Central Hospital of Siping

Siping, China

Central Hospital of Siping

Siping, China
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Jin M.H.,Jilin University | Song P.L.,Central Hospital of Siping | Li N.,Jilin Provincial Peoples Hospital | Li X.J.,Jilin University | Chen J.J.,Jilin University
Neural Regeneration Research | Year: 2012

Dibutyltin dilaurate functions as a stabilizer for polyvinyl chloride. In this study, experimental rats were intragastrically administered 5, 10, or 20 mg/kg dibutyltin dilaurate to model sub-chronic poisoning. After exposure, our results showed the activities of superoxide dismutase and glutathione peroxidase decreased in rat brain tissue, while the malondialdehyde and nitric oxide content, as well as nitric oxide synthase activity in rat brain tissue increased. The cell cycle in the right parietal cortex was disordered and the rate of apoptosis increased. DNA damage was aggravated in the cerebral cortex, and the ultrastructure of the right parietal cortex tissues was altered. The above changes became more apparent with exposure to increasing doses of dibutyltin dilaurate. Our experimental findings confirmed the neurotoxicity of dibutyltin dilaurate in rat brain tissues, and demonstrated that the poisoning was dose-dependent. © 2012, Editorial Board of Neural Regeneration Research. All rights reserved.


Rong G.,Huazheng Eye Hospital of Siping | Sun L.,Huazheng Eye Hospital of Siping | Xu M.-J.,Huazheng Eye Hospital of Siping | Sun M.O.,Central Hospital of Siping
International Journal of Ophthalmology | Year: 2010

AIM: To discuss the effect of laser photocoagulation combined with intravitreous injection in the treatment of diabetic retinopathy (DR) with macular edema(ME). METHODS:Patients who suffered DR(over I) with ME received laser photocoagulation treatment In the whole retina with 532 wave length semiconductor laser instrument. Patients received intravitreous injection of triamcinolone acetonide in a week after operation. RESULTS: After treatment, the eyesight of 218 eyes was improved or non-decreased in total 241 eyes, accounting for 90. 5%. The amount of eyes whose eyesight was decreased was 23, accounting for 9. 5%. Clinical effect was significant. CONCLUSION: Laser photocoagulation combined with intravitreous injection is safe and effective in the treatment of DR with ME.

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