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MarketStudyReport.com adds “Diabetic Retinopathy Market Size By Type (Proliferative Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy), By Management (Anti VEGF Drug, Intra-ocular Steroid Injections, Laser Surgeries, Vitrectomy), Industry Analysis Report, Regional Outlook (U.S., Canada, UK, Germany, Japan, China, Brazil, South Africa), Application Potential, Price Trends, Competitive Market Share & Forecast, 2016 ? 2023” new report to its research database. The report spread across 73 pages with table and figures in it. Diabetic Retinopathy Market size was evaluated at $6.51 billion for 2015 and CAGR of 6.9% was predicted during forecast period. Growing old age population, increasing occurrence of diabetes, fast rise in cases of blindness and rising consciousness about early identification of diabetic retinopathy are the few factors driving the industry expansion. Diabetic retinopathy is an eye disorder that causes damage to the retina blood vessels. It is a common diabetic condition affecting eyes. Persons suffering from diabetes are at greater risk of developing diabetic retinopathy. The condition is mainly caused by high levels of glucose in blood producing changes in eye blood vessels. Retinopathy treatment depends upon ailment phase and is aimed at blocking its growth. Corticosteroids injections, vitrectomy and laser surgery are few of the available ailment treatments. U.S. Diabetic Retinopathy Market size, by management, 2012 ? 2023 (USD Million) U.S. Diabetic Retinopathy Market size, by management, 2012 ? 2023 (USD Million) Screening of retina and line of treatment depends upon the seriousness of the situation ensuring delivery of proper treatment. Diabetes is considered to be main cause of blindness in people. To avoid blindness, people are demanding methods for early identification of ailment, fuelling diabetic retinopathy market trends. Also, old age population is more prone for contracting the ailment and hence promotes the industry growth. Further, technological breakthroughs in retinal screening methods and equipments like utilization of slit lamps and launching of new products like Gly-230 & Optima are the factors predicted to drive the industry expansion. Growing occurrence of diabetes predicted to affect more than 4.6% of world population will also enhance the industry growth. Industry Segmentation Types Different types of diabetic retinopathy are non-proliferative and proliferative. Non-proliferative retinopathy led the industry by contributing more than $4.6 billion in 2015. Growing diabetes occurrence, non-compliant retinal screening of patients and lack of right time diagnosis are factors predicted to fuel the increase in the industry share of non-proliferative retinopathy. Proliferative retinopathy is predicted to register highest CAGR of 7.5% during forecast timeframe. Rising occurrence of diabetes and increasing amount of old age population predicted to enter proliferative retinopathy phase will fuel the industry demand. Treatments Various treatments in diabetic retinopathy are anti-VEGF therapy, laser surgery, vitrectomy and intraocular steroid injection. Anti-VEGF contributed large portion of the industry share in 2015 due to popular utilization of these medicines in treating the ailment and helping patients to recover quickly. But, laser surgery is predicted to register CAGR of 9.4% during the forecast period which is highest among segments. Demand for laser surgery will grow enormously in future owing to increase in aging population and growing occurrence of diabetes all across the world. Regions North America is predicted to contribute maximum revenue share in access of $4 billion by end of forecast timeframe. Growing access to anti-VEGF items like lucentis, eyelea and avastin along with growing consciousness for early diagnosis to avoid further blindness related with diabetes are the factors predicted to drive the industry demand in the region. In 2012, rate of occurrence of diabetic retinopathy in U.S. was predicted to be 5.41% as per Prevent Blindness America with Arizona, New Mexico, Florida, California, Texas and New York having greatest density. In addition to this, favorable regulations, good healthcare facilities and fully grown healthcare infrastructure along with rapid access to different kinds of treatments are few of the key factors driving the industry growth in North America. Further, the old age population base of the region was measured nearly about 67.61 million for 2012 and predicted to touch approximately 81.61 million in 2022. This is also one of the key aspects contributing towards industry dominance by the region MEA and Latin America are predicted to register CAGR of 10.2% and 7.2% respectively and display a good industry growth during forecast timeframe. Favorable government policies and medical guidance are predicted to enhance the rate of detection and treatment propelling diabetic retinopathy market growth in these regions. Growing cases of diabetes mellitus and lack of skilled ophthalmologists are few of the factors contributing to the industry growth in Brazil. Key industry participants profiled in the report include: Actavis PLC Kowa Group ThromboGenics Bayer Healthcare Ampio Pharmaceuticals Glycadia Pharmaceuticals Novartis AG BCN Peptides Regeneron Pharmaceuticals Incorporation Alimera Sciences Genentech Sirnaomics Incorporation To receive personalized assistance, write to us @ [email protected] with the report title in the subject line along with your questions or call us at +1 866-764-2150


