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Mujawar S.A.,Sir Jj Group Of Government Hospitals | Patil V.W.,Sir Jj Group Of Government Hospitals | Daver R.G.,Sir Jj Group Of Government Hospitals
Biomedical Research | Year: 2010

Stressful experiences include major life events, trauma, and abuse and are sometimes related to the environment in the home, workplace, or neighborhood. Acute stress and chronic can both have long-term consequences. Therefore, this study was carried out to investigate cortisol, total testosterone and total homocysteine (tHcy) status in acute myocardial infarction (AMI). Thirty AMI patients were included and diagnosed based on clinical examination, laboratory investigations, electrocardiogram, angiography and other tests. The blood samples were analyzed for cortisol, total testosterone and tHcy. Significantly increased levels of serum cortisol and tHcy, and decreased level of total testosterone were noticed in the pa-tients group as compared to control subjects. Whereas, we found positive and significant correlation between cortisol: testosterone (C/T) ratio and tHcy, and mean blood pressure in AMI patients. This study suggests that, some methods require which reduces the C/T ratio and homocysteine levels may reduce the risk of AMI. Source


Mujawar S.A.,Sir Jj Group Of Government Hospitals | Patil V.W.,Sir Jj Group Of Government Hospitals | Daver R.G.,Sir Jj Group Of Government Hospitals
Indian Journal of Clinical Biochemistry | Year: 2011

The present study was carried out to evaluate the occurrence of association between homocysteine, folic acid and vitamin B12 in patients with preeclampsia. Fifty preeclamptic patients from gynecology ward were studied for estimation of serum homocysteine, folic acid and vitamin B12 over a period of October 2007 to June 2010. Serum homocysteine and folic acid, and vitamin B12 were determined by means of Immulite 1000 analyzer. The statistical analysis of study group of preeclampsia compared with normotensive control group, showed significant alterations in serum homocysteine, folic acid and vitamin B12 concentrations in preeclampsia. Inverse association between serum homocysteine and folic acid, and vitamin B12 levels were observed in preeclampsia. The present study found hyperhomocysteinemia and deficiency of folic acid and vitamin B12 along with increased blood pressure as a risk factor for cardiovascular disease (CVD) in preeclampsia. © 2011 Association of Clinical Biochemists of India. Source

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