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Amsterdam-Zuidoost, Netherlands

Vrouenraets B.C.,Sint Lucas Andreas Hospital
International Journal of Colorectal Disease | Year: 2012

Purpose The exact pathogenesis of diverticular disease of the sigmoid colon is not well established. However, the hypothesis that a low-fibre diet may result in diverticulosis and a high-fibre diet will prevent symptoms or complications of diverticular disease is widely accepted. The aim of this review is to assess whether a high-fibre diet can improve symptoms and/or prevent complications of diverticular disease of the sigmoid colon and/or prevent recurrent diverticulitis after a primary episode. Methods Clinical studies were eligible for inclusion if they assessed the treatment of diverticular disease or the prevention of recurrent diverticulitis with a high-fibre diet. The following exclusion criteria were used for study selection: studies without comparison of the patient group with a control group. Results No studies concerning prevention of recurrent diver-ticulitis with a high-fibre diet met our inclusion criteria. Three randomised controlled trials (RCT) and one case-control study were included in this systematic review. One RCT of moderate quality showed no difference in the primary endpoints. A second RCT of moderate quality and the case- control study found a significant difference in favour of a high-fibre diet in the treatment of symptomatic diverticular disease. The third RCTof moderate quality found a significant difference in favour of methylcellulose (fibre supplement). This study also showed a placebo effect. Conclusion High-quality evidence for a high-fibre diet in the treatment of diverticular disease is lacking, and most recommendations are based on inconsistent level 2 and mostly level 3 evidence. Nevertheless, high-fibre diet is still recommended in several guidelines. © 2011 CARS. Source

Bouwmans A.E.P.,Maastricht University | Vlaar A.M.M.,Sint Lucas Andreas Hospital | Mess W.H.,Maastricht University | Kessels A.,Maastricht University | Weber W.E.J.,Maastricht University
BMJ Open | Year: 2013

Objective: Numerous ultrasound studies have suggested that a typical enlarged area of echogenicity in the substantia nigra (SN+) can help diagnose idiopathic Parkinson's disease (IPD). Almost all these studies were retrospective and involved patients with well-established diagnoses and long-disease duration. In this study the diagnostic accuracy of transcranial sonography (TCS) of the substantia nigra in the patient with an undiagnosed parkinsonian syndrome of recent onset has been evaluated. Design: Prospective cohort study for diagnostic accuracy. Setting: Neurology outpatient clinics of two teaching hospitals in the Netherlands. Patients: 196 consecutive patients, who were referred to two neurology outpatient clinics for analysis of clinically unclear parkinsonism.Within 2 weeks of inclusion all patients also underwent a TCS and a 123I-ioflupane Single Photon Emission CT (FP-CIT SPECT) scan of the brain (n=176). Outcome measures: After 2 years, patients were re-examined by two movement disorder specialist neurologists for a final clinical diagnosis, that served as a surrogate gold standard for our study. Results: Temporal acoustic windows were insufficient in 45 of 241 patients (18.67%). The final clinical diagnosis was IPD in 102 (52.0%) patients. Twenty-four (12.3%) patients were diagnosed with atypical parkinsonisms (APS) of which 8 (4.0%) multisystem atrophy (MSA), 6 (3.1%) progressive supranuclear palsy (PSP), 6 (3.1%) Lewy body dementia and 4 (2%) corticobasal degeneration. Twenty-one (10.7%) patients had a diagnosis of vascular parkinsonism, 20 (10.2%) essential tremor, 7 (3.6%) drug-induced parkinsonism and 22 (11.2%) patients had no parkinsonism but an alternative diagnosis. The sensitivity of a SN+ for the diagnosis IPD was 0.40 (CI 0.30 to 0.50) and the specificity 0.61 (CI 0.52 to 0.70). Hereby the positive predictive value (PPV) was 0.53 and the negative predictive value (NPV) 0.48. The sensitivity and specificity of FP-CIT SPECT scans for diagnosing IPD was 0.88 (CI 0.1 to 0.95) and 0.68 (CI 0.58 to 0.76) with a PPV of 0.75 and an NPV of 0.84. Conclusions: The diagnostic accuracy of TCS in early stage Parkinson's disease is not sufficient for routine clinical use. Source