GAITHERSBURG, Md., Nov. 7, 2016 /PRNewswire/ -- Sirnaomics, Inc. (www.sirnaomics.com), a leading biopharmaceutical company in discovery and development of RNAi therapeutics, announces today that an IND application for a Phase IIa clinical study of the company's leading siRNA therapeutic...


Sun H.,Houston Methodist Hospital | Zhu X.,Jilin University | Lu P.Y.,Sirnaomics | Rosato R.R.,Houston Methodist Hospital | And 2 more authors.
Molecular Therapy - Nucleic Acids | Year: 2014

Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar to antibodies, aptamers interact with their targets by recognizing a specific three-dimensional structure and are thus termed "chemical antibodies." In contrast to protein antibodies, aptamers offer unique chemical and biological characteristics based on their oligonucleotide properties. Hence, they are more suitable for the development of novel clinical applications. Aptamer technology has been widely investigated in various biomedical fields for biomarker discovery, in vitro diagnosis, in vivo imaging, and targeted therapy. This review will discuss the potential applications of aptamer technology as a new tool for targeted cancer therapy with emphasis on the development of aptamers that are able to specifically target cell surface biomarkers. Additionally, we will describe several approaches for the use of aptamers in targeted therapeutics, including aptamer-drug conjugation, aptamer-nanoparticle conjugation, aptamer-mediated targeted gene therapy, aptamer-mediated immunotherapy, and aptamer-mediated biotherapy. © 2014 The American Society of Gene & Cell Therapy.


Mulik S.,University of Tennessee at Knoxville | Xu J.,Sirnaomics | Reddy P.B.J.,University of Tennessee at Knoxville | Rajasagi N.K.,University of Tennessee at Knoxville | And 4 more authors.
American Journal of Pathology | Year: 2012

MicroRNAs (miRNAs) are small regulatory molecules that control diverse biological processes that include angiogenesis. Herpes simplex virus (HSV) causes a chronic immuno-inflammatory response in the eye that may result in corneal neovascularization during blinding immunopathological lesion stromal keratitis (SK). miR-132 is a highly conserved miRNA that is induced in endothelial cells in response to growth factors, such as vascular endothelial growth factor (VEGF). In this study, we show that miR-132 expression was up-regulated (10- to 20-fold) after ocular infection with HSV, an event that involved the production of both VEGF-A and IL-17. Consequently, blockade of VEGF-A activity using soluble VEGF receptor 1 resulted in significantly lower levels of corneal miR-132 after HSV infection. In addition, low levels of corneal miR-132 were detected in IL-17 receptor knockout mice after HSV infection. In vivo silencing of miR-132 by the provision of anti-miR-132 (antagomir-132) nanoparticles to HSV-infected mice led to reduced corneal neovascularization and diminished SK lesions. The anti-angiogenic effect of antagomir-132 was reflected by a reduction in angiogenic Ras activity in corneal CD31-enriched cells (presumably blood vessel endothelial cells) during SK. To our knowledge, this is one of the first reports of miRNA involvement in an infectious ocular disease. Manipulating miRNA expression holds promise as a therapeutic approach to control an ocular lesion that is an important cause of human blindness. © 2012 American Society for Investigative Pathology.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 221.35K | Year: 2012

