Time filter

Source Type

PubMed | Sir Parshurambhau College
Type: | Journal: European journal of medicinal chemistry | Year: 2015

This article emphasizes on the importance of benzofuran as a biologically relevant heterocycle. It covers most of the physiologically as well as medicinally important compounds containing benzofuran rings. This article also covers clinically approved drugs containing benzofuran scaffold.


Ghayal N.A.,Abasaheb Garware College | Dhumal K.N.,University of Pune | Deshpande N.R.,Sir Parshurambhau College | Ruikar A.D.,Sir Parshurambhau College | Phalgune U.D.,CSIR - National Chemical Laboratory
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Cassia uniflora Mill. Non Spreng. a dominant invasive weed from Ganeshkhind area has affected the phytodiversity of Pune University campus (M.S., India). Its leaf leachates inhibited seed germination and seedling growth in test crops like tomato and brinjal at all the concentrations indicating their phytotoxic nature. However, maximum inhibition was recorded at higher concentrations (17.5 - 20%). The allelopathic leaf leachates had also adversely influenced the seedling physiology in both the vegetables. Hence to investigate its phytotoxic nature, isolation and characterization of allelochemicals in it, was undertaken. The leaf samples of Cassia showed the presence of a branched chain saturated aliphatic ester (C 16H 32O 2) which is Dodecane-4yl-butyrate.


Pawar N.R.,Nowrosjee Wadia College | Katikar A.H.,Sir Parshurambhau College | Vaddadi S.,Geological Survey of India | Shinde S.H.,Tilak Maharashtra Vidyapeeth | And 3 more authors.
International Journal of Speleology | Year: 2016

Lava tubes and channels forming lava distributaries have been recognized from different parts of western Deccan Volcanic Province (DVP). Openings of smaller dimension have been documented from the pāhoehoe flows around Pune, in the western DVP. A small lava cave is exposed in Ghoradeshwar hill, near Pune. Detailed field studies of the physical characteristics, structure and morphology of the flows hosting the lava tube has been carried out. This is the first detailed documentation of a lava cave from the DVP. The lava cave occurs in a compound pāhoehoe flow of Karla Formation, characterized by the presence of lobes, toes and small scale features like squeeze-ups. Field observations and measurements reveal that the dimensions of the cave are small, with low roof and a maximum width of 108 cm. The cave morphology along the 20 m passage varies from circular to semi-circular, with a twilight zone to the north. The gentle micro-topography at Ghoradeshwar controlled the advancement of pāhoehoe lobes and toes within the sheet lobe. The pre-flow gradients towards the north led to the progression of flow from the east, where the cave opening is presently seen. Dimensions and related morphology of the lava cave suggest that it can be best described as a small sub-crustal cave formed by draining of an inflated pāhoehoe lava lobe. At Ghoradeshwar, besides the natural lava cave, Buddhist caves carved in pāhoehoe lava flows are also observed, indicating that early man took advantage of the existing openings in pāhoehoe flows and sculpted the caves to suit their requirements. © 2016 Societa Speleologica Italiana. All rights reserved.


Shelke S.H.,P.A. College | Mhaske P.C.,Sir Parshurambhau College | Nandave M.,Narsee Monjee Institute of Management and Higher Studies | Narkhade S.,Narsee Monjee Institute of Management and Higher Studies | And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

A new series of 3-aryl-2-(2-aryl/benzyl-4-methylthiazole-5-yl)thiazolidin- 4-one was synthesized by condensation of 2-aryl/benzyl-4-methylthiazole-5- carbaldehyde, aromatic amines and thioglycolic acid in toluene. All the synthesized compounds are characterized by IR, NMR and elemental or mass analysis. Sixteen out of the newly synthesized compounds were screened for in vivo anti-inflammatory activity using carrageenan-induced rat paw edema method. Some of the synthesized compounds exhibited good anti-inflammatory activity compared with indomethacin. The synthesized compounds were also evaluated for their in vitro antimicrobial activity. Some of the compounds showed mild antibacterial activity while most of the compounds showed good antifungal activity. © 2012 Elsevier Ltd. All rights reserved.


Shelkea S.H.,P.A. College | Mhaskeh P.C.,Sir Parshurambhau College | Bobade V.D.,P.A. College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2012

The synthesis of (±)-pregabalin has been accomplished by oxidation and reduction of 2-benzyl-4-methyl pentanenitrile. The synthetic strategy involves ruthenium chloride catalyzed oxidation of the phenyl ring into carboxylic acid and reduction of nitrile into amine using sodium borohydride and nickel chloride. The approach delineated here is notable for its simplicity and efficient synthesis.


