression of medicinal effects and a drug sustained release property for four weeks or longer, and the pharmaceutical composition is effective in the prevention and treatment of sex hormone-dependent positive or malignant diseases.


Patent
SK Chemicals Co. | Date: 2017-04-12

The present invention relates to a polylactic acid resin composition which has a low glass transition temperature, fusion temperature, and enthalpy of fusion, can be crystallized under commercially meaningful processing conditions, has good film processability such as extrusion properties, has excellent storage stability, and is highly biodegradable. The polylactic acid resin composition comprises a block copolymer comprising a hard segment and a soft segment, the hard segment comprising polylactic acid repeat units, and the soft segment comprising polyurethane polyol repeat units which have polyether-based polyol repeat units linearly connected via a urethane bond, wherein the soft segment is contained by 5% to 35% by weight based on the weight of the block copolymer, and the polylactic acid repeat units include poly(L-lactic acid) repeat units and poly(D-lactic acid) repeat units by a molar ratio of 94:6 to 88:12.


Patent
SK Chemicals Co. | Date: 2017-09-27

The present invention relates to a method for preparing a tris(trialkylsilyl)phosphine in high yield and high purity with safety and no risk of fire or explosion.

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