DESCRIPTION (provided by applicant): The primary function of the skin is to serve as a protective barrier against the environment. Loss of the integrity of large portions of the skin as a result of wounds and wound-related infection may lead to major disability or even death. Every year in the United States more than 1.25 million people suffer burns and 6.5 million have chronic skin ulcers caused by diabetes and other diseases. As many as 15% of patients with diabetes will suffer from a diabetic foot ulcerand, of these patients, 6% will be hospitalized due to infection or other ulcer-related complications. Furthermore, diabetes is the leading cause of nontraumatic amputations of lower extremities in the United States, and approximately 14-24 % of patients with diabetes who develop a foot ulcer will have an amputation. Wounds in the elderly are also slower to heal and the problem is especially compounded in elderly diabetics. In addition, many traumatic wounds are incurred through accidents or from combat casualties and there is a need for an accelerated wound repair treatment for patients who undergo invasive surgery. Wounds incurred by members of the armed forces can be compounded by contamination and the risk of infection based on the environment in which the casualty is received. Consequently, wounds from traumatic injury, burns or diabetes pose an increased burden to the healthcare system and there is an immediate need for improved treatment options that promote and accelerate wound healing while minimizing or inhibiting the risk from infection during the healing process. Such a therapy which further promotes wound healing without scar formation would also be of significant benefit since scars over joints can limit limb motion and can have a strong psychological impact. Consequently, the primary goals in the treatment of wounds are rapid wound closure with minimal appearance of scarring. Recent advances in cellular and molecular biology have greatly expanded our understanding of the biologic processes involved in wound repair and tissue regeneration and have led to improvements in wound care. Cutaneous wound healing differs between fetal and adult skin. Wound repair in adult skin begins with an acute inflammatory phase and ends with the formation of a permanent scar. In contrast, early gestation fetal wounds heal in a near perfect fashion, rapidly and without the production of a scar. Amongst several other targets, factors such as transforming growth factor-ss1 (TGF-ss1), and COX-2 are upregulated in adult tissue and show reduced expression in fetal skin. Using RNA interference (RNAi) to down regulate a target gene expression, we have previously demonstrated that a multi-targeted siRNA cocktail targeting these genes can accelerate wound repair in acute wounds when administered in Histidine Lysine Polymer (HKP) - a branched cationic peptide. The treatment also showed reduced scarring and a return to normal histology of the skin. While these observations suggest a new therapeutic based on this approach, the topical administration of this material may not allow penetration across the tissue in the wound as reepithelialization occurs. The healing process itself may prevent further access of the siRNAs to the site of action within the wound bed. Chitosan - a cationicpolysaccharide - has also been used in wound treatments and can also carry siRNAs. In this proposal Aim 1 seeks to examine whether chitosan and HKP can be modified with transdermal peptides while maintaining their siRNA carrying capability. Aim 2 will evaluate the best carrier from Aim 1 to see if it can increase the degree of penetration of the siRNA formulation through the skin. Upon identification of the optimal delivery vehicle (which may be unmodified), Aim 3 will evaluate the multi- targeted siRNA cocktail formulation in young versus elderly mice in animal models of wound healing. We will further examine the cocktail for efficacy in healing wounds in young and elderly diabetic mice. Demonstration of improved rate of wound repair in these models will bethe first step towards migration of this therapy to the clinic to treat patients with similar conditions. Such a therapy may significantly improve wound healing in the elderly, reduce the complications from diabetes, burns or combat casualties and may help reduce the numbers of amputations that are performed on diabetic patients. PUBLIC HEALTH RELEVANCE: Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing The primary function of the skin is to serve as a protective barrier against the environment. Loss of the integrity of large portions of the skin as a result of wounds and wound-related infection may lead to major disability or even death. Every year in the United States more than 1.25 million people suffer burns and 6.5 million havechronic skin ulcers caused by diabetes and other diseases. As many as 15% of patients with diabetes will suffer from a diabetic foot ulcer and, of these patients, 6% will be hospitalized due to infection or other ulcer-related complications. Furthermore,diabetes is the leading cause of nontraumatic amputations of lower extremities in the United States, and approximately 14-24 % of patients with diabetes who develop a foot ulcer will have an amputation. Wounds in the elderly are also slower to heal and theproblem is especially compounded in elderly diabetics. In addition, many traumatic wounds are incurred through accidents or from combat casualties and there is a need for an accelerated wound repair treatment which diminishes scar formation in patients who undergo invasive or cosmetic surgery. Consequently, wounds in the elderly, from traumatic injury, burns or diabetes pose an increased burden to the healthcare system and there is an immediate need for improved treatment options that promote and accelerate wound healing while minimizing or inhibiting the risk from infection during the healing process. We have previously determined that delivery of two siRNAs silencing two gene targets in parallel to a wound (using a cationic peptide (HKP)) markedly improves the rate of wound closure and also reduced scarring in both mouse and pig excisional wound models. This project will seek to improve upon this observation by developing novel topical delivery vehicles that can further penetrate across the tissue within awound. We will examine whether deeper siRNA delivery across a wound correlates with improved wound healing rate and further reduces scar formation in elderly animals and diabetic animal models. The outcome of this project will be the initial characterization of a valuable therapeutic option for treatment of patients with various types of skin wounds.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 269.30K | Year: 2010