Prins M.C.,Sint Lucas Andreas Hospital | van Meijel J.J.,Sint Lucas Andreas Hospital
Netherlands Journal of Medicine | Year: 2011

A patient with valproic acid induced hyperammonaemic encephalopathy is presented. During chronic treatment with valproic acid this patient developed a potentially life-threatening encephalopathy without signs of liver failure. After discontinuing the valproic acid the patient recovered completely. In the case of a patient presenting with hyperammonaemic encephalopathy, the possibility of the use of valproic acid should not be overlooked. © Van Zuiden Communications B.V. Source

Van Der Ende-Kastelijn K.,Sint Lucas Andreas Hospital | Oerlemans W.,Meander Medical Center | Goedegebuure S.,Sint Lucas Andreas Hospital
Headache | Year: 2012

Background.-Primary exertional headache (PEH) is a long-known phenomenon. Divergent prevalences of between 0.2 and 12.3% are reported among the general population. The aim of this study was to establish the prevalence among an athletic population. Method.-A link to an online questionnaire was sent to all participants of a tough cycling event held in The Netherlands. Results.-Four thousand participants filled out the questionnaire. One thousand eight hundred and ten (45%) stated that they had suffered, at least once in their lives, from exercise-related headaches (EHs). Thirty-seven percent (668) of them had those headaches at least once a month and 10% (174) experienced a weekly occurrence. The rate of female cyclists with a history of EHs was 54%. With an increasing age, a decline of EHs was found. Five hundred eighty-one (37%) of the participants used medication for EHs. Conclusions.-An estimation of the prevalence of PEHs among the studied population by comparison to the International Headache Society criteria resulted in a rate of 26%. The lower prevalence among older cyclists could be caused by avoidance of (high-intensity) exercise due to the burden that EH brings along. PEH appears to be quite common among an athletic population and merits further investigation. © 2012 American Headache Society. Source

Van Maanen J.P.,Sint Lucas Andreas Hospital | Witte B.I.,VU University Amsterdam | De Vries N.,Sint Lucas Andreas Hospital
Sleep and Breathing | Year: 2014

Purpose: The aims of this study are to evaluate the effect of palatal surgery (uvulopalatopharyngoplasty (UPPP) or Z-palatoplasty (ZPP)) with or without (+/-) concomitant radiofrequent ablation of the base of the tongue (RFTB) on body position-specific apnea-hypopnea index (AHI) values in patients with obstructive sleep apnea (OSA) and to compare this treatment outcome to the theoretical effect of (addition of) positional therapy (PT). Methods: Retrospective analysis of pre- and posttreatment polysomnographies in 139 patients who had undergone UPPP/ZPP +/- RFTB was performed. Hypothetical evaluation of the effects of (addition of) ideal PT on AHI in positional OSA (POSA) patients was carried out. Results: Median AHI significantly decreased from 18.0 to 11.2 (p<0.001). Median AHI in all separate positions decreased significantly as well. Sixty-eight patients suffered from POSA and showed a significant decrease in median AHI from 15.5 to 11.5 (p=0.002). In the 71 non-positional OSA (NPOSA) patients, the significant AHI decrease was more outspoken, from 23.0 to 11.0 (p<0.001). Our hypothetical model to treat POSA patients with an ideal PT (as monotherapy or in addition to surgery) resulted in a significant median AHI decrease from 18.0 to 4.5 (p<0.0001). Conclusions: UPPP/ZPP +/- RFTB significantly reduces AHI and all body position-specific AHI values. This reduction is significantly higher in NPOSA than in POSA patients. When considering UPPP/ZPP +/- RFTB, the effect of body position needs to be taken into account. PT, either as monotherapy or in addition to surgery, theoretically has shown to improve treatment results dramatically in POSA patients. Prospective, controlled trials focusing on the effects of this combination of treatments should further evaluate this hypothetical conclusion. © 2013 Springer-Verlag. Source

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