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Shelkea S.H.,P.A. College | Mhaskeh P.C.,Sir Parshurambhau College | Bobade V.D.,P.A. College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2012

The synthesis of (±)-pregabalin has been accomplished by oxidation and reduction of 2-benzyl-4-methyl pentanenitrile. The synthetic strategy involves ruthenium chloride catalyzed oxidation of the phenyl ring into carboxylic acid and reduction of nitrile into amine using sodium borohydride and nickel chloride. The approach delineated here is notable for its simplicity and efficient synthesis.

Shelke S.H.,P.A. College | Mhaske P.C.,Sir Parshurambhau College | Narkhade S.,Narsee Monjee Institute of Management and Higher Studies | Bobade V.D.,P.A. College
Journal of Heterocyclic Chemistry | Year: 2014

In the present investigation, a novel series of 3-(4-(2-substituted thiazol-4-yl)phenyl)-2-(4-methyl-2-substituted thiazol-5-yl)thiazolidin-4-one derivatives were synthesized by condensation of 2-substituted-4-methylthiazole- 5-carbaldehyde with 4-(2-substituted thiazol-4-yl)benzenamine followed by cyclo-condensation with thioglycolic acid in toluene. All the newly synthesized compounds were characterized by spectral (IR, 1H NMR, 13C NMR, and Mass) methods. The title compounds were screened for quantitative antibacterial activity (minimal inhibitory concentration). All compounds 7a-h and 8a-h show moderate to good antimicrobial activity, whereas compounds (7a-h) also show moderate antifungal activity. © 2013 HeteroCorporation.

Datar S.P.,Sir Parshurambhau College | Bhonde R.R.,Manipal University India
Review of Diabetic Studies | Year: 2011

Animal models have been used extensively in diabetes research. Studies on animal models have contributed to the discovery and purification of insulin, development of new therapeutic approaches, and progress in fundamental and clinical research. However, conventional rodent and large animal mammalian models face ethical, practical, or technical limitations. Therefore, it would be beneficial developing an alternative model for diabetes research which would overcome these limitations. Amongst other vertebrates, birds are phylogenically closer to mammals, and amongst birds, the chick has been used as one of the favored models in developmental biology, toxicology, cancer research, immunology, and drug testing. Chicken eggs are readily available, have a short incubation period and easily accessible embryos. Based on these inimitable advantages, the present review article aims to discuss the suitability of the chick as a model system to study specific aspects of diabetes. The review focuses on the application of i) chick pancreatic islets for screening of antidiabetic agents and for islet banking, (ii) shell-less chick embryo culture as a model to study hyperglycemia- induced malformations observed in mammalian embryos, and (iii) chick chorioallantoic membrane (CAM) to examine glucose-induced endothelial damage leading to inhibition of angiogenesis. © by Lab & Life Press/SBDR.

Raundal H.N.,P.A. College | Jadhav R.P.,P.A. College | Patil A.A.,P.A. College | Mhaske P.C.,Sir Parshurambhau College | Bobade V.D.,P.A. College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2015

A series of S-alkyl isothiosemicarbazone derivatives of 2,4,6-trisubstituted pyrimidine have been synthesized. All the synthesized compounds are characterized by IR, NMR and mass spectrometry. Most of the synthesized compounds show significant antibacterial and antifungal activity against the tested microorganisms. © 2015, Scientific Publishers. All rights reserved.

Ghayal N.A.,Abasaheb Garware College | Dhumal K.N.,University of Pune | Deshpande N.R.,Sir Parshurambhau College | Ruikar A.D.,Sir Parshurambhau College | Phalgune U.D.,CSIR - National Chemical Laboratory
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Cassia uniflora Mill. Non Spreng. a dominant invasive weed from Ganeshkhind area has affected the phytodiversity of Pune University campus (M.S., India). Its leaf leachates inhibited seed germination and seedling growth in test crops like tomato and brinjal at all the concentrations indicating their phytotoxic nature. However, maximum inhibition was recorded at higher concentrations (17.5 - 20%). The allelopathic leaf leachates had also adversely influenced the seedling physiology in both the vegetables. Hence to investigate its phytotoxic nature, isolation and characterization of allelochemicals in it, was undertaken. The leaf samples of Cassia showed the presence of a branched chain saturated aliphatic ester (C 16H 32O 2) which is Dodecane-4yl-butyrate.

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