DESCRIPTION (provided by applicant): Glioblastoma Multiforme (GBM), the most common brain cancer of adults, is among the most aggressive and deadly of neoplasm (WHO grade IV), and is accounted for more than 21% of all primary brain and CNS tumors. The annual incidence of GBM in the United States is 3.01 per 100,000 and is an incurable cancer with a median survival of approximately 12 months from diagnosis. Despite decades of intensive surgical treatment, chemotherapy, radiotherapy, and tremendous basic science and clinical research focused on combating this disease, the prognosis remains virtually unchanged, with survival rates still measured in months. The current genetic understanding of GBM has led to the identification of crucial intracellular molecules and their associated signaling pathways as potential therapeutic targets. We are taking the advantage of RNA interference (RNAi) technology for development of the targeted therapeutics. Three small interfering RNA (siRNA) cocktails targeting EGFR-VEGF-AGT, or EGFR-VEGF-MMP9, or EGFR-VEGF-TGF respectively, will be packaged with Histidine and Lysine polymer (HKP) and Saposin C DOPS liposome nanoparticles for treatment of GBM. The antitumor efficacy of these siRNA nanoparticle drugs will be evaluated with human glioma cell lines U87 and murine glioma cells SMA-560 cell tumor models. We will also characterize the HKP and SapC-DOPS nanoparticle systems with the most potent siRNA cocktail and selected a nanoparticle-siRNA cocktail formulation for GBM treatment with the favorable efficacy and safety profile. Lastly, we will evaluate combined regimen of the siRNA cocktail A with TMZ, or cocktail B and C with Avastin, using the U87 and SMA-560 cell tumor models, with the best nanoparticle delivery formulation. A novel therapeutic protocol will be ready for further preclinical study to support a Phase II grant application. PUBLIC HEALTH RELEVANCE: Glioblastoma Multiforme (GBM), the most common brain cancer of adults, is among the most aggressive and deadly of neoplasm (WHO grade IV), and is accounted for more than 21% of all primary brain and CNS tumors. The annual incidence of GBM in the United States is 3.01 per 100,000 and is an incurable cancer with a median survival of approximately 12 months from diagnosis. Despite decades of intensive surgical treatment, chemotherapy, radiotherapy, and tremendous basic science and clinical research focused on combating this disease, the prognosis remains virtually unchanged. We are proposing here to take the advantage of RNA interference (RNAi) technology for development of a novel targeted therapeutic with three small interfering RNA (siRNA) cocktails targeting EGFR-VEGF-AGT, or EGFR-VEGF-MMP9, or EGFR-VEGF-TGF respectively. Two nanoparticle systems, HKP and SapC-DOPS, will be applied with the most potent siRNA cocktail and in combination with the small molecule antagonist drug (TMZ) and monoclonal antibody drug (Avastin) for their antitumor efficacy using both xenograft (U87 cell) and syngeneic (SMA-560 cell) mouse tumor models.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 234.39K | Year: 2010