Shelke S.H.,P.A. College | Mhaske P.C.,Sir Parshurambhau College | Kasam S.K.,Sir Parshurambhau College | Bobade V.D.,P.A. College
Journal of Heterocyclic Chemistry | Year: 2014

In the present investigation, a novel series of 2-[(2-arylthiazol-4-yl)methyl]-5-(alkyl/alkylnitrile thio)-1,3,4-oxadiazole derivatives were synthesized by cyclo-condensation of 2-(2-substituted thiazol-4-yl)aceto hydrazide with carbon disulfide followed by S-alkylation with alkyl halide in dry acetone. All the newly synthesized compounds were characterized by spectral (IR, 1H NMR, 13C NMR, mass, and elemental analysis) methods. The title compounds were screened for in vitro antifungal activity and most of the synthesized compounds show moderate to good antifungal activity. © 2014 HeteroCorporation.


Datar S.P.,Sir Parshurambhau College | Bhonde R.R.,Manipal University India
Review of Diabetic Studies | Year: 2011

Animal models have been used extensively in diabetes research. Studies on animal models have contributed to the discovery and purification of insulin, development of new therapeutic approaches, and progress in fundamental and clinical research. However, conventional rodent and large animal mammalian models face ethical, practical, or technical limitations. Therefore, it would be beneficial developing an alternative model for diabetes research which would overcome these limitations. Amongst other vertebrates, birds are phylogenically closer to mammals, and amongst birds, the chick has been used as one of the favored models in developmental biology, toxicology, cancer research, immunology, and drug testing. Chicken eggs are readily available, have a short incubation period and easily accessible embryos. Based on these inimitable advantages, the present review article aims to discuss the suitability of the chick as a model system to study specific aspects of diabetes. The review focuses on the application of i) chick pancreatic islets for screening of antidiabetic agents and for islet banking, (ii) shell-less chick embryo culture as a model to study hyperglycemia- induced malformations observed in mammalian embryos, and (iii) chick chorioallantoic membrane (CAM) to examine glucose-induced endothelial damage leading to inhibition of angiogenesis. © by Lab & Life Press/SBDR.


Raundal H.N.,P.A. College | Jadhav R.P.,P.A. College | Patil A.A.,P.A. College | Mhaske P.C.,Sir Parshurambhau College | Bobade V.D.,P.A. College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2015

A series of S-alkyl isothiosemicarbazone derivatives of 2,4,6-trisubstituted pyrimidine have been synthesized. All the synthesized compounds are characterized by IR, NMR and mass spectrometry. Most of the synthesized compounds show significant antibacterial and antifungal activity against the tested microorganisms. © 2015, Scientific Publishers. All rights reserved.


Shelke S.H.,P.A. College | Mhaske P.C.,Sir Parshurambhau College | Hande P.,Sir Parshurambhau College | Bobade V.D.,P.A. College
Phosphorus, Sulfur and Silicon and the Related Elements | Year: 2013

A novel series of 1-((4-methyl-2-substituted thiazol-5-yl)methyleneamino)- 2-substituted isothiourea derivatives was synthesized by alkylation of (Z/E)-1-((4-methyl-2-substituted thiazol-5-yl)methylene)thiosemicarbazide with alkylhalide in acetone. All the newly synthesized compounds were characterized by spectral (IR, 1H NMR, 13C NMR, and mass spectrometry) methods. The newly synthesized compounds were screened for in vitro antimicrobial activity. Most of the compounds show moderate to excellent antimicrobial activity. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures and tables.] © 2013 Copyright Taylor and Francis Group, LLC.


PubMed | Sir Parshurambhau College
Type: Journal Article | Journal: The review of diabetic studies : RDS | Year: 2011

Animal models have been used extensively in diabetes research. Studies on animal models have contributed to the discovery and purification of insulin, development of new therapeutic approaches, and progress in fundamental and clinical research. However, conventional rodent and large animal mammalian models face ethical, practical, or technical limitations. Therefore, it would be beneficial developing an alternative model for diabetes research which would overcome these limitations. Amongst other vertebrates, birds are phylogenically closer to mammals, and amongst birds, the chick has been used as one of the favored models in developmental biology, toxicology, cancer research, immunology, and drug testing. Chicken eggs are readily available, have a short incubation period and easily accessible embryos. Based on these inimitable advantages, the present review article aims to discuss the suitability of the chick as a model system to study specific aspects of diabetes. The review focuses on the application of i) chick pancreatic islets for screening of antidiabetic agents and for islet banking, (ii) shell-less chick embryo culture as a model to study hyperglycemia-induced malformations observed in mammalian embryos, and (iii) chick chorioallantoic membrane (CAM) to examine glucose-induced endothelial damage leading to inhibition of angiogenesis.

Loading Sir Parshurambhau College collaborators
Loading Sir Parshurambhau College collaborators