DESCRIPTION (provided by applicant): Each year 10-20% of the US population is infected by the influenza virus, resulting in up to 40,000 deaths and 200,000 hospitalizations. While small molecules and vaccines have shown some benefit, the ability of the virus to mutate rapidly allows escape from such therapeutic pressure and drug-resistant forms are emerging. Furthermore, vaccine development is a prolonged process taking up to a year to identify a suitable formulation and the ability to supply sufficient material for vaccination of a large population faced with a pandemic can take even longer. Stockpiling such vaccines is one way to ensure sufficient supply but incurs huge costs and many such stockpiles expire before needed and have to be discarded. SiRNAs utilize an endogenous mechanism in mammalian cells to induce sequence and target-specific silencing of viral genes and prevent viral replication with a reduction in viral load that can have therapeutic benefits. The major challenge to utilization of siRNAs in a therapeutic or prophylactic approach is the ability to deliver these reagents to the tissues and cells within a patient where the virus causes its effects. This proposal seeks to use nanoparticle delivery of siRNAs able to specifically induce silencing of essential genes needed by the virus for survival and validate the ability to treat influenza in animals as a first step towards therapeutic development for treatment in Man. SiRNAs can be specifically designed in silico to reduce expression of viral gene targets while having no homology for host genes and therefore limited toxicity. SiRNAs can limit viral replication rates in vitro and results demonstrating efficacy of delivery in vivo against other viruses such as SARS corona virus have been published by members of our team. The ability to rapidly design and synthesize siRNAs against any gene, their stability for storage, ease of formulation, and the ability to deliver siRNAs against more than one viral target in the same vehicle make these agents valuable in initial defense against life-threatening pandemics. However, a barrier for their use in flu is the validation of a vehicle that can deliver siRNAs to the appropriate site(s) needed for therapeutic benefit. In early flu symptoms this target would be the lungs while systemic delivery will be required for later stages. Sirnaomics addresses these issues through proprietary nanoparticle delivery technologies that we have successfully used to demonstrate effective siRNA delivery and gene silencing through respiratory as well as systemic routes. This proposal seeks to use these vehicles in in vivo infection models to simultaneously deliver multiple siRNAs against key viral targets to increase efficacy while reducing opportunity for viral escape through mutation. The outcome form this work will be the identification of a novel therapeutic strategy for treatment of influenza. Future work will then allow migration of this cocktail through all the steps necessary to confirm its utility as a therapeutic in treating either seasonal flu or a pandemic. PUBLIC HEALTH RELEVANCE: Each year 10-20% of the US population is infected by the influenza virus, resulting in up to 40,000 deaths and 200,000 hospitalizations. While small molecules and vaccines have shown some benefit, the ability of the virus to mutate rapidly allows escape from such therapeutic pressure and drug-resistant forms are emerging. Furthermore, vaccine development is a prolonged process taking up to a year to identify a suitable formulation and the ability to supply sufficient material for vaccination of a large population faced with a pandemic can take even longer. Stockpiling such vaccines is one way to ensure sufficient supply but incurs huge costs and many such stockpiles expire before needed and have to be discarded. We propose to design siRNAs specifically able to silence viral genes essential for viral replication and use nanoparticle delivery of these siRNAs to validate the ability to treat influenza in animal models as a first step towards therapeutic development in Man. The ability to rapidly design and synthesize siRNAs against any gene, their stability for storage, ease of formulation, and the ability to deliver siRNAs against more than one viral target in the same vehicle make these agents valuable in initial defense against life-threatening pandemics and limits the ability for the virus to escape therapeutic pressure by mutation.


Trademark
Sirnaomics | Date: 2010-01-21

Pharmaceutical preparations for wounds.


The present invention relates to compositions and methods for development of resistance-proof siRNA therapeutics for prevention and treatment of influenza viral infections. The compositions include a pharmaceutical composition comprising siRNA molecules that target conserved regions of an influenza virus gene and a pharmaceutically acceptable polymeric carrier. In one embodiment, the polymeric carrier condenses the molecules to form a nanoparticle.


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